DSpace Arşivi :: by Yazar "Firat, Ugur" değerine göre listeleniyor

Yazar "Firat, Ugur" seçeneğine göre listele

Listeleniyor 1 - 20 / 42

Analysis of cancer cases from Dicle University Hospital; ten years' experience Analysis of cancer cases
(Derman Medical Publ, 2018) Arslan, Necmi; Yilmaz, Ahmet; Firat, Ugur; Tanriverdi, Mehmet Halis
Aim: Cancer is the most common mortality and morbidity reason in the world. In Turkey cancer prevalence is high, and the treatment is expensive. The most important step in preventing and treating cancer is an early diagnosis. We aimed to contribute to the literature by specifying the common cancer types and etiological factors present in Diyarbakir region. Material and Method: Archived biopsy reports of patients diagnosed with malignant cancers after histopathological evaluation were studied retrospectively. The cases were dated between 2001 and 2010 and were all taken from the Dicle University Medical Faculty Hospital. Results: In total, 3624 cases were examined according to age, gender, year, location, and pathological diagnosis. Of the patients, 41.7% of the cases were female, and 58.3% were male. The average age of the patients was 54.8 years, and the most frequent age of cancer occurring were between 51-60 years (26.7%). In the pathological results distribution, the years that had the most cancer cases were 2006 and 2007. In general, the most frequent cancer location was lung (11.9%). In terms of specific types of cancers, the most frequent type was adenocarcinoma (24.1 %). Discussion: The most common type in both genders was adenocarcinoma, and it was found that the most common cancer location was the lung. Our study found that cancer was common in older age groups. We tried to determine the most frequent cancer types in the area by using data from Diyarbakir region.
The anti-oxidant and anti-apoptotic effects of nebivolol and zofenopril in a model of cerebral ischemia/reperfusion in rats
(Pergamon-Elsevier Science Ltd, 2012) Uzar, Ertugrul; Acar, Abdullah; Evliyaoglu, Osman; Firat, Ugur; Kamasak, Kagan; Gocmez, Cuneyt; Alp, Harun
The aim of this experiment was to investigate whether nebivolol and zofenopril have protective effects against oxidative damage and apoptosis induced by cerebral ischemia/reperfusion (I/R). There were seven groups of rats, with each containing eight rats. The groups were: the control group, I/R group, I/R plus zofenopril, I/R plus nebivolol, I/R plus nebivolol and zofenopril. zofenopril only and nebivolol only. Cerebral I/R was induced by clamping the bilateral common carotid artery and through hypotension. The rats were sacrificed 1 h after ischemia, and histopathological and biochemical analyses were carried out on their brains. The total antioxidant capacity was evaluated by using an automated and colorimetric measurement method developed by Erel. I/R produced a significant increase in the levels of total oxidant status and malondialdehyde levels, the number of caspase-3 immunopositive cells and activities of prolidase and paraoxonase in brain when compared with the control group (p<0.05). A significant decrease in brain total antioxidant capacity and nitric oxide levels were found in I/R group when compared with the control group (p<0.05). Both nebivolol and zofenopril treatment prevented decreasing of the total antioxidant capacity and nitric oxide levels, produced by I/R in the brain (p<0.05). Both nebivolol and zofenopril treatment prevented the total oxidant status, malondialdehyde levels, activities of paraoxonase and prolidase from increasing in brains of rats exposed to I/R (p<0.05). In conclusion, both nebivolol and zofenopril protected rats from ischemia-induced brain injury. The protection may be due to the indirect prevention of oxidative stress and apoptosis. (C) 2011 Elsevier Inc. All rights reserved.
ARE ABDOMINAL PAIN AND DISTENTION SYMPTOMS OF BREAST CANCER?
(Aves, 2012) Girgin, Sadullah; Onder, Akin; Kapan, Murat; Firat, Ugur; Arikanoglu, Zulfu; Kucukoner, Mehmet
Breast cancer usually metastasizes to bone, lungs, liver and central nervous system. Rarely, atypical metastases may occur. Isolated peritoneal metastasis of breast cancer is very uncommon. On systemic examination of a 50-yearold woman who presented to our outpatients' clinic with the complaints of abdominal pain and distention, abdominal ascites and a breast mass were found. Biopsy from the breast mass revealed invasive ductal carcinoma and laparoscopic peritoneal biopsy showed peritoneal metastasis of the breast cancer. Palliative chemotherapy was planned. The patient rejected the treatment and has been under follow-up for 6 months does not have any other metastasis now.
Bacterial translocation and inflammatory alterations in an experimental intestinal obstruction model in splenectomized rats
(Aves, 2012) Sirca, Tarik; Onder, Akin; Kapan, Murat; Tekin, Recep; Firat, Ugur; Evliyaoglu, Osman; Taskesen, Fatih
Purpose: Intestinal obstruction leads to an increase in the secretion of pro-inflammatory and inflammatory cytokines, oxidative injury, mucosal barrier dysfunction and bacterial translocation with the deterioration of normal ecological balance. Mitogenic activity resulting from splenectomy is reported to influence the development of bacterial translocation as a result of an increase in the proliferation of T cells and a decrease in the levels of serum tufsin. In this study, we aimed to investigate the effect of splenectomy on bacterial translocation and inflammatory response alterations resulting from the intestinal obstruction in rats. Materials and Methods: Twenty-four rats were divided into 3 groups as follows: Group 1 (Sham), only the ileocecal junction dissection; Group 2 (intestinal obstruction), complete ileal ligation; Group 3 (Splenectomy + intestinal obstruction), splenectomy following complete ileal ligation. 24 hours after the initial laparotomy, rats were sacrificed with the reception of intra-cardiac blood. Peritoneal swap, mesenteric lymph node, liver and ileal specimens, taken in sterile conditions, were examined microbiologically, biochemically and histopathologically. Results: Intestinal obstruction resulted in a significant increase in bacterial translocation, oxidative stress, inflammation, and ileal mucosal injury (p<0.05). No significant difference occurred between the splenectomized and non-splenectomized rats. Similar asimetric dimethylarginine levels were observed in all groups (p>0.05). Conclusions: It was proven that splenectomy has no significant effect on the bacterial translocation and inflammation in experimental intestinal obstruction models in rats.
Brain metastases in HER2-positive metastatic breast cancer patients who received chemotherapy with or without trastuzumab
(Springer Japan Kk, 2015) Kaplan, Muhammet Ali; Ertugrul, Hamza; Firat, Ugur; Kucukoner, Mehmet; Inal, Ali; Urakci, Zuhat; Pekkolay, Zafer
Objective The aim of this study was to assess whether trastuzumab usage is a risk factor for the development of brain metastasis (BM) in human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) and factors affecting survival after development of BM. Materials and methods One hundred thirty-two patients treated with (treatment group) or without trastuzumab (control group) with brain metastasis were retrospectively analyzed. Results Ninety of the 132 HER2-positive MBC patients were in the treatment group and 42 were in the control group. BM was significantly increased in patients who were treated with trastuzumab in two or more lines (58.5 vs 24.1 %, p < 0.001). Trastuzumab and lapatinib usage after BM and age were independent prognostic factors for overall survival in univariate and multivariate analysis. Conclusion The risk for BM was increased in patients who were treated with trastuzumab in two or more lines. Using trastuzumab and lapatinib after BM and age were independent prognostic factors for time to death from BM.
A case of bifocal endometriosis involving a pfannenstiel incision
(Studio K, 2011) Sidik, Evsen Mehmet; Erdal, Sak Muhammet; Yalinkaya, Ahmet; Firat, Ugur; Nur, Caca Fatma
A 25-year-old woman was referred to our clinic for atypical cyclic pain and masses at both ends of a Pfannenstiel incision scar Ultrasound of the anterior abdominal wall showed two masses. Both masses were hypoechoic, heterogeneous lesions located at opposite ends of the scar The lesions were surgically excised with. Microscopic examination revealed endometrial gland structures with endometrial stroma in fibroadipose tissue in sections of both specimens indicative of endometriosis. Incisional endometriosis (IE) is a form of extrapelvic endometriosis especially in scars of obstetric or gynecologic surgery IE may be multifocal at surgical scars. We report the a case of bifocal incisional endometriosis in Pfannesteil scar Whole scar evaluation should be done for incisional endometriosis and surgical excision should be performed for treatment.
The comparison of neuroprotective effects of intrathecal dexmedetomidine and metilprednisolone in spinal cord injury
(Elsevier Science Bv, 2013) Celik, Feyzi; Gocmez, Cuneyt; Kamasak, Kagan; Tufek, Adnan; Guzel, Abdulmenap; Tokgoz, Orhan; Firat, Ugur
Background: The purpose of this study is the investigation of the effects of intrathecally injected dexmedetomidine and methylprednisolone and their dominancy over one another in rats with generated Spinal Cord Injury (SCI). Methods: 40, female, adult Wistar Albino rats weighing 220-260 g were included in the study. The rats were fixed with Intrathecal catheter (IT) and divided into four groups. All subjects were applied T7-10 laminectomy after catheter. Group S (n:10) was injected with IT 10 mu L isotonic saline; Group C (n: 10) with IT 10 mu L isotonic saline after SCI; Group D (n:10) with IT one doze 10 mu L of dexmedetomidine after SCI; Group M (n:10) IT one dose 10 mu L of methylprednisolone. The subjects were sacrificed 72 h after this operation. The damaged area was removed biochemically and histopathologically examined. Results: Antioxidant and inflammatory parameters searched for in all damages tissue were statistically different in all groups from group S. They were different in group M and group D than group C (p < 0.001). After the comparison of group D and group M, PON and IL6 values were higher in group D (p = 0.003, p = 0.035) while the other two biochemical parameters were similar in both groups (Table 1). After histopathologic trials, edemas, bleeding and necrosis were found less in group S while at the most in group C (p < 0.001). In group M and group D, however, they were higher than group S and lower than group C (p < 0.001). After the comparison of group D and group M, while there was no difference in terms of edema necrosis, the amount of bleeding was lower in group D (p < 0.001) (Table 2). Conclusions: It has been discovered that intrathecal use of dexmedetomidine caused neuroprotective effects similar to methylprednisolone. (C) 2013 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
A Comparison of the Effects of Epidural and Spinal Anesthesia With Ischemia-Reperfusion Injury on the Rat Transverse Rectus Abdominis Musculocutaneous Flap
(Lippincott Williams & Wilkins, 2013) Acar, Yusuf; Bozkurt, Mehmet; Firat, Ugur; Selcuk, Caferi Tayyar; Kapi, Emin; Isik, Fatma Birgul; Kuvat, Samet Vasfi
The purpose of this study is to compare the effects of spinal and epidural anesthesia on a rat transverse rectus abdominus myocutaneous flap ischemia-reperfusion injury model. Forty Sprague-Dawley rats were divided into 4 experimental groups: group I (n = 10), sham group; group II (n = 10), control group; group III (n = 10), epidural group; and group IV (n = 10), spinal group. After the elevation of the transverse rectus abdominus myocutaneous flaps, all groups except for the sham group were subjected to normothermic no-flow ischemia for 4 hours, followed by a reperfusion period of 2 hours. At the end of the reperfusion period, biochemical and histopathological evaluations were performed on tissue samples. Although there was no significant difference concerning the malonyldialdehyde, nitric oxide, and paraoxonase levels in the spinal and epidural groups, the total antioxidant state levels were significantly increased, and the total oxidative stress levels were significantly decreased in the epidural group in comparison to the spinal group. The pathological evaluation showed that findings related to inflammation, nuclear change rates and hyalinization were significantly higher in the spinal group compared with the epidural group. Epidural anesthesia can be considered as a more suitable method that enables a decrease in ischemia-reperfusion injuries in the muscle flaps.
Cranial Magnetic Resonance Imaging in the Staging of HER2-positive Breast Cancer Patients
(Karger, 2013) Kaplan, Muhammet A.; Inal, Ali; Kucukoner, Mehmet; Urakci, Zuhat; Ekici, Faysal; Firat, Ugur; Zincircioglu, Seyit B.
Aim: The aim of the current study was to evaluate whether early detection of brain metastases (BMs) could improve survival outcomes in human epidermal growth factor receptor 2 (HER2)-positive breast cancer patients. Material and Methods: HER2-positive breast cancer patients without BMs who had no neurological symptoms within 12 months from diagnosis or relapse time of the disease were included in the study. The patients were distributed into 2 groups: Group 1 comprised patients without metastases; group 2 comprised patients with metastases. The symptomatic historic control group with BMs was defined retrospectively for survival comparisons. Results: 55 (57.3%) and 41(42.7%) patients were in groups 1 and 2, respectively. 11 of the 96 patients (11.5%) had occult BMs, and 9 of them were in group 2 whereas only 2 patients were in group 1 (22% vs. 3.6%, respectively; p = 0.008). While the median survival times from the first metastasis (28.7 vs. 22.5 months, respectively; p = 0.561) and BM (6.8 vs. 6.1 months, respectively; p = 0.511) were similar, cerebral death was numerically different (16.7% vs. 46.3%; p = 0.221) between asymptomatic (n = 9) and symptomatic patients (n = 53). Conclusions: BMs were detected very rarely in asymptomatic, non-metastatic HER2-positive breast cancer patients compared with asymptomatic, metastatic patients. Furthermore, although early detection of BMs decreases the cerebral death rate, it does not prolong the survival rate in metastatic patients.
THE EFFECTS OF ERYTHROPOIETIN ON BACTERIAL TRANSLOCATION AND INFLAMMATORY RESPONSE IN AN EXPERIMENTAL INTESTINAL OBSTRUCTION MODEL IN RATS
(Soc Medical Biochemists Serbia, 2013) Kapan, Murat; Onder, Akin; Yuksel, Hatice; Evliyaoglu, Osman; Firat, Ugur; Tekin, Recep; Gul, Mesut
Background: Intestinal obstruction results in distortion of balance of antiinflammatory cytokines and release of oxidants, and also leads to bacterial translocation, sepsis and multiple organ failure. Asymmetric dimethylarginine is related to multiple organ failure as a new prognostic marker. Erythropoietin reduces the inflammatory response by decreasing the levels of proinflammatory cytokines and cytokine-induced apoptosis. In this study, we aimed to investigate the effectiveness of erythropoietin in reducing the severity of bacterial translocation and inflammatory response after intestinal obstruction and the relation between asymmetric dimethylarginine and inflammatory markers. Methods: Forty Wistar albino rats (200-250 g) were divided into 4 groups as follows: Group 1 (Sham), only ileocaecal junction dissection; Group 2 (Erythropoietin), ileocaecal junction dissection and 3000 IU/kg erythropoietin subcutaneously; Group 3 (Intestinal Obstruction), complete ileal ligation; Group 4 (Intestinal Obstruction + Erythropoietin), complete ileal ligation and 3000 IU/kg erythropoietin subcutaneously. After 24 hours, the rats were sacrificed by taking blood from the heart for biochemical analyses. Peritoneal swab culture, liver, mesenteric lymph nodes, spleen and ileum were collected for microbiological and histopathological examinations. Results: Erythropoietin reduced the secretion of inflammatory cytokines, oxidative damage and bacterial translocation, prevented the formation of inflammatory changes in the intestine, liver, spleen and mesenteric lymph nodes, and also significantly prevented the formation of intestinal damage after intestinal obstruction (p<0.05). Conclusions: Asymmetric dimethylarginine levels did not differ between the groups. Erythropoietin may be useful to preserve from intestinal injury and related sepsis in patients with intestinal obstruction. Asymmetric dimethylarginine is not a suitable prognostic marker.
Effects of Malathion in Fetal Kidney Tissues in Pregnant Rats: Teratogenic Effects Induced by Different Doses
(Kafkas Univ, Veteriner Fakultesi Dergisi, 2012) Alp, Harun; Sak, Muhammet Erdal; Evsen, Mehmet Siddik; Firat, Ugur; Evliyaoglu, Osman; Penbegül, Necmettin; Sancaktutar, Ahmet Ali
The aim of this study was to investigate the teratogenic effects of Malathion (ML) induced by different doses on fetal kidney tissues in pregnant rats. A total of 28 Sprague-Dawley pregnant rats were randomly divided into 4 groups of 7 rats each. Depending on ML dose, four groups were formed, including (I) control, (II) ML 2.5 (ML 2.5 mg/kg/day, orally), (III) ML 5 (5 mg/kg/day, orally), and (IV) ML 10 (10 mg/kg/day, orally). ML application started when the male and female were put together (when mating started). Daily ML application was continued until birth. It was determined that in parallel with dose of ML, ML resulted in toxic effects on serum enzymes (acetyl-cholinesterase (AChE), amylase and lipase) and kidney tissues of pregnant rats, and also -regardless of ML dose in fetal kidneys-it led to teratogenic effects in all the doses. Biochemical data wasconfirmed by histopathologic data. We concluded that ML leads to kidney damage in both pregnant and fetal rats as a result of its teratogenic and toxic effects.
Ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion
(Wolters Kluwer Medknow Publications, 2011) Boyuk, Abdullah; Onder, Akin; Kapan, Murat; Gumus, Metehan; Firat, Ugur; Basarali, Mustafa Kemal; Alp, Harun
Background: The aim of this study was to investigate the possible protective role of antioxidant treatment with ellagic acid (EA) on lung injury after intestinal ischemia-reperfusion (I/R) injury using biochemical and histopatological approaches. Materials and Methods: Forty rats were divided into four groups as control, control + EA, I/R, and I/R + EA. The control and control + EA groups were also anesthetized and subjected to laparotomy, but without clamp application. The control + EA and I/R + EA groups were given EA (85 mg/kg) orally prior to experiment. The I/R and I/R + EA groups underwent 30 minutes of intestinal ischemia and 1 hour of reperfusion. In all groups, serum total antioxidant capacity (TAC) and malondialdehyde (MDA) levels were determined. TAC, total oxidative status (TOS), and oxidative stress index (OSI) in lung tissue were measured. Lung tissue histopathology was also evaluated by light microscopy. Results: TAC levels were higher in control, EA, and I/R + EA groups while TOS, OSI, and MDA levels were lower in these groups compared with I/R group. Serum MDA levels were significantly higher in I/R + EA group than that of control group. Lung tissue TAC levels were lower in I/R + EA group while OSI values were higher in that groups compared with EA group. Histological tissue damage was milder in the EA treatment group than in the I/R group. Conclusion: These results suggest that EA treatment protected the rats lung tissue against intestinal I/R injury.
Ellagic acid attenuates oxidative stress on brain and sciatic nerve and improves histopathology of brain in streptozotocin-induced diabetic rats
(Springer-Verlag Italia Srl, 2012) Uzar, Ertugrul; Alp, Harun; Cevik, Mehmet Ugur; Firat, Ugur; Evliyaoglu, Osman; Tufek, Adnan; Altun, Yasar
The aim of this study was to investigate the possible effects of ellagic acid in brain and sciatic nerve tissues of diabetic rats. Also, the impact of ellagic acid on catalase and paraoxonase (PON-1) activities, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA) and nitric oxide (NO) were examined. The rats were randomly divided into four groups, with eight rats each: Normal controls (not diabetic), only ellagic acid treated (ellagic acid controls, not diabetic), Diabetic controls (streptozotocin, diabetic), ellagic acid-treated diabetic (streptozotocin + ellagic acid). After a 4 week experiment, rats were sacrificed, and biomarkers for oxidative stress in the brain and sciatic nerve tissues of the rats were measured. There was significant depletion in the PON-1, catalase, and TAS levels in the brain and sciatic nerve tissues compared to the control groups (for both parameters, p < 0.05). The values of catalase, PON-1 and TAS reversed back to normal levels in ellagic acid-treated diabetic rats compared to untreated diabetic rats (for both parameters, p < 0.05). The levels of MDA, TOS, NO and, OSI in the brain and sciatic nerve tissues were higher in untreated diabetic rats compared to control group (for both parameters p < 0.05). However, MDA, TOS, OSI, and NO levels were found to be significantly reduced in the ellagic acid-treated diabetic group compared to the untreated diabetic group in these tissues (for both parameters, p < 0.05). In conclusion, the results of the present study suggested that ellagic acid exhibits neuroprotective effects against oxidative damage in diabetic rats.
Germ cell tumor in duodenum
(Turkish Soc Gastroenterology, 2013) Kucukoner, Mehmet; Kaplan, Muhammed Ali; Inal, Ali; Ucmak, Feyzullah; Firat, Ugur; Isikdogan, Abdurrahman
[Abstract Not Available]
HISTOPATHOLOGIC EFFECTS OF GLASS IONOMER BONE CEMENTS APPLICATION TO MAXILLOFACIAL AREA: AN EXPERIMENTAL STUDY IN RABBITS
(Diagnosis Press Ltd, 2012) Yorgancilar, Ediz; Firat, Ugur; Gun, Ramazan; Bakir, Salih; Dasdag, Suleyman; Akkus, Zeki; Gokalp, Osman
Reconstruction of the maxillofacial bone defects and fractures poses a challenge to the surgeons. Various alternatives and materials have been described for these defects and fractures. Glass ionomer bone cements (GICs) have been used extensively in dentistry but recently they have also been utilized in otolaryngology. We hypothesized that GIC can be an alternative material for maxillofacial reconstruction. However, their biocompatibility is of primary importance because this material will be in direct contact with the tissue for a prolonged tune and might affect it. Therefore the aim of this study was to investigate the tissue responses to GIG in the maxillofacial area in rabbits. The study was carried out on 16 New Zealand White rabbits, which were divided into study (n: 8) and control (n: 8) groups. Experimental defects and fractures were created in the nasal bone, maxilla and zygoma in both the study and the control group. The experimental fractures and defects were reconstructed by GIG in the study group. However, the rabbits in the control group were left to natural healing process. The inflammatory reaction and fibrosis in the rabbits of both the study and the control group were compared by using descriptive histopathological analysis 180 days after application. The tissue reactions were graded. GIG showed a slight inflammatory and fibrous reaction in the rabbit of the study group. Nevertheless, statistical difference between the groups was not observed in terms of inflammatory reaction and fibrosis (P>0.05). The results of this study indicated that GIG is a well tolerated material in maxillofacial reconstruction.
Histopathologic results of long-term sildenafil administration on rat inner ear
(W B Saunders Co-Elsevier Inc, 2012) Bakir, Salih; Firat, Ugur; Gun, Ramazan; Bozkurt, Yasar; Yorgancilar, Ediz; Kinis, Vefa; Penbegül, Necmettin
Objectives: Sildenafil, a selective inhibitor of phosphodiesterase type 5, is widely used for the treatment of erectile dysfunction. Although cochlear effects of phosphodiesterase type 5 inhibitors remain still unclear because of inadequate data, some evidence that recently emerged indicates that these medications may be responsible for hearing impairment. In the present study, we aimed to examine the histopathologic effects of long-term sildenafil use on the cochlea in a rat model. Methods: The study was performed with adult male Wistar albino rats. The control group was fed on standard laboratory diet. The study group was applied orally with sildenafil therapy, 1.5 mg/kg once a day for 45 days. Rats were anesthetized and decapitated. Each temporal bone was dissected, and the cochleas were removed en bloc. The inner-ear biopsy specimens were examined histologically with hematoxylin and eosin and caspase 3 immunoreaction under light microscopy. Results: Hematoxylin and eosin staining showed no distinctive difference between the control group and the sildenafil group. With immunohistochemical examination, caspase 3 immunoreactivity was observed in the sildenafil group. In the control group, caspase 3 immunoreactivity was not observed. Conclusions: The caspase 3 immunoreactivity in the sildenafil group was strongly associated with an increase in apoptotic events in the cochlea. Long-term use of sildenafil can cause hearing impairment through increased apoptosis. (c) 2012 Elsevier Inc. All rights reserved.
Hydatid cyst-like intra-abdominal esophageal duplication cyst in an endemic region
(Aves, 2011) Gumus, Metehan; Onder, Akin; Firat, Ugur; Kapan, Murat; Onder, Hakan; Girgin, Sadullah
[Abstract Not Available]
Increased Caspase-3 Immunoreactivity of Erythrocytes in STZ Diabetic Rats
(Hindawi Publishing Corporation, 2012) Firat, Ugur; Kaya, Savas; Cim, Abdullah; Buyukbayram, Huseyin; Gokalp, Osman; Dal, Mehmet Sinan; Tamer, Mehmet Numan
Eryptosis is a term to define apoptosis of erythrocytes. Oxidative stress and hyperglycemia, both of which exist in the diabetic intravascular environment, can trigger eryptosis of erythrocytes. In this experimental study, it is presented that the majority of erythrocytes shows caspase-3 immunoreactivity in streptozocin- (STZ)-induced diabetic rats. Besides that, caspase-3 positive erythrocytes are aggregated and attached to vascular endothelium. In conclusion, these results may start a debate that eryptosis could have a role in the diabetic complications.
An Infantile Splenic Hemangiopericytoma Case Treated with Partial Splenectomy
(Taylor & Francis Inc, 2012) Uygun, Ibrahim; Okur, Hanifi; Firat, Ugur; Otcu, Selcuk; Ozturk, Hayrettin
Splenic hemangiopericytoma is a very rare tumor. So far only 10 patients (9 adults, 1 child) have been reported in the literature and all of them were treated with total splenectomy. Herein, we report the first infant case of the splenic hemangiopericytoma in a 10-month-old girl and the first case that was treated with partial splenectomy for splenic hemangiopericytoma.
Is there Epithelial Tissue in Bone Pate? A Histopathology Study
(Mediterranean Soc Otology & Audiology, 2012) Yorgancilar, Ediz; Firat, Ugur; Alabalik, Ulas; Gun, Ramazan; Yildirim, Muzeyyen; Bakir, Salih; Kinis, Vefa
Objectives: To evaluate the histology of bone pate collected during mastoidectomy in chronic suppurative otitis media (CSOM) patients with or without cholesteatoma. Study Design: Prospective controlled study. Materials and Methods: The study recruited 32 patients (15 males, 17 females; average age 25.3 (range 19-56 years) who underwent mastoidectomy for CSOM: 16 with cholesteatomas (group I) and 16 controls with granulation or polyp tissue (group II). In all patients, bone pate was collected separately from the mastoid cortex (Level 1), subcortical air cells (Level 2), and just before the antrum mastoideum (Level 3). All samples were stained with hematoxylin-eosin (H&E) and immunochemically with a monoclonal antibody against epithelial membrane antigen (EMA). The presence of squamous epithelium in the bone pate was examined under a light microscope. Results: In Group I, we detected epithelial cells in the bone pate samples obtained from the mastoid subcortex (two of 16 patients) and antrum (four of 16 patients) levels. However, no epithelial cells were observed in bone pate from the mastoid cortex. In the controls (group II), no epithelial tissue was observed in any sample from any level. Conclusions: Epithelial cells can inoculate bone pate collected from the subcortical and antral areas of the mastoid bone in patients with cholesteatomatous CSOM. To prevent epithelial cell inoculation, we recommended that bone pate be collected only from the cortical bone of the mastoid.

Yazar "Firat, Ugur" seçeneğine göre listele

Sayfa Başına Sonuç

Sıralama seçenekleri