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Öğe Basal cell carcinoma metastatic to the parotid stroma(Lippincott Williams & Wilkins, 2002) Beniler, E; Kilinç, N; Erdem, I[Abstract Not Available]Öğe Cavernous hemangioma of the uterus (A case report)(I R O G Canada, Inc, 2002) Uzunlar, AK; Yilmaz, F; Kilinç, N; Arslan, ACavernous hemangioma of the uterus is an extremely rare lesion. We report a postmenopausal patient with abnormal uterine bleeding due to hemangioma and simple endometrial hyperplasia.Öğe Evaluation of optimal gastric mucosal biopsy site and number for identification of Helicobacter pylori, gastric atrophy and intestinal metaplasia(H G E Update Medical Publishing S A, 2004) Dursun, M; Yilmaz, S; Yükselen, V; Kilinç, N; Canoruç, F; Tuzcu, ABackground/Aims: The study is designed to identify the optimal gastric mucosal biopsy site and number for identification of Helicobacter pylori, gastric atrophy and intestinal metaplasia. Methodology: Ninety-two patients were included in the study, gastric biopsies were obtained from 5 different sites: lesser curvature of the mid-antrum (A(1)), greater curvature of the mid-antrum (A(2)), incisura angularis (IA), lesser curvature of the mid-corpus (B-1), greater curvature of the mid-corpus (B-2). Helicobacter pylori was evaluated in sections stained with toluidine blue, and histopathological. examination was performed in sections stained with hematoxylineosin. Results: Seventy-three patients were positive for Helicobacter pylori at least in one biopsy site. Helicobacter pylori was positive in 47 patients (64.3%) in A(1), in 54 patients (73.9%) in A(2), in 60 patients (82.1%) in IA, 44 patients (60.2%) in B-1, and in 42 patients (57.5%) in B-2. The highest positivity determined was in the combination of A(2) and IA sites (95.8%). Gastric atrophy was determined in 35 of 73 patients (27.1% in A(1), 20% in A(2),25.7% in IA, 20% in B-1, and 7% in B-2). Intestinal metaplasia was determined in B-1 of the Helicobacter pylori-positive patients (18% in A(1), 16% in A(2), 30.9% in IA, 21.8% in B-1, 12.7% in B-2). Conclusions: It is considered that taking biopsies from both A(1) and IA sites has the highest sensitivity in detecting Helicobacter pylori. However, it is difficult to define a specific site for detecting gastric atrophy and intestinal metaplasia.Öğe Gentian violet solution for staining the anterior capsule(Amer Soc Cataract Refractive Surgery, 2000) Ünlü, K; Askünger, A; Söker, S; Kilinç, N; Karaca, C; Erdinc, MPurpose: To evaluate the histopathological changes after injecting gentian violet solution into the anterior chamber of rats and to describe a technique that uses gentian violet to allow a clear view of the anterior capsule during continuous curvilinear capsulorhexis (CCC) in human eyes with white mature cataract. Setting: Department of Ophthalmology, University of Dicle, Diyarbakir, Turkey. Methods In this masked, experimental study (first stage), 0.05 mL of gentian violet 0.01% or 0.001% solution or balanced salt solution (BSS(R)) (control group) was injected into the anterior chamber of 30 eyes of 30 Wistar albino rats. One, 24, and 48 hours after injection, 4 eyes in each group and 2 eyes in the control group were enucleated, and histopathological examination was performed. In the second stage, these solutions were used for staining the anterior capsule in the 18 human eyes with white mature cataract. The success rate of CCC and intraoperative and postoperative complications were evaluated. Results: Histopathological examination revealed no pathology in any group. A CCC was completed in all cases. No intraoperative or postoperative complications were observed in human eyes except mild corneal edema and mild inflammatory reaction in the anterior chamber that improved within 1 week. Mean follow-up was 3.4 months. Visualization of the anterior capsule was better with gentian violet 0.01% solution. Conclusions: Gentian violet solutions at 0.01% and 0.001% concentrations had no evident toxic effect that caused significant histopathological changes. The staining technique was practical and helped the surgeon visualize the anterior capsule. However, gentian violet may have adverse effects that lead to corneal edema. J Cataract Refract Surg 2000; 26:. 1228-1232 (C) 2000 ASCRS and ESCRS.Öğe Intrapleural fibrinolytic treatment of multiloculated pediatric empyemas(Springer, 2004) Ülkü, R; Önen, A; Onat, S; Kilinç, N; Özçelik, COur objective was to compare the efficacy of adjunctive intrapleural fibrinolytic agents (IPFA) (streptokinase, urokinase) on fibrinopurulent stage empyema and chronic stage empyema in children. IPFA were used in 78 pediatric patients with empyema (36 fibrinopurulent stage empyemas, 42 chronic stage empyemas) between December 1994 and September 2002. Pleural biopsy was done for staging in all cases. Streptokinase 250,000 units in 100 ml normal saline (62 patients) or 100,000 units urokinase in 100 ml normal saline (16 patients) was instilled daily into the patient's chest tube, and the tube was clamped for 4 h, followed by suction. This treatment was continued daily for 2-8 days until resolution was demonstrated by chest radiographs and/or computed chest tomography. Success of treatment was 97.2% (complete response 24/36, partial response 11/36) in the fibrinopurulent stage and 9.4% (complete response 2/42, partial response 2/42) in chronic empyema cases. In one patient with fibrinopurulent empyema, the treatment was stopped due to allergic reaction and pleural hemorrhage; this patient died 1 day later in a septic condition. Although an invasive method, the pleural biopsy technique may be an alternative way of more properly staging thoracic empyema in selected children in whom staging based on radiographic and biochemical findings is doubtful. Intrapleural fibrinolytic treatment is an effective and safe therapy of choice and may have significant benefit in most children with fibrinopurulent phase empyema, except for those with bronchopleural fistula. IPFA do not seem to be effective in children with chronic phase empyema.Öğe Mucinous tumors of the ovary(I R O G Canada, Inc, 2001) Yaldiz, M; Uzunlar, AK; Kilinç, N; Yalinkaya, A; Akkus, M; Tunik, SOvarian mucinous tumors stem from ovarian surface epithelium and are divided into benign, borderline and malignant. If is difficult to differentiate borderline and malignant mucinous tumors. Thirty-eight cases of ovarian mucinous tumors which were diagnosed at the Pathology Department of Dicle University Medical Faculty were reviewed. Of these, 18 (47.3%), six (15.7%) and 14 (36.8%) were benign, borderline and malignant. respectively. The patients' ages ranged from 18 to 67 (average 44.5) years. Bilaterality was detected in 1/18 (5.5%). 0/6 and 4/14 (28.5%) of benign, borderline and malignant mucinous tumors, respectively. Mean tumor size was 26.4 cm. Microscopically, there was no stratification in the benign tumors. The borderline tumors had papillary infoldings and 2-3 layers of atypical epithelial cells but no invasion of the stroma. Malignant tumors had four or more layers of atypical epithelial cells and stromal invasion.Öğe The nitric oxide donor molsidomine prevents ischemia/reperfusion injury of the adult rat small intestine(Springer, 2003) Öztürk, H; Aldemir, M; Dokucu, AI; Yagmur, Y; Kilinç, N; Sahin, AHIt is suggested that gastrointestinal mucosal blood flow depends on a balanced release of vasoactive substances from the endothelium. The present study investigated the effects of molsidomine on the small intestine after ischemia-reperfusion (I/R) injury in four groups of 10 rats each composed: (1) SO, sham operation; (2) untreated I/R; (3) ML, I/R plus molsidomine pretreatment; (4) L-NAME, I/R plus N-omega-nitro-L-arginine methyl ester pretreatment. Intestinal ischemia for 45 min and reperfusion for 60 min were applied. Ileum specimens were obtained to determine the tissue level of malondialdehyde (MDA) and histologic changes. Mean MDA levels in the SO, untreated I/R, ML, and L-NAME groups were 95.60 +/- 2.59, 136.90 +/- 4.35, 121.10 +/- 3.38, and 137.40 +/- 4.42 nmol/g wet tissue, respectively. Although the MDA level in the ML group was higher than in the SO group (P < 0.0001), it was significantly lower compared to the untreated I/R and L-NAME groups (P < 0.0001, P < 0.0001). Mucosal injury scores (MIS) in groups 1-4 were 0.2 +/- 0.42, 3.9 +/- 0.73, 1.5 +/- 0.70, and 4.1 +/- 0.56, respectively. In group 3 the MIS was significantly lower than in groups 2 and 4 (P < 0.0001, P < 0.0001). Molsidomine plays a role in attenuating reperfusion injury of the small intestine by depression of tissue MDA levels and MIS and regulates post-ischemic intestinal perfusion while restoring the intestinal microcirculatory blood flow and histologic injury.Öğe P53, c-erbB-2 expression and steroid hormone receptors in breast carcinoma(Imr Press, 2004) Kilinç, N; Yaldiz, MObjective: The aim of the study was to evaluate the p53 tumor suppressor gene, c-erbB-2 and steroid hormone receptor expression in breast carcinoma by immunohistochemistry and to correlate them with different histopathologic parameters. Materials and Methods: p53, c-erbB-2, steroid hormone receptors and their correlation with age, tumor size, histological grade, axillary lymph-node status, and menopausal status were investigated in 65 breast carcinoma cases. All markers were measured immunohistochemically on paraffin sections. Association between estrogen receptor (ER), progesterone receptor (PgR), p53 and c-erbB-2 expression and clinicopathologic variables were assessed by the chi-square test for qualitative parameters. Results: c-erbB-2 staining was found in 35.3% of breast carcinomas and was associated with ductal subtype and age under 35 (p 0.022, p = 0.003, respectively); p53 staining was seen in 27.6% of cases and was associated with high histological grade and post-menapausal status (p = 0.038, p = 0.002, respectively). Progesterone receptor expression was associated with positive axillary status (p = 0.003). Conclusion: We concluded that expressions of c-erbB-2, p53, ER, and PgR may be used in the evaluation of breast carcinoma. Therefore the present study suggests that p53 expression is a marker of high histological grade in postmenopausal status, and that c-erbB-2 expression is associated with histologically ductal subtype.Öğe Primary gastric choriocarcinoma(I R O G Canada, Inc, 2000) Bayhan, G; Yaldiz, M; Yalinkaya, A; Kilinç, N; Gül, T; Erden, AC[Abstract Not Available]Öğe Survival and reproductive function after treatment of immature ovarian teratoma(I R O G Canada, Inc, 2001) Uzunlar, AK; Yalinkaya, A; Yaldiz, M; Kilinç, N; Gül, TWe conducted a clinical and pathologic review of nine patients with immature ovarian teratoma. The histologic grade of the tumor seemed to be a reliable indicator of prognosis. Low stage and low grade immature ovarian teratomas have an excellent prognosis. Platinum-based chemotherapy has been confirmed to be effective in the management of patients with ovarian germ cell tumors. Low grade pure ovarian immature teratoma is a potentially curable disease and a fertility-sparing surgical approach is possible,
