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Öğe Distraction osteogenesis is inhibited by cancer radiotherapy with Co 60(Canadian Soc Clinical Investigation, 2009) Kesemenli, Cumhur Cevdet; Kaya, Halil; Memisoglu, Kaya; Kaya, Beyza; Dirier, Ahmet; Tosun, Bilgehan; Kilinc, NihalAim: To investigate the effects of radiotherapy on distraction osteogenesis performed on the same bone in an area that has not received radiation. Radiotherapy (Co60) was carried out in a region where tumors may develop, and then, on the assumption that the tumoral region had been removed, distraction osteogenesis was carried out, and the effects were investigated. Method: Thirty New Zealand rabbits were randomized into two groups, a study group (15 rabbits) and a control group (15 rabbits). In the study group, Co60 was administered by teletherapy to the distal half of the left tibia. Rabbits in the control group were kept in the same environment for the same period, but were not subjected to radiotherapy. Four weeks after radiotherapy, osteotomy was performed on the proximal part of the left tibia of all subjects, and distraction was carried out until 10mm. After distraction was completed, the outcomes were evaluated radiologically, scintigraphically, and histopathologically, and the results were compared. Results: New bone formation achieved through distraction osteogenesis in the study group animals was inadequate, while new bone tissue achieved in the control group was superior (P<0.001). Conclusion: Radiotherapy has a negative effect on distraction osteogenesis, even if performed on a different part of the bone.Öğe The effect of low-level laser therapy on the healing of hard palate mucosa and the oxidative stress status of rats(Wiley, 2014) Firat, Ela Tules; Dag, Ahmet; Gunay, Ahmet; Kaya, Beyza; Karadede, Mehmet Irfan; Kanay, Berna Ersoz; Ketani, Aydin[Abstract Not Available]Öğe Effect of rifampin in combination with allogeneic, alloplastic, and heterogenous bone grafts on bone regeneration in rat tibial bone defects(Elsevier Science Inc, 2015) Kaya, Alper; Kaya, Beyza; Aktas, Ayfer; Firat, Ela TulesPurpose: The aim of this study was to evaluate the efficacy of rifampin with allogeneic, alloplastic, and heterogeneous bone graft substitutes on osteogenesis of experimentally created bone defects in rat tibias. Materials and methods: Twenty-eight male Wistar albino rats were used in this study. In each animal, two bone defects (10 mm length x 3 mm width x 2 mm depth) were created in the left and right tibias, respectively. The animals were divided into four groups. In Group 1, the right defects were irrigated with rifampin alone, and the left defects were irrigated with sterile saline alone. In Group 2, the right defects were filled with rifampin and allogeneic bone graft, and the left defects were filled with allogeneic bone graft alone. In Group 3, the right defects were treated with rifampin and alloplastic bone graft, and the left defects were filled with alloplastic bone graft alone. In Group 4, the right defects were filled with rifampin and heterogeneous bone graft, and the left defects were filled with heterogeneous bone graft alone. Results: The animals were sacrified on the 21st postoperative day. Histopathological analysis of samples was performed to evaluate the process of bone regeneration and the presence of spongeous bone, cortex bone, and bone marrow. Bone union (p = 0.023) and spongeous bone (p = 0.030) values were higher in Group 1A (rifampin alone) than those in Group 1B (saline alone). Bone union (p<0.001) and spongeous bone (p<0.001) values in Group 2B (allograft + saline) were higher than those in Group 2A (allograft + rifampin). These differences were statistically significant. Conclusions: Topical rifampin can accelerate the bone repair process, but the combination of rifampin and allogeneic bone grafts can also reduce new bone formation in osseous defects. Further studies involving long-term follow-up with a larger number of cases and different antibiotic agents should be conducted. These will provide additional data regarding new bone formation, especially in contaminated bone defects, resulting from use of antibiotic-supplemented bone grafts. (C) 2013 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI. Published by Elsevier Ltd. All rights reserved.*Öğe The Effects of Low-Level Laser Therapy on Palatal Mucoperiosteal Wound Healing and Oxidative Stress Status in Experimental Diabetic Rats(Mary Ann Liebert, Inc, 2013) Firat, Ela Tules; Dag, Ahmet; Gunay, Ahmet; Kaya, Beyza; Karadede, Mehmet Irfan; Kanay, Berna Ersoz; Ketani, AydinObjective: The biostimulation effects of low-level laser therapy (LLLT) have recently been demonstrated. In this study, we aimed to investigate the effects of LLLT on palatal mucoperiostal wound healing and oxidative stress status in experimental diabetic rats. Materials and methods: Forty-two male Wistar rats that weighed 250-300 g were used in this study. Experimental diabetes was induced in all of the rats using streptozotocin. A standardized full thickness wound was made in the mucoperiosteum of the hard palates of the rats using a 3 mm biopsy punch. The rats were divided into groups: 1 (control group, non-irradiated), and 2 (experimental group, irradiated). Treatment using a GaAlAs laser at a wavelength of 940 nm and at dose of 10 J/cm(2) began after surgery, and was repeated on the 2nd, 4th, and 6th days post-surgery. Seven animals from each group were killed on the 7th, 14th, and 21st day after surgery. Biopsies were performed for the histological analysis and blood samples were collected by cardiac puncture for biochemical analysis. Results: The histopathological findings revealed reduced numbers of inflammatory cells, and increased mitotic activity of fibroblasts, collagen synthesis, and vascularization in rats in group 2. The total oxidative status was significantly decreased in the laser-treated group on the 21st day. Conclusions: LLLT elicits a positive healing effect on palatal mucoperiostal wounds, and modulates the oxidative status in experimental diabetic rats.Öğe Effects of Systemic Zoledronic Acid Administration on Osseointegration of Hydroxyapatite-Coated and Resorbable Blast Material Surface Implants in Rabbit Models(Quintessence Publishing Co Inc, 2012) Yaman, Ferhan; Agacayak, Serkan; Atilgan, Serhat; Benlidayi, Emre; Ucan, Musa Can; Erol, Behcet; Kaya, BeyzaPurpose: It is unknown whether zoledronic acid (ZA) interferes with initial bone healing at implant sites. The goal of this study was to examine the effects of systemic zoledronic acid administration on osseintegration of hydroxyapatite (HA)-coated and resorbable blast material surface (RBM) implants in rabbit models. Materials and Methods: Twenty-eight male New Zealand rabbits (aged 6 to 12 months) were used in this study. Rabbits were randomly assigned to four groups. In group A, HA-coated implants were placed in the right tibia of seven rabbits. In group B, RBM-surface implants were placed in the right tibia of seven rabbits. In group C, HA-coated implants were placed in seven rabbits with intravenous (IV) administration of ZA. Finally, in group D. ROM-surface implants were placed in seven rabbits with IV administration of ZA. For groups C and D, IV zoledronic acid (0.1 mg/kg) was performed monthly during the entire osseointegration period. All of the rabbits were sacrificed 12 weeks after the implantation, and tibial specimens were harvested. Histomorphometric bone-to-implant contact (BIC) analysis and the data were statistically analyzed. Results: The highest BIC percentage was detected in group D, with a mean value of 56.73% +/- 1.85%, as compared with 45.80% +/- 3.77% in group C, 35.11% +/- 0.76% in group B, and 3114% +/- 1.04% in group A. Conclusions: Histomorphometric analyses showed significant improvement in the osseointegration of implants in the RBM-surface ZA group compared with the HA-coated ZA group. The results of this study suggest that systemic ZA administration may improve osseointegration of titanium implants in bone. INT J ORAL MAXILLOFAC IMPLANTS 2012;27:1443-1447Öğe Guided bone regeneration with polyethylene membrane, zoledronic acid and hydroxiapatide bone graft in peri-implant bone defect: An experimental study(Allied Acad, 2017) Yaman, Ferhan; Dundar, Serkan; Cakmak, Omer; Saybak, Arif; Kirtay, Mustafa; Kaya, Beyza; Kom, MustafaThis study aimed to determine the guided bone regeneration (GBR) capacity of peri-implant bone defect treatment, either with only a hydroxyapatite bone graft or with a hydroxyapatite bone graft mixed with zoledronic acid (ZA) and employing polyethylene glycol (PEG) barrier membranes. In this study, four male New Zealand rabbits were used. First, the rabbits were randomly divided into two groups, the hydroxyapatite graft group (HA) (n=2) and the HA graft + zoledronic acid group (HA+ZA) (n=2). For the HA group, peri-implant GBR was performed with only an HA bone graft, and a resorbable PEG barrier membrane was placed over each surgical defect to cover the peri-implant bone defects. For the HA+ZA group, peri-implant GBR was performed with an HA bone graft that had previously been mixed with ZA. A resorbable PEG barrier membrane was placed over each surgical defect to cover the peri-implant bone defects. Experiments were performed using a standardised peri-implant bone tissue defect model in rabbit tibia for 60 days. Circumferential defects were surgically induced around the dental implants on the tibias of four rabbits. Sixty days after the surgical procedures, the rabbits were sacrificed, and their tibias with the graft sites were harvested for histologic evaluation. In the HA+ZA group, significantly more new bone formation was detected as compared with the HA group (P<0.05). Within the limitations of this study, locally administered ZA with an HA synthetic graft and PEG membrane was a more effective method as compared to using only a graft in a peri-implant GBR procedure. Additionally, a PEG membrane should be useful in GBR as a barrier membrane. Further studies are needed to confirm these results.Öğe Investigation of the effect of denosumab and ozone application on bone healing in critical size bone defects(Dicle Üniversitesi Diş Hekimliği Fakültesi, 2024) Keskin, Ersin; Kaya, Beyza; Aktaş, AyferAims: In maxillofacial surgery, various drugs are used in order to accelerate the recovery of defects caused by any reason. Several studies have shown that denosumab from bisphosphonate group drugs used in osteoporosis patients has positive effects on new bone formation. In general medicine and dentistry, ozone is in widespread use as an alternative treatment and has positive effects on new bone formation. The aim of this study was to evaluate new bone formation by performing denosumab and ozone on critical-sized rat calvarium defects. Methods: In our study, 40 Sprague Dawley rats were used. Rats were divided into 4 groups. Only grafts were placed in the control group. After applying graft to ozone group (O) and ozone and denosumab (O-D) groups, topical ozone was applied for 15 seconds. Denosumab group (D) and O-D group were injected subcutaneously (s.c) 10 mg/kg Prolia (denosumab) every 4 weeks for 8 weeks. 5 animals from each group at the end of week 4, while the other five animals in the group at the end of 8 weeks after being sacrificed for histopathological examination was performed. The differences between the groups were evaluated by statistical analysis. Results: After histopathological examination, better bone formation was observed in the ozone and denosumab treated groups compared to the control group. There was no statistically significant difference between the groups except for the control group, however, new bone formation was determined in the groups treated with denosumab compared to the ozone group. Conclusion: As a result of our study, we believe that the application of ozone and denosumab has a positive effect on the formation of new bone, but more comprehensive studies on the subject are needed.Öğe Investigation of the Effects of Thymoquinone and Dental Pulp-Derived Mesenchymal Stem Cells on Tibial Bone Defect Models(Lippincott Williams & Wilkins, 2024) Ozden, Ersin; Kaya, Beyza; Guler, RidvanThe thymoquinone obtained from Nigella sativa increases osteoblastic activity and significantly reduces the number of osteoclasts, thereby accelerating bone healing. In addition, mesenchymal stem cells isolated from various tissues are considered a potential cell source for bone regenerative therapies. The aim of this study is to investigate the effectiveness of thymoquinone, a current and novel agent, in combination with mesenchymal stem cells derived from the dental pulp in promoting bone healing. In the study, 28 male Sprague Dawley rats were used. The rats were divided into 4 groups, each consisting of 7 rats: the control group (group 1) (n=7), thymoquinone group (group 2) (n=7), stem cell group (group 3) (n=7), stem cell+thymoquinone group (group 4) (n=7). A bone defect of 4 mm in diameter and 5 mm in length was created in the left tibial bones of all rats with a trephine bur. In group 1, no procedure was applied to the defect area. Group 2 was applied thymoquinone (10 mg/kg) with oral gavage. In group 3, stem cells were used locally to the defect area. In group 4, stem cells and thymoquinone (10 mg/kg) was applied to the defect area. All rats were killed on the 28th day of the experiment. Tibia tissues extracted during sacrifice were histomorphologically examined in a fixative solution. Significant differences were found in terms of new bone formation and osteoblastic activity values in the thymoquinone (P<0.05), stem cell (P<0.05), and stem cell+thymoquinone (P<0.05) groups compared to the control group. In addition, while there was no significant difference in the thymoquinone group compared to these stem cell+thymoquinone group in terms of osteoblastic activity (P>0.05), the difference in terms of new bone formation was found to be significantly lower. No significant differences among the other groups were observed in new bone formation and osteoblastic activity (P>0.05). According to the results of our study, stem cell+thymoquinone treatment for bone defects is not only more effective than thymoquinone or stem cell treatment alone but also induces greater development of bone trabeculae, contributes to the matrix and connective tissue formation, and increases the number of osteoblasts and osteocytes involved in bone formation.Öğe Maksiller sinüse yer değiştirmiş diş kökünün caldwell luc ile çıkarılması: Olgu sunumu(Dicle Üniversitesi, Diş Hekimliği Fakültesi, 2022) Ergen, Ozan; Yavuz, Osman; Kaya, BeyzaAnatomik boşluklara yer değiştirme, diş çekimi komplikasyonları arasında sık görülür. Özellikle maksiller molar dişlerin, maksiller sinüse anatomik yakınlığından dolayı sinüs içine yer değiştirmiş köklerle sık karşılaşılır. Sinüs içine yer değiştirmiş köklerin çıkarılmasında farklı yöntemler vardır. Bu olgumuzda maksiller sinüse yer değiştirmiş köklerin Caldwell Luc operasyonu ile çıkarılması sunulmuştur.Öğe Three-dimensional finite element analysis of the effect of endosteal implants with different macro designs on stress distribution in different bone qualities(Quintessence Publishing Co. Inc., 2019) Yalçın, Mustafa; Kaya, Beyza; Laçin, Nihat; Arı, EmrePurpose: The aim of this study was to analyze stress distribution on four different implant designs and four different qualities of cortical bone surrounding the implant crest modules using three-dimensional finite element analysis. Materials and Methods: Four different implant designs of the same diameter and length (3.75 × 11.5 mm) were used. Rhinoceros 4.0 3D modeling software was used for preparing the four types of bone quality (D1, D2, D3, and D4). Mandibular second premolar crowns were constructed as prosthetic superstructures of the implants, and a total force of 300 N was vertically applied to the crowns. Stress distribution on dental implants and cortical bone of D1, D2, D3, and D4 bone quality was evaluated. Results: Among all of the implants, the maximum von Mises stress value on cortical bone surrounding the neck region of the implants was found in D4 bone quality, while the minimum stress was detected in D1 bone quality. The stress distribution on the threads of dental implants exhibited the most homogenous distribution in D1 bone quality, while higher von Mises stress values were observed in the apical blade segment of the implants in D3 and D4 bone quality. Conclusion: It was found that the maximum stress of cortical bone surrounding the implant crest module decreased as the bone density increased. The microthreads on the implant crest module might cause an increase in stress to cortical bone surrounding the neck region of implants.
