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    Acute Acalculous Cholecystitis due to Viral Hepatitis A
    (Hindawi Ltd, 2013) Kaya, Safak; Eskazan, Ahmet Emre; Ay, Nurettin; Baysal, Birol; Bahadir, Mehmet Veysi; Onur, Arzu; Duymus, Recai
    Inflammation of the gallbladder without evidence of calculi is known as acute acalculous cholecystitis (AAC). AAC is frequently associated with gangrene, perforation, and empyema. Due to these associated complications, AAC can be associated with high morbidity andmortality. Medical or surgical treatments can be chosen according to the general condition of the patient, underlying disease and agent. Particularly in acute acalculous cholecystitis cases, early diagnosis and early medical treatment have a positive effect on the patient and protect them from surgical trauma. ACC is a rare complication of acute viral hepatitis A. Herein, we present an adult patient of acalculous cholecystitis due to acute viral hepatitis A. She responded to the conservative management.
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    Acute colitis presenting with hematochezia in a patient with chronic myeloid leukemia during dasatinib therapy
    (Aves, 2014) Eskazan, Ahmet Emre; Hatemi, Ibrahim; Aydin, Seniz Ongoren; Ar, Muhlis Cem; Soysal, Teoman
    [Abstract Not Available]
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    Brucellar pericarditis: a report of four cases and review of the literature
    (Elsevier Sci Ltd, 2013) Kaya, Safak; Eskazan, Ahmet Emre; Elaldi, Nazif
    Background: Brucellosis, a disease endemic in many countries including Turkey, is a systemic infectious disease. Cardiovascular complications are not frequent, and endocarditis is the main cardiac manifestation of brucellosis. Pericarditis in the absence of concomitant endocarditis is extremely rare. Methods: In this report, we present four patients with pericarditis caused by brucellosis in the absence of concomitant endocarditis, along with a review of the published literature on brucellar pericarditis. We also searched for clinically silent pericardial effusion among patients with brucellosis. We performed routine transthoracic echocardiography (TTE) on 72 consecutive patients with newly diagnosed brucellosis in the absence of any signs and symptoms of pericarditis over a period of 6 months. Results: Three of our patients with brucellar pericarditis recovered fully after antibiotics. The other patient received 6 days of antibiotic treatment, and her signs and symptoms regressed, but after this the patient was lost to follow-up. We did not detect pericarditis among the 72 newly diagnosed patients. Conclusions: Brucellar pericarditis is a rare clinical entity, and the morbidity and mortality in patients with brucellar pericarditis is low. Pericardiocentesis should only be performed in patients with cardiac tamponade. Moreover, the choice of antibiotics and the duration of treatment do not differ between brucellosis cases with or without isolated pericarditis. Although the prevalence of pericarditis in brucellosis is low, brucellar pericarditis should always be kept in mind in patients with acute or chronic pericarditis, especially in areas where brucellosis is endemic. (C) 2013 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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    Cyclosporin A therapy on idiopathic thrombotic thrombocytopenic purpura in the relapse setting: two case reports and a review of the literature
    (Wiley-Blackwell, 2013) Yilmaz, Murvet; Eskazan, Ahmet Emre; Unsal, Abdulkadir; Taninmis, Hakan; Kara, Ekrem; Cetiner, Mustafa; Ferhanoglu, Burhan
    BackgroundThrombotic thrombocytopenic purpura (TTP) is a life-threatening disease, characterized by microangiopathic hemolytic anemia, thrombocytopenia, fever, neurologic disturbances, and renal failure. Plasma therapy has dramatically improved prognosis of TTP, whereas recurrent acute episodes still occur in approximately 40% of patients. Moreover, patients with acquired ADAMTS13 deficiency, which is a significant factor for relapse, may require additional immunosuppressive treatment to get a durable remission. Study Design and MethodsWe hereby report two patients with a history of relapsed idiopathic TTP, who both received cyclosporin A (CSA) as a prophylactic manner after the remission was achieved. We also discuss the efficacy of CSA in patients with relapsed idiopathic TTP with a review of the published literature. ResultsUnder CSA therapy, both patients maintained their clinical remission state, and the ADAMTS13 levels were normalized. ConclusionTo conclude, CSA therapy may be useful for the prevention of relapsed idiopathic TTP in patients with a history of frequent relapses.
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    Cytopenia in adult brucellosis patients
    (Medknow Publications & Media Pvt Ltd, 2018) Kaya, Safak; Elaldi, Nazif; Deveci, Ozcan; Eskazan, Ahmet Emre; Bekcibasi, Muhammed; Hosoglu, Salih
    Background & objectives: Brucellosis can lead to haematological abnormalities including cytopenia confusing with haematological malignancies. The aim of this study was to compare the main characteristics of brucellosis patients without cytopenia (Group 1) and with cytopenia (Group 2). Methods: This five-year period study which was performed in two referral hospitals in Turkey, included all adult brucellosis patients. Abnormally, low counts of leucocyte or haemoglobin or platelets in a patient were considered as cytopenia. The demographics, clinical, laboratory, treatment and outcome data were analyzed. Results: A total of 484 brucellosis patients were enrolled. Among the cases, 162 (33.5%) of them had cytopenia. One hundred and four (21.5%) had anaemia, 88 (18.8%) had thrombocytopenia, 71 (14.6%) had leucopenia and 28 (5.8%) had pancytopenia. The mean age of group 2 was 35.01 +/- 16.05 yr and it was 33.31 +/- 14.39 yr in group 1. While there was no difference between the groups in terms of duration of treatment, the median length of hospital stay (LOS) was significantly longer in group 2 (9 vs 10 days; P<0.001). The most frequently applied combination therapy consisted of doxycycline plus rifampicin and doxycycline plus streptomycin regimens. No significant difference was observed in terms of duration of treatment, LOS and restoration time of cytopenia between the patients who received either of these combinations. Interpretation & conclusions: Our findings suggested that the patients with cytopenia should be investigated for brucellosis, especially if living in, or with a history of travel to, endemic areas, in view of the increase in world travel.
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    Dasatinib May Override F317L BCR-ABL Kinase Domain Mutation in Patients with Chronic Myeloid Leukemia
    (Galenos Yayincilik, 2013) Eskazan, Ahmet Emre; Soysal, Teoman
    [Abstract Not Available]
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    Intracranial extramedullary hematopoiesis in patients with thalassemia: a case report and review of the literature
    (Wiley, 2012) Eskazan, Ahmet Emre; Ar, Muhlis Cem; Baslar, Zafer
    BACKGROUND: Extramedullary hematopoiesis (EH) is a compensatory phenomenon that results in the production of blood cell precursors outside the marrow in patients with chronic hemolytic anemia and ineffective erythropoiesis. EH usually involves the liver, spleen, and lymph nodes. It can also be found at paravertebral, intrathoracic, or pelvic locations. Intracranial EH is a rare entity and often asymptomatic but can sometimes lead to symptomatic tumor-like masses. Treatment options are controversial and include hypertransfusion, surgical excision, radiotherapy, and hydroxyurea (HU). STUDY DESIGN AND METHODS: Successful treatment of an intracranial EH mass with HU and blood transfusions in a beta-thalassemia major patient was discussed along with a review of the published literature on intracranial EH in thalassemia. RESULTS: In our patient, the extramedullary hematopoietic mass in the interhemispheric fissure showed a marked improvement after 6 months of HU and hypertransfusion therapy. In the English literature, there are a few cases with intracranial EH and thalassemia, which were treated with different treatment modalities, with different outcomes. CONCLUSION: There is no standard treatment approach in patients with symptomatic EH. HU with hypertransfusion regimen is a reasonable first-choice modality in treating intracranial EH masses.
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    Patient characteristics and management practices in chronic myeloid leukemia in Turkey: reflections from an expert meeting
    (Taylor & Francis, 2022) Eskazan, Ahmet Emre; Ali, Rıdvan; Alnıgeniş, Ebru; Ayyıldız, Orhan; Haznedaroğlu, İbrahim; Kırkızlar, Onur; Kurtoğlu, Erdal; Malhan, Simten; Öksüz, Ergün; Polat, Özlem; Saydam, Güray; Sönmez, Mehmet; Toprak, Selami Koçak; Toptaş, Tayfur; Turgut, Mehmet
    Introduction The therapeutic landscape of chronic myeloid leukemia (CML) has evolved significantly since the introduction of imatinib. The European LeukemiaNet (ELN) recommendations serve as a guide for diagnosis, treatment, and monitorization of CML, but availability and accessibility of diagnostic tools and medications affect their applicability. Areas covered This article provides an overview of the current clinical management of CML in Turkey with reference to the key outputs of the online expert meeting held in November 2020. The applicability of the ELN 2020 recommendations for treating CML in clinical practice was also discussed. Expert opinion Imatinib is the only reimbursed and the most preferred first-line treatment in CML restricting the upfront use of second-generation tyrosine kinase inhibitors (TKIs), thereby limiting the applicability of treatment-free remission approach in Turkey. The ELN recommendations about using the EUTOS Long-Term Survival (ELTS) score for risk assessment and focusing on patient reported outcomes and quality of life can be enhanced with educational activities. The widespread availability of standardized technical infrastructure for diagnosing and monitoring CML will contribute to better disease management. Establishing a sustainable national database for CML is valuable for observing patient characteristics and disease outcomes as well as the impact of treatment patterns over time.
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    Simultaneous Detection of B-Cell Chronic Lymphocytic Leukemia and Colon Adenocarcinoma in the Same Mesenteric Lymph Node
    (Galenos Yayincilik, 2013) Eskazan, Ahmet Emre; Berk, Selin; Ozden, Ferhat; Erdamar, Sibel; Tuzuner, Nukhet; Soysal, Teoman
    [Abstract Not Available]
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    Successful Management of Chronic Refractory Immune Thrombocytopenia with Laparoscopic Splenectomy in a Patient with Acute Promyelocytic Leukemia
    (Springer India, 2013) Eskazan, Ahmet Emre; Salihoglu, Ayse; Gulturk, Emine; Aydin, Seniz Ongoren; Tuzuner, Nukhet; Aydin, Yildiz
    Acute promyelocytic leukemia (APL) is a particular type of acute myeloid leukemia with characteristic biological and clinical features, the frequent association at diagnosis of a severe hemorrhagic diathesis. Immune thrombocytopenia (ITP) is a common autoimmune disease characterized by low platelet counts and an increased risk of bleeding. Here we present a patient with the diagnosis of APL who achieved and maintained a remission with an induction consisting of idarubicin and ATRA, and then developed corticosteroid refractory ITP which is successfully treated with laparoscopic splenectomy.
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    Two Cases of Autoimmune Hemolytic Anemia Secondary to Brucellosis: A Review of Hemolytic Disorders in Patients with Brucellosis
    (Japan Soc Internal Medicine, 2014) Eskazan, Ahmet Emre; Dal, Mehmet Sinan; Kaya, Safak; Dal, Tuba; Ayyildiz, Orhan; Soysal, Teoman
    Brucellosis is a worldwide zoonotic disease associated with hemolytic complications, including thrombotic microangiopathy (TMA) and hemolytic anemia. Autoimmune hemolytic anemia (AIHA) is a rare clinical presentation of this disease. In this report, we describe the cases of two patients with brucellosis who presented with Coombs-positive AIHA. We also include a review of the literature on the hemolytic complications of brucellosis. Both patients were successfully treated with a combination of doxycycline and rifampicin in addition to steroids. In the medical literature, there are several cases of TMA associated with brucellosis, although only a few cases of Coombs test-positive AIHA have been reported. Antibiotic therapy is the mainstay of treatment, and the selection of antibiotics and duration of treatment do not differ between brucellosis patients with and without hemolysis. Although rare, the potential for brucellosis should always be kept in mind in patients who present with hemolysis, especially those living in areas where brucellosis is endemic.