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Öğe Comparison of the therapeutic efficiency of verapamil, captopril and GBE, in prevention of the warm ischemia-reperfusion injury of kidneys(2000) Otçu S.; Özer M.; Öztürk H.; Dokucu A.I.; Gezici A.; Yücesan S.Injury related to warm ischemia is a problem in renal transplantation. In this study the therapeutic efficiency of verapamil, captopril and Ginkgo-Biloba-Extract (GBE) in prevention of the warm ischemia reperfusion injury is investigated. Fifty Sprague-Dawley rats were divided in 5 groups. Right nephrectomy was performed in the sham group while a right nephrectomy and a 30 minute ischemia and 60 minute reperfusion was applied to the left kidney in the remaining groups. Among the remaining 4 groups verapamil, captopril and GBE were administered before the ischemia while the fourth group formed the control group. All rats had a left nephrectomy on the 8th postoperative day after having a Tc 99m DMSA scintigraphy and blood urea, creatinine sampling. Kidneys were histopathologically investigated. In the three treatment groups, blood urea and creatinine levels were significantly lower than the control group and radioisotope uptake was significantly higher. When treatment groups are compared among each other, although there is no significant change in the blood urea and creatinine levels (p>O.05), radioisotope uptake is significantly higher in the GBE group and the results are statistically significant (p<0.05). Histopathologically the control group revealed gross necrosis while the captopril and verapamil group had less necrosis and glomeruli and distal tubules were preserved in the GBE group. As a conclusion, all three agents are effective in preventing warm ischemia of the kidney. GBE has a more potent effect in the prevention mechanism.Öğe The effect of the selective cyclooxygenase II inhibitor parecoxib on renal morphology and function in acute unilateral ureteral obstruction(Acta Medica Mediterranea, 2014) Tutus A.; Deliktas H.; Gedik A.; Gezici A.; Ozekinci S.; Sahin H.Objectives: This experimental study aimed to examine the efficacy of parecoxib in the treatment of kidney obstruction. The histopathological and scintigraphic effects of the selective cyclooxygenase II (COX-II) inhibitor parecoxib on renal morphology and function were determined following surgically induced unilateral ureteral obstruction. Materials and methods: The study included 20 male Sprague-Dawley rats that were assigned to 2 groups of 10 each. The rats underwent diethylenetriamine pentaacetic acid (DTPA) renal scintigraphy to calculate basal glomerular filtration rate (GFR) values at the beginning of the study. The left ureters in groups 1 and 2 were ligated distally. The rats in group 2 received parecoxib 5 mg·kg-1·d-1 for 21 d post surgery, whereas those in group 1 received nothing. At the end of postoperative d 21 DTPA renal scintigraphy was repeated in all the rats before undergoing bilateral nephrectomy. All kidneys were evaluated histologically. Results: Histologically, there were no differences between the right kidneys in groups 1 and 2, whereas the occurrence of cortical congestion, glomerular congestion, interstitial inflamation + congestion, and interstitial fibrosis was significantly lower in the left kidneys in group 2 than in those in group 1 (cortical congestion: P = 0.005; glomerular congestion: P = 0.03; interstitial inflamation + congestion: P = 0.01; interstitial fibrosis: P = 0.005). Scintigraphically, left kidney and right kidney GFR values in group 2 were higher than those in group 1; the difference was significant (left kidneys: P = 0.001; right kidneys: P = 0.009). Conclusion: Histopathologically and scintigraphically, kidney function was preserved at the highest level in group 2. Parecoxib treatment was effective in preserving renal function in the obstructed and non obstructed (contralateral) kidneys, and can be administered during the obstruction period until the time radical treatment of obstruction can be performed.Öğe The effects of osteoporosis on distraction osteogenesis: An experimental study in an ovariectomised rabbit model(2003) Arslan H.; Ketani A.; Gezici A.; Kapukaya A.; Necmioğlu S.; Kesemenli C.; Subasi M.The effects of oestrogen deficiency-associated osteoporosis on callus distraction were investigated in rabbits. Twenty-four female New Zealand rabbits 5 to 6 months old were used. Ovariectomy was performed on 12 rabbits, which composed the osteoporotic model group. Six weeks later, osteotomy was carried out and Ilizarov external fixators were applied to the right proximal tibial metaphyses in both the osteoporotic model group and the control group. Beginning one week postosteotomy, the metaphyses were distracted 0.35 mm twice daily for 3 weeks, and the average length increase obtained for both groups was 17.2 mm (minimum: 16.8, maximum: 19 mm). Following a postdistraction waiting period of 6 weeks for newbone formation, the subjects were sacrified and specimens were examined histopathologically. Radiography was carried out at one-week intervals during the distraction period and at 2-week intervals during the waiting period, and scintigraphy was performed at the end of each period. On histopathologic examination, a significant difference in callus remodeling was observed between the control and osteoporotic model groups. On radiologic evaluation it was observed that, while both groups had inadequate callus tissue at the end of the waiting period, callus formation and remodeling occurred later in the model group than in the control group, and the new bone was more osteoporotic. Osteoporosis associated with estrogen deficiency adversely affects the outcome of callus distraction. Nonetheless, radiographic findings in rabbits indicate that the effects may not be so great as to preclude clinical procedures. It was concluded that these results should be supported with clinical studies.Öğe Is there an association between immunohistochemical parameters of breast cancer and metabolic parameters obtained with 18F-fluorodeoxyglucose PET / CT?(DergiPark, 2019) Tuzcu S.A.; Gezici A.; Taşdemir B.; Kaplan İ.; Büyükbayram H.; Çetin F.A.Introduction: The aim of our study to investigate relationship between 18F -fluorodeoxyglucose PET/CT (18F-FDG PET/CT) metabolic parameters and immunohistochemical factors in breast carcinomas. Material and method: Patients with breast carcinomas who underwent 18F-FDG PET/CT imaging at our department between May 2018 and November 2019 were included in this study. A total of 146 female patients were included (aged 49.1 ± 13.4years; range, 26-87 years). PET scanning was performed in 3D mode from the skull ceiling to the middle of the thigh. Metabolic parameters such as TLG (Total lesion glycolysis), MTV (Metabolic tumor volume), SUVmean and SUVmax values were calculated. We obtained the histopathological findings, including the size of invasive cancer, histological type, histological grade, ER and PR status, epidermal growth factor receptor (HER2) and Ki-67 of the primary tumor by reviewing the pathology reports. Result: SUV max and SUVmean of Oestrogen receptor negative group were statistically higher than Oestrogen receptor positive group (p=0.009). SUVmean of progesterone receptor negative group were statistically higher than progesterone receptor positive group (p=0.05). Ki-67 of the Oestrogen receptor negative group and progesterone receptor negative group were statistically higher than Oestrogen receptor and progesterone receptor positive group (p=0.001, 0,001 respectively). Both SUVmax and SUVmean of Ki-67 positive group were statistically higher than Ki-67negative group (p=0.0001). Conclusions: 1-SUV max, SUVmean and Ki-67 of Oestrogen receptor negative group were statistically higher than Oestrogen receptor positive group. 2-SUVmean and Ki-67 of progesterone receptor negative group were statistically higher than progesteron receptor positive group. 3-HER2 positive and/or triple negative breast cancers were not associated with 18F-FDG PET/CT metabolic parameters © 2019 Published by International Archives of Medical Research. All rights reservedÖğe The role of L-Arginine, a nitric oxide precursor, on deteriorating cardio-respiratory effects in experimentally produced traumatic diaphragmatic injury(2002) Öztürk H.; Gezici A.; Otçu S.; Dokucu A.I.; Kaya S.; Kirbaş G.; Yücesan S.Aim: In this study we aimed to in vestigate the protective effects of L-Arginine on cardio-respiratory complications in a diaphragmatig rupture model. Method: 40 Sprague-Dawley rats were used in this study. In Group I, only thoracotomy was performed. In Group II, III and IV, following left thoracotomy, the stomach was pulled into thorax and the intraabdominal pressure was increased by an insufflator. L-Arginine (L-Arg) was given in GIII and L-NAME was given in GIV at the 45th minute of the study, The parameters such as arterial blood pressure (BP), heart rate (HR), arterial blood gases analysis (pO2, pCO2, pH) and pulmonary scintigraphy were measured at the baseline, 30th, 45th and 60th minutes of the study. The left lungs were extracted for histopathological examination. Results: In the values of blood gases analysis following the performing herniation model the pO2 and pH values decreased and pCO2 values increased in GII in comparison with GI. The mean values of blood gases analysis in GIII following L-Arg infusion at the 60th minute of the study were found to be increased for pO2 and pH values and to be decreased for pCO2 values in comparison with the values of GII. Following L-NAME administration to the GIV, there was no difference found between GII and GIV. Pulmonary uptake decreased in GII, GIII and GIV when compared with GI, whereas pulmonary uptake in GIII was significantly increased in comparison with GII and GIV. Conclusion: The use of the precursor of nitric oxide, L-Arginine, may provide protective effects on cardio-respiratory complications related to organ herniation in the acute period of traumatic diaphragmatic rupture.
