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  • [ X ]
    Öğe
    Efficacy of topical tacrolimus for the treatment of persistent pruritus ani in patients with atopic dermatitis
    (Taylor & Francis Ltd, 2013) Ucak, Haydar; Demir, Betul; Cicek, Demet; Dertlioglu, Selma Bakar; Akkurt, Zeynep Meltem; Ucmak, Derya; Halisdemir, Nurhan
    Background: Pruritus ani (PA) is defined as intense chronic itching affecting perianal skin. Objective: We aimed to determine the efficacy of topical tacrolimus treatment in atopic dermatitis (AD) patients who have PA. Methods: The study included 32 patients with AD who were suffering PA. Patients were randomized into two groups. In total, 16 patients used 0.03% tacrolimus ointment and 16 patients used vaseline as placebo. All groups applied topical treatments to their perianal area twice daily for 4 weeks. The treatments were then reversed for 4 weeks after a 2 weeks wash out period. Results: In total, 32 patients with AD who had refractory anal itching were enrolled in this study. None of the patients had obtained successful results with previous treatments. There was a statistically significant decrease in the recorded EASI, DLQI and itching scores for the tacrolimus group compared to the placebo group at weeks 4 and 6 of treatment (p < 0.05). Conclusion: Topical tacrolimus treatment was well tolerated and effective in controlling persistent PA in AD patients.
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    Öğe
    Lepromatöz lepralı hastaların yaşam kalitesi
    (2014) Uçak, Haydar; Çiçek, Demet; Bakar, Selma Dertlioğlu; Demir, Şükrü; Güler, Kubilay; Halisdemir, Nurhan; Demir, Betül
    Amaç: Lepra Mycobacterium leprae basilinin neden olduğu deri ve periferik sinir sistemini etkileyen kronik granulomatöz bir infeksiyon hastalığı olup, tutulum derecesine bağlı olarak şiddetli deformitelere neden olabilmektedir. Bu çalışmada lepramatöz lepralı hastalarda yaşam kalitesini ölçmeyi amaçladık. Gereç ve Yöntem: Otuz beş lepramatöz lepralı ve 35 sağlıklı kontrol çalışmaya alındı. Hastalara Dermatoloji Yaşam Kalite İndeksi (DYKİ) ve Kısa Form-36 (KF-36) anketi uygulandı. Yaşam kalitesi ile yaş, cinsiyet, evlilik durumu ve göz sakatlığının derecesi arasındaki ilişki ölçüldü ve sağlıklı kontrollerle karşılaştırıldı. Bulgular: Lepralı hasta grubunda alt grupların tamamı ve toplam DYKİ skorunda sağlıklı kontrollere oranla anlamlı artış gözlendi (p<0,05). Görme sakatlığı düzeyi Evre 2 olan hastaların semptom/hisler ve okul/iş hayatı açısından Evre 1 olanlara oranla anlamlı düzeyde daha fazla etkilendiği saptandı (p=0,04, p=0,03, sırasıyla). Lepralı hasta grubunda KF-36 fiziksel fonksiyon, fiziksel rol güçlüğü, genel sağlık, vitalite, sosyal fonksiyon ve emosyonel rol güçlüğü skorları sağlıklı kontrol grubuyla karşılaştırıldığında, istatistiksel olarak daha düşük bulundu (p<0,05). Sonuç: Biz lepramatöz lepralı hastalarda DYKİnin sağlıklı kontrollere kıyasla azaldığını, göz sakatlık düzeyi arttıkça yaşam kalitesinin olumsuz yönde etkilendiğini saptadık. KF-36 ile lepramatöz lepralı hastaların fiziksel fonksiyon, fiziksel rol güçlüğü, genel sağlık, vitalite, sosyal fonksiyon, emosyonel rol güçlüğü ve mental sağlık durumlarının olumsuz yönde etkilendiğini saptadık. (Türk­derm 2014; 48: 146-51)
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    Öğe
    Quality of life in lepromatous leprosy patients
    (Deri Zuhrevi Hastaliklar Dernegi, 2014) Demir, Betul; Ucak, Haydar; Dertlioglu, Selma Bakar; Demir, Sukru; Guler, Kubilay; Cicek, Demet; Halisdemir, Nurhan
    Background and Design: Leprosy is a chronic infectious disease caused by Mycobacterium leprae bacillus affecting the skin and peripheral nervous system. Leprosy can lead to severe deformities depending on the extent of the disease. In this study, we aimed to investigate the quality of life of patients with lepromatous leprosy. Materials and Methods: Thirty-five patients with lepromatous leprosy and 35 healthy controls were included in the study. The patients were evaluated with the Turkish version of the Dermatology Life Quaky Index (DLQI) and the 36-Item Short Form Health Survey (SF-36). The relationship of quality of life with age, gender, marital status, and the grade of the visual impairment was studied and compared with the healthy controls. Results: Total and all the subgroup DLQI scores were higher in the leprosy group than in the control group (p<0.05). The patients with grade 2 visual impairment were more severely affected by the disease with regard to symptoms/feelings and school/work life as compared to the patients with grade 1 visual impairment (p=0.04, p=0.03, respectively). SF-36 physical functioning, physical role functioning, general health perceptions, vitality, social role functioning, and emotional role functioning scores were statistically lower in the patient group than in the control group (p<0.05). Conclusion: We observed that DLQI scores were lower in patients with lepromatous leprosy than in the control group, while increasing impairment in eyes was found to have a negative impact on quality of life. The SF-36 revealed that physical functioning, physical role functioning, general health perceptions, vitality, social role functioning, emotional role functioning, and mental health were negatively influenced in patients with lepromatous leprosy.
  • Küçük Resim
    Öğe
    Serum preptin and amylin values in psoriasis vulgaris and Behçet's patients
    (Wiley, 2016) Doğan, Fatma Başkaya; Çiçek, Demet; Aydın, Süleyman; Dertlioğlu, Selma Bakar; Halisdemir, Nurhan; Uçak, Haydar; Demir, Betül; 0000-0001-8405-7730; 0000-0001-6162-3250; 0000-0003-2151-7917; 0000-0002-6190-5124
    BackgroundInsulin resistance is found in both psoriasis and Behcet's disease. No study has yet explored whether preptin and amylin, two hormones associated with insulin resistance, are involved in the insulin resistance observed in patients with psoriasis and Behcet's disease. ObjectivesWe aimed to explore how the amounts of preptin and amylin change in psoriasis and Behcet's disease and whether they are involved in the etiopathology of these two diseases, by comparing hormone levels in patients and healthy controls. MethodsThe study registered 30 patients with psoriasis, 30 patients with Behcet's disease, and 30 healthy volunteers (as a control group). Fasting blood sugar, triglyceride, LDL, VLDL, HDL, total cholesterol, HbA1c, C-peptide, insulin, and serum preptin and amylin levels were measured in all subjects. ResultsSerum preptin and amylin levels were significantly lower in the patients with psoriasis and Behcet's disease than in the control group (P < 0.001, P = 0.004, and P = 0.008, respectively). A comparison of the serum preptin and amylin levels between the patients with psoriasis and Behcet's disease did not reveal a statistically significant difference. Serum insulin level and The homeostasis model assessment of insulin resistance (HOMA-IR) index were significantly lower in the psoriasis patient group relative to the control group (P = 0.02 and P = 0.03, respectively), while the values for the Behcet's disease group did not differ significantly from those for the control group ConclusionsSerum levels of preptin and amylin were significantly lower in patients with psoriasis and Behcet's disease, indicating that these hormones may be a factor for development of metabolic syndrome in these two diseases.