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Öğe Acute thrombus formation on an Occlutech ASD Occluder device during transcatheter closure: Case report(Ortadoğu Reklam Tanıtım Yayıncılık, 2016) Bilik, Mehmet Zihni; Akıl, Mehmet Ata; Acet, Halit; Kaya, Hasan; Ertaş, FarukAcute thrombosis during transcatheter device closure of atrial septal defect is a very rare but important complication. A 67-year-old woman with secundum type atrial septal defect underwent closure with the Occlutech Figula device. Acetilsalicylic acid and clopidogrel had been started one day before procedure and heparin was given at the beginning of the procedure. During the intervention a thrombus on the left atrial disk was detected by transesophageal echocardiography (TEE). The delivery system and thrombus were succesfully removed from circulation. Additional heparin bolus was given and the procedure was completed succesfully. The control TEE showed good device position and no thrombus formation on the device. The patient was discharged without any complication.Öğe Ankilozan spondilit hastalarında serum ADMA düzeyleri ve aortun elastik özelliklerinin değerlendirilmesi(Kartal Koşuyolu Yüksek İhtisas Eğitim ve Araştırma Hastanesi, 2013) Kaya, Hasan; Tekbaş, Ebru Öntürk; Ertaş, Faruk; İnci, Ümit; Oylumlu, Mustafa; Yüksel, Murat; Aydın, Mesut; Batmaz, İbrahim; Yüksel, Hatice; Ülgen, Mehmet SıddıkÖz: Giriş: Ankilozan spondilit kronik infl amatuvar bir hastalık olup, kardiyovasküler komplikasyonlarla ilişkili olabilmektedir. Bu çalışmada amacımız, kardiyak tutulum olmayan ankilozan spondilit hastalarında aortun elastik özellikleri ile serum asimetrik dimetilarjinin (ADMA) düzeylerinin araştırılmasıdır.Hastalar ve Yöntem: Elli beş ankilozan spondilit hastasıyla benzer yaş ve cinsiyette 30 sağlıklı birey çalışmaya alındı. Açlık glukoz, serum lipidleri, C-reaktif protein (CRP), eritrosit sedimentasyon hızı (ESH) ve ADMA düzeyleri çalışıldı. Aortik strain, distensibilite ve sertlik indeksi transtorasik ekokardiyografi de aort çapı ölçümleri ve eş zamanlı kan basıncı ölçümleriyle hesaplandı. Bulgular: Ankilozan spondilit grubunda ESH ve CRP düzeyleri yüksekti. Serum ADMA düzeyleri ankilozan spondilit grubunda kontrol grubuna göre anlamlı olarak yüksekti (0.76 ± 0.19 ve 0.55 ± 0.12, p< 0.001). Alt grup analizinde, anti-TNF-alfa tedavisi alan grupta konvansiyonel tedavi grubuna göre daha düşük ADMA düzeyi ölçüldü (0.68 ± 0.15 ve 0.87 ± 0.18, p< 0.001). Ortalama aortik strain ve distensibilite değerleri ankilozan spondilit grubunda daha düşük iken, sertlik indeksi daha yüksek saptandı. Korelasyon analizinde ADMA düzeyleri ile aortun elastik özellikleri arasında ilişki izlenmezken, ankilozan spondilit grubunda hastalık süresi ile aortik strain ve distensibilite arasında ters yönde anlamlı korelasyon izlendi.Sonuç: Çalışmamızda elde ettiğimiz sonuçlar kardiyak tutulumun olmadığı ankilozan spondilit hastalarında aortik elastisitenin bozulduğunu ve ADMA düzeylerinin arttığını göstermektedir. Ayrıca, aortun elastik özellikleri ile ADMA düzeyleri arasında anlamlı ilişki saptanamamıştır.Öğe Assessment of Serum ADMA Levels and Aortic Elastic Properties in Patients With Ankylosing Spondilitis(Elsevier Science Inc, 2013) Kaya, Hasan; Tekbas, Ebru Onturk; Ertas, Faruk; Inci, Umit; Oylumlu, Mustafa; Yuksel, Murat; Aydin, Mesut[Abstract Not Available]Öğe Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension(Türk Kardiyoloji Derneği, 2013) Yıldız, Abdulkadir; Kaya, Hasan; Ertaş, Faruk; Oylumlu, Mustafa; Bilik, Mehmet Zihni; Yüksel, Murat; Polat, Nihat; Akıl, Mehmet Ata; Atılgan, Zuhal; Ülgen, Mehmet SıddıkObjectives: Pulmonary hypertension (PH) is composed of a heterogeneous group of disorders marked by increased pulmonary artery resistance leading to right heart failure, with high mortality. Evidence is increasing to propose that inflammation plays a significant role in the pathophysiological mechanism. Increased prevalence of PH in patients with systemic inflammatory diseases is already known. Herein, we sought to evaluate the association between neutrophil to lymphocyte ratio (N/L ratio) and pulmonary arterial hypertension (PAH). Study design: Twenty-five patients with PAH and 25 controls were evaluated. Baseline clinical and echocardiographic variables were obtained. Complete blood counts in all patients and controls were reviewed retrospectively. Results: The N/L ratio was higher in patients with PAH compared to healthy volunteers (p=0.05). A cut-off value of 1.65 for N/L ratio predicted the presence of PAH with 72% sensitivity and 69% specificity. After multivariate analysis, only N/L ratio remained a significant predictor of PAH. Conclusion: We showed for the first time that N/L ratio was significantly increased in patients with PAH compared to controls.Öğe Association Between Neutrophil to Lymphocyte Ratio and Severity of Coronary Artery Disease(Sage Publications Inc, 2014) Kaya, Hasan; Ertas, Faruk; Soydinc, Mehmet Serdar[Abstract Not Available]Öğe Association Between Neutrophil to Lymphocyte Ratio and Severity of Coronary Artery Disease(Sage Publications Inc, 2014) Kaya, Hasan; Ertas, Faruk; Islamoglu, Yahya; Kaya, Zekeriya; Atilgan, Zuhal Ariturk; Cil, Habib; Caliskan, AhmetThe aim of this study is to investigate the association between neutrophil to lymphocyte ratio (NLR) and severity of coronary atherosclerosis. A total of 172 patients undergoing coronary angiography were included in the study. Control group consisted of patients with normal coronary arteries. Patients with coronary stenosis were divided into 2 groups by use of Gensini scores. The NLR was higher in severe atherosclerosis group compared with mild atherosclerosis and control groups (P < .001). In correlation analysis, NLR showed significant correlation with Gensini score. A cutoff value of 2.5 for NLR predicted severe atherosclerosis with a sensitivity and specificity of 62% and 69%, respectively. After multivariate analysis, high levels of NLR were independent predictors of severe atherosclerosis together with glucose and high-density lipoprotein. Our study suggests that the NLR is a predictor of severe atherosclerosis that may be useful for cardiac risk stratification in patients with coronary artery disease.Öğe The association between platelet/lymphocyte ratio and coronary artery disease severity(Turkish Society of Cardiology, 2015) Yüksel, Murat; Yıldız, Abdulkadir; Oylumlu, Mustafa; Akyüz, Abdurrahman; Aydın, Mesut; Kaya, Hasan; Acet, Halit; Polat, Nihat; Bilik, Mehmet Zihni; Alan, SaitObjective: In this study, we aimed to explore the association between platelet-to-lymphocyte ratio (PLR) and the severity of atherosclerosis in coronary artery disease (CAD). Methods: Clinical and laboratory data of 388 patients who underwent coronary angiography were evaluated retrospectively. Gensini score, which indicates the severity of atherosclerosis, was calculated for all of the patients. Patients with CAD were categorized as mild and severe atherosclerosis, according to their Gensini score. Eighty patients with normal coronary arteries formed the control group. Mean PLR values of the three study groups were compared. Also, PLR value was tested for whether it showed a positive correlation with Gensini score. Results: The mean PLR of the severe atherosclerosis group was significantly higher than that of the mild atherosclerosis and controls groups (p<0.001). Also, PLR was positively correlated with Gensini score in CAD patients. A cut-off value of 111 for PLR predicted severe atherosclerosis with 61% sensitivity and 59% specificity. Pre-procedural PLR level was found to be independently associated with Gensini score, together with WBC, age, and low HDL level, in the multivariate analysis. Conclusion: Our study suggests that high PLR appears to be additive to conventional risk factors and commonly used biomarkers in predicting severe atherosclerosis. (Anatol J Cardiol 2015; 15: 640-7).Öğe Association of Primum-Type Atrial Septal Defect and Patent Foramen Ovale in a Patient with Holt-Oram Syndrome(2019) Kaya, Hasan; Yavuz, Celal; Ertaş, Faruk; Çoşkun, Mehmet SaitA 49-year-old woman with dwarfism reported signs of shortness of breath. A physical examination of the patient revealed congenital deformities in the hands and feet (Figure 1). Radiographs showed that the extremities of both her hands had metatarsal polydactyly; moreover, with her feet seem to have epiphyseal dysplasia and polysyndactyly were determined (Figure 2). Telecardiography showed cardiomegaly, and electrocardiography showed rightaxial deviation and right ventricular hypertrophyÖğe The Atrial Fibrillation in Turkey: Epidemiologic Registry (AFTER)(Via Medica, 2013) Ertas, Faruk; Eren, Nihan Kahya; Kaya, Hasan; Aribas, Alpay; Acar, Goksel; Kanadasi, Mehmet; Gedik, SelcukBackground: AFTER (Atrial Fibrillation in Turkey: Epidemiologic Registry) is a prospective, multicenter study designed with the aim of describing the prevalence and epidemiology of AF practice in Turkey. This study aims to evaluate stroke risk in non-valvular atrial fibrillation (AF) and anticoagulant drug utilization within conformity to AF guidelines. Methods: Patients were recruited in 17 referral hospitals reflecting all the population of 7 geographical regions of Turkey. 2242 consecutive patients who had been admitted with AF on ECG were included in the study. 1745 of these patients, who had non-valvular AF, were included in the statistical evaluation. Stroke risk was evaluated with the CHA(2)DS(2)-VASc score. Results: The average age of participants was determined to be 69.2 +/- 11.5 years (56% female). Persistent-permanent AF was found to be the most common type of non-valvular AF (78%). The most common comorbid disorder was hypertension (73%). It was found that oral anticoagulant therapy was used by 40% of all patients, 37% of whom had effective INR (2.0-3.0). Upon multivariate analysis, age was found to be the only independent predictor of stroke among the variables' effects on thromboembolic events that created CHA2DS2-VASc abbreviations (OR 1.026, p < 0.001). Conclusions: These results suggest that stroke risk scores should be thoroughly heeded based on guidelines, and that anticoagulation must be applied according to their guidance.Öğe Atrial Fibrillation in Turkey: Epidemiologic Registry (AFTER) study design(Turkish Soc Cardiology, 2013) Ertas, Faruk; Kaya, Hasan; Yuksel, Murat; Soydinc, Mehmet Serdar; Alan, Sait; Ulgen, Mehmet SiddikObjective: Atrial fibrillation (AF) is an important health problem in Turkey. However, no prospective, multicenter, large trial reflecting national data has been published so far. Therefore, the aim of this study was to follow, analyze and evaluate patients with AF in a large multicenter nation-wide trial. Methods: Two thousand three hundred consecutive patients with AF in their electrocardiogram, reflecting all the population of seven geographical regions of Turkey will be included in the study. The patients will be followed up for two years and death, transient ischemic attack, stroke, systemic thromboembolism, major bleeding, hospitalization will be recorded as the primary end-point. Results: Will be available at the end of the study; preliminary results will be due December 2012. Conclusion: General risk profile of patients with AF, frequency of anticoagulation, frequency of effective treatment and risks of bleeding will be evaluated according to the current guidelines. Major adverse events and their independent predictors will be determined.Öğe Atrial Fibrillation in Turkey: Epidemiologic Registry (AFTER) study design(2013) Soydinç, Mehmet Serdar; Ertaş, Faruk; Yüksel, Murat; Kaya, Hasan; Ülgen, Mehmet Sıddık; Alan, SaitAmaç: Atriyal fibrilasyon (AF) ülkemiz için önemli bir sağlık sorunudur. Ülkemizde ileriye dönük, çok merkezli ve ülke epidemiyolojisini yansıtan ölçekte herhangi bir çalışma mevcut değildir. Bu çalışmayla ülkemizde çok merkezli bir çalışmada AF hastalarının epidemiyolojik verilerinin öne dönük olarak analizi, takibi ve değerlendirilmesi amaçlandı. Yöntemler: Ülkemizden yedi coğrafi bölgeye ait nüfusu yansıtacak şekilde elektrokardiyografisinde en az bir defa AF atağı tespit edilmiş olan ardışık 2300 hasta çalışmaya alınacaktır. Hastalar ikinci yılın sonunda majör kardiyak sonlanım noktaları (ölüm, geçici iskemik atak, inme, siste- mik tromboembolizm, major kanama ve hastane yatışı) açısından değerlendirilecektir. Bulgular: Çalışma sonunda elde edilecektir. İlk bulguların Aralık 2012 tarihinde elde edilmesi planlanmaktadır. Sonuç: AFTER (Atrial Fibrillation in Turkey: Epidemiologic Registry) çalışması ile kılavuzların önerileri doğrultusunda ülkemizdeki AF hastalarının genel risk profili, oral antikoagülan tedavi kullanım sıklığı, tedavi alan hastalarda hedef INR değerlerine ulaşılıp ulaşılmadığı ve hastaların kana- ma riskleri belirlenecektir. Çalışma sonunda ülkemizde AF’li hastalarda majör istenmeyen olay sıklığı ve bu olayların bağımsız belirteçleri de belirlenecektir.Öğe Öğe Bouncing ball myxoma in the left atrial cavity(Oxford Univ Press, 2012) Ertas, Faruk; Kaya, Hasan; Caliskan, Ahmet; Yavuz, Celal[Abstract Not Available]Öğe Carotid Artery Stiffness in Patients With Neurally Mediated Syncope(Amer Inst Ultrasound Medicine, 2012) Elbey, Mehmet Ali; Atilgan, Zuhal; Cil, Habib; Kaya, Hasan; Ertas, Faruk; Aydin, Mesut; Ozaydogdu, NecdetObjectives-Neurally mediated syncope is defined as a transient loss of blood flow to the brain, resulting in vasodilatation, bradycardia, or both. The pathophysiologic mechanisms of neurally mediated syncope are not clear. In this study, we investigated carotid artery elasticity parameters in patients with neurally mediated syncope. Methods-The study was conducted on 41 patients who were examined by the tilt table test. Group 1 constituted of 21 patients who had a positive response to the tilt table test. Clinical and hemodynamic parameters were compared with patients in a negative tilt table test group (group 2). The systolic and diastolic diameters of the carotid arteries, carotid distensibility, carotid strain, carotid stiffness index, and carotid elastic modulus of the left carotid arteries were calculated by a high-resolution ultrasound device. Results-No differences in hemodynamic variables or clinical parameters were detected between the groups. Carotid distensibility (mean +/- SD, 1.6 +/- 0.6 versus 2.2 +/- 0.8 cm(2) x dyne(-1) x 10(-6); P = .044) and strain (6.8% +/- 1.7% versus 8.2% +/- 1.9%; P = .026) were lower in group 1 than in group 2. The carotid elastic modulus (0.88 +/- 0.33 versus 0.74 +/- 0.25 cm(2) x dyne(-1) x 10(-6); P = .002) and stiffness index (6.7 +/- 0.4 versus 6.2 +/- 0.5; P = .038) were higher in group 1. Conclusions-In this study, we concluded that elastic properties of the carotid artery are impaired in patients with neurally mediated syncope. This finding suggests that impaired carotid arterial elasticity may be a factor in the pathophysiologic mechanisms of neurally mediated syncope.Öğe Cateheter ablation treatment of atrioventricular nodal re-entrant tachycardia(Dicle Üniversitesi Tıp Fakültesi, 2012) Tanboğa, İbrahim Halil; Kurt, Mustafa; Işık, Turgay; Kaya, Ahmet; Aksakal, Enbiya; Ekinci, Mehmet; Bakırcı, Eftal Murat; Kaya, Hasan; Sevimli, SerdarObjectives: In this study, we aimed to evaluate our clinical experience about the catheter ablation of atrioventricular nodal reentrant tachycardia (AVNRT) including complications and long-term outcomes. Materials and Methods: The study population consisted of 166 patients with AVNRT, 52 of whom from hospital-1 and 114 of who from hospital-2. Radio-frequency (RF) ablation therapy was applied after the basic electrophysiology study. Complications in RF ablation and long-term recurrences were noted. Results: More than 90% of the patients had symptoms persisting for more than one year and again more than 90% of those were suffering at least 2 episodes per month. The success rate of RF ablation was 98.2% for the entire study population. The recurrence rate was observed to be 3% (n=5) throughout the follow-up period. In the multivariate Cox regression analysis; young age, operator`s experience (Hospital 1 vs. 2), and presence of atypical AVNRT were the independent predictors of long-term recurrence. Major complications related to AVNRT ablation are not encountered frequently. Death, myocardial infarction and stroke were not seen in any of the patients, however, two patients developed deep vein thrombosis. Minor complications in RF ablation included asymptomatic minimal/mild pericardial effusion (n=5), femoral hematoma requiring no transfusion (n=5) and transient AV block (n=5). Atrio-ventricular block requiring permanent pacemaker implantation was found only in one patient (0.6%). Conclusion: Radio-frequency catheter ablation in patients with AVNRT appears to be a safe and effective method. The presence of atypical AVNRT, young age and operator`s experience were observed to be the independent predictors of long-term recurrence.Öğe Circadian Variation of Blood Pressure Is Impaired in Normotensive Pregnant Women with Gestational Diabetes Mellitus(Taylor & Francis Inc, 2013) Soydinc, Hatice Ender; Davutoglu, Vedat; Sak, Muhammet Erdal; Ercan, Suleyman; Evsen, Mehmet Siddik; Kaya, Hasan; Oylumlu, MuhammedData about circadian blood pressure (BP) in normotensive patients with gestational diabetes mellitus (GDM) are lacking. Thus, we sought to compare dipper and nondipper circadian variation of BP profile between normotensive women complicated with GDM and normal pregnant women. Forty-two women with GDM and 33 normal uncomplicated pregnant women who met the entry criteria for the study were enrolled in the study. Twenty-four-hour noninvasive ambulatory blood pressure monitoring and echocardiography to measure the left ventricle mass index and diastolic parameters were performed. Nocturnal blood pressure dipping was calculated as follows: (awake BP - sleep BP) x 100/awake BP. Patients with a nocturnal reduction in average daytime systolic BP and diastolic BP of less than 10% were classified as nondippers. Left ventricle mass index was higher in normotensive pregnant women with GDM group than in normal pregnant subjects (101.98 +/- 24 g/m(2) vs. 90.67 +/- 15 g/m(2), P < .018). Significant nocturnal systolic and diastolic nondippings were observed in GDM groups compared with normal subjects. From diastolic variables, the mitral E velocity and isovolumetric relaxation time were compatible with diastolic dysfunction relaxation abnormalities (P = .003 and P = .015, respectively) in nondipper group. From all confounding factors, only E velocity (P = .002) and diagnosis of GDM (P < .001) were predictive of nondipper circadian variation. This study shows that (i) circadian BP is impaired in normotensive pregnant subjects with GDM, (ii) the left ventricle mass index is higher in pregnant subjects with GDM than in normal pregnant subjects who despite a 24-hour BP are within normal limits, and (iii) in nocturnal nondipper group, the tendency to having diastolic relaxation abnormalities is noted.Öğe Clopidogrel resistance in patients with type 2 Diabetes Mellitus: A comparison between oral antidiabetic agents and insulin(Drunpp-Sarajevo, 2012) Ariturk, Zuhal; Cil, Habib; Gunduz, Ercan; Yavuz, Celal; Kaya, Hasan; Ertas, Faruk; Oylumlu, MustafaBackground: Clopidogrel resistance has been found in certain patient populations, including patients with acute coronary syndrome, ischemic stroke, patients undergoing percutaneous coronary intervention with a drug-eluting stent, diabetes mellitus, ischemic stroke and stent restenosis. The aim of this study was to assess clopidogrel resistance in diabetic patients taking oral antidiabetic drugs and insulin. Methods and Results: Platelet aggregation was measured after clopidogrel treatment in 101 diabetic patients undergoing percutaneous coronary intervention. Two diabetic patient subpopulations were compared: patients who used insulin (group 1) and patients who used oral antidiabetic agents (group 2). Clopidogrel nonresponders and responders were defined by a relative inhibition of adenosine diphosphate (20 mol/L) induced platelet aggregation of < 10% and >= 30%, respectively. Among group 1 patients, 12.5% were clopidogrel nonresponders and Among group 2 patients, 9.4% were clopidogrel nonresponders. There were no statistical differences found between the two groups (P=0.618). Conclusions: This study demonstrates that there was no significant difference in the clopidogrel resistance between type 2 diabetes mellitus patients taking insulin or oral antidiabetes medication. The clinical implications of this finding are unknown and need to be evaluated in large-scale clinical trials.Öğe Correlation between the body fat composition and high sensitive C-reactive protein in Turkish adults(2012) Aydın, Mesut; Dumlu, Talha; Alemdar, Recai; Kayapınar, Osman; Celbek, Gökhan; Karabacak, Ahmet; Türker, Yasin; Kaya, Hasan; Ertaş, Faruk; Atılgan, Zuhal Arıtürkobjectives. Te adipose tissue is an active immune organ. High sensitive C-reactive protein CRP (hs-CRP) is a strong independent predictor of a possible future myocardial infarction and stroke, and it has also been shown to be related to the sub clinical atherosclerosis. Te aim of this study was to investigate the relation between the body fat composition, metabolic syndrome, and the hs-CRP plasma levels. Methods. Total 246 consecutive Turkish subjects, admitted to the internal medicine clinic with the diagnosis of diabetes mellitus, insulin resistance or metabolic syndrome, were included into the study. Te total body fat composition was measured in every participant with a commercially available bio-impedance meter. Te hs-CRP levels, body composition parameters, and biochemical variables were compared. Results. Te hs-CRP levels increased in parallel with the body weight in Turkish subjects. Tis increase was significant especially in the women. Te waist circumference, body mass index (BMI), and body composition variables (visceral fat level, total body fat, and total body muscle mass) were significant correlates of the hs-CRP. Te waist circumference and BMI were independent predictors of the hs-CRP. Conclusion. Te waist circumference, BMI, and body composition variables (visceral fat level, total body fat and total body muscle mass) were significant correlates of the hs-CRP in Turkish adults. Body weight control may account for an important target especially in patients with the metabolic syndrome.Öğe An epidemiological study to evaluate the use of vitamin K antagonists and new oral anticoagulants among non-valvular atrial fibrillation patients in Turkey- AFTER*-2 study design(Türk Kardiyoloji Derneği, 2015) Ertaş, Faruk; Kaya, Hasan; Yıldız, Abdulkadir; Davutoğlu, Vedat; Kiriş, Abdulkadir; Dinç, Lale; Kafes, Habibe; Avcı, Anıl; Çalapkorur, Bekir; Ertaş, Gökhan; Gül, Mehmet; Ay, Nuray Kahraman; Bulur, Serkan; Durukan, Mine; Eren, Murat; İlhan, İbrahim; Küçük, Murathan; Özpelit, Ebru; Şimşek, Hakkı; Uçar, F. Mehmet; Yıldız, Ahmet; Şahin, Yıldıray; Ayhan, Erkan; Çağlayan, Emre; Güngör, Hasan; Özyurtlu, Ferhat; Şen, Nihat; Vatan, Bülent; Vatansever, Fahriye; Kobat, Mehmet Ali; Temiz, Ahmet; Taylan, Gökay; Dönmez, İbrahim; Erkuş, M. Emre; Söylemez, Selami; Zengin, Halit; Gündüz, Mahmut; Tuncez, Abdullah; Karavelioğlu, Yusuf; Gökdeniz, Tayyar; Koza, Yavuzer; Aktop, Ziyaeddin; Katlandur, Hüseyin; Özer, Pelin Karaca; Yüksel, Murat; Acet, Halit; Çil, Habib; Alan, Sait; Toprak, NizamettinObjectives: Atrial fibrillation (AF) is one of the most common causes of preventable ischemic stroke and is related to increased cardiovascular morbidity and mortality. There is a lack of data in Turkey on the use of new oral anticoagulants (NOACs), and time in therapeutic INR range (TTR) in vitamin K antagonist users and AF management modality. In this multi-center trial, we aimed to analyze, follow and evaluate the epidemiological data in non-valvular AF patients. Study design: Four thousand one hundred consecutive adult patients from 42 centers with at least one AF attack identified on electrocardiography will be included in the study. Patients with rheumatic mitral valve stenosis and prosthetic valve disease will be excluded from the study. At the end of one year, the patients will be evaluated in terms of major cardiac end points (death, transient ischemic attack, stroke, systemic thromboembolism, major bleeding and hospitalization). Results: First results are expected in June 2015. Data about major cardiovascular end-points will be available in January 2016. Conclusion: The rates and kind of oral anticoagulant use, TTR in vitamin K antagonist users and main management modality applied in non-valvular AF patients will be determined by AFTER-2 study. In addition, the rate of major adverse events (MACEs) and the independent predictors of these MACEs will be detected (AFTER-2 Study ClinicalTrials.gov number, NCT02354456.).Öğe Epidemiology of atrial fibrillation in Turkey: preliminary results of the multicenter AFTER study Reply(Turkish Soc Cardiology, 2013) Ertas, Faruk; Kaya, Hasan; Ozhan, Hakan[Abstract Not Available]
