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  • [ X ]
    Öğe
    Blood glucose fructosamin and HbAlc levels in cases with diabetes mellitus
    (1992) Yenice N.; Kaplan A.; Batun S.; Canoruc N.
    In this research serum glucose, fructosomin and erytroid HbAlc levels were investigated in 50 patiens with diabetes mellitus (Type I and II) and result were compared with the normal control values. (25 normal people) In the control group the levels of serum glucose, fructosamin and erytroid HmAlc were obtained as % 94.52 ± 7.7 mg; 2.29 ± 0.299 mmol/L; % 7.02 ± 0.742 respectively. In cases with Diabetes mellitus the levels of serum glycose, fructosamin and erytroid HbAlc were obtained as % 270.83 ± 98.49 mg, 4.02 ± 0.942 mmol/L, % 13.09 ± 2.387 respectively. The levels of serum glucose, fructosamine and erytroid HbAlc were increased significantly in patients with diabetes mellitus as compared with control group (p < 0.001). The serial determinations of serum fructozamin and erytroid HbAlc levels are of value in cases with diabetes mellitus in the diagnosis, treatment and in estimation of complications of diabetes mellitus which will appear in future.
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    Öğe
    Relation between pathogenesis of liver cirrhosis, hepatic encephalopathy and serum cytokine levels-what is the role of tumor necrosis factor-alpha?
    (2010) Goral V.; Atayan Y.; Kaplan A.
    Background and objective: Hepatic encephalopathy (HE) is a major complication characterized with neuropsychiatric symptoms that occurs as a consequence of acute or chronic liver disease. It's etiology and pathogenetical mechanisms are not clearly understood and probably it is multifactorial. There are some reported studies about the role of tumor necrosis factor-alpha (TNF-?) and other inflammatory cytokines on the pathogenesis of HE. In this study, we aimed to investigate the relation between pathogenesis of HE and TNF-?, IL-1?, IL-2R, IL-6, IL-8 and IL-10, relation between the severity of HE and the levels of these cytokines. Methods: Eighty patients with liver cirrhosis [50 patients with clinical findings of HE (group 1) and 30 without any symptoms of HE (group 2)] and 30 healthy controls (group 3) were included into the study. Serum TNF-?, IL-1 ?, IL-2R, IL-6, IL-8 and IL-l0 levels of patients and control subjects were studied with chemiluminescent method. Results: There were statistical difference between serum TNF-?, IL-1 ?, IL-2R, IL-6, IL-8 levels of patients with liver cirrhosis and healthy subjects (P < 0.05), and between patients with and without HE (P < 0.05). There was a correlation between the severity of liver cirrhosis according to Child-Pugh classification and cytokine levels. The severity of HE (grade 1-4) was closely related with cytokine levels, especially TNF-?. On the other hand, there was no relation between cytokine levels and the etiological factors. Conclusion: We found a positive correlation between serum inflammatory cytokine levels (TNF-?, IL-1?, IL-2R, IL-6, IL-8) and the severity of liver cirrhosis. In addition, our findings suggested that this relation is independent from etiological factors.
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    Öğe
    The role of CA 72-4, a new tumor marker in gastric cancer
    (Turkiye Klinikleri, 2006) Göral V.; Yeşilbağdan H.; Kaplan A.; Şit D.; Çelik M.
    Objective: Gastric cancer is among the most frequent malignancies throughout the world. Many studies are carried out with tumor markers, tumor suppressive genes and oncogenes in the diagnosis of gastric cancers and the prediction of prognosis. The role of CA 72-4, a new tumor marker in the diagnosis of gastric cancer, and the correlation between CA 72-4 and CA 19-9, CA 15-3, CA 125, carcinoembryonic antigen (CEA) were investigated in this study. Material and Methods: CEA, CA 19-9, CA 125, CA 15-3, CA 72-4, erythrocyte sedimentation rate, AST, ALT, albumin and hematocrit values were examined in patients with gastric cancer. Age, sex, clinical manifestations, physical examination findings, localization (proximal/distal) and histological typing of the tumor according to Lauren classification, lymph node involvement, metastasis state, and tumor grade and the patient's performance status were evaluated. Results: Serum CEA, CA 19-9, CA 125, CA 15-3 levels were quite high in our study patients with gastric cancer. All patients whose CA 72-4 level was over 100 U/ml were advanced cases (grade IV). These 4 markers seemed to increase relatively consistently with tumor involvement and tumor grade. Although CA 72-4 is more sensitive, all other tumor markers except for CA 15-3 play an important role in the diagnosis and determining the prognosis in patients with gastric cancer. We determined that the serum CA 72-4 level in the group with cancer was significantly elevated with respect to the control group. This elevation was correlated with tumor expansion and tumor grade. Particularly in patients with liver metastases, CA 72-4 level was higher. Conclusion: We suggest that CA 72-4 level is a valuable parameter in determining the prognosis of gastric cancer and recommend its use as a laboratory test. Copyright © 2006 by Türkiye Klinikleri.