Yazar "Karabacak, Ahmet" seçeneğine göre listele

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    Association of omentin Val109Asp polymorphism with coronary artery disease
    (2014) Karabacak, Ahmet; Başar, Cengiz; Bulur, Serkan; Aslantaş, Yusuf; Özhan, Hakan; Memişoğulları, Ramazan; Kaya, Ertuğrul
    Objective: Coronary artery disease (CAD) is the most important morbidity and mortality disease in the world. It is also one of the leading causesof death in Turkey. Omentin, a recently found adipocytokine, is reported to regulate insulin sensitivity. It has anti-inflammatory properties and isinversely associated with CAD. Omentin gene polymorphism in patients with CAD has not been studied yet. The aim of this study is to investigatethe relationship between omentin Val109Asp polymorphism and CAD.Methods: This is an observational study on genetic association. 157 consecutive patients who had undergone coronary angiography wereincluded in the study. Seventy-five of them had CAD and the rest serves the control group. Val109Asp polymorphism was analyzed and com-pared. Chi-square test was used in comparison of genotype frequencies, whereas ANOVA and chi-square tests were used in comparison ofclinical characteristics according to the genotypes.Results: There was no significant difference between CAD patients and control subjects regarding omentin Val109Asp polymorphism. However, a 2.5fold increase in Val/Val (homozygous mutant) genotype was detected in patients with CAD. The OR (80% Cl) for Val/Val genotype was 3.46 (1.14-10.49).Conclusion: Although no significant difference was detected regarding omentin Val109Asp polymorphism, Val/Val genotype frequency was found to bemore in patient group than control group. In conclusion, it may be speculated that Val/Val genotype increases the tendency for CAD, but this experimentshould done with larger population to clarify this issue.
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    Correlation between the body fat composition and high sensitive C-reactive protein in Turkish adults
    (2012) Aydın, Mesut; Dumlu, Talha; Alemdar, Recai; Kayapınar, Osman; Celbek, Gökhan; Karabacak, Ahmet; Türker, Yasin; Kaya, Hasan; Ertaş, Faruk; Atılgan, Zuhal Arıtürk
    objectives. Te adipose tissue is an active immune organ. High sensitive C-reactive protein CRP (hs-CRP) is a strong independent predictor of a possible future myocardial infarction and stroke, and it has also been shown to be related to the sub clinical atherosclerosis. Te aim of this study was to investigate the relation between the body fat composition, metabolic syndrome, and the hs-CRP plasma levels. Methods. Total 246 consecutive Turkish subjects, admitted to the internal medicine clinic with the diagnosis of diabetes mellitus, insulin resistance or metabolic syndrome, were included into the study. Te total body fat composition was measured in every participant with a commercially available bio-impedance meter. Te hs-CRP levels, body composition parameters, and biochemical variables were compared. Results. Te hs-CRP levels increased in parallel with the body weight in Turkish subjects. Tis increase was significant especially in the women. Te waist circumference, body mass index (BMI), and body composition variables (visceral fat level, total body fat, and total body muscle mass) were significant correlates of the hs-CRP. Te waist circumference and BMI were independent predictors of the hs-CRP. Conclusion. Te waist circumference, BMI, and body composition variables (visceral fat level, total body fat and total body muscle mass) were significant correlates of the hs-CRP in Turkish adults. Body weight control may account for an important target especially in patients with the metabolic syndrome.
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    Öğe
    Impact of Body Mass Index on Left Ventricular Diastolic Dysfunction
    (Wiley, 2012) Cil, Habib; Bulur, Serkan; Turker, Yasin; Kaya, Ahmet; Alemdar, Recai; Karabacak, Ahmet; Aslantas, Yusuf
    Background: The prevalence of obesity is increasing in the developed and developing world. It is an independent risk factor for heart failure. Left ventricular (LV) diastolic dysfunction has been demonstrated to be a strong predictor of heart failure. In the present study we aimed to assess the impact of body weight on LV diastolic function. Methods: The study was conducted on 2,228 participants (1,424 women, 804 men with a mean age of 49). Traditional and tissue Doppler echocardiographic examination were performed in all of the participants. The demographic and echocardiographic data were compared. Multivariate logistic regression analysis was used to assess the independent predictors of association of LV diastolic function. The study sample was divided into four groups: group 1 (body mass index [BMI] < 25.0 kg/m2), group 2 (BMI 25.029.9 kg/m2), group 3 (BMI = 3039.9 kg/m2), and group 4 (BMI = 40 kg/m2). Results: Septal E was significantly lower in groups 2 and 3 compared to group 1 (P = 0.003). Septal A and septal A were significantly higher whereas septal E and lateral E were significantly lower in the groups 2, 3, and 4 compared to the normal weight group (P < 0.001). Lateral A, deceleration time, and ejection time were significantly higher in obese when compared to the normal weight (P = 0.025, P < 0.001, and P = 0.009, respectively). The E/E ratio was significantly higher in groups 2, 3, and 4 compared to the group 1 (P < 0.001). Logistic regression analysis revealed that age, BMI (OR = 1.060 [95% CI = 1.040 and 1.080]; P < 0.001), hypertension, and diabetes mellitus were independent predictors of LV diastolic dysfunction. Conclusion: BMI is an independent predictor of LV diastolic dysfunction along with age, hypertension, and diabetes mellitus. (Echocardiography 2012;29:647-651)