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    Bruxism: is it a new sign of the cardiovascular diseases?
    (Verduci Publisher, 2011) Atilgan, Z.; Buyukkaya, R.; Yaman, F.; Tekbas, G.; Atilgan, S.; Gunay, A.; Palanci, Y.
    Aim: To determine the relationship between bruxism and cardiovascular diseases. Materials and Methods: 120 patients who referred to the Dentistry Faculty with the complaint of bruxism were selected. All patients gave informed consent for participation in the study. All of the patients were examined and bruxism was classified. And also these were examined by B-mode ultrasound to measure the Intima Media Thickness (IMT) at the far wall of the common carotid artery. A wide range of vascular risk factors including age, gender, body mass index, and previous history were surveyed. Spearman correlation analysis was performed to ascertain quantitative comparison, Mann-Whitney U and Kruskal-Wallis test were used for comparison of means Results: There were 66 (55%) male and 54 (45%) female patients, with a female to male ratio of 1/1.2. The mean age was 35.6 +/- 1,25 years (range 18-65 years). In the analysis of bruxism classification and IMT there was a statistical significance between bruxism classification subgroup 1, 2, 3 and IMT. There was no statistical significance between bruxism classification Subgroup 4 and IMT due to the small number of the patients (n=12). Conclusions: Stressful situations can cause both bruxism and cardiovascular disease such as coronary artery diseases, hypertension, arrhythmias, cardiomyopathy. The statistical analysis supported this hypothesis. However, we need to new studies with large number of samples to confirm this hypothesis. Clearly, future studies in this field will need to take into consideration the influence of the following variables: age, use of medication or drugs, smoking habits, and other sleep disorders.
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    A case of Beckwith-Wiedemann syndrome with peculiar dental findings
    (Ariesdue Srl, 2016) Callea, M.; Yavuz, I.; Clarich, G.; Gunay, A.; Vinciguerra, A.; Unal, M.; Sahbaz, C.
    Background Beckwith-Wiedemann syndrome (BINS, OMIM 130650) is a rare genetic disorder characterised by overgrowth, tumor predisposition and congenital malformations. Few systemic manifestations and oral features have been reported so far. Case report We report on a case of BWS, describing all features expanding the knowledge on oro-dentofacial phenotypes, along with a review of the literature.
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    Influence of caffeic acid phenethyl ester on bone healing in a rat model
    (Sage Publications Ltd, 2013) Ucan, M. C.; Koparal, M.; Agacayak, S.; Gunay, A.; Ozgoz, M.; Atilgan, S.; Yaman, F.
    Objective To examine the effects of caffeic acid phenethyl ester (CAPE; a component of honey bee-hive propolis with antioxidant, anti-inFLammatory, antiviral and anticancer properties) on bone regeneration and fibrotic healing in a rat model. Methods Male Sprague-Dawley rats (n=63; mean age 7 weeks; weight 280-490g) were randomly divided into three groups: A, cranial defect with no bone healing treatment (n=21); B, cranial defect treated with CAPE (n=21); C, cranial defect treated with CAPE and -tricalcium phosphate/hydroxyl apatite (n=21). Rats were anaesthetized with ketamine (8mg/100g) by intraperitoneal injection and a cranial critical size bone defect was created. Following surgery, CAPE (10 mu mol/kg) was administered by daily intraperitoneal injection. Seven rats in each group were killed at days 7, 15 and 30 following surgery. Bone regeneration, fibrotic healing and osteoblast activity were evaluated by histopathology. Results Statistically significant differences in healing were found between all groups. There were no statistically significant within-group differences between day 7 and 15. At day 30, bone healing scores were significantly higher in groups B and C compared with group A. Conclusion CAPE significantly improved bone-defect healing in a rat model, suggesting that CAPE has beneficial effects on bone healing.
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    Phosphodiesterase-5 inhibitors may facilitate bone defect recovery
    (Verduci Publisher, 2011) Yaman, F.; Atilgan, S.; Gunes, N.; Agacayak, S.; Gunay, A.; Ucan, M. C.; Bakir, S.
    Background and Objectives: Bone healing is still one of the most important problems of the oral and maxillofacial surgery procedures. This study was designed to evaluate the effect of sildenafil citrate (which is used for erectile dysfunction) on bone defect healing in an experimental animal model. Materials and Methods: A total of 42 male Wistar-albino rats were randomly assigned to the control group (n=21) or the study group (n=21). The control group was fed on a standard laboratory diet until 12 h before surgery, whereas the study group received Sildenafil citrate via orogastric tube 10 mg/kg once a day for 30 days. Under anaesthesia, a 3x3x2 mm depth defect was made on tibia of each rat. 7 animals from each group were euthanised on postoperative days 7,15 and 30. Bone samples were taken for examination, histologically on day 7, by 3D dental tomography on day 15, and for bone strength resistance on day 30. Results: Statistically significant differences were determined between the groups from the inflammatory and repair phase, with the healing process being more advanced in the Sildenafil group. Conclusions: Sildenafil citrate can be used as a supporting factor to accelerate the healing process of bone. In future comprehensive studies will need to demonstrate the Sildenafil citrate affect on bone defect healing.
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    The reliability of microleakage studies using dog and bovine primary teeth instead of human primary teeth
    (Ariesdue Srl, 2013) Yavuz, I.; Tumen, E. C.; Kaya, C. A.; Dogan, M. S.; Gunay, A.; Unal, M.; Toptanci, I. R.
    Aim This was to investigate if dental restorations on human, dog and bovine primary teeth are equatable for microleakage analysis, and the respective marginal adaptation deficiency in in vitro conditions. Materials and methods In order to determine the level of microleakage in Class V polyacid-modified composite restorations of human, dog and bovine primary teeth, samples were evaluated by dye-leakage method in sections of the inner area of the restorations. Results We found no leakage in 6 out of 10 (60%) human restorations, in 7 out of 10 (70%) of dog and in 7 out of 10 (70%) of bovine teeth. The levels of dye-microleakage were tested with Kruskal-Wallis one-way variant analysis method. The relative leackage differences were not statistically significant among all species (p>0.05). Conclusion We concluded that dog and bovine primary teeth might be suitable for in vitro studies instead of human ones.