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    An Analysis on Aerodynamic and Acoustic Changes After Thyroidectomy
    (Int College Of Surgeons, 2016) Yilmaz, Beyhan; Bakir, Salih; Yilmaz, Edip Erdal; Senhul, Engin; Uslukaya, Omer; Gul, Aylin; Ozkurt, Fazil Emre
    The purpose of this study was to investigate the aerodynamic and acoustic changes after thyroidectomy without laryngeal nerve injury by using objective methods. Voice samples of sustained /alpha/ recorded from 44 adults preoperatively and nearly 1 week and 3 months after thyroidectomy were analyzed for mean vocal fundamental frequency (Mean Fo, Hz), maximum fundamental frequency (Max Fo, Hz), minimum fundamental frequency (Min Fo, Hz), jitter, shimmer, glottal to noise excitation ratio (GNE), irregularity, noise, overall severity, S time, Z time, S/Z ratio, and maximum phonation time (MPT). Voice samples were analyzed using the lingWAVES software. The comparisons of preoperative and early and late postoperative acoustic parameters revealed significant differences in Mean F0, Max F0, MPT, and S Time between the early and late postoperative periods. The voice changes after thyroidectomy were not affected by age, sex, or surgical procedure, but they differed between the benign and malignant nature of the tumor. Patients with malignant tumors showed a greater decrease in Mean F0 and Max F0 compared with the patients with benign tumors, and this difference was statistically significant. Voice changes may occur after thyroidectomy even in the patients with no evidence of laryngeal nerve damage, and these changes can be assessed with objective measurement methods. This information should be explained to the patients during the preoperative counseling, and proper informed consent is ethically and legally required for all planned thyroidectomies.
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    Cultural adaptation of an olfactory test: the odour in bottle test (vol 52, pg 172, 2014)
    (Int Rhinologic Soc, 2014) Gul, Aylin; Akdag, Mehmet; Ozkurt, Fazil Emre; Yilmaz, Beyhan; Sengul, Engin; Bakir, Salih; Topcu, Ismail
    [Abstract Not Available]
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    Culturally modified olfactory test adapted to East-Turkey: A comparison with Sniffin' Sticks
    (Wiley, 2021) Demir, Songul; Sizer, Bilal; Gul, Aylin; Topcu, Ismail
    Background Although the Sniffin' Sticks test (SST) is a widely used odor test, aplicability of odor tests is limited because of the high cost of the test and the regional-cultural differentiation of odor recognition. We aimed to evaluate our regional odor norms by applying the SST with a Modified odor test (MOT) we created for this study, and to develop a test similar to the SST, which was less expensive and probably had a higher odor definition for our region. Methods This study includes 201 healthy volunteers: 91 men and 110 women over the age of 18 were included in the study. Tests were compared by applying the SST and MOT to all volunteers. Results In all subjects, for the SST: the mean Threshold score (TS), Discrimination score (DS), and Identification score (IS) were, respectively, 10.73 +/- 2.35, 11.11 +/- 11.94 and 11.32 +/- 2.15. TheTDI mean score was found to be 33.11 +/- 5.9. In the TDI score, the 10th percentile value was found to be 26. For the MOT, the mean TS(mTS), DS(mDS), and IS(mIS) were 10.88 +/- 2.31, 12 +/- 2.06, and 11.95 +/- 2.07, respectively, the modified test TDI(mTDI) mean was 34.68 +/- 6.47. The mTDI 10th percentile value was found to be 26. In all volunteers, there was no statistically significant difference between the two tests for the mean threshold score, while the difference in the mean discrimination score, the average identification score, and the average TDI (thresold, discrimination, sum of identification scores) score was statistically significant (P < .01). Conclusion This study is the first study to compare the SST and the MOT in our region. Making low-cost modifications by adding more probable smells to the smell tests and using them in studies involving more participants will be more meaningful in evaluating normative odor scores and will result in more widespread use.
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    Does Short Term Usage of Fresh Pomegranate Juice (FPJ) Protect Cochlear Hair Cells after Cisplatin-Based Chemo-Irradiation?
    (Aves, 2014) Akdag, Mehmet; Dasdag, Suleyman; Alabalik, Ulas; Yilmaz, Beyhan; Altas, Sevcan; Zincircioglu, Seyit Burhanedtin; Gul, Aylin
    OBJECTIVE: The aim of this study was to investigate the protective effect of short-term usage of fresh pomegranate juice (FPJ) on ototoxicity after cisplatin-based chemo-irradiation. MATERIALS and METHODS: The study was carried out on 56 adult Wistar Albino rats, which were divided into 8 groups (n: 7 for each group). The first group was accepted as the sham control group. However, rats in the seven experimental groups were treated with FPJ; cisplatin; irradiation; irradiation plus FPJ; cisplatin plus FPJ; both cisplatin and irradiation; and combined use of cisplatin, irradiation, and FPJ, respectively. Ototoxicity was evaluated by Distortion Product Otoacoustic Emissions (DPOA), histopathology, and paracochlear protein carbonyl content. RESULTS: The results of the study showed that cisplatin, irradiation, and both cisplatin and irradiation treatments affected hair cells dramatically. However, the results of cisplatin plus FPJ and combined use of cisplatin, irradiation, and FPJ indicated that FPJ plays an important role in protecting hair cells in the inner ear. Additionally, the findings of signal-noise ratio and protein carbonyl values also supported the results stated above. CONCLUSION: Fresh pomegranate juice treatment can be a supportive agent to reduce hair cell injury in the inner ear of patient treated by cisplatin, radiotherapy, or cisplatin-based chemo-irradiation. However, more performance is necessary for further studies, especially on long-term treatment with FPJ.
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    Effect of caffeic acid phenethyl ester on myringosclerosis development in the tympanic membrane of rat
    (Springer, 2015) Kinis, Vefa; Ozbay, Musa; Alabalik, Ulas; Gul, Aylin; Yilmaz, Beyhan; Ozkurt, Fazi Emre; Sengul, Engin
    Myringosclerosis is hyalinization and calcification of certain areas of the tympanic membrane, especially the fibrous lamina propria layer and appears as white sclerotic lesions. Ventilation tube insertion is one of the most performed operations in the pediatric otorhinolaryngology practice to treat chronic otitis media with effusion. Myringosclerosis is a very common sequela of ventilation tube insertion. In this experimental study, our aim was to show the histopathological effects of caffeic acid phenethyl ester on myringosclerosis development in rat tympanic membrane after myringotomy. The rats were randomly categorized into four experimental groups including the comparison group (n = 4), non-treated group (n = 7), the saline (control) group (n = 7), the caffeic acid phenethyl ester group (n = 7). Non-treated group did not receive any treatment for 15 days. Saline (2.5 mL/kg, intraperitoneal) was administered to the third group once a day for 15 days. Fourth group received caffeic acid phenethyl ester intraperitoneally once a day at a dose of 10 mu mol/kg for 15 days. Myringotomy was performed on the right tympanic membrane of all rats except comparison group using a sterile pick with the help of an operating microscope. Histopathological examination of myringosclerosis formation was done by a pathologist under light microscope. In histopathological analysis of groups, the severity of inflammation was milder in caffeic acid phenethyl ester group compared to non-treated and saline groups (p < 0.05). There was less myringosclerotic plaques in caffeic acid phenethyl ester group than in non-treated and saline groups (p < 0.05). TM thickness measurements were very close to each other in non-treated and saline groups. The tympanic membrane thickness of caffeic acid phenethyl ester group was much thinner than the other two groups (p < 0.05). Caffeic acid phenethyl ester decreases inflammation severity and the formation of myringosclerotic plaques. These two effects resulted in thinner tympanic membranes of rats which were treated with caffeic acid phenethyl ester. As a result, caffeic acid phenethyl ester has potential preventive effects on myringosclerosis development after myringotomy and ventilation tube insertion.
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    Effects of caffeic acid phenethyl ester on wound healing of nasal mucosa in the rat: an experimental study
    (W B Saunders Co-Elsevier Inc, 2014) Kinis, Vefa; Ozbay, Musa; Akdag, Mehmet; Alabalik, Ulas; Gul, Aylin; Yilmaz, Beyhan; Ozkan, Hakan
    Purpose: Wound healing of the nasal mucosa is a highly complex process that restores the anatomical and functional integrity of tissue that has been exposed to trauma. In this experimental study, our aim was to use histopathological examination to investigate the effects of caffeic acid phenethyl ester on the wound healing of rat nasal mucosa after mechanical trauma. Materials and methods: The rats were randomly divided into 3 experimental groups: a non-treated group (n = 7), a control saline group (n = 7) and a caffeic acid phenethyl ester group (n = 7). The non-treated group received no treatment for 15 days. The second group was administered saline (2.5 mL/kg, intraperitoneal) once a day for 15 days. The third group received caffeic acid phenethyl ester intraperitoneally at a dose of 10 mu mol/kg once a day for 15 days. At the beginning of the study, unilateral mechanical nasal trauma was induced on the right nasal mucosa of all rats in the three groups using a brushing technique. Samples were stained using hematoxylin and eosin solution and were examined by a pathologist using a light microscope. Results: The severity of inflammation was milder in the caffeic acid phenethyl ester group compared with that in the non-treated and saline groups (P < 0.05). The subepithelial thickness index was lower in the experimental group (P < 0.05). Goblet cell and ciliated cell loss was substantially reduced in the experimental group compared with the non-treated and saline groups (P <0.05). Conclusions: Caffeic acid phenethyl ester decreases inflammation and the loss of goblet cells and ciliated cells. Therefore, caffeic acid phenethyl ester has potential beneficial effects on the wound healing of nasal mucosa in the rat. (C) 2014 Elsevier Inc. All rights reserved.
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    The Effects of Hyperbaric Oxygen Therapy Against Streptomycin Ototoxicity
    (Derman Medical Publ, 2014) Bakir, Salih; Ozbay, Musa; Kinis, Vefa; Yorgancilar, Ediz; Gun, Ramazan; Gul, Aylin; Alabalik, Ulas
    Aim: Hyperbaric oxygen (HBO) is an important adjuvant therapy and being increasingly used in the treatment of various disorders because of having an important antioxidant activity. This experimental study was designed to determine the possible protective effect of HBO therapy on streptomycininduced ototoxicity. Material and Method: Twenty-eight adult Wistar albino rats were divided into four groups: Streptomycin (n= 7), saline (n= 7), HBO (n= 7), and streptomycin plus HBO (n= 7). The HBO administered rats were placed into a large pressure chamber and received 100% oxygene at 2.5 atmosphere absolute for 60 minutes per day in a period of seven days. Rats were tested with DPOAE (Distortion Product Otoacoustic Emissions) in the beginning and the end of study. The animals in all groups were sacrificed under general anesthesia on the seventh day. Biopsy specimens from inner ear were stored for histopathologic examination with hematoxylin and eosin (H& E) under light microscopy. Results: Outer hair cells shown by light microscopic images were mostly preserved in control and HBO group. DPOAE measurements revealed no significant differences between the beginning and the end (p> 0.05). Streptomycin and streptomycin plus HBO treated rats showed loss of hair cells and auditory functions significantly (p< 0.05). Between the groups of streptomycin and streptomycin plus HBO; there was no statistically significance according to the analysis of the histopathological scores and DPgram results (p> 0.05). Discussion: HBO has probably no harmful effect on hair cells. But it seems to be not beneficial in a streptomycin-induced cochlear damage rat model.
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    The effects of oral isotretinoin (13-Cis retinoic acid) on the inner ear: A prospective clinical study
    (Canadian Soc Clinical Investigation, 2014) Akdag, Mehmet; Akkurt, Zeynep M.; Gul, Aylin; Ucmak, Derya; Yilmaz, Beyhan; Sengul, Engin; Topcu, Ismail
    Purpose: The purpose of this study was to investigate the effect of oral isotretinoin, a drug used in the treatment of acne vulgaris, on hearing function determined by serial audiology examinations. Methods: Forty patients with acne vulgaris were included in this study. Nine patients were excluded from the study because of inconsistent follow-up. The hearing of each participant was tested with pure tone audiometry and transient evoked autoacoustic emissions before and two and four weeks after treatment with isotretinoin (0.3-0.6 mg/kg/day) in the remaining 31 patients (62 ears). Results: Th e di ff erences between the mean values of the pre- treatment and post-treatment pure tone hearing thresholds at 1000, 2000, 4000 and 6000 Hz frequencies were statistically signi fi cant (p< 0.05), but there was no signi fi cant di ff erence between the pretreatment and post- treatment values at 250 and 500 Hz frequencies (p> 0.05). The difference between the pre-treatment and post-treatment signal-noise ratio values of the transient evoked autoacoustic emissions was not significantly different (p> 0.05). Conclusion: Our results suggest that the use of isotretinoin may cause bilateral hearing threshold changes. Further animal and human studies are required to investigate and characterize isotretinoin- induced neurophysiological alterations in hearing.
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    THE EFFICACY OF DOPPLER ULTRASOUND ON CHRONIC SUPPURATIVE OTITIS MEDIA
    (Carbone Editore, 2015) Gul, Aylin; Akdag, Mehmet; Ozkurt, Fazil Emre; Aguloglu, Bulent; Ozkan, Hakan; Akturk, Adem; Yilmaz, Beyhan
    Aims: The diagnostic techniques used in the diagnosis of lateral sinus thrombosis are invasive and pose a risk of stroke. For this reason, we aimed to evaluate the efficiency of Doppler ultrasonography, a simple, fast, and non-invasive technique in this field. Materials and methods: Patients presenting at our clinic with one-sided, chronic suppurative otitis media were included in the study. Internal jugular vein and internal carotid artery Doppler tests were conducted on the patients. The healthy ears of the patients were used as the control group. The values were compared statistically. Results: A total of 40 patients were included in the study 17 male (42.5%) and 23 female (57.5%). Seventeen patients had suppurative otitis media with cholesteatoma, and 23 patients had suppurative otitis media without cholesteatoma. According to Doppler ultrasonography parameters, no statistically significant differences were observed. However, when the chronic suppurative otitis media patients were compared to those without cholesteatoma, the internal jugular vein diameter was found to be reduced significantly in the group with cholesteatoma (p=0.047). Conclusion: The results of our study suggest that Doppler ultrasonography can be considered as a useful, fast, easy, and non-invasive method in the prognosis of cases with suspected lateral sinus thrombosis.
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    Efficacy of N-Acetylcysteine on Wound Healing of Nasal Mucosa
    (Lippincott Williams & Wilkins, 2015) Yilmaz, Beyhan; Turkcu, Gul; Sengul, Engin; Gul, Aylin; Ozkurt, Fazil Emre; Akdag, Mehmet
    Postoperative nasal mucosa healing is a highly complex and organized process, and the success rates of endoscopic sinus surgery and septoplasty surgeries are closely associated with the postoperative wound healing processes. In this experimental study, the authors' aim was to use histopathologic examination to investigate the effects of N-Acetylcysteine (NAC) on the wound healing of rat nasal mucosa after mechanical trauma. Twenty-one Sprague-Dawley rats were randomly divided into 3 groups: the nontreated group (N = 7), the control saline group (N = 7), and the NAC group (N = 7). No treatment was given to the nontreated group for 15 days. The control saline group received intraperitoneal injection of saline (2.5 mL/kg, intraperitoneal) for 15 days and the NAC group was intraperitoneally injected with NAC at a dose of 300 mg/kg/day for 15 days. At the beginning of the study, unilateral mechanical nasal trauma was induced with an interdental brush inserted through the right nostril in all rats. Samples were stained using hematoxylin and eosin solution, and were examined by a pathologist using a light microscope. The severity of inflammation was milder in the NAC group compared with that in the nontreated and saline groups (P < 0.05). The subepithelial thickness index was lower in the experimental group (P < 0.05). Goblet cell loss was reduced in the experimental group compared with the nontreated and saline groups (P < 0.05). NAC decreases inflammation and goblet cell loss. Therefore, NAC has potential beneficial effects on the wound healing of nasal mucosa in rats.
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    THE HISTOMORPHOLOGIC EFFECTS OF HYPERBARIC OXYGEN THERAPY ON SUBMANDIBULAR, THYROID GLANDS AND TRACHEA
    (Diagnosis Press Ltd, 2013) Akdag, Mehmet; Gul, Aylin; Bakir, Salih; Ozkurt, Fazil Emre; Alabalik, Ulas; Topcu, Ismail
    The aim of this experimental study was to investigate the efficacy of hyperbaric oxygen (HBO) therapy in the neck region of rats based on morphologic changes induced in the exocrine and endocrine glands and trachea. Samples of submandibular glands, thyroid gland and trachea were collected following sacrifice and neck dissection of the animals. The samples were processed for light microscopy and morphometric analysis. HBO administered rats were placed into a large pressure chamber and received 100 % oxygen at 253.3125 kPa (2.5 ata) for 60 min per day for a period of seven days. HBO-treated rats showed no statistically significant differences from the control group, according to the analysis of the histopathological scores (p = 0.930). HBO could probably be considered as neither helpful, nor harmless, on the submandibular glands, thyroid glands and trachea in rats.
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    Long-term Follow-up Results of the Patients Suffering from Sudden Hearing Loss
    (Mediterranean Soc Otology & Audiology, 2013) Akdag, Mehmet; Gul, Aylin; Bakir, Salih; Gun, Ramazan; Ozbay, Musa; Kinis, Vefa; Yorgancilar, Ediz
    Objective: The aim of this follow-up study was to evaluate the time-dependent course of hearing recovery in idiopathic SHL patients. Materials and Methods: Forty-four unilateral idiopathic SHL patients treated with the same standard regimen for 10 days were retrospectively reviewed, then they were invited to return to our hospital for their last visit and last audiogram during the study period. Gender, age, duration and severity of hearing loss, the shape of the audiogram and, the presence of tinnitus were evaluated. Thus, the long-term audiometric data, the final hearing outcome and, the rates of hearing recovery was obtained. Results: There was a significant difference in the degree of hearing loss and the rates of hearing recovery between early stage and long-term follow-up (p<0,001). The most common audiogram shape was flat. Hearing was significantly worse in SHL patients with tinnitus compared to SHL patients without tinnitus (p<0,001). Conclusion: Our results revealed that even if the failure of an initial 10-day course of treatment, a delayed recovery continues and there may still be enough time for complete recovery except profound SHL. Tinnitus on presentation with SHL and profound SHL has been identified as a negative prognostic indicator.
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    Managment of orbital complications of sinusitis
    (Consel Brasil Oftalmologia, 2014) Ozkurt, Fazil Emre; Ozkurt, Zeynep Gursel; Gul, Aylin; Akdag, Mehmet; Sengul, Engin; Yilmaz, Beyhan; Yuksel, Harun
    Purpose: We reported on the clinical approaches of ophthalmology and otorhinolaryngology departments in the treatment of the orbital complications of sinusitis. We also included an in-depth literature review. Methods: We retrospectively reviewed the medical files of 51 patients from January 2008 to January 2014. The records were evaluated for age, gender, type of orbital complications, symptoms, predisposing factors, imaging studies, medical and surgical management, culture results, and follow-up information. SPSS version 15.0 software (Statistical Analysis, The Statistical Package for Social Sciences Inc, Chicago, IL) was used for the statistical analysis. Results: Fifty-one patients met the criteria, with available medical records, for the study (29 male, 22 female). Thirty-two (62.7%) were diagnosed with preseptal cellulitis and 19 (37.3%) with postseptal cellulitis. After a detailed evaluation, 15 were diagnosed with a subperiosteal abscess (SPA), and 4 were diagnosed with orbital cellulitis. The age and gender was similar for the two groups. Five patients with medial SPA were treated with endoscopic sinus surgery, one patient with inferior SPA was treated with external surgery, and six patients with other localizations were treated with a combination of endoscopic sinus surgery and external surgery. All patients presented with periorbital erythema and edema. The length of hospitalization and duration of symptoms were similar in both groups. Visual acuity was between 1/10 to 10/10 (mean 7/10) and statistically significant for preseptal and postseptal cellulitis groups (p<0.001). All patients received intravenous antibiotics upon the first day of admission. Conclusion: Orbital complications of acute sinusitis required intensive follow-up and a multidisciplinary approach. A contrast-enhanced paranasal sinus computerized tomography (CT) scan can detect the extent of the infection. An initial trial of intravenosus (IV) antibiotics may be appropriate when close monitoring is possible. Surgery may be indicated when there has been no improvement within 48 hours of intravenous treatment, loss of visual acuity (under 8/10), and a non-medial abscess.
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    Our Tympanoplasty Results
    (Derman Medical Publ, 2013) Gul, Aylin; Bilek, Haluk; Samanci, Bayer; Samanci, Seyla; Bakir, Salih
    Aim: To review early stage results of the operated patients with the diagnosis of chronical otitis media. Material and Method: 49 chronic otitis media diagnosed patients who underwent type 1 tympanoplasty, type 3 tympanoplasty and modified radical mastoidechtomy between January 2011 and January 2012 were examined retrospectively. The age during the surgery, perforation types of eardrum (central, attik, subtotal), graft success, and pre-operative and post-operative, in the 3rd month, pure tone odiometry results were evaluated. Results: 49 patients were included. Intact with 39 patients and reperforation with 10 patients were observed. Based on pure tone odiometry results; in 23 patients, who underwent type 1 tympanoplasty and used temporal fascia autografts, an average of 7.7 dB; in 18 patients, who used tragal cartilage graft, an average of 11.9 dB; in 3 patients, who underwent type 3 tympanoplasty, an average of 14.3 dB and in 5 patients, who underwent modified radical mastoidechtomy, an average of 21.4 dB hearing gain was observed. Discussion: In early post-operative period, of patients who underwent Tympanoplasty, age, gender, perforation location, operation technique, and hearing gain results were assessed.
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    Patients With Congenital Choanal Atresia Treated by Transnasal Endoscopic Surgery
    (Lippincott Williams & Wilkins, 2014) Kinis, Vefa; Ozbay, Musa; Akdag, Mehmet; Cetin, Muzeyyen; Gul, Aylin; Yilmaz, Beyhan; Sengul, Engin
    Congenital choanal atresia (CCA) is defined as a congenital failure in the development of communication between the nasal cavity and nasopharynx in newborns. It is the most common congenital anomaly of nose. Most of the patients presented with unilateral CCA. Neonates with bilateral CCA have severe respiratory distress after birth. Airway control with orotracheal intubation should be done immediately to save the life of neonate with bilateral CCA. After airway control, surgery should be performed as soon as possible. The aim of surgery is to create a patent nasal passage and to prevent restenosis with minimal morbidity. Transnasal endoscopic surgery of CCA has become the most popular treatment method. The retrospective review of 33 patients with CCA was presented in this study. The patients who were diagnosed at the neonate period and operated on in 6 months after birth were grouped as I (neonate). The patients who were diagnosed 6 months after birth were grouped as II (child-young adult). All patients were treated by transnasal endoscopic surgery. Stent were put in all patients to prevent restenosis. Although the restenosis rate was higher in group I (53.8%) than in group II (23.1%), it did not cause a statistically significant difference. Overall success rate of our surgical approach was 61.5%. Despite the surgical developments and many treatment modalities, restenosis is still the most challenging problem in CCA.
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    The Protective Effect of Intratympanic Dexamethasone on Streptomycin Ototoxicity in Rats
    (Sage Publications Inc, 2017) Gul, Aylin; Sengul, Engin; Yilmaz, Beyhan; Ozkurt, Fazil Emre; Akdag, Mehmet; Keles, Aysenur; Topcu, Ismail
    The purpose of this experimental study was to investigate the protective role of intratympanically administered dexamethasone on the inner ears of rats that were exposed to streptomycin ototoxicity. Twenty-four adult Wistar albino rats were separated into 4 groups: Group 1 (only streptomycin), Group 2 (only intratympanic dexamethasone), Group 3 (streptomycin and intratympanic dexamethasone), and Group 4 (streptomycin and intratympanic saline). All rats were evaluated with distortion product otoacoustic emissions (DPOAE) tests before the start of treatment and on the day it ended. On the 45th day, after the final DPOAE tests, animals of all groups were sacrificed under general anesthesia. The differences between the amplitudes of DPOAE results were determined, and hearing results were statistically analyzed. Also, the cochleas of each rat were histopathologically evaluated under a light microscope with hematoxylin and eosin staining. In the intratympanic dexamethasone group it was observed that cochlear hair cells were mostly protected. No significant difference was seen between the DPOAE results before and after treatment (p > 0.05). On the other hand, loss was observed in the hearing functions and hair cells of the rats that received streptomycin and streptomycin plus intratympanic saline (p < 0.05). In the streptomycin plus intratympanic dexamethasone group, the cochlear hair cells were partially protected. A significant difference was observed when the DPOAE results (DP-grams) of the streptomycin plus intratypmanic dexamethasone group were compared to those of the streptomycin plus intratympanic saline group (p < 0.05). After the experimental study, ototoxic effects of the administration of streptomycin and intratympanic dexamethasone were observed on the rats' cochlear hair cells. We conclude that intratympanic dexamethasone has protective effects against this cochlear damage in rats.
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    Radiologic and Surgical Findings in Chronic Suppurative Otitis Media
    (Lippincott Williams & Wilkins, 2014) Gul, Aylin; Akdag, Mehmet; Kinis, Vefa; Yilmaz, Beyhan; Sengul, Engin; Teke, Memik; Meric, Faruk
    Our aim in this study was to evaluate the efficiency of preoperative temporal bone computed tomography (CT) in detecting pathologic conditions in patients with chronic suppurative otitis media (CSOM). The intraoperative findings and temporal bone CT results of 350 patients who were diagnosed with CSOM between September 1, 2010, and June 1, 2013, were compared. Comparison parameters were as follows: the presence of cholesteatoma, erosion of the outer ear bone canal, erosion of the middle ear chain, erosion of the dural plate, erosion of the lateral semicircular canal, erosion of the sigmoid sinus wall, and dehiscence of the facial canal. The contribution of CT was limited in showing the outer ear canal destruction, dural plate destruction, facial canal destruction, lateral semicircular canal destruction, and destruction of the sigmoid sinus wall. However, CTwas more sensitive in detecting cholesteatoma and erosion of the ossicular chain. These results indicate that preoperative CT of patients with CSOM serves as an important guide for otolaryngologists, although there are limitations in the evaluation of the CT results.
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    Rare Head and Neck Trauma due to Construction Nail: Case Report
    (Aves, 2014) Aguloglu, Bulent; Gul, Aylin; Ozbay, Musa; Ozkurt, Fazil Emre; Cetin, Muzeyyen; Topcu, Ismail
    Introduction: Oropharyngeal penetrating trauma is encountered more often in children under the age of 5 due to lack of their selfprotection. Case Report: In this paper, a 2-year-old girl who had penetrating oropharyngeal trauma after falling on a construction nail was presented. As a consequence of the physical examination and radiological examination applied to the patient, it was seen that the foreign body reached the clivus in the base of the skull, through the nasopharynx, passing by the hard and soft palate junction. In the status of the patient, who was operated on, no additional clinical aspects or neurological or lack of visual activity was observed in the post-operative period. As there was no complication during the follow-ups, the patient was discharged with recommendations. Conclusion: Oropharyngeal penetrating trauma should be careful in terms of mortality and morbidity due to the proximity to vital organs.
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    Titanium Implant Medialization Laryngoplasty Application in the Case of a Silicone and Gore-Tex Extrusion
    (Derman Medical Publ, 2014) Bakir, Salih; Akdag, Mehmet; Gul, Aylin; Yilmaz, Beyhan; Sengul, Engin
    Though the surgical technique of medialization laryngoplasty (ML) has been standardized today, the ideal implant has not been well-defined yet. Various non-absorbable materials such as autogenous cartilage, silicone, hydroxylapatite, Goretex, and titanium have been used for ML Titanium implant ML is a new technique and any complication has not been reported so far. Core-tex and silicone implants have been used more longer and both of them are accepted safe and easy to handle materials. Extrusion of Gore-ten or silicone material after ML has been rarely reported. We present a case of a 38-year-old man with history of silicone and then Gore-tex implant extrusion after ML Titanium implant was performed on the patient. Although rare, the possibility of silicone and Gore-ten extrusion after MT operation must not be ignored. Titanium implant may be a good alternative in such cases.

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