Yazar "Karabacak, Mustafa" seçeneğine göre listele

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    Association between oxidative stress index and serum lipid levels in healthy young adults
    (Pakistan Medical Assoc, 2014) Turkdogan, Kenan Ahmet; Akpinar, Orhan; Karabacak, Mustafa; Akpinar, Hatice; Turkdogan, Figen Tunali; Karahan, Oguz
    Objectives: To investigate the relationship between lipid levels and oxidative stress index in healthy young adults. Methods: The study was camed out at the Department of Emergency Service, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey, between January 2011 and July 2012. A total of 100 healthy adult volunteers were enrolled in the study. Venous blood samples (10 ml) were collected from all individuals, and serum lipid parameters, total antioxidant capacity and total oxidative levels were studied. SPSS 15 was used for statistical analysis. Results: Overall, there were 84 (84%) males and 16 (16%) females. The mean age fo the male population was 30 +/- 3 years, while that of the females was 31 +/- 3 years. Overall age ranged from 25 to 35 years. A statistically significant correlation was found between the oxidative stress index and serum cholesterol (p<0.001; r=0.596), triglyceride (p<0.001; r=0.476) and low-density lipoprotein levels (p<0.001; r=0.318). However, no significant correlation was found between oxidative stress index and serum high-density lipoprotein levels (p=0.564; r=0.058). Conclusion: The results showed that even at an early age, there is a direct linear correlation between oxidative stress and serum lipid levels.
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    Evaluation of Pericardial Fluid C-Type Natriuretic Peptide Levels in Patients Undergoing Coronary Bypass Surgery
    (Georg Thieme Verlag Kg, 2017) Guclu, Orkut; Karahan, Oguz; Karabacak, Mustafa; Yuksel, Volkan; Huseyin, Serhat; Mavitas, Binali
    Background Neurohumoral and hemodynamic mechanisms have an effect on cardiac activity. C-type natriuretic peptide (CNP) is accessible in the cardiovascular system. The aim of this study was to determine whether CNP concentrations in pericardial fluid and blood are related to cardiac dysfunction in patients undergoing coronary artery bypass graft surgery. Materials and Methods In this study, 40 patients undergoing coronary artery bypass grafting were enrolled. The patients were separated into two groups according to left ventricular (LV) ejection fraction (EF): group 1 contained 28 patients with normal LV systolic function (LVEF >= 50%) and group 2 contained 12 patients with impaired LV systolic function (LVEF < 45%). Plasma and pericardial fluid samples were acquired during surgery to measure CNP levels. Results In group 1, CNP levels were detected to be 0.46 +/- 0.10 ng/mL in plasma and 0.66 +/- 0.8 ng/mL in pericardial liquid. In group 2, these levels were 0.51 +/- 0.09 and 0.79 +/- 0.12 ng/mL, respectively. CNP levels were determined to be significantly higher in patients with low EF compared with those with normal EF in pericardial fluid concentrations (p = 0.013). Conclusions CNP level in pericardial fluid is a more sensitive and proper marker of LV dysfunction than CNP levels in plasma. To the best of our knowledge, this study is the first to examine pericardial fluid CNP levels in patients undergoing coronary artery bypass surgery. It may have a valuable role in organizing cardiac remodeling and hypertrophy.
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    Fasudil umblikal ven endotelinde hücre proliferasyonunu artırıyor
    (2014) Polat, Zübeyde Akın; Karahan, Oğuz; Karabacak, Mustafa; Güven, Fatma Mutlu Kukul; Türkdoğan, Kenan Ahmet; Orhan, Hikmet; Tunalı, Figen Türkdoğan
    Amaç: Bu çalışma ile rho kinaz inhibitörünün vasküler endotel hücreleri üzerine olan etkileri araştırılmıştır.Materyal metod: İnsan umbilikal ven endotel hücrelerinin (HUVEC) Amerikan Tip Kültür Koleksiyonu'ndanelde edildi. Hücreler kuyu başına toplam hacmi 100 ul olan jelatin kaplı mikrotitre plaklar içinde mililitrede104 hücre olacak şekilde 96 kuyuya ekildi. Bazal grup ile 5mMol ve 6mMol konsantrasyonlarda rho kinazinhibitörü uygulanan iki grup olmak üzere üç grup oluşturuldu. İlaç uygulanmış kültürler ve ilaç uygulanmayanbazal kültürler 72 saat takip edildi. Bulgular: Kontrol hücreleri ile rho kinaz inhibitörü (fasudil) verilenhücreler arasında doğrusal artan, kuvvetli bir ilişki saptanmıştır. Fasudil konsantrasyonu mMol olanlarınortalaması 1.063 iken, mMol olanların ortalaması 1.147 olmuştur. Bu ortalamalar arasında istatistiki olarakanlamlı fark bulunmuştur (p:0,044). Zamana göre hücre sayılarında 24 saat ile 48 saat süreleri arasındaönemli ölçüde fark oluşurken, 48 saat ile 72 saat arasında istatistiksel olarak fark oluşmamıştır.Sonuç: Fasudil endotel hücre üzerine sitotoksisite göstermeyip aksine proliferasyonu arttırıyor. Bu da endotelhücre proliferasyonunun artarak neointimal hiperplazi ile vasküler stenoza neden olan stent stenozu gibi hastalıklar için kötü bir durum oluşturmaktadır.
  • Küçük Resim
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    Impact of COVID-19 outbreak on patients with ST-segment elevation myocardial infarction (STEMI) in Turkey: results from TURSER study (TURKISH St-segment elevation myocardial infarction registry)
    (Springer, 2021) Kiris, Tuncay; Avcı, Eyüp; Ekin, Tuba; Akgün, Didar Elif; Tiryaki, Mücahit; Yidirim, Arafat; Hazır, Kutluhan; Murat, Bektaş; Yeni, Mehtap; Altındağ, Rojhad; Gül, Sefa; Arık, Baran; Güzel, Tuncay; Murat, Selda; Öz, Ahmet; Karabacak, Mustafa; Aktaş, Zihni; Yıldırım, Tarık; Kılıçaslan, Barış; Ergene, Asim Oktay
    Objective We aimed to investigate both the impact of COVID-19 pandemic on ST-segment elevation myocardial infarction (STEMI) admission, and demographic, angiographic, procedural characteristics, and in-hospital clinical outcomes of patients with COVID-19 positive STEMI in Turkey. Methods This was a multi-center and cross-sectional observational study. The study population included 1788 STEMI patients from 15 centers in Turkey. The patients were divided into two groups: COVID-19 era (March 11st–May 15st, 2020; n=733) or pre- COVID-19 era group (March 11st–May 15st, 2019; n=1055). Also, the patients in COVID-19 era were grouped as COVID-19 positive (n=65) or negative (n=668). Results There was a 30.5% drop in STEMI admission during COVID-19 era in comparison to pre-COVID-19 era. The patients admitted to the medical centers during COVID-19 era had a longer symptom-to-frst medical contact time [120 (75–240) vs. 100 (60–180) minutes, p<0.001]. COVID-19 positive STEMI patients had higher thrombus grade and lower left ventricular ejection fraction compared to COVID-19 negative patients. COVID-19 positive patients had higher mortality (28% vs. 6%, p<0.001) and cardiogenic shock (20% vs. 7%, p<0.001) rates compared with those without COVID-19. Matching based on propensity scores showed higher mortality and high thrombus grade in STEMI patients who were infected by SARS-COV-2 (each p<0.05). Conclusions We detected signifcantly lower STEMI hospitalization rates and signifcant delay in duration of symptom onset to frst medical contact in the context of Turkey during the COVID-19 outbreak. Moreover, high thrombus grade and mortality were more common in COVID-19 positive STEMI patients.
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    The VKORC1 gene homozygous polymorphism is markedly higher in Crimean Congo Hemorrhagic Fever patients.
    (Allied Acad, 2013) Turkdogan, Kenan Ahmet; Karabacak, Mustafa; Akpinar, Orhan; Karahan, Oguz; Guven, Fatma Mutlu Kukul; Engin, Aynur; Turkdogan, Figen Tunali
    In Crimean-Congo Hemorrhagic Fever (CCHF), the main target of the virus is endothelial cells, monocytes and hepatocytes. The virus in these cells leads to the development of capillary vessels dysfunction, which induces clinical and pathological changes during the disease. Increase in capillary permeability and coagulation dysfunction constitute a tendency to bleed. In the current study, we aimed to investigate the relationship between VKORC1 and bleeding tendency in CCHF. Forty-eight consecutive patients with a laboratory-confirmed diagnosis of CCHF were treated with blood products, and 37 healthy volunteers as the control group were prospectively enrolled into the study. The DNA was obtained from each sample using PCR amplification method, and VKORC1 1639 G>A gene polymorphisms were scanned in the DNA samples. In CCHF group of patients with bleeding VKORC1 gene were analyzed. Normal genotype was detected in 5 (22.7%) patients, homozygote mutation was detected in 2 (9.1%) patients and heterozygote mutation was detected in 15 (68.2%) patients, respectively. Furthermore, the G allele frequency was statistically higher in study group (51 [53%] vs. 27 [36%]) (p<0.005). It seems to be that VKORC1 gene A allele frequencies saliently higher in CCHF. This might be associated with increased bleeding risk in CCHF. Analyzing of VKORC1 gene polymorphisms could help in the risk stratification of patients with CCHF.