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    Investigation of functional sperm membrane integrity after consequence of anti–hypoosmotic swelling test technique: An electron microscopic study
    (Journal of Reproductive Medicine, Inc., 2015) Tutsi Y.; Akkus M.; Tunik S.; Nergiz Y.; Kaplanoglu I.; Nasir Y.
    OBJECTIVE: Infertility is described as the inability of a couple to conceive after 1 year of unprotected intercourse. Male factor is assumed to be responsible for 50% of cases of infertile couples. It is a common clinical problem, affecting approximately 13– 15% of couples worldwide. In this study we aimed to investigate the effects of hypoosmotic swelling (HOS) and anti-HOS tests on sperm membrane integrity at the ultrastructural level. STUDY DESIGN: Twenty-nine infertile and 10 fertile men were included in this study. The fertile and infertile subjects were classified according to Kruger and WHO criterion. All semen samples were examined and analyzed based on WHO guidelines. Sperm viability was determined by using the eosin Y staining method. After HOS and anti-HOS tests were applied, the samples were evaluated at the ultrastructural level. RESULTS: Normal structural features of all regions of sperm were observed in sections of sham normospermia. Some histopathological changes were seen in HOS and anti-HOS group sections. CONCLUSION: The HOS procedure was found not to cause degenerative changes in the sperm ultrastructure. The anti-HOS procedure can be applied in normospermic and oligospermic groups. © Journal of Reproductive Medicine®, Inc.
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    Light microscope evaluation of iron accumulation in term placentas of subjects with preeclampsia
    (Acta Medica Mediterranea, 2014) Nasir Y.; Nergiz Y.; Aktaş A.; Akdeniz N.
    Aims: In this study, the aim was to investigate if the the use of placental iron storages detection could be used. Materials and Methods: This study was performed on 30 placentas, 20 preeclamptic and 10 normal gestations, of 36 weeks or more. Paraffin sections of preeclamptic and normotensive placental tissues were stained with Hematoxylin and Eosin, Masson's Trichrome, and Prussian Blue. Results: Evaluation of preeclampsia group placentas showed as most common findings: increased syncytial node in villus, cytotrophoblast proliferation, increased volume and number of fetal capillary, and increased fibrinoid accumulation. Among preeclampsia group placental tissue samples, Prussian Blue staining was observed most commonly in fetal central cross-sections. In most prominently Prussian Blue stained villus, presence of syncytial nodes and close neighboring between iron accumulation and syncytial kodes ere interesting findings. Statistical analysis of data was made by SPSS software using Mann Whitney U test and p values under 0.05 ere accepted as statistically significant. Conclusion: Studies of placental light microscopy are important in the clarification of preeclampsia etiopathogenesis and more studies with wider scope are needed.
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    Öğe
    Ultrastructural effects of tamoxifen on uterus in rats
    (2009) Deveci E.; Nasir Y.; Deveci Ş.
    Tamoxifen is a triphenylethylene derivative commonly used in the treatment of breast cancer The Wistar rats (9 weeks old, 180-200 g body weight) used in these trials were divided into two groups of 20 animals each (control and experimental group). Animals of the experimental group were given drinking water containing 200 ?g/kg tamoxifen citrate for a period of 30 day. At the end of exposure, body and uterus weights were measured. There was no statistical difference in the uterus weights between the control and treated groups (p < 0,05). Squamous metaplasia, characterized by the presence of stratified squamous epithelium on the lumenal surface of the uterus and the lining of the luminal surface of uterine glands was seen in some animals that had received tamoxifen. Ultrastructural changes were revealed in the form of vacularization of cell cytoplasm and The cytoplasm contained areas of low electron density. Not only was the cytoplasm full with intense crystalized and degeneration in mitochondria.