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    Comparison of the susceptibility of Pseudomonas aeruginosa and Escherichia coli, isolated from clinical specimens to ticarcillin, ticarcillin/clavulanic acid and piperacillin/tazobactam
    (1997) Atmaca S.; Gul K.
    In this study, the susceptibilities of 50 Pseudomonas aeruginosa and 50 Escherichia coli strains isolated from clinical specimens, against ticarcillin, ticarcillin/clavulanic acid and piperacillin/tazobactam were investigated by disk diffusion method. Of pseudomonas aeruginosa isolates, 54% were found to be sensitive to ticarcillin, 74% to ticarcillin/clavulanic acid, whereas 24% of Escherichia coli isolates were sensitive to ticarcillin (susceptible + moderately susceptible), and 94% to ticarcillin/clavulanic acid. It was determined that 23% of P. aeruginosa and 4% of E. coli isolates brought about a zone diameter equal to or below 15 mm against piperacillin/tazobactam. As a result, P. aeruginosa and E. coli isolates were found to be susceptible to both of the beta-lactam/beta-lactamase inhibitor combinations.
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    Effect of omeprazole, clarithromycin and amoxicillin therapy on duodenal ulcer and Helicobacter pylori eradication
    (1997) Goral V.; Tas M.; Gul K.; Canoruc F.
    Helicobacter pylori (H. pylori) is the most important factor in the pathogenesis of duodenal ulcer (DU). Eradication of H. pylori does lower the recurrence rate of DU. The aim of this study was to evaluate the efficacy, tolerability and compliance of a triple therapy with omeprazole and amoxicillin plus clarithromycin. 24 patients (22 males, 2 females, age range 21-27) with duodenal ulcer were treated for 2 weeks with omeprazole 20 mgr b.i.d. 28 plus amoxicillin 1 g b.i.d. plus daintromycin 250 mg. b.i.d. H. pylori (+) duodenal ulcer cases which were treated for 2 weeks with omeprazole 20 mgr b.i.d. plus amoxicillin 1 gr b.i.d., using as control groups. Diagnosis was made by upper G.I. endoscopy and by obtaining multiple biopsies from antral mucosa. Standard H.E., Giemsa stains and rapid urease test were performed for the diagnosis of H. pylori infection. Patients were endoscoped before and at the end of therapy and 1 month after completion of therapy. Eradication was defined as all tests were negative at the final evaluation. In the third endoscopy H. pylori positivity was found as 8%. The eradication was therefore reached in 22 patients (92%). At the control group, the eradication rate was calculated as 79% (p<0.05). It is concluded that a 2 weeks trial of triple therapy with omeprazole, clarithromycin and amoxicillin is very effective and well tolerated for the eradication of H. pylori infection.
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    Influence of zinc on imipenem susceptibility of Pseudomonas aeruginosa
    (1996) Atmaca S.; Gul K.; Ulak G.; Cicek R.; Atmaca M.
    The influence of zinc on imipenem susceptibility of Pseudomonas aeruginosa was investigated. In this study, two different amounts of zinc containing media were used, the first of which was Oxoid MHA containing 0.45 ?g/ml zinc, and the second Oxoid MHA supplemented with zinc-acetate, 64 times as much zinc as the first media. The percentage of P. aeruginosa isolates resistant to imipenem significantly increased (P < 0.001) in zinc-supplemented media, whereas the activity of ceftazidime against P. aeruginosa isolates was similar in both media.
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    Seroprevalence of serum HBSAg positivity and hepatitis delta virus infection among blood donors in Southeastern Turkey
    (2014) Mese S.; Nergiz S.; Tekes S.; Gul K.
    Aims. HBV and HDV infection is still a serious health problem in Southeastern Turkey. In this study, we aim to investigate the prevalence serum HBsAg along with HDV infection among volunteer blood donors. Materials and Methods. This single centre and prospective study was performed in 6200 consecutive volunteer blood donors admitted to the Central Blood Bank of Dicle University Hospital. All adult blood donors included males and females were screened for HBsAg positivity. The positive serum samples for HBsAg were assessed for total anti-delta antibodies using the micro-ELISA method. Serum samples of anti-delta antibody positive cases were then examined for the presence of serum HDV RNA by real time, reverse transcription PCR method. Results. Six thousand two hundred adult volunteer blood donors were enrolled to the study. Of all analyzed blood donors, 6004 (96.8%) were men and 196 (3.2%) were women. Serum HBsAg positivity was found in 3% (186/6200) of 6200 blood donors. The mean age and female/ male ratio of HBsAg positive cases (n=186) were 32.85±10.04 years and 12/174, respectively. Serum anti-delta antibodies were detected in 6.98% (13/186) of HBsAg positive cases. The mean age of anti-delta antibody positive cases (n=13) was 44.5±13.61 years and female/ male ratio was 1/12. Moreover, 2 cases, (15.39%, 2/13) that were positive for anti-delta antibody, had serum HDV RNA positivity. Conclusions. It would be appropriate for HBsAg positive volunteer blood donors to be assessed regarding concurrent HDV infection as well. The magnitude of the contribution and benefi t that this screening would provide to our region, which is endemic for HDV infection, is the early diagnosis and management of this devastating disease. The real viremia in these cases can be best shown by using sensitive real time PCR method for the presence of serum HDV RNA. © Società Editrice Universo (SEU).