Increased Caspase-3 Immunoreactivity of Erythrocytes in STZ Diabetic Rats

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Tarih

2012

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Yayıncı

Hindawi Publishing Corporation

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Eryptosis is a term to define apoptosis of erythrocytes. Oxidative stress and hyperglycemia, both of which exist in the diabetic intravascular environment, can trigger eryptosis of erythrocytes. In this experimental study, it is presented that the majority of erythrocytes shows caspase-3 immunoreactivity in streptozocin- (STZ)-induced diabetic rats. Besides that, caspase-3 positive erythrocytes are aggregated and attached to vascular endothelium. In conclusion, these results may start a debate that eryptosis could have a role in the diabetic complications.

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Kaynak

Experimental Diabetes Research

WoS Q Değeri

Q3

Scopus Q Değeri

N/A

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