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Öğe The Association of Inteleukin (IL)-17 and IL-23 with rheumatic mitral stenosis(Oxford Univ Press, 2016) Bilik, M. Z.; Polat, N.; Kaplan, I.; Akil, M. A.; Halit, A.; Yuksel, M.; Aydin, M.[Abstract Not Available]Öğe The Effect of interleukin 23 levels on clinical and paboratory parameters of patients with ankylosing spondylitis(Univ West Indies Faculty Medical Sciences, 2021) Elbey, B.; Ayyıldız, O.; Yazgan, U. C.; Çevik, R.; Kaplan, I.; Sarıyıldız, M. A.Objective: In the present study, we aimed to investigate the relationship between interleukin 23 (IL-23) and the clinical and laboratory parameters in patients with ankylosing spondylitis (AS). Ankylosing spondylitis causes structural and functional inability, particularly in the axial skeleton, and results in the inflammatory lower back pain. At the same time, we aimed to investigate the relationship between IL-23 levels and disease related variables in patients with AS. Methods: A total of 38 patients with AS (33 males and 5 females) and 42 healthy controls (32 males and 10 female) were enrolled in the study. The demographic characteristics of the participants were recorded. As laboratory findings, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and IL-23 values were noted. Bath AS Disease Activity Index, Bath AS Functional Index, Visual Analogue Scale, and AS Quality of Life scales of the patients were measured. Results: The mean age of the AS group and the control subjects was 32.4 +/- 7.06 and 30.0 +/- 6.24 years, respectively. The ESR, CRP and IL-23 levels were significantly higher in the AS group compared to those of the healthy controls (p < 0.001, p < 0.013, p < 0.012, respectively). There was a significant correlation between ESR, CRP, and IL-23 levels in patients with AS (r = 0.328, p = 0.030 and r = 0.392, p = 0.008, respectively). While 12 subjects (31.5%) were positive for peripheral arthritis, 26 patients were negative (68.4%). The IL-23 levels were significantly higher in the group that was positive for peripheral arthritis (p < 0.05). Conclusion: Interleukin 23 may play a role in the progression and/or pathogenesis of AS and is most likely involved in the joint problems independent of the classic inflammatory response measures.Öğe Evaluation of autonomic nervous system in acute stroke through the assessments of heart rate variability and catecholamine levels(Springer Heidelberg, 2014) Akil, E.; Akil, M. A.; Kaplan, I.; Bilik, M. Z.; Tamam, Y.[Abstract Not Available]Öğe Evaluation of autonomic nervous system in acute stroke through the assessments of heart rate variability and catecholamine levels(Wiley-Blackwell, 2014) Akil, E.; Akil, M. A.; Kaplan, I.; Bilik, M. Z.; Tamam, Y.[Abstract Not Available]Öğe Neuroprotective effects of carvacrol and pomegranate against methotrexate-induced toxicity in rats(Verduci Publisher, 2013) Celik, F.; Gocmez, C.; Bozkurt, M.; Kaplan, I.; Kamasak, K.; Akil, E.; Dogan, E.BACKGROUND: Studies related to the use of various antioxidant and anti-inflammatory drugs to decrease the toxic side effects related to MTX have been carried out. However, since no medicine providing full protection against the side effects of MTX has been discovered, the discovery of new agents is required. AIM: The aim of this study was to determine whether methotrexate (MTX) causes oxidative stress and an inflammatory response in sciatic nerve, as well as whether carvacrol (CAR) and pomegranate (POM) have protective effects against the resulting oxidative stress and inflammatory response. MATERIALS AND METHODS: 32 adult male Wistar albino rats were used in the study. The animals were divided into 4 groups: Group C: the rats were not given any medication; Group MTX: On study day 2, the rats were given a single dose of 20 mg/kg MTX, administered intraperitoneally; Group MTX+CAR: On study day one, the rats were administered a single dose of 73 mg/kg CAR intraperitoneally. On study day two, a single dose of 20 mg/kg MTX was administered intraperitoneally; Group MTX+POM: For seven days starting from the study day one, rats were given 225 mg/kg POM extract once a day through orogastric gavage. On study day two, a single dose of 20 mg/kg MTX was administered intraperitoneally. All animals were sacrificed on the day eight. TOS, TAS, MDA, TNF-alpha and IL-1 beta levels were evaluated in the sciatic nerve tissue. RESULTS: In comparison to the control group, a decrease in TAS levels and an increase in TOS, MDA, IL-1 beta and TNF-alpha levels were detected in the MTX group. Compared to the MTX group, the MTX+CAR group had a significant increase in TAS level and significant decreases in TOS, MDA, IL-1 beta and TNF-alpha levels. In comparison to the MTX group, the MTX+POM group had a significant decrease in MDA, IL-1 beta and TNF-alpha levels. When the MTX+CAR and MTX+POM groups were compared, the TNF-alpha level measured was lower in the MTX+CAR group. CONCLUSIONS: In this work, we have shown that MTX causes a significant oxidative stress and inflammatory response in rats' sciatic nerve tissue and that CAR had an antioxidant effect in this system. Furthermore, we have proven, for the first time, that both CAR and POM decreased the pro-inflammatory response.Öğe Protective effect of wolfberry extract on acetic acid-induced colitis in rats(Univ West Indies Faculty Medical Sciences, 2021) İçer, M.; Gündüz, E.; Zengin, Y.; Dursun, R.; Durgun, Hasan Mansur; Alabalık, U.; Kaplan, I.; Güloğlu, C.Objective: To investigate the protective effect of wolfberry (WB) against acetic acid-induced colitis in rats. Methods: The rats were divided into four groups with eight rats in each group: the control group, WB group, colitis group and WB + colitis group. Distal colitis was induced in rats by intracolonic instillation of 4% acetic acid. Woliberry + colitis group received 100 mg/kg of WB extract dissolved in saline through the intraperitoneal route for 7 days. Acute colitis was created on the 8th day, and the rats were sacrificed 48 hours later Colonic damage was assessed by macroscopic and histological criteria as well as biochemical markers. Results: Mean total antioxidant capacity (TAC), total oxidant status (TOS), tumour necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6 levels were significantly higher in the colitis group compared with the control and WB groups (p < 0.05). The WB + colitis group had significantly lower TAC, TOS, TNF-alpha, IL-1 beta and IL-6 levels compared with the colitis group (p < 0.05). The analyses of the histopathological findings indicated that the colitis group had a significantly higher histopathological damage score than the control group (3.12 +/- 0.45, 0 +/- 0.00, respectively; p < 0.05). Histopathological damage score was significantly higher in the WB + colitis group than in the control group and statistically significantly lower than the colitis group (1.62 +/- 0.44, 0 +/- 0.00, respectively; 3.12 +/- 0.45, respectively; p < 0.05 for both comparisons). Conclusion: Wolfberry extract is an agent that is effective for preventing acetic acid-induced colitis in rats.Öğe SERUM GDF-15 LEVEL IN BEHCET'S DISEASE: RELATIONSHIP BETWEEN THE DISEASE ACTIVITY AND CLINICAL PARAMETERS(Bmj Publishing Group, 2015) Sariyildiz, M. A.; Yazmalar, L.; Batmaz, I.; Alpayci, M.; Burkan, Y. K.; Sula, B.; Kaplan, I.[Abstract Not Available]Öğe Study of aqueous ecballium elaterium as fibrinolytic in the rabbit model of intrapleural empyema(Wolters Kluwer Medknow Publications, 2021) Şahin, A.; Oruç, M.; Meteroğlu, F.; Erbey, A.; Alabalık, U.; Kaplan, I.Aims: We aimed to investigate of intrapleural use of ecballium elaterium (EE) in a rabbit model empyema. Methods: An empyema was induced in 21 rabbits after inoculation of Staphylococcus aureus. Glucose levels, pH, lactate dehydrogenase levels, and amounts of pleural drainage were evaluated in addition to pleural and empyema scores. The rabbits were divided into three groups, each 7, the isotonic solution, the streptokinase, and the ecballium group. Results: At autopsy, there was no difference in pH, glucose, and LDH levels in three groups. The mean pleural drainage was greater in the ecballium group. A significant difference was detected between groups in terms of drainage amounts and pleural and empyema scores (P < 0.05). A significant difference in pleural and empyema scores was detected in the ecballium and streptokinase groups (P < 0.05). EE group had significant differences in drainage amounts and plural and empyema scores regard to the control group (P < 0.05). No significance was found between streptokinase and EE groups. Conclusion: We conclude that intrapleural use of EE is at least as effective as streptokinase for the treatment of empyema.
