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  • Küçük Resim
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    Effect of cardio-gastric interaction on atrial fibrillation in GERD patients
    (Dicle Üniversitesi Tıp Fakültesi, 2023) Günlü, Serhat; Araç, Eşref; Aktan, Adem; Kayan, Fethullah; Altıntaş, Bernas; Karahan, Mehmet Zülkif
    Objective: Atrial fibrillation (AF) and gastroesophageal reflux disease (GERD) are very common in daily clinical practice. Post-prandial AF episodes have been reported in GERD patients. Although it was reported in previous studies that it was caused by sympathovagal imbalance, there are no studies on cardiac conduction system involvement. In this study, we aimed to evaluate whether the risk of developing AF increases in untreated GERD patients with non-invasive electrophysiological tests. Methods: The research was prospectively performed. Endoscopy was performed on the individuals due to reflux complaints. ECG was recorded at 25mm/s and 10 mm/mV amplitude, and 24-hour Holter ECG (three-channel; V1, V2, and V5) was performed. ECG parameters were measured and Holter ECG results were analyzed. Results: A total of 120 individuals, 60 patients and 60 controls, were included. No significant statistically differences existed between groups for hypertension, diabetes, smoking, or dyslipidemia (p>0.05). In terms of heart rate, Pmax, Pmin, QTd, and QTcd, there were no significant differences across the two groups (p>0.05). P-wave dispersion (Pd) was substantially higher in the study group (p=0.014). Comparing the heart rate variabilities of 24-hour Holter ECG recordings across the groups, the standard deviation of R-R intervals (SDNN) was substantially higher in the study group (p<0.001). Low Frequency (LF) and LF/HF were significantly higher in the control group (p<0.001 and p=0.003, respectively). AF was detected in nine individuals on Holter ECG. Conclusion: Pd duration and risk of developing AF were higher in GERD patients.
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    Öğe
    Effects of treatment with hydroxychloroquine and azithromycin on the index of cardiac electrophysiological balance in patients with COVID-19: A retrospective cohort study
    (Selçuk BAŞAK, 2021) Araç, Songül; Karahan, Mehmet Zülkif; Özel, Mehmet; Yiğit, Ramazan; Akkoç, Hasan; Araç, Eşref
    Background/Aim: The common cardiac toxicities of hydroxychloroquine (HCQ) and azithromycin (AZ) are not well defined in COVID-19 patients. Index of cardiac electrophysiological balance (iCEB) is used as a novel risk marker for drug-induced arrhythmias. The purpose of this study was to evaluate ventricular repolarization using iCEB and other conventional ECG parameters such as the end of electrocardiographic T wave (Tp-e) interval, Tp-e/QT ratio, and Tp-e/ heart rate-corrected QT (QTc) ratio in COVID-19 patients treated with HCQ and AZ. Methods: This retrospective study enrolled 164 patients diagnosed with COVID-19 pneumonia in the Emergency Department (ED) and then transferred to the ward or the intensive care unit in April 2020. Results: A total of 164 patients with a mean age of 47 (18) years (range: 18-97 years) included 83 (50.6%) females. There were 38 and 126 patients in Groups HTQ and HTQ+AZ, respectively. On the 5th day of hospitalization, all patients’ heart rates were significantly lower (P
  • Küçük Resim
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    Primary PCI in a patient with congenitally corrected transposition of the great arteries
    (Elsevier B.V., 2016) Öztürk, Önder; Öztürk, Ünal; Nergiz, Şebnem; Karahan, Mehmet Zülkif; 0000-0002-0166-9668
    Congenitally corrected transposition of the great arteries (CCTGA) is a rare disease in which there is both ventriculoarterial and atrioventricular discordance. The systemic ventricle is of right morphology and patients are at high risk of developing systemic ventricular dysfunction. We report on a 41 year old male patient with primary PCI and congenitally corrected transposition of the great arteries.