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    EFFECT OF FISH-OIL ON INDOMETHACIN-INDUCED GASTRIC-LESIONS IN RATS
    (Ecv-Editio Cantor Verlag Medizin Naturwissenschaften, 1995) GUZEL, C; ULAK, G; SERMET, A; CICEK, R; ULAK, M
    The effect of fish oil in promoting the healing of indometacin-induced gastric lesions was investigated in Wistar albino rats, After indometacin treatment (30 mg/kg, s.c.), animals were given fish oil, olive oil, or normal diet for 48 h. Thr ulcer index was found to be decreased to 2.1 +/- 1.8 mm with fish oil 13.7 +/- 5.4 mm with olive oil, and 14.6 +/- 2.4 mm with normal diet. Fish oil showed a potent healing-promoting effect on acute gastric erosions and ulcers induced by indometacin anti significantly, enhanced the mucus content of the mucosa (p < 0.05).
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    EFFECT OF ORAL PYRIDOXINE HYDROCHLORIDE SUPPLEMENTATION ON IN-VITRO PLATELET SENSITIVITY TO DIFFERENT AGONISTS
    (Ecv-Editio Cantor Verlag Medizin Naturwissenschaften, 1995) SERMET, A; AYBAK, M; ULAK, G; GUZEL, C; DENLI, O
    Effect of vitamin B-6 (pyridoxine-HCl, CAS 58-56-0) on platelet aggregation, plasma lipids and serum zinc level was investigated. The trial comprised 24 healthy male volunteers, aged between 19-24 years. The subjects were randomized in two groups 12 and treated for 4 weeks by a single daily oral dose of 5 mg/kg vitamin B-6 or placebo. Pyridoxine inhibited ADP- or epinephrine-induced aggregation by 48% and 41% (p < 0.001), respectively, whereas there was no change in control group. No significant effect on either, bleeding time, coagulation time or on platelet count was demonstrated in subjects given placebo. Pyridoxine prolonged both bleeding and coagulation time but not over the physiological limits. It had no effect on platelet count. These observations strongly suggest that vitamin B-6, with no effect on platelet count, not only inhibits platelet aggregation but also prolongs clotting time. Pyridoxine significantly reduced total plasma lipid and cholesterol levels, whereas it enhanced HDL-cholesterol level. Serum zinc level was also significantly increased by pyridoxine (p < 0.001). These findings suggest that oral vitamin B-6 inhibits platelet aggregation in normal subjects.
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    PROTECTIVE EFFECT OF FISH-OIL AGAINST STRESS-INDUCED GASTRIC INJURY IN RATS
    (Ecv-Editio Cantor Verlag Medizin Naturwissenschaften, 1995) ULAK, G; CICEK, R; SERMET, A; GUZEL, C; ULAK, M; DENLI, O
    The effect of fish oil and olive oil on the gastric mucosal damage induced by cold-restraint str ess !:as investigated in rats. The oils were dietary supplemented for 3 weeks. The results demonstrate that a diet containing fish oil when ingested for 3 weeks before exposure to stress, protected from gastric ulceration significantly (p < 0.01) and led to a statistically significant increase both in mucus and phospholipid con tent of the gastric mucosal barrier (p < 0.02 and p < 0.001, resp.) in cold-restraint stress-induced gastric injury in rats. However; further studies are required to determine the role of dietary fish oils in the prophylaxis and treatment of peptic ulcer.