Histopathological assessment of the prophylactic effect of gingko-biloba extract on intestinal ischemia-reperfusion injury
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Tarih
1999
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Univ Catholique Louvain-Ucl
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this experimental study, the prophylactic effects of Gingko-Biloba Extract (GBE) were examined after experimental ischemia on intestinal wall damage. 50 Wistar-Albino rats (2.5 month old) were gathered and separated into 5 groups (n:10), Group 1 was subjected to a laparotomy (sham-operated group) whereas all other experimental groups were subjected to an occlusion of their superior mesenteric arteries for 30 minutes and a period of 20 minutes reperfusion following occlusion. Group 2 was not given any prophylactic agent during the experiment (untreated control group). GEE was administered in a dosage of 50 mg/kg (i.v.) as a prophylactic agent to Group 3 one hour prior to laparotomy whereas Group 4 was given GEE at 50 mg/kg (i.v.) just before ischemia, Group 5 was given GEE in the same dosage just before reperfusion, Immediately after reperfusion, a biopsy was taken from the ileum (10 cm proximity to ileocaecal valve) for histopathological assessment. A significant prophylactic effect of GEE was observed in Group 5 in which GEE was administered just before reperfusion.
Açıklama
Anahtar Kelimeler
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Kaynak
Acta Gastro-Enterologica Belgica
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
62
Sayı
4
