Yazar "Sakar M.N." seçeneğine göre listele

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    Comparison of the efficacy of letrozole and gonadotropin combination versus gonadotropin alone in intrauterine insemination cycles in patients with unexplained infertility
    (Yuzuncu Yil Universitesi Tip Fakultesi, 2020) Oğlak S.C.; Sakar M.N.; Ege S.; Otçu S.M.Ö.; Obut M.; Kahveci B.; Yıldız İ.
    This study aimed to determine the outcomes of combined treatment of letrozole (LTZ) with recombinant follicle-stimulating hormone (rFSH) in comparison with rFSH alone in intrauterine insemination (IUI) cycles. This study consisted of 86 patients who experienced 106 IUI cycles. Patients were classified into two treatment groups: group I underwent a combination of LTZ plus rFSH, and group II received rFSH alone. Ovulation was tr iggered with human chorionic gonadotropin (hCG), and IUI performed 36 hours later. The number of follicles ?18 mm, endometrial thickness, required dose of FSH, duration of ovulation induction (OI), clinical pregnancy rates, multiple pregnancy rates, spontaneous abortion rates, and live birth rates were evaluated. The total required rFSH dose during the OI was significantly lower in the LTZ-rFSH combination group than the rFSH alone group (401.2±177.1 IU and 770.1±345.8 IU, respectively, p<0.001). The days of stimulation with rFSH were also lower in the LTZ co-treatment group than the rFSH-alone group (5.2±1.3 days and 10.1±3.0 days, respectively, p<0.001). Clinical pregnancy rate was 17.0% in LTZ-rFSH group, and 15.2% in rFSH group (p>0.05). The combined use of LTZ with rFSH resulted in a lower required dose of rFSH, a similar and ac ceptable endometrial thickness at the day of hCG administration, and comparable pregnancy rate compared with rFSH alone. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
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    Distribution of gynecologic malignancies in an epidemiologic study from southeast of Turkey
    (2011) Sakar M.N.; Gul T.; Atay A.E.
    Retrospective evaluation of 105 patients with gynecologic malignancy. One hundred and five patients with gynecologic malignancies diagnosed at Obstetrics and Gynecology Clinics of Medical School, Dicle University, Diyarbakir, between 2001 and 2005 were analyzed retrospectively. Gynecologic malignancies were classified. Distribution of 105 patients with gynecologic malignancies were; cervical cancer 19.04%, endometrial cancer 21.90%, uterine sarcoma 10.47%, primary ovarian cancer 40.95%, metastatic ovarian cancer 5.71%, carcinoma of the fallopian tubes 0.95%, choriocarcinoma 0.95%. 17 of 20 (85%) patients with invasive cervical cancer were in stage?IIa. Endometrioid cancer was the predominant (86.95%) histologic type in 23 patients with endometrial cancer. Leiomyosarcoma was the most frequent (72.72%) histologic type in 11 patients with uterine sarcoma. 33 of 43 patients (76.74%) with ovarian cancer had epithelial type carcinoma. Six patients had metastatic ovarian cancer and 4 patients (66.66%) in this group had Krukenberg tumors (signet-ring cells), 1 patient had primary tubal adenocarcinoma and 1 patient had choriocarcinoma. Ovarian cancer was the most frequent gynecologic malignancy in our study.
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    The evaluation of paraoxonase 1 activity in patients with gestational diabetes
    (Acta Medica Mediterranea, 2013) Atay A.E.; Sakar M.N.; Culcu N.S.N.; Simsek H.; Akbas H.; Acar M.; Isik B.
    Material and methods: Sixty five patients with GDM and 66 healthy pregnants were enrolled. Paraoxonase activity, insulin levels, HOMA-IR, demographic features and anthropometric measurements were evaluated. Results: The mean paraoxonase activity was significantly diminished in patients with GDM (p:0,004). Insulin level and HOMA-IR were significantly higher in GDM patients (p:0,004 and p:0,001; respectively). The mean interval between present and previous pregnancy was significantly shorter in patients group (p:0,004). There was a significant correlation between PON1 activity and serum LDL, HDL levels and weight gained during pregnancy (p:0,001,p<0,001 and p:0,002; respectively) but not with weight and parity. However HOMA-IR was significantly correlated with weight and parity (p:0,001 and p:0,002; respectively). Discussion: Diminished PON1 activity and enhanced oxidative stress accompany to insulin resistance in the pathogenesis of GDM. Oxidative stress is associated with weight gained during first 2 trimesters of pregnancy rather than obesity.
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    Neurofibromatosis and pregnancy: Three case-reports
    (2007) Sakar M.N.; Gül T.
    Three pregnant women with neurofibromatosis were hospitalized due to hypertension and pain of labor were evaluated according to their obstetrical complications. The first case was diagnosed as preeclampsia and term pregnancy with contractions while the second as prior cesarean section and term pregnancy with contractions and the third as preterm labor and deep anemia. Immediate cesarean section was performed due to cephalopelvic disproportion in the first case and low height in the second case. Besides, the third case had normal vaginal delivery on the same day. No postpartum complications were developed in the first two cases whereas in the third case a decreas in hematocrit level and acute abdomen were seen on the third day of postpartum period. Retroperitoneal hematoma was observed in this patient who was immediately taken to surgery. Hypertension and hemiplegia were seen in the patient on the postoperative 11th day. Intrahemispheric hemorrhage was reported in cranial computerized tomography. There are several discussions on pregnancy and neurofibromatosis. It was reported, in the only large serial trial that neurofibromatosis does not increase the obstetrical complications; whereas there are also several case reports which demonstrate complications as hypertension, IUGR, stillbirth, spontaneous abortion, preterm labor are increased in pregnancies with neurofibromatosis. In one of the cases the pregnancy followed up without any complication. The existence of complications in the other two cases suggests that pregnancy of neurofibromatosis patients should be carefully followed up until the contradictions are entirely ended.
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    Neurofibromatosis and pregnancy: Three case-reports
    (2007) Sakar M.N.; Gül T.
    Three pregnant women with neurofibromatosis were hospitalized due to hypertension and pain of labor were evaluated according to their obstetrical complications. The first case was diagnosed as preeclampsia and term pregnancy with contractions while the second as prior cesarean section and term pregnancy with contractions and the third as preterm labor and deep anemia. Immediate cesarean section was performed due to cephalopelvic disproportion in the first case and low height in the second case. Besides, the third case had normal vaginal delivery on the same day. No postpartum complications were developed in the first two cases whereas in the third case a decreas in hematocrit level and acute abdomen were seen on the third day of postpartum period. Retroperitoneal hematoma was observed in this patient who was immediately taken to surgery. Hypertension and hemiplegia were seen in the patient on the postoperative 11th day. Intrahemispheric hemorrhage was reported in cranial computerized tomography. There are several discussions on pregnancy and neurofibromatosis. It was reported, in the only large serial trial tliat neurofibromatosis does not increase the obstetrical complications; whereas there are also several case reports which demonstrate complications as hypertension, IUGR, stillbirth, spontaneous abortion, preterm labor are increased in pregnancies with neurofibromatosis. In one of the cases the pregnancy followed up without any complication. The existence of complications in the other two cases suggests that pregnancy of neurofibromatosis patients should be carefully followed up until the contradictions are entirely ended.
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    Uterus didelphys with a pregnancy ruptured in the second trimester: A case report
    (2007) Sakar M.N.; Gül T.
    Uterus didelphys takes place in the Class III in the classification of Müllerian malformation according to American Society for Reproductive Medicine. The case with spontaneous pregnancy consulted with the complaints of abdominal pain developed in the second trimester, an ache in both shoulders and vomitting. Acute abdominal findings were observed in the examination. An eighteen week, two- day fetus with no cardiac activity in uterin cavity and common free fluid in abdomen was observed through ultrasonography. Free fluid was observed to be hemoragic in parasynthesis accompanied with ultrasonography. The patient was taken to an immediate surgery. The patient was observed to have uterus didelphys, and to have a rupture in hypoplasic hemiuterus where pregnancy occured. The patient's hypoplasic hemiuterus ruptured due to pregnancy was removed. The case with uterus didelphys whose pregnancy ended up in the second trimester has been presented with clinical findings.