Comparison of the therapeutic efficiency of verapamil, captopril and GBE, in prevention of the warm ischemia-reperfusion injury of kidneys
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Tarih
2000
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Injury related to warm ischemia is a problem in renal transplantation. In this study the therapeutic efficiency of verapamil, captopril and Ginkgo-Biloba-Extract (GBE) in prevention of the warm ischemia reperfusion injury is investigated. Fifty Sprague-Dawley rats were divided in 5 groups. Right nephrectomy was performed in the sham group while a right nephrectomy and a 30 minute ischemia and 60 minute reperfusion was applied to the left kidney in the remaining groups. Among the remaining 4 groups verapamil, captopril and GBE were administered before the ischemia while the fourth group formed the control group. All rats had a left nephrectomy on the 8th postoperative day after having a Tc 99m DMSA scintigraphy and blood urea, creatinine sampling. Kidneys were histopathologically investigated. In the three treatment groups, blood urea and creatinine levels were significantly lower than the control group and radioisotope uptake was significantly higher. When treatment groups are compared among each other, although there is no significant change in the blood urea and creatinine levels (p>O.05), radioisotope uptake is significantly higher in the GBE group and the results are statistically significant (p<0.05). Histopathologically the control group revealed gross necrosis while the captopril and verapamil group had less necrosis and glomeruli and distal tubules were preserved in the GBE group. As a conclusion, all three agents are effective in preventing warm ischemia of the kidney. GBE has a more potent effect in the prevention mechanism.
Açıklama
Anahtar Kelimeler
Captopril, Ginkgo-Biloba-Extract, Ischemia-Reperfusion İnjury, Renal, Verapamil
Kaynak
Pediatrik Cerrahi Dergisi
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
14
Sayı
2
