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  • Küçük Resim
    Öğe
    Effect of Helicobacter pylori infection on the first-line treatment outcomes in patients with immune thrombocytopenic purpura
    (Verduci Editore s.r.l, 2022) Doǧan, Ali Alp; Ekinci, Ömer; Ebinç, Senar
    OBJECTIVE: Helicobacter pylori (H. pylori) eradication therapy is known to increase the platelet count, but in immune thrombocytopenic purpura (ITP), the effect of H. pylori infection on the response to treatment is not clear. This study aims to determine whether the response to the first-line treatment is affected by the states of H. pylori-positivity and -negativity in ITP patients. PATIENTS AND METHODS: Adult newly diagnosed or chronic ITP patients who had not received eradication therapy for H. pylori infection were included. Characteristics of the patients, presence and severity of bleeding, initial platelet count, administered treatments, and treatment response rates were inspected. RESULTS: Of 119 total patients, 66 (55.5%) were female, 32 (26.9%) were H. pylori-positive, 87 (73.1%) were H. pylori-negative. H. pylori-positive and H. pylori-negative groups were not significantly different in terms of age (p=0.127), gender (p=0.078), diagnosis status (p=0.094) and the distribution of bleeding symptoms (p=0.712). The most common treatment was standard-dose steroid in both groups (62.5% vs. 68.9%, p=0.524). Rates of complete response, partial response, no response were comparable for the two groups (respectively, 75% vs. 73.6%, and 18.8% vs. 19.5%, and 6.2% vs. 6.9%), and there was no significant difference between the groups (p=0.283). CONCLUSIONS: It can be stated, according to the present study, that in ITP patients in whom treatment is indicated, the response to the firstline treatment without the administration of H. pylori eradication therapy is similar between H. pylori-positive and H. pylori-negative patients.
  • Küçük Resim
    Öğe
    Laboratory and clinical characteristics of patients diagnosed with hellp syndrome due to microangiopathic hemolytic anemia and/or thrombocytopenia
    (Van Yüzüncü Yıl Üniversitesi Tıp Fakültesi, 2020) Ekinci, Ömer; Ebinç, Senar
    Objective: We aimed to present the pregnant patientswho were consulted with hematologists formicroangiopathic hemolytic anemia and/orthrombocytopenia and were diagnosed HELLPsyndrome.Materials and Methods: A total of 32 patients, whowere diagnosed with HELLP syndrome, were included inthis study. Patients with other microangiopathichemolytic anemia, including pre-eclampsia, eclampsia,thrombotic thrombocytopenic purpura, hemolytic uremicsyndrome, disseminated intravascular coagulation etc.were excluded.Results: The median age of all patients was 30.45 ±16.22 (18-52) years. According to the Mississippiclassification; 12 patients (37.5%) were in class 1 while 15patients (46.9%) were in class 2, and there was acuterenal failure in 4 patients (33.3%) in class 1 and 3patients (20%) in class 2. There was no acute renal failurepresent in the class 3 including a total of 5 patients(15.6%). There was renal failure in 6 (42.9%) of 14patients (43.7%) with HELLP syndrome, whosehemoglobin value was less than or equal to 8 gr/dl. Inpatients with HELLP syndrome, the renal failure risk ofthose whose hemoglobin value was less than or equal to8 gr/dl was significantly higher than those whosehemoglobin value was greater than 8 gr/dl (OR: 12.75, p= 0.0285).Conclusion: The mechanism of occurrence of HELLPsyndrome is not clear and have many overlapping clinicalaspects with the other thrombotic microangiopathicsyndromes. Renal failure is a complication of HELLPsyndrome. The most associated cases with renal failureare the presence of DIC and severe anemia in HELLPsyndrome. The hemoglobin value of less than 8 gr/dl is asignificant risk factor for renal failure in HELLPsyndrome.