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    Effect of nicotine exposure during gestation on neonatal rat ovaries
    (E-Century Publishing Corp, 2016) Gorkem, Umit; Togrul, Cihan; Seckin, Kerem Doga; Karsli, Mehmet Fatih; Deveci, Engin; Gungor, Tayfun
    The purpose of present study was to investigate effects of nicotine on follicular development in the neonatal rats. In this study, 14 adult Sprague-Dawley rats weighing 230-260 g (+/- 10 g) were used as experimental animal. After detecting pregnancies with vaginal smear method, pregnant rats were two equal groups were separated. The pregnant females were treated with the nicotine for 21 days and litters were sacrificed at first day of birth. The ovaries of litters were processed through routine paraffin embedding method, serially sectioned by microtome, stained with hematoxylin-Eosin and immunohistochemical technique investigated by light microscope. In the ovary of group treated nicotine, Preventing follicular development was observed in granular degeneration and luteal cells. It was also observed in inflammation and bleeding vessels. Immunohistochemical localization of vimentin was restricted to the granulosa cells and stromal area. Nicotine treatment group in granular cells and luteal cells in E-cadherin expression was weak. We concluded that nicotine might affect the cellular junctions in the ovarian follicular development. The high intensity in the staining with vimentin observed in the granulosa cells of the follicles is probably due to functional changes that occur during the process of cystogenesis.
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    Expression of pSTAT3 and TNF-? in Normotensive and Severe Preeclamptic Placentas
    (Sci Printers & Publ Inc, 2017) Togrul, Cihan; Gorkem, Umit; Irtegun, Sevgi; Tahaoglu, Ali Emre; Gungor, Tayfun; Deveci, Engin
    OBJECTIVE: To examine histopathologic changes and correlation between TNF-alpha and pSTAT3 expression levels by western blot and immunohistochemical methods in preeclamptic placentas. STUDY DESIGN: Obstetrical properties and bio-chemical and hematological features of patients with preeclampsia and healthy subjects were compared. Paraffin sections obtained from placenta were stained with hematoxylin-eosin for histopathologic examination. RESULTS: In histopathologic examination of preeclamptic placentas, cytotrophoblastic cellular proliferation, fibrinoid necrosis, endothelial proliferation, and calcified and hyalinized villous spots were observed. CONCLUSION: In preeclamptic placentas, we observed that trophoblastic invasion may downregulate STAT3 phosphorylation and can correlate with TNF-alpha elevation. Even though trophoblast invasion may interfere with both vascular and immune systems, TNF-alpha is not directly involved in the STAT3 signaling pathway in the preeclamptic placenta. (Anal Quant Cytopathol Histpathol 2017; 39: 149-156)
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    Histopathological and Immunohistochemical Changes in the Amniotic Membrane of Gestational Diabetic Mothers
    (Soc Chilena Anatomia, 2017) Togrul, Cihan; Gorkem, Umit; Coskun, Bugra; Nergisli, Cansu Kubra; Gungor, Tayfun; Deveci, Engin
    The aim of this study is to examine the changes in the amniotic membrane diagnosed with gestational diabetes mellitus. In this study, as a control group human amnion membrane from normotensive pregnancies was collected from diabetic women at 28-35 weeks of gestation. Gestational diabetes (n=6) and normal amnion membrane (n=6) for a total of 12 units were received. Amniotic membrane thickness was measured (p<0.0001) and it was significantly higher in GDM groups compared to control group. The diameter of the amniotic epithelial cell nuclei was measured (p=0.0022). Gestational diabetes results show that there was weakening between amniotic epithelial cell-cell junction. This study showed that structural changes in epithelial cells of amniotic membrane were formed due to diabetes. The membrane thickness has led to structural changes in diameter and in diabetes group cause extracellular matrix to increase, thus leading to MMP-9 expression increase eventually disrupting matrix balance. In addition, with cd44 increase angiogenesis has been induced and thought to influence material pass between fetus and mother.
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    The Impact of Surgical Staging on the Prognosis of Mucinous Borderline Tumors of the Ovaries: A Multicenter Study
    (Int Inst Anticancer Research, 2017) Gungorduk, Kemal; Asicioglu, Osman; Braicu, Elena Ioana; Almuheimid, Jumana; Gokulu, Sevki Goksun; Cetinkaya, Nilufer; Gungor, Tayfun
    Background/Aim: The purpose of this study was to prove the effect of complete surgical staging of patients with mucinous borderline ovarian tumors (mBOTs) especially appendectomy on progression-free survival (PFS) and overall survival (OS). Patients and Methods: The database of 14 gynecological oncology departments from Turkey and Germany were comprehensively searched for women who underwent primary surgery for an ovarian tumor between January 1, 1998, and December 31, 2015, and whose final diagnosis was mBOT. Results: A total of 364 patients with mBOT with a median age of 43.1 years were included in this analysis. The median OS of all patients was 53.1 months. The majority of cases had Stage IA (78.6%). In univariate and multivariate analyses, radical surgery, omentectomy, appendectomy, lymphadenectomy, and adding adjuvant chemotherapy were not independent prognostic factors for PFS and OS. Furthermore, FIGO stage (>= IC vs. = IC vs.