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    A novel predictor in patients undergoing heart valve surgery: systemic inflammation response index: a single center cross-sectional study
    (Verduci Publisher, 2023) Karacalilar, M.; Demir, M.
    OBJECTIVE: Inflammation plays a pivotal role in heart valve disease (HVD). This study aimed at evaluating the prognostic value of systemic inflammation response index (SIRI) after valve replacement surgery.SUBJECTS AND METHODS: The study en-rolled 90 patients who underwent valve replace-ment surgery. SIRI was calculated using labo-ratory data on admission. Receiver operating characteristic (ROC) analysis was used to calcu-late the optimal cutoff values of SIRI for predict-ing mortality. Univariable and multivariable COX analysis was used to assess the relationship of SIRI with clinical outcomes.RESULTS: 5-year mortality rate was high-er in SIRI >= 1.55 group than SIRI <1.55 group [16 (38.1%) vs. 9 (18.8%)]. In receiver operating char-acteristic analysis, the optimal cutoff values for SIRI were 1.55 (area under the curve 0.654, p: 0.025). Univariable analysis revealed that SIRI [OR: 1.41, 95%CI (1.13-1.75), p<0.001] was an in-dependent predictor of 5-years mortality. Multi -variable analysis revealed that glomerular filtra-tion rate (GFR) [OR: 0.98, 95%CI (0.97-0.99)] was an independent predictor of 5-years mortality.CONCLUSIONS: Although SIRI is a preferable parameter for the detection of long-term mortali-ty, it failed to predict in-hospital and 1-year mor-tality. Larger multi-center studies are needed to investigate effect of SIRI on prognosis.