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  • Küçük Resim
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    COVID-19’ da ayaktan tedavi
    (Dicle Üniversitesi Tıp Fakültesi, 2021) Pervane, Vasfiye Demir; Çelepkolu, Tahsin
    COVİD-19 enfeksiyonu Çin’in Wuhan kentinde tespit edilen daha sonrasında tüm dünyaya yayılarak pandemiye neden olan SARS-CoV-2 enfeksiyonunun neden olduğu mortalite ve morbiditesi yüksek klinik bir durumdur. Dünya genelinde 218 milyondan fazla kişi bu enfeksiyondan etkilenmiş ve bu hastalık 4,5 milyondan fazla kişinin de ölümüne neden olmuştur. COViD-19 enfeksiyonu genelde hafif orta seyirli bir klinik seyir göstermekle beraber %2 oranında ölümle sonuçlanabilmektedir. COVİD-19 hastalığının tedavisine dönük güncel kesin bir tedavisi olmamakla beraber yoğun bilimsel çalışmalar ve ilaç araştırmaları yapılmaktadır. Ülkeler kendi sağlık politikaları ve imkanlarına uygun olarak ayaktan ve yatan hasta tedavi protokollerini belirlemektedir. SARS-CoV-2’i hedef alan monoklonal antikor tedavisinin COVİD-19’u hafif-orta seviyede geçiren ayaktan hastalarda kullanılması yönünde değerlendirilmekte ve klinik çalışmalar bu ajanlardan fayda görüldüğünü göstermektedir. Monoklonal antikor olan Casirivimab-imdevimab, Sotrovimab hafif-orta seviyede COViD-19 hastalığını geçiren, tıbbi olarak kötüleşme ihtimali bulunan seçilmiş ayaktan hastalar için acil kullanım yetkisi ile ABD’de acil serviste kullanıma sunulmuştur. Çalışmalarda favipravirin viral arınmayı arttırdığı; göğsün radyolojik değerlendirmelerinin ve klinik semptomların favipravir ile daha iyiyiye gittiği gösterilmiştir. Ülkemizde ayaktan ve yatan hasta tedavi protokollerinde de favipravire yer verilmektedir. Ayaktan COVİD-19 hastalarında güncel olarak immun plazma tedavisi, sistemik glukokortikoid, kolşisin, ivermektin, fluvoksamin, hidroksiklorokin+azitromisin gibi ilaç tedavilerinin hastalığın seyrine etkisi kısıtlı ve tartışmalıdır. Yüksek kalitede doğru bilgi için ilaçlara dönük randomize kontrollü çalışmaların yürütülmesine ihtiyaç vardır. Ayaktan hastaların takibinde hastaların izolasyonu, ilaç tedavileri, hastalık ve alarm semptomları hakkında bilgilendirmeleri, enfeksiyon sonrası aşılanmaları, teletıp desteği ile gerekli yönetimin ve desteğin sağlanması da son derece önemlidir.
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    Öğe
    The effect of body mass index and anxiety status on blood pressure in patients admitted to family medicine outpatient clinic
    (2022) Pervane, Vasfiye Demir; Kuyumcu, Mahır; Dündar, Ahmet; Yılmaz, Ahmet; Ayan, Orhan
    Introduction: Hypertension is a global public health problem that is the leading cause of preventable death in the world and a disease which can cause many morbidities and mortality if not controlled or treated effectively. In many studies, it has been determined that anxiety and body mass index(BMI) are among the factors affecting hypertension. However, different results have been obtained in many studies in terms of the relationship between anxiety and hypertension. This study was carried out with the aim to evaluate the effect of body mass index and anxiety on blood pressure and the factors affecting blood pressure in patients who applied to outpatient clinic of family medicine at Dicle University Faculty of Medicine.Methods: 403 patients aged between 18- 65 years, who applied to outpatient clinic of family medicine at Dicle University Faculty of Medicine between 01.04.2018 and 01.07.2018, were included in this cross-sectional study. The population of the study was the province where the study was carried out, and the sample size was calculated with a power of 80%. The patients' body mass index and anxiety scores from Beck anxiety scale were calculated and measurements of arterial blood pressure were performed. The relationship between BMI, Beck anxiety scores and blood pressure of patients were investigated.Results: Of the participants, 50.1% were male, 49.9% were female and the average age was 34.11 in years. Of the patients, the mean BMI as 25.52 kg/m², the mean anxiety score as 7.40 and the arterial blood pressures as 117.80/75.54 mmHg were measured. It was found that arterial blood pressure raised significantly as the BMI group increased. While the relationship between the severity of anxiety and systolic blood pressure was significant, its relationship with diastolic blood pressure was not significant. There was a positive correlation between BMI, anxiety score and systolic and diastolic blood pressure.Conclusions: According to the results of this study, it was found that the increase in BMI and Beck anxiety scores may be related with increase in arterial blood pressure. This result showed that common health problems in primary care such as anxiety, obesity and hypertension may be associated with each other, and it can be effectively fought against hypertension and its complications with the perspective of family medicine and biopsychosocial approach.
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    Öğe
    Rabies Disease and Prophylaxis Knowledge Among Turkish Medical Students: Insights from a Cross-Sectional Study
    (Mdpi, 2025) Pervane, Vasfiye Demir; Erten Bucaktepe, Pakize Gamze; Ince, Fatma Meral; Demir, Dicle; Koc, Simanur
    Rabies is a fatal infectious disease that can be prevented with vaccination. The aim of this study was to evaluate the level of rabies knowledge among medical faculty students. This cross-sectional study included students in the medical faculty of a university hospital. The level of rabies knowledge was evaluated with a questionnaire evaluating 70 parameters. A total of 892 students participated in this study. Medical students knew that dogs and cats transmit rabies at high rates (96.9% and 87.4%, respectively) but understood less about other animals. Pregnancy (45.2%), being >65 years of age, having a chronic disease, and being immunosuppressed were indications for rabies vaccine, with rates between 31.4 and 37.4%. In total, 64.3% of respondents stated that the nearest health center should be approached to seek medical care, without first touching the wound. While indications for vaccination were correctly reported to be high after bites or scratches (74.2-94.6%), such indications were considered to be lower for other types of contact (46.2-66.6%). Indications for rabies immunoglobulin administration were correctly recognized at rates between 15.9% and 57.8%. Overall, the mean rabies knowledge level was 41.82 (Max. score 70). There was a statistically significant relationship between the total and subgroup rabies knowledge scores and class level, having taken a rabies course, a history of dog bites among the respondents or their family members, and possessing information about rabies. It was determined that the rabies knowledge levels among the students were insufficient. Having received lessons about rabies or a history of being bitten by an animal with suspected rabies were found to be important factors for increased knowledge about rabies.
  • Küçük Resim
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    Sosyoekonomik düzeyi yüksek okul çağı çocuklarının ağız diş sağlığı açısından incelenmesi
    (Türkiye Tabipleri Birliği, 2021) Toktaş, İzzettin; Erdem, Özgür; Eratilla, Veysel; Pervane, Vasfiye Demir; Yosunkaya, Ahmet
    Amaç: Bu araştırmada amacımız sosyoekonomik düzeyi yüksek çocukların ağız-diş sağlığının incelenmesi ve yüksek sosyoekonomik durum ile diş çürüğü ve diş fırçası kullanımı arasında ilişkinin araştırılmasıdır. Gereç-Yöntem: Tanımlayıcı kesitsel tipte olan bu araştırma, Diyarbakır’da ilkokul, ortaokul ve lise seviyesinde eğitim veren bir özel okulda gerçekleştirildi. Öğrenciler, okullarında iki diş hekimi tarafından ağız-diş muayenesinden geçirildi. Bulgular anket formuna kaydedildi. Çalışmaya katılan diğer araştırmacılar tarafından öğrencilerle yüz yüze görüşülerek anket uygulandı. Elde edilen veriler SPSS 15.0 paket programı kullanılarak sayı, yüzde ve ortalama ± standart sapma (SD) ile birlikte istatistik analizinde Ki-kare, Kruskal-Wallis, Mann-Whitney U testi kullanıldı. p<0,05 değeri istatistiksel olarak anlamlı kabul edildi. Bulgular: Toplam 563 öğrenciyle görüşüldü. Öğrencilerin %25,0’ı ilkokul (n=141), %31,3’ü ortaokul (n=176) ve %43,7’si ise lise (n=246) öğrencilerinden oluşmaktaydı. Çürük oranı ilkokulda en yüksek (%63,1) iken, lisede en düşük (%37,8) olarak bulundu (p<0.001). Öğrencilerin DMFT indeksine bakıldığında ilkokulda 2,7 iken, ortaokul (1,3) ve lisede (1,5) ikinin altında bulundu. Annesi çalışan çocukların diş çürüğü oranı annesi ev hanımı olanlara göre düşük ve istatistiksel olarak anlamlı bulundu. Öğrencilerin çoğunda (%91,1) diş ipi kullanma alışkanlığı olmadığı saptandı. Sonuç: Sosyoekonomik gelişmişlik düzeyi yüksek olan çocuklarda ağız diş sağlığı göstergesi olan DMFT indeksi Dünya Sağlık Örgütünün gösterdiği hedeflere uygun olarak düşük bulunmuştur.
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    Öğe
    The relationship between thyroid functions, vitamin B12, and lipid profiles across different BMI categories in adults
    (MediHealth Academy Yayıncılık, 2025) Pervane, Vasfiye Demir; Gokdemır, Ozden; Aygün, Olgu; Gündoğdu, Sevgi Ceylan; Bucaktepe, Pakize Gamze Erten; Çelepkolu, Tahsin
    Aims: Obesity is a multifactorial condition characterized by abnormal or excessive fat accumulation that adversely impacts health and disrupts various metabolic processes. This study aimed to assess thyroid function tests, vitamin B12 levels, and lipid profiles in normal, overweight, and obese adults, and to elucidate the correlation with body-mass index (BMI) values. Methods: This study was planned as a retrospective descriptive cross-sectional study. Within the scope of the study, age, gender, occupation, history of chronic diseases, smoking, alcohol use and drug use; weight, height, BMI, blood pressure; TSH, free T3, free T4, total cholesterol, LDL-cholesterol, HDL-cholesterol, VLDL-cholesterol, triglyceride, fasting blood glucose, vitamin B12, folate, ferritin, serum iron level, iron binding capacity and whole blood parameter values were retrieved and recorded by reviewing health records retrospectively. Patients were grouped according to BMI values, and the relationships between obesity, sociodemographic characteristics and blood parameters were analyzed. Results: A total of 539 patients were analyzed, with 63.6% identified as women. The average age of the patients was 36.88±13.75 years (range: 13-79), and the average BMI was 26.92±6.37 kg/m². Analysis revealed that 40% of patients were classified as normal weight, 30.1% as overweight, 26.1% as obese, and 3.8% as underweight based on BMI criteria. The classification of obesity indicates that class 1 obesity accounts for 59.7%, while class 2 and class 3 obesity each represent 20.1% of the total cases. The obesity rate was 72.1% in women and 27.9% in men, with a statistically significant difference observed between genders and BMI groups (p<0.001). The prevalence of B12 deficiency was 1.2%, and no significant association was observed among BMI groups. The study identified a statistically significant difference in total cholesterol (p<0.001), HDL (p=0.001), LDL (p<0.001), VLDL (p<0.001), triglycerides (p<0.001), and BMI groups. Conversely, no significant relationship was observed between B12 values and TSH (p=0.430), fT3 (p=0.462), or fT4 (p = 0.279). Conclusion: In conclusion, our findings indicate that BMI significantly influences the lipid profile of individuals; however, it does not exhibit a direct relationship with B12 levels or thyroid functions. Given the fact that obesity elevates cardiometabolic risks, particularly through heightened lipid levels, it is essential to monitor not only obese individuals but also those at risk for it as well, to reduce obesity and prevent its onset.