Yazar "Oktay, Mehmet Faruk" seçeneğine göre listele

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  • [ X ]
    Öğe
    Association between cupular deposits and otosclerosis
    (Amer Medical Assoc, 2006) Hayashi, Hideo; Cüreoǧlu, Sebahattin; Schachern, Patricia A.; Oktay, Mehmet Faruk; Fukushima, Hisaki; Sone, Michihiko; Paparella, Michael Mauro; 0000-0001-9220-7073; 0000-0001-7380-610X
    Objective: To evaluate whether otosclerosis is an underlying mechanism for the production of cupular deposits and to study the association between cupular deposits and dysequilibrium in otosclerosis. Design: Retrospective human temporal bone (TB) study. The incidence of cupular deposits in these 70 TBs was analyzed. Correlations between cupular deposits and vestibular symptoms, endosteal involvement of the otosclerotic focus, stapedial fixation, and clinical history of stapes surgery were evaluated. Setting: Otolaryngology laboratory in a tertiary academic medical center. Patients: The study material consisted of 35 human TBs with otosclerosis and 35 age-matched controls. Main Outcome Measures: Morphometric evaluations of the incidence of cupular deposits, endosteal involvement of the otosclerotic focus, and stapedial fixation were made by light microscopy. Clinical records were reviewed retrospectively for clinical history of stapes surgery and prevalence of vestibular symptoms. The incidence of cupular deposits was compared between the otosclerotic and control groups. Correlations between cupular deposits and vestibular symptoms, endosteal involvement of the otosclerotic focus, stapedial fixation, and clinical history of stapes surgery were evaluated in the subjects with otosclerosis. Results: The incidence of cupular deposits in TBs with otosclerosis was significantly higher than in those without whereas there was no correlation between the incidence of the deposits and dysequilibrium in cases of otosclerosis. An increase in deposits did not correlate with stapedial fixation, stapes surgery, or endosteal involvement. Conclusions: Our results suggest otosclerosis as an underlying mechanism for the production of cupular deposits; however, we did not find an association between these deposits and vestibular symptoms.
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    Öğe
    A case of solitary angiokeratoma circumscriptum of the tongue
    (2007) Topçu, İsmail; Yıldırım, Müzeyyen; Kılınç, Nihal; Oktay, Mehmet Faruk
    Anjiyokeratom sirkumskriptum nadir görülen bir vasküler bozukluktur. Lezyonlar doğum sırasında vardır ve genellikle alt ekstremiteyi etkiler. Dokuz yaşındaki bir kız çocuğu, dilin dorsal bölümünde pembe renkli, küçük yükseltiler oluşturan lezyonlarla başvurdu. Bu durumun doğumdan beri var olduğu öğrenildi. Hastanın öyküsünde geçirilmiş travma, şiddetli soğuk etkisi veya vücudun başka yerlerinde benzer lezyon oluşumu yoktu. Sert yiyeceklerden sonra ağrı ve nadir olarak lezyondan kan gelmesi gibi yakınmaları vardı. Fizik muayenede, dilin dorsal yüzünde gruplar halinde, eritematöz, parlak papüller görüldü. Ağız mukozasında başka lezyon yoktu. Lezyondan alınan insizyonel biyopsiden sonra soliter anjiyokeratom sirkumskriptum tanısı kondu.
  • Küçük Resim
    Öğe
    Effüzyonlu otitis media hastalarından elde edilen orta kulak effüzyonlarında immünoglobulin değerleri
    (Dicle Üniversitesi, Tıp Fakültesi, 1999) Oktay, Mehmet Faruk; Topçu, İsmail
    Effüzyonlu otitis media hastalarından elde edilen orta kulak effüzyonlarında immünoglobulin değerleri
  • Küçük Resim
    Öğe
    İki olgu nedeniyle mukormikozis
    (Dicle Üniversitesi Tıp Fakültesi, 2007) Oktay, Mehmet Faruk; Yıldırım, Müzeyyen
    Mukormikozis nadir görülen, invaziv ve fulminan seyirli saprofitik bir fungal enfeksiyondur. Bazı tipik klinik bulguları vardır ve genellikle diyabetli immun sistem bozukluğu olan veya immunosupresif tedavi alan hastalarda enfeksiyona yol açmaktadır. Bu çalışmada kliniğimizde takip edilen iki mukormikoz olgusunu sunduk. İlk olgu, 2 yaşında diyabetik ketoasidozlu kız çocuğuydu. Her iki nazal vestibül, nazal septum ve bunlara komşu nazal dorsumda nekroz ve hiperemi mevcuttu. İkinci olgu ise diyabetik ketoasidozu bulunan 17 yaşında bayan hasta idi. Auriküla ve dış kulak yolunda nekroz, aynı tarafta komplet fasiyal sinir paralizi mevcuttu. Her iki hastada histopatolojik ve mikrobiyolojik değerlendirme için doku örneği alındıktan sonra sistemik Amfoterisin B tedavisi başlandı. İkinci hastada nekrotik dokular debride edildi. İlk hasta tedavinin başlangıcından iki gün sonra, ikinci hasta ise tedaviden sonraki yedinci gün kaybedildi. Nadir görülen bu saprofitik enfeksiyonların bakteriyolojik ve histolojik özellikleri ile birlikte tedavi alternatifleri tartışıldı.
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    Öğe
    İnsan temporal kemik laboratuvarı prosedürleri:Genel bir bakış
    (2006) Oktay, Mehmet Faruk; Cüreoğlu, Sebahattin; Schachern, Patricia A.; Paparella, Micheal M.
    İnsan kulağındaki yapılar genellikle yaşam boyunca "erişilemez" özellikte olup, altta yatan hastalıklara ait patolojik değişikliklerin incelenebilmesi postmortem çalışmalarla mümkün olabilmektedir. İnsan temporal kemik (İTK) laboratuvarları bu açıdan eşsiz bir materyal kaynağı sunarlar. Bu laboratuvarlar, temporal kemik kesitlerindeki histolojik bulgularla hastanın ölmeden önceki kulak patolojisinin karşılaştırılmasına, hastalıklı olguları diğer olgularla karşılaştırmaya ve elde edilen bilgilerin diğer laboratuvarlarla paylaşılmasına olanak verir. Bu makalede insan temporal kemik laboratuvarlarının işlevinin tanıtılması amaçlandı ve yapılan histopatolojik işlemlerin ayrıntılı analiziyle birlikte bu laboratuvarlar hakkında genel bir bakış açısı sunuldu.
  • [ X ]
    Öğe
    Preventing cisplatin induced ototoxicity by N-acetylcysteine and salicylate
    (2010) Samancı, Baver; Oktay, Mehmet Faruk; Topçu, İsmail; Yıldırım, Müzeyyen; İnançlı, Hasan Mete; Enöz, Murat
    Amaç: Bu çalışmada salisilat ve N-asetilsistein kullanımıyla cisplatin kaynaklı ototoksisitenin azaltılabilirliği ya da engellenebilirliği araştırıldı. Hastalar ve Yöntemler: Solid organ tümörü nedeniyle cisplatin kemoterapi kullanan 54 hasta (28kadın, 26 erkek; ort. yaş 37±9.5; dağılım 29-71yıl) çalışmaya dahil edildi. Hastalar her bir grupta18 kişi olacak şekilde rastgele üç gruba ayrıldı.İlk grup (kontrol grubu) sadece cisplatin aldı,ikinci grup N-acetylcysteine (NAC; 600 mg/gün)ile birlikte cisplatin aldı ve üçüncü grup salisilat(300 mg/gün) ile birlikte cisplatin aldı. Bütün hastalar yüksek frekans odyometri ve işitsel beyinsapı yanıtını içeren odyolojik incelemeyle değerlendirildi. Bulgular: Cisplatin tedavi protokolüne N-asetilsisteine eklenmesiyle, 10.000 ve 12.000 Hz frekanslarındaki cisplatin kaynaklı ototoksik hasarın azaldığı görüldü. Cisplatine ile salisilat alan hastalarınişitme kayıbı seviyelerinde herhangi bir azalmagörülmedi. Sonuç: Çalışmamızda işitsel beyin sapı yanıtı testisonuçlarına bakıldığında ne N-asetilsistein ne desalisilat alan hastalar arasında cisplatin ototoksisitesini azaltma yönünden anlamlı fark bulundu.
  • Küçük Resim
    Öğe
    Protective effects of some antineoplastic agents on ischemia-reperfusion injury in epigastric island skin flaps
    (Wiley-Liss, 2006) Aşkar, İbrahim; Oktay, Mehmet Faruk; Gürlek, Ali; Baç, Bilsel
    Neutrophil depletion has a beneficial effect on ischemic myocardium and skeletal muscle upon reperfusion. Antineoplastic agents reduce blood neutrophils effectively, and lead to neutrophil depletion. The purpose of this study was to investigate the effects of four antineoplastic agents in low doses (cyclophosphamide, cisplatinum, mitomycin-C, and 5-fluorouracil) on ischemia-reperfusion injury, using an epigastric island skin-flap model in rats. Fifty male Sprague-Dawley rats, weighing 250-300 g, were randomly divided into five groups, each consisting of 10 rats: control, cyclophosphamide, cisplatinum, mitomycin-C, and 5-fluorouracil groups. Epigastric island skin flaps (measuring 3.5 x 4 cm) were raised and subjected to 10 h of in situ ischemia, followed by 7-day reperfusion and evaluation. Treatment with antineoplastic agents (cyclophosphamide, cisplatinum, mitomycin-C, and 5-fluorouracil) was used to introduce neutropenia. Complete blood counts, cutaneous bleeding time, and skin-flap survival were evaluated. Additionally, levels of malonyldialdehyde (MDA), nitric oxide (NO), glutathione (GSH), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) were measured from extracted skin tissue. Numbers of leukocytes and platelets were decreased in all experimental groups. However, neutropenia and thrombocytopenia were not seen. Cutaneous bleeding activity was prolonged in all experimental groups, but not above the normal value. MDA and NO levels were found to be lower in all four antineoplastic agent groups than in the control group, while GSH, GSH-Px, and SOD enzyme activities were significantly higher (P < 0.05). However, MDA and NO levels were significantly decreased in the cyclophosphamide and 5-fluorouracil groups, as compared to the cisplatinum and mitomycin-C groups (P < 0.01). Also, GSH, GSH-Px, and SOD enzyme activities were significantly increased in the cyclophosphamide and 5-fluorouracil groups, compared to the other two antineoplastic agent groups (P < 0.01). We conclude that antineoplastic agents have beneficial effects on ishemia-reperfusion injuries when their doses are carefully adjusted, by decreasing the number of leukocytes and platelets, and altering the activity of free oxygen radicals. (c) 2006 Wiley-Liss, Inc.
  • Küçük Resim
    Öğe
    Salutary effects of radiopaque contrast media on the survival of random-pattern skin flaps in the rat
    (Wiley, 2004) Aşkar, İbrahim; Bozkurt, Mehmet; Oktay, Mehmet Faruk; Gürlek, Ali; Keleş, Celalettin
    The radiopaque contrast medium diatrizoate, has a vasodilator effect so that it is used in sudden-deafness secondary ischemic injury. However, ischemic problems are encountered, especially when longer flaps are elevated. A longer flap also has ischemic and relatively ischemic tissue, and may obtain some benefit from contrast media. Forty male Sprague-Dawley rats, weighing about 350-400 g, were used, and randomly divided into four groups (n = 10 rats each group): group 1 was the control, group 2 the diatrizoate, group 3 the iopamidol, and group 4 the iothalamate group. A rectangular 3 x 10 cm caudally based dorsal skin flap was elevated, and sutured back to its original place. In the control group, no pharmacologic agent was administered. Sodium-meglumine-diatrizoate 10 mg/kg/day was administered parenterally in the first experimental group (diatrizoate group); iopamidol 10 mg/kg/day in the second experimental group (iopamidol group); and iothalamate sodium 10 mg/kg/day in the third experimental group (iothalamate group) for 7 postoperative days. On postoperative day 7, all flaps were photographed, and the area of flap survival was measured by using a polar planimeter. The results were statistically evaluated with the Kruskal-Wallis test and Mann-Whitney U-test (P = 0.05). The mean flap survival ranged from 79% in the iopamidol group to 83% in the diatrizoate group, and was significantly greater in all experimental groups (P < 0.05) compared to the control group (59%). There was no significant difference between experimental groups (P < 0.05). We believe that radiopaque contrast media have a beneficial effect in improving skin flap viability when distal flap necrosis is a potential complication of longer flaps.
  • Küçük Resim
    Öğe
    Tuberculous parotitis: A review of seven cases
    (İstanbul Üniversitesi Tıp Fakültesi, 2007) Oktay, Mehmet Faruk; Aşkar, İbrahim; Yıldırım, Müzeyyen; Topçu, İsmail; Meriç, Faruk
    Objectives: Tuberculous parotitis is rare even in countries where tuberculosis is widespread. We evaluated seven patients with tuberculous parotitis together with clinical and histopathologic findings, and management. Patients and Methods: In a period of 13 years, seven patients (5 males, 2 females; mean age 32 years; range 23 to 47 years) were diagnosed and treated for tuberculous parotitis. All the patients had a clinical suspicion of a parotid gland tumor. Results: The lesions were localized on the left in four patients, and on the right in three patients. The duration of disease varied from seven months to three years. The masses were localized, mobile, and measured 3 to 6 cm in diameter; one was fistulized. There was no evidence for active pulmonary tuberculosis. Chest radiograms showed old tuberculous lesions in two patients. The PPD skin test results were positive (>12 mm induration) in five patients (71%). Computed tomography or magnetic resonance imaging obtained in five patients showed mass formation suggesting a benign parotid gland tumor. Fineneedle aspiration cytology performed in three patients and cultivation performed in the fistulized case were all non-diagnostic. Superficial parotidectomy was performed in six patients and enucleation was performed in one patient. Histopathologic examination showed tubercles composed of macrophages, epithelioid cells and Langhans giant cells, and central caseous necrosis. Following diagnosis, all patients were treated with a fourdrug chemotherapy regimen. There was no evidence for recurrence within a mean of 15-month follow-up. Conclusion: Tuberculosis of the parotid gland should be considered in the differential diagnosis of patients presenting with a solitary tumor in the parotid gland.