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    Öğe
    Micronized purified flavonoid fraction may prevent formation of intraperitoneal adhesions in rats
    (Elsevier Science Inc, 2005) Yilmaz, HG; Tacyildiz, IH; Keles, C; Gedik, E; Kilinc, N
    Objective: To evaluate the efficacy of an anti-inflammatory and capillary regulator drug, micronized purified flavonoid fraction (MPFF), in the prevention of postoperative formation of adhesions. Design: A double-blind, controlled study evaluated the efficacy of MPFF in reducing postoperative adhesion formation in a rat model. Setting: Animal care facility of an academic research setting. Animal(s): Thirty Sprague-Dawley female rats randomly divided into three groups. Intervention(s): Starting on day of surgery, group 2 rats received oral MPFF (100 mg/kg per day for 7 days). Group 3 rats were intraperitoneally injected with 5 mL of saline (containing 200 mg/kg per day of MPFF for 3 days). Control rats received no medication. A standardized surgical trauma was applied in all animals. Three weeks after surgery, the rats were killed, and the adhesions were scored according to macroscopic and microscopic scales. Main Outcome Measure(s): Postoperative adhesions. Result(s): Both oral and intraperitoneal administration of MPFF reduced the scores of adhesions according to macroscopic and microscopic scales. There was no difference between the routes of administration. Conclusion(s): A statistically significant reduction in postoperative formation of adhesions was observed after oral and intraperitoneal administration of MPFF in our experimental animal model. However, further studies are required to reveal its mechanism of action.
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    Öğe
    Relation between severity of injury and the early activation of interleukins in multiple-injured patients
    (Karger, 2005) Yagmur, Y; Ozturk, H; Unaldi, M; Gedik, E
    The aim of this study was to evaluate the relation between severity of injury and the early activation of interleukins in multiple-injured patients. Ninety-nine patients with multiple injuries were included in this prospective study. Plasma levels of interleukin (IL)-1, IL-2, IL-6, IL-8 and TNF-alpha were measured. Injury Severity Score ( ISS), Revised Trauma Score (RTS), Glasgow Coma Score (GCS) and the Acute Physiology and Chronic Health Evaluation II (APACHE- II) were all recorded. Of the 99 patients, 82 were male and 17 were female. The mean age was 26.6 +/- 20.7 years. The mortality rate for this series was 17%. Patients who died from trauma exhibited a significant increase for IL-2, IL-6 and IL-8 in comparison with patients who survived. Significant differences for ISS, RTS and GCS were found between survivors and non-survivors. Values in all patients with ISS 1 16 were increased and these increases were significant for IL-6 and IL-2. These data show that the initial increase of IL-2, IL-6 and IL-8 might predict the patients with a high possibility of mortality and a significant increase of IL-2 and IL-6 in patients with ISS > 16 might be used in a new developed trauma score combined with ISS as an indicator for the injury severity. Copyright (C) 2005 S. Karger AG, Basel.