Yazar "Ozhasenekler, A." seçeneğine göre listele
Listeleniyor 1 - 4 / 4
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Benefit of hemodialysis in carbamazepine intoxications with neurological complications(Verduci Publisher, 2012) Ozhasenekler, A.; Gokhan, S.; Guloglu, C.; Orak, M.; Ustundag, M.Aim: It is aimed to share the fact that hemodialysis is also useful in carbamazepine intoxications with prominent neurological side effects in cases hemoperfusion is not available. Patients and Method: Files of 49 patients presenting our Emergency Room with a prediagnosis of carbamazepine intoxication were analyzed retrospectively. Demographic and laboratory data of patients were recorded on study form. Patients were divided into two groups as those applied hemodialysis (Group 1) and those not applied hemodialysis (Group 2). Group 1 included 13 patients while group 2 did 36. Results: Statistically significant differences were detected between groups in terms of heart rate, Glasgow Coma scale score, presence of convulsions, midriasis and blood carbamazepine levels at the time of presentation. It was observed that carbamazepine levels decreased by 58% via hemodialysis in those receiving hemodialysis. Discussion: Hemodialysis is simple, cheap, widespread and easier to apply compared to hemoperfusion. It has been shown that acute carbamazepine intoxication can be treated with low flow-high activity standard hemodialysis and it is a good therapeutic option.Öğe Effect of L-ornithine L-aspartate on Liver Injury Due to Acute Ethyl Alcohol Intoxication in Rats(Univ West Indies Faculty Medical Sciences, 2015) Durgun, H. M.; Ozhasenekler, A.; Dursun, R.; Basarali, M. K.; Turkcu, G.; Orak, M.; Ustundag, M.Objective: Ethyl alcohol is a substance that is widely used worldwide and known to exert toxic effects on liver. In this study, we aimed to examine the effect of L-ornithine L-aspartate (LOLA) on the toxicity of a single dose of ethyl alcohol in rats. Subjects and Method: We used 32 randomly selected male Sprague-Dawley rats weighing 200-250 g. The rats were grouped into four groups with each group containing eight rats: Group 1: the control group, Group 2: the ethyl alcohol group, Group 3: the LOLA group and Group 4: the ethyl alcohol+LOLA group. Ethyl alcohol was administered orally through a nasogastric tube at a dose of 6 g/kg after diluting with distilled water. One hour after ethyl alcohol administration, LOLA was administered to pre-specified groups orally through a nasogastric tube at a dose of 200 mg/kg after diluting with distilled water. Liver tissue and blood samples were obtained from all rats 24 hours later to study total antioxidant capacity (TAC), total oxidant status (TOS) and oxidative stress index (OSI) levels in liver samples, and aspartate aminotransferase (AST), alanine transferase (ALT), TAC, TOS and OSI levels in blood samples. Results: Serum TAC, TOS and OSI levels were higher in the groups that were administered ethyl alcohol. In addition, tissue TAC level was higher and TOS and OSI levels were lower in groups that were given ethyl alcohol. No significant changes were observed in serum and tissue TAC, TOS, OSI, ALT and AST levels in the LOLA administered groups. Conclusion: This study showed that LOLA was not biochemically effective and exerts no oxidative stress reducing activity in liver injury due to acute ethyl alcohol toxicity.Öğe Neutrophil lymphocyte ratios in stroke subtypes and transient ischemic attack(Verduci Publisher, 2013) Gokhan, S.; Ozhasenekler, A.; Durgun, H. Mansur; Akil, E.; Ustundag, M.; Orak, M.OBJECTIVES: This investigation was conducted to test the value of Neutrophil Lymphocyte Ratio (NLR), which has been shown in some recent studies to be a prognostically important and an easy-to-measure inflammatory marker, in patients presenting to Emergency Service with stroke (ischemic and hemorrhagic) and transient ischemic attack. MATERIALS AND METHODS: A total of 868 patients were enrolled, who presented to our Emergency Service with cerebrovascular accident (stroke and transient ischemic attack) and admitted to Neurology Clinic. Demographic characteristics and comorbidities of patients were recorded. The patients were divided into 3 groups as acute ischemic stroke (AIS), acute hemorrhagic stroke (AHS) and transient ischemic attack (TIA). Patients with AIS were classified into subgroups in terms of TOAST (trial of 10172 stroke treatment) criteria. Admission NLR levels were compared across all groups. RESULTS: A total of 868 patients were enrolled, 51.6% of which were male and 48.4% were female. AIS rate was 75.3%, AHS rate was 14.3% and TIA rate was 10.7%. In all of patients, mortality rate was 10.7%. NLR was significantly higher in patients who died (p < 0.001). NLR level in patients with TIA was significantly lower than those of AIS and AHS groups (p < 0.001). Among AIS subgroups, NLR level was significantly higher in group with great artery atherosclerosis or atherothrombosis compared to other groups (p < 0.001). CONCLUSIONS: NLR may be used as a simple and easy-to-measure marker for prediction of short-term prognosis and in-hospital mortality in both ischemic and hemorrhagic stroke patients.Öğe PENETRATING TRANSCRANIAL FOREIGN BODIES INJURIES: CASE REPORT(Aves, 2007) Al, B.; Orak, M.; Ozhasenekler, A.; Icer, M.; Cakmak, E.Intracranial drilling wounds related to falling from high places are rarely seen. The methods that are used in diagnosis, and developing complications, and treatment procedures can be changed according to the shape of trauma, and to the entry place of foreign body, and to the situation of patient. An eleven years old boy was brought to our clinic with complaint of head down falling from roof on the top of an iron spit. In his examination, the iron spit entered from inferior of right mandible and passed through to the brain parenchyma and came out of left frontal zone. On admission, the Glasgow Coma Scale was 15/15. At the operating room of emergency service the iron spit was taken out under local anesthesia without needing craniotomy. The patient who had no complication without ptosis on right lid, and deviated pupil to left side was discharged at his twelfth days of admission. As a result, in intracranial foreign bodies if not more then one lobe had been damaged, and one site of body is outside, the foreign body can be taken out carefully without needing craniotomy.
