Yazar "Polat, N." seçeneğine göre listele

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    Association between the neutrophil to lymphocyte ratio and prehypertension
    (Aepress Sro, 2015) Aydin, M.; Yuksel, M.; Yildiz, A.; Polat, N.; Bilik, M. Z.; Akil, M. A.; Acet, H.
    OBJECTIVES: To explore the neutrophil-lymphocyte ratio (NLR) in patients with prehypertension (PHT). BACKGROUND: Inflammation plays an important role in the development of cardiovascular diseases. A pathophysiological link also exists between inflammation and PHT. NLR is a simple marker for the assessment of inflammatory status. There is a lack of data regarding the association between NLR and pre-hypertensive state. METHODS: The present cross-sectional study included 33 newly diagnosed PHT patients and 35 normotensive control subjects. Prehypertension was defined as a systolic blood pressure (BP) of 120-139 mm Hg and/or a diastolic BP of 80-89 mm Hg. RESULTS: Patients were divided into tertiles based on NLR values: 1.17 (0.9-1.42) in tertile 1; 1.57 (1.43-1.78) in tertile 2; and 2.40 (1.82-4.5) in tertile 3. The frequency of PHT was significantly higher for patients in the upper NLR tertile compared to the middle and lower NLR tertiles (21 (91.3 %), 7 (30.4 %), and 5 (22.7 %), respectively; p<0.001). Systolic BP and diastolic BP were significantly higher among patients in the upper NLR tertile than among those in the other NLR tertiles. CONCLUSION: An association exists between PHT and NLR. NLR measurement, as well as monocyte count, may be used to indicate increased risk of prehypertension (Tab. 2, Ref. 48). Text in PDF www.elis.sk.
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    The Association of Inteleukin (IL)-17 and IL-23 with rheumatic mitral stenosis
    (Oxford Univ Press, 2016) Bilik, M. Z.; Polat, N.; Kaplan, I.; Akil, M. A.; Halit, A.; Yuksel, M.; Aydin, M.
    [Abstract Not Available]
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    Markers of endothelial dysfunction in ocular Behcet's Disease
    (Oxford Univ Press, 2014) Oylumlu, M.; Yuksel, M.; Oylumlu, M.; Turkcu, F. M.; Yildiz, A.; Bilik, M. Z.; Polat, N.
    [Abstract Not Available]
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    New inflammatory markers in preeclampsia: echocardiographic epicardial fat thickness and neutrophil to lymphocyte ratio
    (Oxford Univ Press, 2014) Oylumlu, M.; Ozler, A.; Yildiz, A.; Oylumlu, M.; Acet, H.; Polat, N.; Soydinc, H. E.
    [Abstract Not Available]
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    Platelet to lymphocyte ratio is a predictor of in-hospital mortality patients with acute coronary syndrome
    (Oxford Univ Press, 2014) Oylumlu, M.; Yildiz, A.; Oylumlu, M.; Yuksel, M.; Polat, N.; Bilik, M. Z.; Akyuz, A.
    [Abstract Not Available]
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    Predictive value of lymphocyte to monocyte ratio for cardiac syndrome X
    (Verduci Publisher, 2022) Akil, M. A.; Oylumlu, M.; Demir, M.; Ozbek, M.; Polat, N.; Acet, H.; Bilik, M. Z.
    OBJECTIVE: Cardiac syndrome X (CSX) is typically described with ischemia in stress tests in addition to angina-like chest pain and without stenosis in coronary angiography. We aimed at determining the relationship between LMR and CSX. PATIENTS AND METHODS: We retrospectively collected patients with CSX between January 2016 and December 2019. Patients with typical angina-like chest pain, normal 12-lead electro-cardiography at rest, a positive response to the exercise test (> 0.1 mV ST-segment depression at 80 ms after the J point in two or more contiguous leads) or ischemia on myocardial perfusion scintigraphy and normal coronary angiography were included in the study as CSX patients. RESULTS: This study consisted of 116 patients with CSX and 153 control groups. The mean age of the patients with CSX was 52.7 +/- 9.7 years, and the mean age of the control group was 53.7 +/- 10.6 years (p= 0.416). The patients with CSX were more likely to have higher monocyte counts and LMR. According to the Pearson correlation test, the CRP value negatively correlated with the LMR. In multivariate logistic regression analysis, LMR remained a significant predictor of CSX. In ROC analysis, LMR <4.1 had 64% sensitivity and 50% specificity (ROC area under curve: 0.587, 95% CI: 0.519-0.655, p=0.015) in accurately predicting a CSX diagnosis. CONCLUSIONS: We showed that lower LMR levels were associated with the presence of CSX.
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    Serum GDF-15 level in rheumatoid arthritis: relationship with disease activity and subclinical atherosclerosis
    (Publisaude-Edicoes Medicas Lda, 2017) Tanrikulu, O.; Sariyildiz, M. A.; Batmaz, I; Yazmalar, L.; Polat, N.; Kaplan, I; Cevik, R.
    Objectives: Growth differentiation factor (GDF)-15 was originally identified as a factor secreted by activa ted macrophages, and plays an important role in cell growth and differentiation. GDF-15 plays an important role in cell growth, signal transduction, and apoptosis regulation. The aim of this study was to evaluate the serum GDF-15 levels and their relationship with di sease- related characteristics in patients with rheumatoid arthritis (RA). Materials and methods: Forty-six patients diagnosed with RA and 36 demographically matched healthy control subjects participated in this study. GDF-15 levels were measured in blood samples from patients and controls. The disease activity score-28 (DAS28) was used to evaluate the disease activity of RA. The quality of life was evaluated using the disease-specific rheumatoid arthritis quality of life (RAQoL) scale. The health assessment questionnaire (HAQ) was used to evaluate the functional status. The degree of joint damage was assessed according to Larsen's method. Atherosclerosis was assessed by a cardiologist with the help of echocardiography according to the carotid intima media thickness (CIMT) method; vascular stiffness was assessed by using the flow mediated dilatation (FMD) method. Results: Serum GDF-15 levels were significantly hi gher in RA patients when compared to the control sub jects (p< 0.05). RA patients were divided into two groups according to the disease activity; while 26 subjects (57%) were in the active group, 20 patients were in the non-active group (43%). Serum GDF-15 levels were significantly higher in the group that was considered to have an active disease. According to Pearson's correlation, serum GDF-15 levels were positively correlated with erythrocyte sedimentation rate (ESR) le vels, morning stiffness, DAS28 score, tender joint count, and CIMT (p<0.05). Conclusion: GDF-15 may play a role in the pathway of disease activity, joint involvement, and atherosclerosis in patients with rheumatoid arthritis.