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    Effects of gallic acid on ischemia-reperfusion induced testicular injury in a rat testicular torsion model
    (SCI Printers & Publication INC, 2021) Söğütçü, Nilgün; Yokuş, Beran
    OBJECTIVE: Testicular torsion is a common urological complication mostly affecting adolescents and young men. In this study we investigated biochemical and immunohistochemical effects of gallic acid on the damage induced by testicular torsion-detorsion. STUDY DESIGN: Forty male rats were divided into 4 groups of 10 animals each: control, torsion, torsion/detorsion, and torsion/detorsion + gallic acid. Testicles were removed from the scrotum, and 2.5-hour ischemia was applied to the left testis by twisting the spermatic cord 720 degrees clockwise. Then 3-hour reperfusion was allowed for detorsion. Gallic acid 20 mg/kg was orally administered to the torsion/detorsion + gallic acid group before reperfusion. Biochemical parameters of testicular tissue (MDA, SOD, CAT, and GSH levels) were measured. Testicular tissues were immune-stained with caspase-3 and TNF-alpha antibody. RESULTS: MDA levels in the torsion/detorsion + gallic acid group were close to those in the control group; however, it was higher in the torsion/detorsion group as compared to the control group. Compared to control group, SOD, CAT, and GSH activities were significantly increased in the torsion/detorsion + gallic acid group. However, those values were decreased in the torsion-detorsion group. Spermatogenic cells and interstitial cells showed positive caspase-3 expression in the torsion and torsion-detorsion groups; however, expression level was decreased in the torsion/detorsion + gallic acid group. TNF-alpha expression was observed in degenerated spermatogonia, Leydig cells, and macrophages in the torsion and torsion-detorsion groups. In the torsion/detorsion + gallic acid group, TNF-alpha expression was observed in some interstitial region rather than in cells of seminiferous tubules. CONCLUSION: Gallic acid treatment could be an alternative therapy in testicular ischemia-reperfusion injury to decrease inflammation, germ cell degeneration, and apoptosis.
  • Küçük Resim
    Öğe
    Güneydoğu Anadolu'daki Hodgkin Hastalığı'nın klinikopatolojik özellikleri
    (2016) Söğütçü, Nilgün; Yılmaz, Fahri
    Hodgkin hastalığı (HH), reaktif yangısal hücrelerden oluşan, fibrozisin eşlik ettiği bir zeminde neoplastik RS hücreleri ve diğer Hodgkin hücreleri ile karakterize malign lenfomadır. HH için geliştirilen Rye sınıflandırması uzun yıllar kullanılmıştır. Lenfomalar için önerilen son REAL ve WHO sınıflandırmaları HH'nı da kapsamaktadır. Bu çalışmadaki amacımız bölgemizdeki HH'nın klinikopatolojik özelliklerini incelemektir. Bu çalışmada, Dicle Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı'nda 1987- 2003 tarihleri arasında, HH tanısı alan 160 olgu, Rye ve WHO sınıflandırmasına göre yeniden incelenerek subtiplerine ayrıldı. Bu tiplerin yaş, cins, lokalizasyon, evre ve B semptomları gibi parametreler arasındaki ilişki araştırıldı. Olgularımızın 111'i (%69.4) erkek, 49'u (%30.6) kadın olup, erkek/kadın oranı 2.3/1 'idi. En çok olgu (%25.6) 2. dekatta izlendi ve olgularımızın 95 (%59.4)'i ilk üç dekattaydı. Olgularımızın 109 (%68.1)'unda servikal, 14 (%8.8)'ünde aksiller, 13 (%8.1 )'ünde abdominal, 9 (%5.6)'unda supraklavikuler, 9 (%5.6)'unda inguinal ve 6 (%3.7)'sında mediastinal lenf düğümleri tutulmuştu. Rye sınıflamasına göre; 160 olgumuzun 39 (%24.4)'u LZHH, 33 (%20.6)'ü NSHH, 62 (%38.8)"si MSHH ve 26 (%16.2)'sı LFHH idi. MSHH en sık, LFHH ise en az görülen histolojik alttiplerdi. WHO sınıflandırmasına göre olgularımızın -3 (%1.9)'ü NLPHH, 157 (%98.1)'si klasik tip HH idi. 32 olguya immunohistokimyasal boyama yapıldı. Dosyalarına ulaşılan 90 olgunun- 47'sinde B semptomları vardı ve NSHH, MSHH ile LFHH olguları daha ileri evrelerde saptandı. Sonuç olarak; gelişmiş batı ülkelerinin aksine, bulgularımız ülkemiz gibi sosyoekonomik yönden benzer ülkelerin bulguları ile uyumludur. Bununla birlikte, bölgemizde özellikle MSHH başta olmak üzere olgularımızın daha erken yaşlarda görüldüğü izlenmektedir. ¦ >¦ Anahtar kelimeler: Hogkin hastalığı, klasifikasyon, histolojik alttipler
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    Öğe
    The Importance of the Tumor Sidedness and Its Relationship with Other Clinicopathological Features in Patients with Colorectal Cancer
    (2021) Yerlikaya, Halis; Söğütçü, Nilgün; Yılmaz, Engin Deniz; Laçin, Sahin
    Aim: Colorectal cancer (CRC) is one of the most common and mortal diseases and prognostic factors have a crucial role in stratifying patients. We aimed to evaluate the importance of CDX2 expression, serum CEA level, and tumor sidedness in CRC patients. Material and Method: Patients diagnosed with colorectal cancer between September 2014 and December 2019 were included in the study. Serum CEA level, primary tumor bias, CDX2 expression and other demographic characteristics were recorded as variables. All study analyzes were performed using SPSS version 22 statistical software (IBM Corporation). Results: 152 patients with CRC were included, 64 (42.1%) of patients were female and 88 (57.9%) of patients were male, the median age of patients was 55 (range 18–93). The median survival of patients with serum CEA level <3.5ng/ml, and the patients with CEA level >3.5 ng/ml was 35.1 and 26.6 months, respectively, and the difference between groups was a statistically significant (p=0.006). There was a positive correlation between disease stage and serum CEA level, metastatic patients had higher serum CEA level than non-metastatic patients (p=0.009). In terms of tissue CDX2 expression, eleven patients (7.2%) had CDX2 expression negative, 136 (89.5%) of patients had CDX2 expression positive. The difference between OS rates of patients according to CDX2 expression status was not significant (p=0.7). Despite the longer survival of patients with left-sided than right-sided, the difference was not significant, the median OS was 67.6 and 29.7 months, respectively (p=0.3). The median follow-up time was 24.1 months. Conclusion: The serum CEA level was found as a clear prognostic factor for CRC patients. Additionally, CDX2 expression positive and left-sided primary tumors had longer survival as reported in the literature. Also, our patient stratification model based on tumor sidedness and serum CEA level obtained promising outcomes but need to be confirmed by larger and prospective trials.
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    Öğe
    Nadir bir periorbital kitle lezyonu: Pilomatriksoma
    (Gazi Göz Vakfı, 2012) Evşen, Sina; Söğütçü, Nilgün; Arı, Şehmus
    Öz:Atmış yedi yaşında erkek hasta göz polikliniğimize sağ kaş bölgesinde üç aydan beri giderek büyüyen kitle şikayeti ile baş vurdu. Sağ kaş medialinde 15x10x4 mm boyutlarında kırmızı mor renkli, yüzeyi pürüzlü, ağrısız, hareketli kitle mevcuttu. Kitle üst göz kapağına doğru büyümüştü. Klinik muayenede malign bir cilt lezyonundan şüphelenilen hastaya eksizyonel biyopsi uygulandı. Histopatolojik incelemede pilomatriksoma tanısı kondu. Pilomatriksoma genellikle çocukluk çağında periorbital bölgede izlenen nadir bir tümördür. Ancak 50-65 yaşları arasında da görülebilmektedir. Özellikle bu yaşlarda periorbital bölgede izlenen ve malignite düşündüren kitle lezyonlarında pilomatriksoma klinik olarak ayırıcı tanıda akla gelmelidir.
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    Öğe
    Spontaneous Uterine Rupture at The 13th Weeks of Gestation Caused by Placenta Percreata: A Case Report
    (2020) Söğütçü, Nilgün; Şeker, Erdal; Elçi, Evindar
    To describe the management of a ruptured uterus caused by placenta percreta at the 13th week of gestation. Spontaneous rupture of the nonlaboringuterus is a relatively rare occurrence in obstetrics. It is associated with massive intra-peritoneal bleeding which can be mortal if notrecognized.A 33-year-old patient presented with severe abdominal pain at the 13th week of gestation at the emergency service of Health Sciences UniversityGazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey. The patient’s ultrasonography revealed free fluid in the abdomen, placenta previaand anomaly in the fetus.Magnetic resonance imaging (MRI) was performed for differential diagnosis of free fluid. MRI showed hematoma between the bladder and uterus.After the signs of hypovolemic shock developed, we performed an immediate laparotomy and a ruptured uterus was detected. The fetus wasremoved and a hysterectomy was performed. Pathology results showed placenta percreta. After a few days in hospital and transfusion of 5 liters ofblood, the patient was discharged in a healthy condition.In a pregnant woman with severe abdominal pain, even in the 13th week of gestation, a placenta acreta has to be considered as a differentialdiagnosis. If there is no benefit of the other treatments, hysterectomy is a life-saving intervention.