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Öğe A comprehensive study of right and left inferior phrenic artery variations in 1000 patients with multidetector computed tomography angiography: an important study for HCC(Springer France, 2021) Ekingen, Arzu; Cetincakmak, Mehmet GuliPurpose To investigate the anatomic variations in the origins of the right and left inferior phrenic arteries (IPAs) using multidetector computed tomography and to classify their combined variations. Methods This retrospective study included patients undergoing abdominal aorta angiography between January 2015 and October 2019. The RIPA and LIPA origins were evaluated both separately and combined on three-dimensional images. The variant patterns of the IPAs were determined and classified. The numerical evaluation of the data was performed with SPSS 21. Results In total, 1000 patients (478 women, 522 men) were evaluated. The IPAs originated from a common trunk or a common root in 360 (36.00%) patients, while the IPAs originated independently without a common trunk in 609 (60.90%) patients. The most common combined variant detected in the present study was IPAs originating as a common trunk from the coeliac trunk in 197 (19.70%) patients; 14 (1.40%) patients had no inferior phrenic artery (IPA), and 17 (1.70%) patients had only one IPA. Conclusion Fifty-two different types of variations in the combined origin of the inferior phrenic arteries were described in this study for the first time in the literature. Awareness of the anatomic variations in the IPAs, which is critical for hepatocellular carcinoma origins, may benefit various clinical procedures, such as transcatheter arterial chemoembolization, organ transplantations, laparoscopic surgical procedures, and radiological procedures.Öğe Distance measurements and origin levels of the coeliac trunk, superior mesenteric artery, and inferior mesenteric artery by multiple-detector computed tomography angiography (Sep, 10.1007/s12565-020-00571-x, 2020)(Springer, 2021) Ekingen, Arzu; Hatipoglu, Eyup Savas; Hamidi, CihadIn the original publication of the article, the second sentence under the Materials and methods heading should read as We retrospectively reviewed images of 261 (115 female, 146 male) patients obtained by MDCTA technique between 2016 and 2017 in the Department of Radiology of the Medical Faculty, University of Dicle..Öğe Distance measurements and origin levels of the coeliac trunk, superior mesenteric artery, and inferior mesenteric artery by multiple-detector computed tomography angiography (Sep, 10.1007/s12565-020-00571-x, 2020, )(Springer, 2021) Ekingen, Arzu; Hatipoğlu, Eyüp Savaş; Hamidi, CihadThe aim of this study is to determine vertebral levels of the coeliac trunk, the superior mesenteric artery, and the inferior mesenteric artery originated from the abdominal aorta and to calculate the distance measurements between these arteries and between these arteries and the aortic bifurcation by multidetector computed tomography angiography technique. It was determined that the nine diferent vertebral levels of the coeliac trunk, the nine diferent vertebral levels of the superior mesenteric artery, and the eleven diferent vertebral levels of the inferior mesenteric artery. The distance measurements between the coeliac trunk and the superior mesenteric artery, the inferior mesenteric artery, the aortic bifurcation were found signifcant between female and male. In this study, it was determined more diferent levels than the levels described in classical anatomy. The preoperative information of these morphological variations can contribute to the reduction of surgical time and perioperative vascular complications especially for anterior lumbar interbody fusion and defning the location of the primary lymphatic drainage site for gastrointestinal malignancies.Öğe Farklı meslek gruplarında çalışan ve çalışmayan kadınların vücut yağ yüzdesi üzerine etkisi(2015) Ekingen, ArzuSon çalışmalarda yaşla birlikte yağsız vücut kitlesinde ve yağ oranında değişmeler olduğu bildirilmektedir. Kadınlarda deri altı yağ tabakası erkeklere oranla daha fazladır. Yediğimiz besinlerden ihtiyaç fazlası olan bütün karbonhidratlar, yağ ve proteinler yağ dokusuna dönüşerek depo edilirler. Anatomik ve fizyolojik fonksiyonlar için, yağ her sağlıklı bireyde belli oranda mutlaka bulunması gereken temel öğelerden biridir (1). Vücutta bulunması gereken minimal yağ miktarı konusunda biyolojik bir eşik olduğu kabul edilmektedir. Bu eşiğin altına inildiğinde bireyin sağlığının tehlikeye gireceği çeşitli araştırıcılar tarafından bildirilmektedir (2). Araştırma, Batman merkezinde bulunan resmi kurumlarda farklı meslek gruplarında çalışan kadınlar ve çalışmayan ev hanımları arasında bulunan denekler üzerinde gerçekleştirilmiştir. Örneklem büyüklüğü, evreni bilinen örneklem formülü kullanılarak 30-40 yaş grubunda farklı meslek gruplarında çalışan 209 kadın ve 203 çalışmayan ev hanımı kadınlarda planlanan ölçümler alındı. Farklı meslek gruplarında çalışan ve çalışmayan kadınların vücut yağ yüzdesi üzerine etkisi, fiziksel ve antropometrik karakteristik sonuçlarının incelenmesi Tablo 2. de gösterilmiştir. Farklı meslek grubunda çalışan ve çalışmayan ev hanımı kadınların subscapular, biceps, triceps, suprailiac, ağırlık, bel ve kalça ölçüm ortalamaları arasında istatistiksel olarak anlamlı farklılıklar (p<0.05) saptanmıştır. Boy değişkeni ortalamalarında anlamlı farklılık (p >0.05) saptanmamıştır. Subscapular bölgesinden ölçümü alınan deri altı yağ kalınlığı farklı meslek gruplarında çalışan kadınlarda 14.0 ± 5.4 mm, çalışmayan ev hanımı kadınlarda deri altı yağ kalınlığı 17,4 ± 7,0 mm olarak ölçüldü.Biceps bölgesinden ölçümü alınan deri altı yağ kalınlığı farklı meslek gruplarında çalışan kadınlarda 10,6 ± 4,1mm, çalışmayan ev hanımı kadınlarda deri altı yağ kalınlığı 12,3 ± 4,3mm olarak ölçüldü. Triceps bölgesinden ölçümü alınan deri altı yağ kalınlığı farklı meslek gruplarında çalışan kadınlarda 18,0 ± 6,4 mm, çalışmayan ev hanımı kadınlarda deri altı yağ kalınlığı 20,3 ± 5,9 mm olarak ölçüldü. Suprailiac bölgesinden ölçümü alınan deri altı yağ kalınlığı farklı meslek grubunda çalışan kadınlarda 15,0 ± 5,3 mm, çalışmayan ev hanımı kadınlarda deri altı yağ kalınlığı 17,0 ± 7,5 mm olarak ölçüldü. Sonuç olarak çalışmayan ev hanımı kadınlar, farklı meslek gruplarında çalışan kadınlardan daha az hareket etikleri için kiloları ve yağlanma oranları daha fazla bulundu. Farklı meslek gruplarında çalışan kadınların sürekli hareket halinde oluşları, eğitim düzeylerinin yüksek oluşu kilo ve vücut yağ yüzdelerinde düşüşlere neden olmuştur. Anahtar Kelimeler: Vücut Kompozisyonu, Vücut yağ yüzdesi, Skinfold, Anthropometrik, Çalışan KadınlarÖğe Immunoexpression of vascular endothelial growth factor, ?-cell lymphoma 2 and cluster of differentiation 68 in cerebellar tissue of rats treated with Ganoderma lucidum(Universidad de la Frontera, 2018) Özevren, Hüseyin; İrtegün, Sevgi; Ekingen, Arzu; Tuncer, Cudi Mehmet; Özkorkmaz, Ebru Gökalp; Deveci, Engin; Deveci, ŞenayTraumatic brain injury (TBI) can potentially lead to hemorrhages in all areas of the skull, which can damage cells andnerve connections. This study aims to investigate the protective effects of Ganoderma lucidum polysaccharides (GLPS) as a antioxidant oncerebellar cell tissues after traumatic brain injury in rats. Sprague Dawley rats were subjected to TBI with a weight-drop device using 300 g-1m weight-height impact. The groups are consisted of control, trauma, and trauma+Ganoderma lucidum groups. At seven days post-braininjury, experimental rats were decapitated after intraperitoneal administration of ketamine HCL (0.15 ml/100 g body weight). Cereballarsamples were taken for histological examination or determination of malondialdehyde (MDA) and glutathione (GSH) levels andmyeloperoxidase (MPO) activity. Significant improvement was observed in cells and vascular structures of Ganoderma lucidum treatedgroups when compared to untreated groups. It is believed that Ganoderma lucidum may have an effect on the progression of traumatic braininjury. Ganoderma lucidum application may affect angiogenetic development in blood vessel endothelial cells, decrease inflammatory cellaccumulation by affecting cytokine mechanism and may create apoptotic nerve cells and neuroprotective mechanism in glial cellsÖğe Investigation of antioxidant effects of rosmarinic acid on liver, lung and kidney in rats: A biochemical and histopathological study(Via Medica, 2020) Oǧuz, Abdullah; Böyük, Abdullah; Ekinci, Aysun; Alabalık, Ulaş; Türkoǧlu, Ahmet; Tuncer, Cudi M.; Ekingen, Arzu; Deveci, Engin; Gültürk, Barış; Aday, U.Background: The aim of the study was to investigate the protective effects of rosmarinic acid in rats exposed to hepatic ischaemia/reperfusion (I/R) injury. Materials and methods: Thirty-two rats were randomly classified into four groups of 8 rats each: laparotomy without medication, rosmarinic acid (dose of 50 mg/kg via oral gavage) followed by laparotomy, laparotomy followed by hepatic I/R, and hepatic I/R with rosmarinic acid. Serum aspartate aminotransferase, alanine aminotransferase, and malondialdehyde levels and total oxidant activity and total antioxidant capacity levels of the liver, lung, and kidney were assessed. The histopathologic assessment was also performed. Results: Rosmarinic acid significantly reduced liver function test parameters and decreased oxidative stress and abnormal histopathologic findings in the liver. The oxidative stress in the lung significantly increased in the I/R group but significantly decreased in the I/R + rosmarinic acid group due to the addition of rosmarinic acid. Rosmarinic acid led to no reduction in oxidative stress in kidney following hepatic I/R injury. There were no statistically significant differences among the groups regarding histopathologic changes in kidney and lung sections. Conclusions: Rosmarinic acid has antioxidant properties and is an effective hepatoprotective agent. However, although rosmarinic acid provides useful effects in the lung by increasing antioxidant capacity and reducing oxidative stress after I/R injury, it does not ameliorate histopathologic changes. These findings suggest that rosmarinic acid is likely to provide favourable outcomes in the treatment of hepatic I/R injury. CopyrightÖğe Investigation of proper hepatic artery and gastroduodenal artery variations by multidetector computed tomography angiography method(Taylor & Francis Ltd, 2020) Ekingen, Arzu; Tuncer, Mehmet Cudi; Ertugrul, OzgurPurpose: The purpose of this study is to evaluate the clinical anatomic variations of the proper hepatic artery (PHA) and the gastroduodenal artery (GDA). For this purpose, angiographic images of patients were evaluated. Materials and methods: We retrospectively reviewed the multiple-detector computed tomography angiography images of 671 patients. Results: In this retrospective study, 35 different types were identified as associated with PHA and GDA. There were 292 patients (43.52%; 175 females and 117 males) included in normal anatomical classification. Different anatomic variations were detected in 300 patients (44.71%; 129 females and 171 males). In 79 patients, arterial branch follow-up failed. These patients were evaluated as an unidentified group. Conclusion: We described different vascular variations in the PHAs and GDAs of our patients.Öğe Level of Variations of the Aortic Bifurcation and Distance Measurements between the Aortic Bifurcation and the Common Iliac Bifurcations(Wolters Kluwer Medknow Publications, 2022) Ekingen, Arzu; Cetincakmak, Mehmet GuliIntroduction: The purpose of the present study was to investigate the vertebral levels of the aortic bifurcation (AB) in patients with and without the abdominal aorta (AA) deviation and to measure the distances between the AB and the right-left common iliac bifurcations (CIBs) which are crucial anatomical information, especially for anterior lumbar interbody fusion surgery. Additionally, we made comparisons levels of the AB according to sex and examined whether the results were statistically significant, which we could not find other studies comparing gender in literature. Material and Methods: The images of 721 patients, undergoing angiography with multidetector computed tomography between January 2016 and October 2019, were reviewed retrospectively. The AB levels of the patients with and without the AA deviation were classified and evaluated separately. It was measured the distances between the level of the AB and the right and left CIBs with the 3-dimensional ruler technique in only 207 of 721 patients. Results: It was detected seven different vertebral levels of the AB among patients (116 patients) with the AA deviation, in which is the highest L4-upper (27.59%), and 11 different vertebral levels of the AB among patients (605 patients) without the AA deviation, in which is the highest L4-upper (22.48%). When comparing cases with and without AA deviation, a statistically significant difference was found between the sexes (P < 0.05). Discussion and Conclusion: The presented study demonstrates that there is a significant relationship between the genders at some levels. The preoperative information of the morphological variations of the AB may be very useful for laparoscopic, invasive procedures, and spinal surgery procedures. At the same time, these variation information reveals new information for anatomy.Öğe Splenic artery angiography: Clinical classification of origin and branching variations of splenic artery by multi-detector computed tomography angiography method(Via Medica, 2020) Ekingen, Arzu; Hatipoǧlu, Eyüp Savaş; Hamidi, Cihad; Tuncer, Cudi Mehmet; Ertuǧrul, ÖzgürBackground: The splenic artery (SA) variations are rarely reported in the literature. Knowledge of the range of the SA and other arterial anomalies and their specific frequencies is very important ever for every visceral surgeon as well as for treatment of gastrointestinal bleeding, organ transplantation, transarterial chemoembolisation of neoplasm, infusion therapy, therapeutic arterial ligation, iatrogenic injuries. At the literature, there are more studies on the coeliac trunk, superior mesenteric artery and hepatic artery variations, but studies on the SA variations are uncommon. The studies on the SA variations are mostly in the form of case reports, but there are not many studies with large population on this issue. The purpose of this study was to evaluate the SA alone and to determine the variations determined separately from the other arteries. Accurate awareness of all the possible anatomic variations is crucial in the upper abdomen surgery. Materials and methods: Seven hundred fifty patients undergoing multi-detector computed tomography angiography between 2015 and 2017 were retrospectively evaluated for the SA variations. We created a new classification system to determine anatomic variations of the SA. Results: Twenty-three different types were identified related to anatomic variations in the origin and branching pattern of the SA. While 596 (79.47%) patients had standard SA anatomy, 154 (20.53%) patients had variant SA anatomy. Conclusions: The SA has quite different variation types and the practical context of the issue is of primary importance in surgery, gastroenterology, oncology and radiology. Liver and pancreas transplantation, splenectomy, embolisation of tumours of the abdominal organs, as well as other numerous diagnostic and therapeutic procedures, require detailed anatomical knowledge.Öğe Truncus coeliacus, arteria mesenterica superior ve arteria mesenterica inferior varyasyonlarının multidedektör bilgisayarlı tomografi tekniği ile incelenmesi(Dicle Üniversitesi, Sağlık Bilimleri Enstitüsü, 2018) Ekingen, Arzu; Hatipoğlu, E. SavaşAmaç: Çalışmamızda abdomen bölgesinde bulunan yapı ve organların çoğunun arteriel vaskülarizasyonunu sağlayan ve aorta abdominalis'in en önemli tek dalları olan; truncus coeliacus, arteria mesenterica superior, arteria mesenterica inferior varyasyonlarının ve aralarında bulunan mesafe ölçümlerinin belirlenmesi amaçlandı. Gereç ve Yöntem: Çalışmada; 2016 ile 2017 yılları arasında Dicle Üniversitesi Tıp Fakültesi'nde multidedektör bilgisayarlı tomografi tekniği ile elde edilmiş 261 (115 kadın, 146 erkek) hastanın görüntüleri retrospektif olarak incelendi. Çalışmaya 16-83 yaş aralığı dahil edildi. Çalışma sonucunda elde edilen veriler SPSS programında istatistiksel olarak değerlendirildi. Truncus coeliacus, arteria mesenterica superior ve arteria mesenterica inferior'da saptanan varyasyonlar; orjin noktasındaki varyasyonlar, ana dallarındaki varyasyonlar ve bu arterlerin ne çeşit dallanma gösterdiklerine yönelik varyasyonlar olmak üzere üç kategoride yapıldı. Bulgular: Truncus coeliacus ve ana dallarının oldukça farklı varyasyon tiplerine sahip olduğu anlaşıldı. Truncus coeliacus'un en fazla varyasyon gösteren dalı arteria gastrica sinistra olarak, en az varyasyon gösteren dalı ise arteria splenica (lienalis) olarak saptandı. Arteria mesenterica superior ve arteria mesenterica inferior'un truncus coeliacus'a göre daha az varyasyon gösterdiği belirlendi. Sonuç: Truncus coeliacus, arteria mesenterica superior ve arteria mesenterica inferior varyasyonlarının bilinerek yapılan abdominal teşhis ve tedavi girişimlerinin daha başarılı olacağı kanaatine varıldı.
