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Protective effects of caffeic acid phenethyl ester on isoniazid and rifampicin-induced hepatic and pancreatic injury
(Univ West Indies Faculty Medical Sciences, 2021) Türkçü, G.; Avcı, Y.; Evliyaoğlu, O.; Gökalp, O.; Gümüş, M.; Tanrıkulu, A. C.; Abakay, A.; Büyükbayram, H.; Fırat, U.
Objective: To investigate the protective effects of caffeic acid phenethyl ester (CAPE) against isoniazid (INH)- and rifampicin (RFP)-induced hepatic and pancreatic damage. Methods: Eighty adult rats were randomly divided into eight groups: control, INH, RFP, INII+RFP, INII+CAPE, RFP+CAPE, INII+RFP+CAPE, and CAPE. Both _MI and RFP were orally administered for 30 days at a dose of 50 mg/kg/day. Caffeic acid phenethyl ester was intraperitoneally injected for 30 days (10 mu mol/kg). Blood samples, hepatic and pancreatic tissues were obtained on day 30. Results: Total oxidant status levels were significantly higher in MI and/or RFP-treated groups than those of control and CAPE groups, while total antioxidant status and paraoxonase levels were significantly reduced in INH-RFP groups compared with the group receiving CAPE. Histopathological deterioration was observed in RFP and INH groups in pancreatic and hepatic tissue. However, significant amelioration was observed in CAPE-treated groups. Conclusion: Our findings suggest that CAPE may be a promising agent to prevent the side effects of INH and RFP treatment on hepatic and pancreatic tissues.