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Öğe Does biomass exposure affect serum MDA levels in women?(Taylor & Francis Ltd, 2005) Isik, B; Isik, RS; Akyildiz, L; Topçu, FIt is believed that the inhalation of biomass fuel, a substance that is used for bread baking and heating in rural areas, is associated with chronic obstructive pulmonary disease (COPD) and pulmonary symptoms. The products of biomass are claimed to affect the oxidant/antioxidant imbalance, which plays a significant role in such a disease COPD. In our study, the serum level of malonyldialdehyde (MDA) was accepted as a marker of oxidant/antioxidant imbalance, and it was measured by the thiobarbituric acid method. A total of 43 women living in the central and rural areas of Diyarbakir was chosen randomly for the study and they were divided into two groups. The first group, also called the study population, consisted of 28 women living in rural areas. The mean age of the sample was 43 yr (range 31-63 yr). All were healthy and nonsmokers. Among these women the mean duration of the exposure to biomass was 12 h/wk for 25 yr. The mean MDA level (+/-SD) was 3281 +/- 0.789 nmol/ml. The second group, the control population, consisted of 15 healthy women of age 42 yr (range 30-65 yr). They were again nonsmokers and healthy. These women were selected from the central Diyarbakir. The mean MDA level (+/-SD) was 1.474 +/- 0.630 nmol/ml. The difference between two populations were statistically significant (p < 0.0001). In conclusion, we believe that the high level of serum MDA in women is a result of biomass exposure.Öğe Effect of winter air pollution on lipid peroxidation product levels of patients with chronic obstructive pulmonary disease(Mrs Pushpa Agarwal, 2006) Isik, B; Hamamci, C; Isik, RAir pollution and its effects on human health have been considered to the a serious problem in urban areas. The health hazards of outdoor air pollution are manifest across a wide spectrum of effects. Patients with. respiratory disease and chronic obstructive pulmonary disease (COPD), given their abnormal responses to noxious gases and particles. The causes of oxidative stress in COPD are cigarette smoking, air pollution and increase of free radicals in respiratory epithelial cells by inflammation and infections. In the present study, we aim to investigate the effect on oxidative stress due to air pollution in patients with COPD in Diyarbakir (SE Anatolia) Turkey. Clinically stable COPD outpatients (n = 52) and healthy controls (n = 42) were studied. The lipid peroxidation product malonyldialdehyde (MDA) in serum samples was measured spectrophometrically by the Buege method. The serum MDA levels of patients with COPD (3.06 +/- 0.7 nmol/ml) were significantly higher than those of control groups (0.62 +/- 0.19 nmol/mL) (p < 0,001)Öğe Histopathological assessment of the prophylactic effect of gingko-biloba extract on intestinal ischemia-reperfusion injury(Univ Catholique Louvain-Ucl, 1999) Önen, A; Deveci, E; Inalöz, SS; Isik, B; Kilinc, MIn this experimental study, the prophylactic effects of Gingko-Biloba Extract (GBE) were examined after experimental ischemia on intestinal wall damage. 50 Wistar-Albino rats (2.5 month old) were gathered and separated into 5 groups (n:10), Group 1 was subjected to a laparotomy (sham-operated group) whereas all other experimental groups were subjected to an occlusion of their superior mesenteric arteries for 30 minutes and a period of 20 minutes reperfusion following occlusion. Group 2 was not given any prophylactic agent during the experiment (untreated control group). GEE was administered in a dosage of 50 mg/kg (i.v.) as a prophylactic agent to Group 3 one hour prior to laparotomy whereas Group 4 was given GEE at 50 mg/kg (i.v.) just before ischemia, Group 5 was given GEE in the same dosage just before reperfusion, Immediately after reperfusion, a biopsy was taken from the ileum (10 cm proximity to ileocaecal valve) for histopathological assessment. A significant prophylactic effect of GEE was observed in Group 5 in which GEE was administered just before reperfusion.Öğe Influence of transition metal ions on NMR proton T1 relaxation times of serum, blood, and red cells(Humana Press Inc, 1999) Yilmaz, A; Yurdakoç, M; Isik, BThe spin-lattice relaxation rates (1/T1) of serum, whole blood, and red cells were measured vs several concentrations of transition metal ions. For comparative purposes, the similar experiments were repeated in water. The rates show a linear dependence on concentration of each ion for water, but nearly a linear dependence for blood and its constituents. The influence of each ion on 1/T1 in a sample was expressed by the slope (relaxivity) of the least-squares fitting of 1/T1 vs ion concentration. The relaxivities of Mn(II) in serum and of Fe(III) in serum and blood are greater than those in water, whereas the relaxivities of these ions in the other cases and of all the other ions in call cases are smaller than those in water. However, the relaxivity data show that Cr(III) in serum and blood affects the 1/T1 rates. The ratio of relaxivity of each sample to that of water is known as proton relaxation enhancement (PRR) factor (epsilon). The epsilon factors for present data suggest that the added ions are bound to proteins, and only Mn(II) in serum and Fe(III) in blood and serum are accessible to water.Öğe Potentiation of cisplatin-induced nephrotoxicity in rats by allopurinol(Urban & Fischer Verlag, 2000) Erdinç, M; Erdinç, L; Nergiz, Y; Isik, BCisplatin (CDDP) is an effective chemotherapeutic agent used against various human malignancies. However, it induces nephrotoxicity, a severe side effect in which oxygen free radicals have been implicated to play an important role. The effect of allopurinol (Allp) given in a dose of 50 mg/kg su:,cutaneously (sc) for five days was examined on induced nephrotoxicity by a single dose of 5 mg/kg CDDP intraperitoneally (ip) in male wistar rats. Serum creatinine and blood urea nitrogen (BUN) concentrations were found significantly higher in the group given both Allp and CDDP than in the group given CDDP alone, p < 0.001, rind histopathological examination showed more excessive degree of proximal tubular necrosis in the kidneys of animals given CDDP plus Allp than in those treated with CDDP alone. Increased renal lipid peroxidation, p < 0.001 associated with these pathological alterations suggested that oxidative stress may be involved in the potential:ion of CDDP-induced nephrotoxicity by Allp.Öğe Trace elements and oxidative stress in chronic obstructive pulmonary disease(Saudi Med J, 2005) Isik, B; Isik, RS; Ceylan, A; Calik, OObjectives: Many trace elements have activator or inhibitor roles in the antioxidative defense systems in diseases such as chronic obstructive pulmonary diseases (COPD). In this study, we aimed to show the levels of trace elements with action in oxidative stress, and to show the levels of malondialdehyde (MDA) as a marker of oxidative stress, and the activity of paraoxonase (PON1) as an antioxidant in COPD and smokers. Methods: We included 25 patients with COPD, and 20 healthy non-smokers in the study. We selected them from the hospitalized patients at the Hospital of Dicle University, Turkey, between April 2003 and January 2004. The clinical condition of the patients was stable. Results: The serum copper (Cu) and MDA concentrations in COPD patients were higher than the control group. There were no differences in zinc (Zn) concentration and Cu/Zn ratio between COPD patients and the control group. We found lower serum PON1 activities in COPD patients compared with the control group. There was no statistically significant difference in Zn concentration and Cu/Zn ratio between smokers and non-smokers in COPD. There were statistically significant differences in Cu, MDA concentrations and serum PON1 activities between smokers and non-smokers in COPD. Conclusions: We could suggest that trace elements such as Cu, oxidants and antioxidants such as MDA and PON1 have roles in oxidative stress, and in COPD.
