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    Atypical familial Papillon-Lefevre syndrome
    (European Acad Dermatology & Venereology, 2001) Inalöz, HS; Harman, M; Akdeniz, S; Inalöz, SS; Isik, AG
    The Papillon-Lefevre syndrome is a rare autosomal recessive disorder. Consanguinity seems a notable prerequisite. Papillon-Lefevre syndrome manifests in the first 6 months of life with rapidly progressive periodontitis and severe alveolar bone destruction leading to early loss of both the deciduous and permanent teeth in association with palmo-plantar hyperkeratosis. We present two unusual cases of familial Papillon-Lefevre syndrome, one of whom has only late onset of mild skin lesions and the other has severe skin lesions and relatively mild periodontal disease. A number of other cases recently described have also had atypical features.
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    Coexistence of psoriasis vulgaris and bullous disorders
    (Wiley, 1999) Aytekin, S; Inalöz, HS; Harman, M; Akdeniz, S; Deveci, E; Inalöz, SS
    [Abstract Not Available]
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    Congenital non-familial unilateral basaloid follicular hamartoma
    (Wiley, 1999) Harman, M; Inalöz, HS; Akdeniz, S; Inalöz, SS; Aslan, A
    Basaloid follicular hamartoma is not a well-recognized clinical entity and has often been diagnosed as trichoepithelioma or basal cell carcinoma. It is a unique benign follicular tumour which comprises a variety of clinical manifestations. We present the case of a 24-year-old male with unilateral basaloid follicular hamartoma present at birth and later misdiagnosed as basal cell carcinoma. Histological features of basaloid follicular hamartoma are nor always diagnostic and clinico-pathological correlation is particularly important to distinguish this benign hamartoma from other basaloid tumours including basal cell carcinoma. Continuous follow-up of our patient did not reveal any clinical or histological malignant transformation. (C) 1999 Elsevier Science B.V. All rights reserved.
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    Effects of nimodipine and ofloxacin on staphylococcal brain abscesses in rats
    (Ecv-Editio Cantor Verlag Medizin Naturwissenschaften, 1997) Ceviz, A; Inalöz, SS; Çiçek, R; Sari, I; Gül, K; Sanli, A
    The therapeutic effects of nimodipine (GAS 66085-59-4) and ofloxacin (GAS 82419-36-1) were investigated against experimental brain abscess formation in rats. Nimodipine, a 1,4-dihydropyridine derivative, is chemically related to nifedipine but the smooth muscle relaxant effect preferentially acts on cerebral arteries. Ofloxacin is a member of 4-Quinolone broad spectrum antibiotics. Ninety-six male Sprague-Dawley rats were inoculated intracortically with Staphylococcus aureus and then different groups were treated with either saline. ofloxacin or the combination of ofloxacin and nimodipine. The rate of brain abscess formation and mortality were considerably decreased by nimodipine and ofloxacin therapy. Combination therapy was found histologically to be considerably more effective than ofloxacin alone against brain abscess formation in rats.
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    Histopathological assessment of the prophylactic effect of gingko-biloba extract on intestinal ischemia-reperfusion injury
    (Univ Catholique Louvain-Ucl, 1999) Önen, A; Deveci, E; Inalöz, SS; Isik, B; Kilinc, M
    In this experimental study, the prophylactic effects of Gingko-Biloba Extract (GBE) were examined after experimental ischemia on intestinal wall damage. 50 Wistar-Albino rats (2.5 month old) were gathered and separated into 5 groups (n:10), Group 1 was subjected to a laparotomy (sham-operated group) whereas all other experimental groups were subjected to an occlusion of their superior mesenteric arteries for 30 minutes and a period of 20 minutes reperfusion following occlusion. Group 2 was not given any prophylactic agent during the experiment (untreated control group). GEE was administered in a dosage of 50 mg/kg (i.v.) as a prophylactic agent to Group 3 one hour prior to laparotomy whereas Group 4 was given GEE at 50 mg/kg (i.v.) just before ischemia, Group 5 was given GEE in the same dosage just before reperfusion, Immediately after reperfusion, a biopsy was taken from the ileum (10 cm proximity to ileocaecal valve) for histopathological assessment. A significant prophylactic effect of GEE was observed in Group 5 in which GEE was administered just before reperfusion.