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  • Küçük Resim
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    Evaluation of patients with fibrotic interstitial lung disease: Preliminary results from the Turk-UIP study
    (Aves, 2021) Musellim, Benan; Moğulkoç, Nesrin; Uzun, Oğuz; Akyıl, Fatma Tokgöz; Türktaş, Haluk; Kumbasar, Özlem Özdemir; Okumuş, Gülfer; Oğuş, Candan; Dirol, Hülya; Zamani, Adil; Sevim, Tülin; Annakkaya Ali Nihat; Özyurek, Berna Akıncı; Hanta, İsmail; Aydemir, Yusuf; Edis, Ebru Çakır; Kurt, Bahar; Tertemiz, Kemal Can; Tabak, Levent; Yazıcı, Onur; Erdoğan, Yurdanur; Ateş, Güngör; Türker, Hatice; Salepçi, Banu; Hazar, Armağan; Niksarlıoğu Elif Yelda; Kara, Bilge Yılmaz; Köktürk, Nurdan; Kalpaklıoğlu, Füsun; Uzel, Işıl; Özsu, Savaş; Atahan, Ersan; Fendoğlu, Türkan Zeynep; Süreyya, Yılmaz; Başyiğit, İlknur; Çamsarı, Güngör; Tuncay, Esin; Yılmazel, Elif Uçar; Kanmaz, Dilek; Ekici, Aydanur; Topçu, Füsun; Uzaslan, Esra; Bozkuş, Fülsen; Barış, Serap Argun; Duru, Serap; Altınışık, Göksel; Bingöl, Züleyha; Tunacı, Atadan; Savaş, Recep; Alper, Fatih; Bayraktaroğlu, Selen; Can, Tuba Selçuk; Demir, Ali Arslan
    OBJECTIVE: Differential diagnosis of idiopathic pulmonary fibrosis (IPF) is important among fibrotic interstitial lung diseases (ILD). This study aimed to evaluate the rate of IPF in patients with fibrotic ILD and to determine the clinical-laboratory features of patients with and without IPF that would provide the differential diagnosis of IPF. MATERIAL AND METHODS: The study included the patients with the usual interstitial pneumonia (UIP) pattern or possible UIP pattern on thorax high-resolution computed tomography, and/or UIP pattern, probable UIP or possible UIP pattern at lung biopsy according to the 2011 ATS/ERSARS/ALAT guidelines. Demographics and clinical and radiological data of the patients were recorded. All data recorded by researchers was evaluated by radiology and the clinical decision board. RESULTS: A total of 336 patients (253 men, 83 women, age 65.8 +/- 9.0 years) were evaluated. Of the patients with sufficient data for diag-nosis (n=300), the diagnosis was IPF in 121 (40.3%), unclassified idiopathic interstitial pneumonia in 50 (16.7%), combined pulmonary fibrosis and emphysema (CPFE) in 40 (13.3%), and lung involvement of connective tissue disease (CTD) in 16 (5.3%). When 29 patients with definite IPF features were added to the patients with CPFE, the total number of IPF patients reached 150 (50%). Rate of male sex (p<0.001), smoking history (p<0.001), and the presence of clubbing (p=0.001) were significantly high in patients with IPE None of the women <50 years and none of the men <50 years of age without a smoking history were diagnosed with IPE Presence of at least 1 of the symptoms suggestive of CTD, erythrocyte sedimentation rate (ESR), and antinuclear antibody (FANA) positivity rates were significantly higher in the non-IPF group (p<0.001, p=0.029, p=0.009, respectively). CONCLUSION: The rate of IPF among patients with fibrotic ILD was 50%. In the differential diagnosis of IPF, sex, smoking habits, and the presence of clubbing are important. The presence of symptoms related to CTD, ESR elevation, and EANA positivity reduce the likelihood of IPF.
  • Küçük Resim
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    Prospective cross-sectional multicenter study on domiciliary noninvasive ventilation in stable hypercapnic COPD patients
    (Dove Medical Press Ltd., 2018) Yazar, Esra Ertan; Özlü, Tevfik; Sarıaydın, Muzaffer; Taylan, Mahşuk; Ekici, Aydanur; Aydın, Derya; Coşgun, İbrahim Güven
    Background: Domiciliary noninvasive ventilation (NIV) use in stable hypercarbic COPD is becoming increasingly widespread. However, treatment compliance criteria and factors related to compliance remain to be defined. Methods: This research was designed as a prospective, cross-sectional, multicenter real-life study. Chronic hypercapnic COPD patients who were using domiciliary NIV for at least 1 year and being followed up in 19 centers across Turkey were included in the study. The patients who used NIV regularly, night or daytime and $5 hours/d, were classified as “high-compliance group,” and patients who used NIV irregularly and ,5 hours/d as “low-compliance group.” Results: Two hundred and sixty-six patients with a mean age of 64.5±10.3 years were enrolled, of whom 75.2% were males. They were using domiciliary NIV for 2.8±2 years. Spontaneous time mode (p,0.001) and night use (p,0.001) were more frequent in the high-compliance group (n=163). Also, mean inspiratory positive airway pressure values of the high-compliance group were significantly higher than the low-compliance group (n=103; p,0.001). Cardiac failure (p=0.049) and obesity (p=0.01) were significantly more frequent in the high-compliance group. There were no difference between 2 groups regarding hospitalization, emergency department and intensive care unit admissions within the last year, as well as modified Medical Research Council dyspnea and COPD Assessment Test scores. With regard to NIV-related side effects, only conjunctivitis was observed more frequently in the high-compliance group (p=0.002). Conclusion: Determination of the patients who have better compliance to domiciliary NIV in COPD may increase the success and effectiveness of treatment. This highly comprehensive study on this topic possesses importance as it suggests that patient and ventilator characteristics may be related to treatment compliance.