DSpace Arşivi :: by Yazar "Hoşoglu S." değerine göre listeleniyor

Listeleniyor 1 - 1 / 1

Effects of nimodipine on the cerebrovascular and neuronal changes during pneumococcal meningitis in the rat
(Akademiai Kiado Rt., 1997) Hoşoglu S.; Ceviz A.; Serdar Kemaloglu M.; Sari I.; Inalöz S.; Geyik M.F.; Kökoglu Ö.F.
It was investigated whether treatment with the calcium channels blocker Nimodipine, a 1,4-dihydropyridine derivative, influences vasculopathy and neuronal injury in experimental pneumococcal meningitis. Rats were randomly assigned to one of three experimental groups. The first group (Control group, n=20) was given saline (0.4 ml/day) intraperitoneally (ip), whereas the second group (group C, n=22) was treated only with ceftriaxone in a dosage of 30 mg/day/ip. The third group (group C-N, n=22) was treated with the combination of ceftriaxone 30 mg/day/ip, and nimodipine 0.6 mg/day/ip. Treatment was begun at the time of inoculation in all three groups. The control group was compared clinically and histopathologically with groups C and C-N at 24 h, three and six days after inoculation. Six rats in the control group and eight rats in group C and group C-N were sacrificed at 24 hours and seven rats in each group were sacrificed on the third and sixth day after inoculation. Clinically, there were no significant differences between group C and group C-N (p>0.05). There were significant differences between group C and group C-N for vasculopathy and neuronal injury (p<0.0001 and p<0.005, respectively). © 1997 Akadémiai Kiadó.