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Öğe Can calcium dobesilate be used safely for peripheral microvasculopathies that require neoangiogenesis?(Int Scientific Literature, Inc, 2013) Demirtas, Sinan; Caliskan, Ahmet; Guclu, Orkut; Yazici, Suleyman; Karahan, Oguz; Yavuz, Celal; Mavitas, BinaliBackground: Calcium dobesilate (CaD) is a member of the synthetic veno-active drug family. Only a small number of reports are available that describe the micro-angiogenic effects of CaD in the current literature. Material/Methods: The antiangiogenic potential of CaD was compared with bevacizumab (Bb), which is a potent angiogenesis inhibitor, in a chick chorioallantoic membrane model. Four different concentrations (10-7, 10-6, 10-5, and 10-4 M) of drug pellet were prepared for each drug. Changes in vessel formation were scored and compared for each drug according to the previous literature. Result: The antiangiogenic behavior of CaD was lower than Bb, despite the significant dose-dependent manner of escalation. The anti-angiogenic scores of CaD were determined as 0.20, 0.47, 0.66, 1.0 in 10-7, 10-6, 10-5, and 10-4 M concentrations, respectively (average score >0.5 was significant). Conclusions: According to the data obtained, this agent should be used carefully for cases in which angiogenesis plays an important role in healing.Öğe DIETARY ADDITION OF CAFFEIC ACID PHENETHYL ESTER PROTECTS MYOCARDIAL TISSUE AGAINST ETHAMBUTOL INDUCED OXIDATIVE STRESS(Nobel Ilac, 2013) Yavuz, Celal; Demirtas, Sinan; Yazici, Suleyman; Caliskan, Ahmet; Guclu, Orkut; Karahan, Oguz; Mavitas, BinaliObjective: The myocardial effect of ethambutol (ETM) has not yet been clarified. The main purpose of this study was to determine both the oxidative status in myocardial tissue after administration of ETM and the adjuvant benefits of caffeic acid phenethyl ester (CAPE). Material and Method: Twenty four male rats were divided into three experimental groups as follows: a control group (without any drug administration) was created for obtaining normal myocardial tissue; an ETM group (rats received only ETM for thirty days) was created for ethambutol administration; and an ETM+CAPE group was created for administration of the full regimen (rats received ETM+CAPE for thirty days). Rats were sacrified at the end of day 30 and heart tissues were obtained for histopathological and biochemical examination. Oxidant and antioxidant parameters were biochemically investigated in all tissue samples. Results: In the ETM group, myocardial malondialdehyde (MDA) levels and total oxidant status (TOS) were significantly higher than in the control group (p<0.001). Conversely, total antioxidant capacity (TAC), the activity of superoxide dismutase (SOD) and of serum paraoxonase (PON1) were reduced in the ETM group (p<0.05). Furthermore, MDA and TOS activity was significantly reduced in the ETM+CAPE group (p<0.05); TAC, SOD and PON1 activities were increased with adjuvant CAPE therapy (in the ETM+CAPE group) rather than in the ETM group. Conclusion: ETM may lead to increased myocardial oxidative stress due to lipid peroxidation. Nevertheless, adjuvant CAPE administration seems to provide a partial enhancement of myocardial damageÖğe Evaluation of Pericardial Fluid C-Type Natriuretic Peptide Levels in Patients Undergoing Coronary Bypass Surgery(Georg Thieme Verlag Kg, 2017) Guclu, Orkut; Karahan, Oguz; Karabacak, Mustafa; Yuksel, Volkan; Huseyin, Serhat; Mavitas, BinaliBackground Neurohumoral and hemodynamic mechanisms have an effect on cardiac activity. C-type natriuretic peptide (CNP) is accessible in the cardiovascular system. The aim of this study was to determine whether CNP concentrations in pericardial fluid and blood are related to cardiac dysfunction in patients undergoing coronary artery bypass graft surgery. Materials and Methods In this study, 40 patients undergoing coronary artery bypass grafting were enrolled. The patients were separated into two groups according to left ventricular (LV) ejection fraction (EF): group 1 contained 28 patients with normal LV systolic function (LVEF >= 50%) and group 2 contained 12 patients with impaired LV systolic function (LVEF < 45%). Plasma and pericardial fluid samples were acquired during surgery to measure CNP levels. Results In group 1, CNP levels were detected to be 0.46 +/- 0.10 ng/mL in plasma and 0.66 +/- 0.8 ng/mL in pericardial liquid. In group 2, these levels were 0.51 +/- 0.09 and 0.79 +/- 0.12 ng/mL, respectively. CNP levels were determined to be significantly higher in patients with low EF compared with those with normal EF in pericardial fluid concentrations (p = 0.013). Conclusions CNP level in pericardial fluid is a more sensitive and proper marker of LV dysfunction than CNP levels in plasma. To the best of our knowledge, this study is the first to examine pericardial fluid CNP levels in patients undergoing coronary artery bypass surgery. It may have a valuable role in organizing cardiac remodeling and hypertrophy.Öğe Factor-Xa inhibitors protect against systemic oxidant damage induced by peripheral-ischemia reperfusion(Springer, 2014) Caliskan, Ahmet; Yavuz, Celal; Karahan, Oguz; Yazici, Suleyman; Guclu, Orkut; Demirtas, Sinan; Mavitas, BinaliFactor-Xa inhibitors are often used for prophylaxis and for the treatment of thrombotic vascular disorders. However, it is not known whether they are beneficial during the recanalization of the thrombotic vascular segment and during tissue reperfusion. Herein, we describe an animal study that was designed to investigate the possible protective effects and antioxidant properties of factor-Xa inhibitors. Forty rats were included in the study and were randomly divided into five equal groups. The first group served as a control group from which we obtained basal oxidant and antioxidant parameters. Peripheral ischemia was induced in the second group (sham group) for 6 h, and plasma levels of nitrogen oxide (NOx), prolidase and malondialdehyde (MDA) were obtained after 30 min of reperfusion. The sham group did not receive any drugs. Oral rivaroxaban (3 mg/kg) was administrated to Group III, intraperitoneal enoxaparin sodium (250 U/kg) was administrated to Group IV, and intraperitoneal bemiparine sodium (250 U/kg) was administrated to Group V 1 week prior to the induction of peripheral ischemia (for 6 h)-reperfusion. After 30 min of reperfusion, blood samples were obtained and NOx, prolidase and MDA levels in these groups were detected, and the rats were sacrificed. NOx levels were statistically similar (p > 0.05) between Groups I, II, III, IV, and V (20.7 +/- A 10.4, 17.4 +/- A 9.7, 25.9 +/- A 24.2, 27.0 +/- A 11.9, 23.3 +/- A 17.3 mu mol/L, respectively). MDA levels were significantly lower (p < 0.05) in Groups III (rivaroxaban), IV (enoxaparin sodium), and V (bemiparine sodium) (24.9 +/- A 11.9, 25.9 +/- A 4.4, 25.4 +/- A 10.8 mu mol/L, respectively) when compared with the sham group (Group II) (75.6 +/- A 24.3 mu mol/L). Prolidase levels were higher (p > 0.05) in the ischemia reperfusion groups (659.2 +/- A 130.6 in II (sham), 1,741.0 +/- A 1,530.6 in III (rivaroxaban), 2,453.8 +/- A 1,590.4 in IV (enoxaparin sodium), and 889.2 +/- A 574.7 U/g in V (bemiparine sodium) than in the control group (144.6 +/- A 131.8 U/g). Ischemia-reperfusion events may occur in prothrombotic disorders. During these events, prophylactic or therapeutic factor-Xa inhibitors can protect against thrombosis and oxidative reperfusion injury. The new oral factor-Xa inhibitor, rivaroxaban, appears to provide the same antioxidant support as injectable low molecular weight heparins (LMWHs).Öğe Investigation of the antiangiogenic behaviors of rivaroxaban and low molecular weight heparins(Lippincott Williams & Wilkins, 2014) Yavuz, Celal; Caliskan, Ahmet; Karahan, Oguz; Yazici, Suleyman; Guclu, Orkut; Demirtas, Sinan; Mavitas, BinaliAntithrombotic agents play important roles in the prophylactic and therapeutic management of many cardiovascular disorders. Therefore, many researchers have focused on developing new strategies for anticoagulation. New oral anticoagulants and factor Xa inhibitors are products of such research. Although they are identified as advantageous, there are limited data available about their multisystemic interactions. Thus, the antiangiogenic behaviors of oral factor Xa inhibitors and low molecular weight heparins (LMWHs) were investigated in this study. The chick chorioallantoic membrane (CAM) model was designed to investigate the antiangiogenic potential of new oral factor Xa inhibitors (rivaroxaban) and LMWHs (enoxaparin sodium and tinzaparin sodium). Four different molar concentrations (10(-4), 10(-5), 10(-6), and 10(-7) mu mol/l) were studied for each drug. Each concentration was studied on 20 fertilized eggs. Vessel structures were evaluated under a stereoscopic microscope, and vessel formation was scaled according to previous literature. Both enoxaparin and tinzaparin sodium have increased antiangiogenic efficacy on CAM in a dose-dependent manner. However, this increased efficacy did not reach significant levels (average score < 0.5). On the contrary, while rivaroxaban showed dose-dependent antiangiogenic properties similar to enoxaparin and tinzaparin, a significant average antiangiogenic score (0.7) was detected at 10(-4) mu mol/l concentrations. New oral anticoagulants seem to be more favorable. However, their safety for the cardiovascular system needs to be clarified through microsystem studies on, for example, angiogenesis.Öğe Removal of Broken Hemodialysis Catheter from Subclavian Vein via Snare Under Fluoroscopy(Turk Nefroloji Diyaliz Transplantasyon Dergisi, 2014) Gulclu, Orkut; Yavuz, Celal; Demirtas, Sinan; Caliskan, Ahmet; Yazici, Suleyman; Karahan, Oguz; Mavitas, BinaliVenous access with a central catheter is typically a necessary technique for hemodialysis. Although, central venous catheters are widely used, they may cause life-threatening complications by migration of fractured catheter pieces. Thus, venous catheters should be controlled routinely by medical staff or the patients themselves. In this paper we report a case of a fractured catheter with vena cava migration in which there were no symptoms and describe the non-surgical retrieval of the migrated catheter by snare technique.Öğe Rosuvastatin may have Neuroprotective Effect on Spinal Cord Ischemia Reperfusion Injury(Bentham Science Publ, 2013) Yavuz, Celal; Demirtas, Sinan; Guclu, Orkut; Karahan, Oguz; Caliskan, Ahmet; Yazici, Suleyman; Mavitas, BinaliIschemia reperfusion injuries can be threatening to end organ viability and can progress, with mortal and morbid outcomes. In particular, neural tissues are highly sensitive to hypoxia and reperfusion stress. This study aimed to determine the neuroprotective effects of rosuvastatin on spinal cord ischemia reperfusion injury. Forty male Sprague-Dawley rats were divided into four equal groups: group I (control), group II (sham with simple laparotomy), group III (ischemia-reperfusion), group IV (ischemia-reperfusion group with continuous rosuvastatin utilization), and group V (ischemia-reperfusion group with rosuvastatin-withdrawal after reperfusion). Spinal cord ischemia was induced by clamping the aorta below the left renal artery and above the aortic bifurcation. Reperfusion was provided after 72nd hours of ischemia. After reperfusion, blood samples and spinal cord tissue samples were taken from all the rats. Oxidative and antioxidant markers from both serum and tissue samples were evaluated, and tissues were examined histopathologically. There were no significant differences between the control and sham groups. A notable increase in oxidative markers was observed in group III compared to group I. In addition, a significant decrease in antioxidant markers was detected in group III. However, there was a marked preservation in the tissue and blood samples of groups IV and V compared to group III in terms of oxidative damage. Additionally, definitive prophylaxes were seen in the histopathological examination of the tissue samples in groups IV and V compared with group III. These significant findings show that rosuvastatin has a considerable protective effect on neural tissue against oxidative damage. Likewise, the early withdrawal of rosuvastatin has a clear neuroprotective effect similar to that of continuous therapy. Nevertheless, other systematic effects and beneficial neural effects of statins should be investigated in further clinical trials.Öğe Simple blood tests as predictive markers of disease severity and clinical condition in patients with venous insufficiency(Lippincott Williams & Wilkins, 2016) Karahan, Oguz; Yavuz, Celal; Kankilic, Nazim; Demirtas, Sinan; Tezcan, Orhan; Caliskan, Ahmet; Mavitas, BinaliChronic venous insufficiency (CVI) is a progressive inflammatory disease. Because of its inflammatory nature, several circulating markers were investigated for predicting disease progression. We aimed to investigate simple inflammatory blood markers as predictors of clinical class and disease severity in patients with CVI. Eighty patients with CVI were divided into three groups according to clinical class (grade 1, 2 and 3) and score of disease severity (mild, moderate and severe). The basic inflammatory blood markers [ neutrophil, lymphocyte, mean platelet volume (MPV), white blood cell (WBC), platelet, albumin, D-dimer, fibrinogen, fibrinogen to albumin ratio, and neutrophil to lymphocyte ratio] were investigated in each group. Serum neutrophil, lymphocyte, MPV, platelet count, D-dimer and neutrophil to lymphocyte ratio levels were similar among the groups (P>0.05). Although the serum WBC levels were significant in the clinical severity groups (P<0.05), it was useless to separate each severity class. However, albumin, fibrinogen and the fibrinogen to albumin ratio were significant predictors of clinical class and disease severity. Especially, the fibrinogen to albumin ratio was detected as an independent indicator for a clinical class and disease severity with high sensitivity and specificity (75% sensitivity and 87.5% specificity for clinical class and 90% sensitivity and 88.3% specificity for disease severity). Serum fibrinogen and albumin levels can be useful parameters to determine clinical class and disease severity in patients with CVI. Moreover, the fibrinogen to albumin ratio is a more sensitive and specific predictor of the progression of CVI. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.Öğe Values of troponin T and myoglobin predictive of non-cardiac ischemia in rats(Mashhad Univ Med Sciences, 2014) Guclu, Orkut; Caliskan, Ahmet; Karahan, Oguz; Demirtas, Sinan; Yazici, Suleyman; Yavuz, Celal; Mavitas, BinaliObjective(s): Biochemical markers are important for the timely diagnosis and follow-up of ischemic events. Most of the markers have been previously studied in the context of cardiac ischemia. However, research on markers of non-cardiac events has been insufficient. Therefore, we investigated the relationship between troponin and myoglobin which are commonly used markers of cardiac ischemia, in non-cardiac ischemia. Materials and Methods: Forty-eight rats were equally divided into six groups. Group I was the control group. Group II was the sham group and received a simple laparotomy. The superior mesenteric artery was clamped in groups III and IV in order to create mesenteric ischemia. The left femoral artery was clamped in groups V and VI in order to create peripheral ischemia. Intracardiac blood samples were taken from all groups (during the 3rd hour of ischemia in groups III and V and the 6th hour of ischemia in group IV and VI) and troponin T and myoglobin levels were measured. Results: Troponin and myoglobin levels were statistically similar in groups I and II. Moreover, increments were detected for troponin and myoglobin in ischemia groups according to group I and II. Furthermore, higher troponin Tlevels were detected after three hours of mesenteric ischemia and higher myoglobin values were observed after six hours of mesenteric ischemia (P<0.05). Conclusion: Troponin T and myoglobin are not specific for non-cardiac ischemia, and they may be useful for detecting other ischemic events.
