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    Comparison of the Effect of Periodontal Therapy and Diode Decontamination and Periodontal Therapy Alone on the Amount of TNF-? in Systemically Healthy Chronic Periodontitis Patients
    (Science Printers and Publishers Inc., 2020) Doğru A.G.; Toprak Ö.; Üner D.D.; İzol B.S.; Kaplan İ.; Doğru M.; İpek F.
    OBJECTIVE: To evaluate the outcome of initial periodontal therapy and additional diode laser decontamination therapy on clinical parameters and the amount of tumor necrosis factor alpha (TNF?) in gingival crevicular fluid (GCF) in patients with chronic periodontitis. STUDY DESIGN: The study included 22 patients who were diagnosed with chronic periodontitis and who had at least 1 (?5 mm) periodontal pocket in the posterior region of each upper left hemiarcade. The study was designed as a splitmouth study involving mechanical therapy on the right side and nonsurgical periodontal therapy plus diode laser decontamination therapy on the left side. RESULTS: A statistically significant decrease was observed in clinical parameters at 3 months when compared to the values at baseline in both treatment areas. The change in clinical parameters at 3 months after therapy was not significantly different between the groups (p>0.05). The comparison of GCF TNF? levels at baseline and at 3 months in the 2 treatment areas identified significant changes in the TNF? levels in the hemiarcade treated with laser diode contamination therapy, whereas the changes in the hemiarcade treated with nonsurgical periodontal therapy were not significant (p>0.05). A betweengroup comparison revealed no statistically significant difference at 3 months posttherapy, while the difference at 1 month was found to be statistically significant. CONCLUSION: The study found that laser therapy in addition to nonsurgical periodontal therapy has a positive effect on the clinical parameters and proinflammatory TNF? levels in the early period but makes no contribution in the long term. © 2020 Science Printers and Publishers Inc.. All rights reserved.
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    Is there an association between immunohistochemical parameters of breast cancer and metabolic parameters obtained with 18F-fluorodeoxyglucose PET / CT?
    (DergiPark, 2019) Tuzcu S.A.; Gezici A.; Taşdemir B.; Kaplan İ.; Büyükbayram H.; Çetin F.A.
    Introduction: The aim of our study to investigate relationship between 18F -fluorodeoxyglucose PET/CT (18F-FDG PET/CT) metabolic parameters and immunohistochemical factors in breast carcinomas. Material and method: Patients with breast carcinomas who underwent 18F-FDG PET/CT imaging at our department between May 2018 and November 2019 were included in this study. A total of 146 female patients were included (aged 49.1 ± 13.4years; range, 26-87 years). PET scanning was performed in 3D mode from the skull ceiling to the middle of the thigh. Metabolic parameters such as TLG (Total lesion glycolysis), MTV (Metabolic tumor volume), SUVmean and SUVmax values were calculated. We obtained the histopathological findings, including the size of invasive cancer, histological type, histological grade, ER and PR status, epidermal growth factor receptor (HER2) and Ki-67 of the primary tumor by reviewing the pathology reports. Result: SUV max and SUVmean of Oestrogen receptor negative group were statistically higher than Oestrogen receptor positive group (p=0.009). SUVmean of progesterone receptor negative group were statistically higher than progesterone receptor positive group (p=0.05). Ki-67 of the Oestrogen receptor negative group and progesterone receptor negative group were statistically higher than Oestrogen receptor and progesterone receptor positive group (p=0.001, 0,001 respectively). Both SUVmax and SUVmean of Ki-67 positive group were statistically higher than Ki-67negative group (p=0.0001). Conclusions: 1-SUV max, SUVmean and Ki-67 of Oestrogen receptor negative group were statistically higher than Oestrogen receptor positive group. 2-SUVmean and Ki-67 of progesterone receptor negative group were statistically higher than progesteron receptor positive group. 3-HER2 positive and/or triple negative breast cancers were not associated with 18F-FDG PET/CT metabolic parameters © 2019 Published by International Archives of Medical Research. All rights reserved