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Öğe Assessment of Technetium-99m Labeled Macroaggregated Albumin Rhinoscintigraphy for the Measurement of Nasal Mucociliary Transport Rate: Intratest, Interobserver, and Intraobserver Reproducibility(Hindawi Ltd, 2014) Dostbil, Zeki; Dag, Yusuf; Cetinkaya, Ozlem; Akdag, Mehmet; Tasdemir, BekirObjectives. The measurement of mucociliary transport velocity by rhinoscintigraphy with Tc-99m-macroaggregated albumin (Tc-99m-MAA) is reliable measure of mucociliary clearance. The aim of this study is to assess the intratest, interobserver, and intraobserver reproducibility of nasal mucociliary transport rate (NMTR) measurement. Materials and Methods. Twenty-two subjects were evaluated to determine intratest reproducibility and a group of 35 subjects was examined to determine inter and intraobserver reproducibility. Rhinoscintigraphy with Tc-99m-MAA was used to measure NMTR in all study subjects. Paired NMTR measurements were compared using a range of statistical methodologies. Intraclass correlation coefficients (ICC) and repeatability coefficients and Bland-Altman plots were applied to assess the degree of intratest, interobserver, and intraobserver variation. Results. Statistical analysis of test and retest experiments demonstrated the statistical equivalence of intratest NMTR measurements, interobserver NMTR measurements, and intraobserver NMTR measurements. The intratest ICC, interobserver ICC, and intraobserver ICC were 0.96, 0.83, and 0.91, respectively, indicating that intratest and intraobserver reproducibility are excellent and interobserver reproducibility is good. Conclusions. Rhinoscintigraphy using Tc-99m-MAAresults in highly reproducible measurement of NMTR. The use of radionuclide imaging in measuring NMTR results in excellent intratest and intraobserver reproducibility and good interobserver reliability.Öğe A comparison of acoustic radiation force impulse imaging and scintigraphy in the functional evaluation of the major salivary glands(Lippincott Williams & Wilkins, 2015) Tasdemir, Bekir; Goya, Cemil; Dostbil, Zeki; Sengul, Engin; Sezgin, Ilhan; Hattapoglu, SalihPurpose This study aimed to determine the efficacy of acoustic radiation force impulse (ARFI) imaging for the functional assessment of salivary glands by comparing ARFI with salivary gland scintigraphy. Materials and methods We prospectively evaluated 60 parotid (P) glands and 60 submandibular (SM) glands of 30 patients using salivary gland scintigraphy and ARFI elastography. The average pixel uptake and the excretion fraction (EF) in the P and SM glands were determined scintigraphically. The degree of stiffness in the P and SM glands at prelemon and postlemon stimulation periods were measured elastographically with ARFI. Changes in the degree of stiffness of the P and SM glands were also calculated with lemon stimulation. The scintigraphic and elastographic parameters were then compared statistically. Results We found a moderate linear correlation between the excretion function and the changes in the degree of stiffness of the P and SM glands induced by lemon stimulation (P<0.001, r=0.661; P<0.001, r=0.530, respectively). We also found a weak positive correlation between the EF and the degree of stiffness of the P and SM glands in the prelemon stimulation period (P=0.001, r=0.405; P<0.001, r=0.480, respectively). However, we did not find any significant correlation between other scintigraphic and elastographic parameters. Conclusion ARFI imaging may play a role in the determination of the EF of P and SM glands by measuring tissue elasticity changes with lemon stimulation. However, ARFI does not seem to be a suitable substitute for scintigraphy in the evaluation of the parenchymal function of P and SM glands. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.Öğe Comparison of left ventricular functional parameters obtained from three different commercial automated software cardiac quantification program packages and their intraobserver reproducibility(Springer, 2011) Dostbil, Zeki; Ariturk, Zuhal; Cil, Habib; Elbey, Mehmet Ali; Tekbas, Ebru; Yazici, Mehmet; Yildiz, IsmailObjective ECG-gated myocardial perfusion scintigraphy (MPS) can be used to determine several cardiac functional parameters (e. g., left ventricular ejection fraction (LVEF), end-diastolic volume (EDV), and end-systolic volume (ESV)). In this study, we aimed to compare these cardiac functional parameters calculated by the following cardiac quantification programs: Emory Cardiac Toolbox (ECTb), Quantitative Gated SPECT (QGS), and Myometrix. We also evaluated reproducibility of the cardiac programs. Methods Fifty-seven patients (27 male, 30 female) at Elazig Research and Training Hospital from 2008 to 2009 were included in this study. In all patients, (99m)Tc-MIBI ECG-Gated (8-bin frame mode) myocardial perfusion scintigraphies were performed. By using 3 different cardiac quantification programs (ECTb, QGS, and Myometrix); LVEF, EDV, and ESV were calculated. The same raw data of MPS images were reprocessed at different time periods, and these 3 parameters were recalculated. LVEF, EDV, and ESV yielded by 3 different programs were compared for interprogram variability assessment, and parameters calculated at two different time periods were compared to evaluate intraprogram reproducibility. Results There were statistically significant differences between ECTb, QGS, and Myometrix programs for LVEF, EDV, and ESV (p < 0.001). There was also a statistically significant correlation between LVEF and EDV (p < 0.001, r = 0.546; p < 0.001, r = 0.45, respectively), but no statistically significant correlation was present between the ESV values (p > 0.05, r = 0.09). Statistically significant differences were not found between the values of LVEF, EDV, and ESV obtained from the first and second reconstruction analysis of 3 cardiac quantification programs. Discussion Different MPS cardiac software programs give variable (but correlated) LVEF and left ventricular volumetric measures. Those obtained from different cardiac softwares cannot be used interchangeably. Our findings have shown that ECTb, QGS, and Myometrix programs are reproducible, with respect to LVEF, EDV, and ESV.Öğe Effect of cigarette smoking on nasal mucociliary transport rate: Rhinoscintigraphic evaluation with using 99mTc-macroaggregated albumin(Drunpp-Sarajevo, 2012) Dostbil, Zeki; Dag, Yusuf; Abakay, Abdurrahman; Bakir, Salih; Sezgi, Cengizhan; Abakay, Ozlem; Sen, HadiceObjectives: Cigarette smoking has harmful effects on mucociliary transport (MCT) in respiratory system. We aimed to investigate the association between nasal mucociliary transport rate (NMTR) and duration and amount of smoking in chronic cigarette smokers. Materials and Methods: Fifty four current cigarette smokers and 40 healthy non-smokers were included in this study. In all cases, we measured the NMTR using Tc-99m-macroaggregated albumin (Tc-99m-MAA) rhinoscintigraphy. Results: The mean NMTR of the smokers was lower than that of the healthy non-smoker controls (5.63 +/- 2.78; 9.44 +/- 2.09, respectively) (p<0.0001). There were not statistically significant correlation between NMTRs and year of smoking, and smoking pack-year in smokers (p>0.05; r=0.003, r=-0.2, respectively) whereas there was a statistically significant correlation between NMTRs and cigarettes per day in smokers (p=0.024; r=-0.307). Conclusions: Our findings demonstrated that cigarette smoking decreases the nasal NMTR in chronic term. Impaired mucociliary transport in respiratory system may have harmful effects on the human health. The degree of impairment in NMTRs in smokers may increase as the number of cigarettes per day increases.Öğe Effect of imaging time on post stress left ventricular ejection fraction and volume measures by gated myocardial perfusion single photon emission computed tomography(2010) Çil, Habib; Arıtürk, Zuhal; Tekbaş, Ebru; Dostbil, Zeki; Taşdemir, Bekir; Elbey, Mehmet AliAmaç: Efor sonrası sol ventrikül ejeksiyon fraksiyonu (LVEF) ve sol ventrikül volüm değerlerinin koroner arter hastalığı bulunan hastalardaki kardiyak ölüm tahmininde katkısı vardır. Bu çalışmada, efor sonrası görüntüleme zamanının Quantitative Gated SPECT (QGS-Cedars-Sinai) programı ile hesaplanan efor sonrası LVEF, end-diastolik volüm (EDV) ve end-sistolik volüm (ESV) üzerine etkisini araştırmayı amaçladık. Hastalar ve yöntem: Bu çalışma 2008 ve 2009 yıllarında Elazığ Eğitim ve Araştırma Hastanesi Nükleer Tıp Birimine göğüs ağrısı nedeniyle Kardiyoloji Kliniğinden gönderilen 36 hasta üzerinde yapıldı. Tüm hastalara efor esnasında yapılan 99mTc-Mibi enjeksiyonunu takiben 20. ve 40. dakikalarda EKG-gated (8-bin frame modunda) miyokard perfüzyon SPECT sintigrafisi uygulandı. Kardiyak kantifikasyon yazılımı olan QGS programı kullanılarak LVEF, EDV ve ESV hesaplandı. İlk ve ikinci görüntülemelerden elde edilen LVEF, EDV ve ESV değerleri istatistiksel olarak birbirleri ile karşılaştırıldı.Bulgular: İlk ve ikinci görüntülemelerden elde edilen LVEF, EDV ve ESV değerleri arasında istatistiksel olarak anlamlı farklılık bulunmadı (p>0.05).Sonuç: Efor sonrası sol ventrikül fonksiyon parametreleri koroner arter hastalığı bulunan hastalardaki prognoz değerlendirmesinde önemlidir. Efor bitiminden 20-40 dakika sonra yapılan miyokard perfüzyon SPECT sintigrafisi efor sonrası LVEF, EDV ve ESV değerleri açısından tekrarlanabilir değerler vermektedir.Öğe Effect of R-CHOP chemotherapy on liver and mediastinal blood pool 18F-FDG standardized uptake values in patients with non-Hodgkin's lymphoma(Elsevier Science Inc, 2015) Kaya, Bugra; Dostbil, Zeki; Ismailoglu, Murat; Tasdemir, Bekir; Sahin, OzlemAim: We aimed to investigate the impact of chemotherapy on F-18-FDG uptake in the liver and mediastinal blood pool (MBP) among patients with non-Hodgkin's lymphoma. Methods: Twenty-three patients with NHL underwent baseline, interim, and postchemotherapy F-18-FDG PET/CT. SUVmax and SUVmean values of the liver and MBP at imaging time were compared statistically. Results: We did not find any significant differences between the liver and mediastinum SUVmean and SUVmax values (P>.05). Conclusions: Our study demonstrates that the F-18-FOG uptake in the liver and MBP are not significantly affected by R-CHOP chemotherapy in patients with NHL. (C) 2015 Elsevier Inc. All rights reserved.Öğe Effectiveness of the addition of the brain region to the FDG-PET/CT imaging area in patients with suspected or diagnosed lung cancer(Springer-Verlag Italia Srl, 2016) Tasdemir, Bekir; Urakci, Zuhat; Dostbil, Zeki; Unal, Kemal; Simsek, F. Selcuk; Teke, Fatma; Goya, CemilPurpose We aimed to evaluate the effectiveness of the brain region imaging in FDG-PET/CT scanning of patients with suspected or diagnosed lung cancer. Materials and methods We performed the study retrospectively on the medical charts of 427 patients. We divided the FDG-PET/CT field of view (FOV) into four major imaging regions: brain, head-neck, abdomen and pelvis. Metastatic findings on these regions were checked and determined the potential of these findings to affect the chemotherapy or radiotherapy protocol or surgical management. If metastatic findings had a potential to modify these parameters, we named this situation as clinical contribution. Considering the number of bed positions of these regions, we calculated the clinical contribution of each region and named as effective clinical contribution. Then, we calculated the metastatic findings, clinical contribution, and effective clinical contribution ratios. Results We found different brain metastasis ratios for lung cancer, solitary pulmonary mass (SPM), and solitary pulmonary nodule (SPN) groups (8.7, 2.8 and 0.9 %, respectively). In addition, the clinical contribution and effective clinical contribution ratios in the brain region for these three groups were 6.4, 2.8, 0.0 and 6.4, 2.8, 0.0 %, respectively. The highest metastatic findings (30.6 %) and clinical contribution (9.8 %) ratios were found in the abdomen region of the lung cancer group. However, the highest effective clinical contribution ratio (6.8 %) was found in the brain region within the same group. Conclusions The addition of the brain region to the limited whole-body FOV in FDG-PET/CT scanning seems to be effective in the lung cancer and SPM groups, but not in the SPN group.Öğe Evaluation of Clinical Contributions Provided by Addition of the Brain, Calvarium, and Scalp to the Limited Whole Body Imaging Area in FDG-PET/CT Tumor Imaging(Hindawi Ltd, 2014) Tasdemir, Bekir; Dostbil, Zeki; Inal, Ali; Unal, Kemal; Yildirim, Sule; Simsek, F. SelcukPurpose. The aim of this study was to detect additional findings in whole body FDG-PET/CT scan including the brain, calvarium, and scalp (compared to starting from the base of the skull) in cancer patients and to determine contributions of these results to tumor staging and treatment protocols. Materials and Methods. We noted whether the findings related to the brain, calvarium, and scalp in 1359 patients had a potential to modify staging of the disease, chemotherapy protocol, radiotherapy protocol, and surgical management. We identified rates of metastatic findings on the brain, calvarium, and scalp according to the tumor types on FDG-PET/CT scanning. Results. We found FDG-PET/CT findings for malignancy above the base of the skull in 42 patients (3.1%), one of whom was a patient with an unknown primary tumor. Twenty-two of the metastatic findings were in the brain, 16 were in the calvarium, and two were in the scalp. Conclusion. This study has demonstrated that addition of the brain to the limited whole body FDG-PET/CT scanning may provide important contributions to the patient's clinical management especially in patients with lung cancer, bladder cancer, malignant melanoma, breast cancer, stomach cancer, and unknown primary tumor.Öğe Evaluation of the nasal mucociliary transport rate by rhinoscintigraphy before and after surgery in patients with deviated nasal septum(Springer, 2010) Polat, Cahit; Dostbil, ZekiIn this study, we have investigated the effect of nasal septal deviation (NSD) on nasal mucociliary activity and how does a septoplasty operation affecs the nasal mucociliary transport rate in the first and third months during the post-operative period. Twenty-two patients who were diagnosed with NSD and 22 healthy controls were studied using rhinoscintigraphy with Tc-99m-macroaggregated albumin (Tc-99m-MAA). On each case, the nasal mucociliary transport rate (NMTR) was measured pre-operatively only on five cases, on the first and third months of post-operative period. The NMTRs of patients with a deviated septum were significantly lower than the NMTRs of the healthy controls on both the convex and concave sides. Significant improvement was observed in the first post-operative month. On the concave and convex sides, the average postop third month post-operative NMTR value was higher than the first month post-operative NMTR values. It was concluded that the septoplasty operation improves reduced NMTRs after surgery. The effect of nasal surgery on nasal mucociliary activity may be more accurately evaluated in the third month than the first month of post-operative period.Öğe Evaluation of the nasal mucociliary transport rate by rhinoscintigraphy in marble workshop workers(Sage Publications Inc, 2011) Dostbil, Zeki; Polat, Cahit; Karakus, Askeri; Bakir, Salih; Yuce, SalimMarble workers are occupationally exposed to intense environmental marble dust in their workplace. We aimed to investigate the effect of occupational marble dust exposure on nasal mucociliary transport rate (NMTR). Seventeen marble workers and 18 healthy controls were studied. In all subjects, NMTRs were measured by Tc-99m-MAA rhinoscintigraphy. NMTRs of workers and control groups were compared by statistically. Mean NMTR was found as 9 +/- 1.8 mm/min in marble workers whereas mean NMTR of healthy controls was 9.6 +/- 2.2 mm/min. There was no statistically significant difference between NMTRs of workers and control groups (p > 0.05). This study has shown that occupationally exposured marble dusts may not cause functional impairment on NMTR in marble workshop workers.Öğe F-18 fdg pet/ct imaging in a patient presenting with mediastinal lymphadenopathies: a case of sarcoidosis(Drunpp-Sarajevo, 2012) Dostbil, Zeki; Kaya, Bugra; Sari, Oktay; Varoglu, ErhanF-18 FDG PET/CT has been used increasingly in evaluation of pulmonary and mediastinal lesions. However, inflammatory and granulomatous disorders may show increased F-18 FDG uptake on PET scanning. So, some benign conditions may cause false-positive results in cancer investigation. In this case, F-18 FDG PET/CT findings were presented in a patient with sarcoidosis who was investigated for primarily suspected malignancy.Öğe FDG-PET/BT ile tespit edilen küçük hücreli akciğer kanserinin kemik iliği metastazı(2015) Dostbil, Zeki; Kaya, Buğra; Serdengeçti, Mustafa; İsmailoğlu, MuratÖksürük, hemoptizi, kilo kaybı, yaygın kemik ağrısı şikayetleri ile başvuran elli dokuz yaşında erkek hastanın kontrastlı toraks BT'sin- de sağ akciğerde kitle tespit edildi. Kitlenin biopsi sonucu küçük hücreli akciğer kanseri (KHAK) olarak rapor edildi. Yaygın kemik ağrısı şikayeti olan hastanın kemik sintigrafisi normal olarak değerlendirildi. Evreleme amacıyla yapılan FDG-PET/BT'de kemik ili- ğinde heterojen artmış FDG (florodeoksi glukoz) tutulumu saptandı. Kemik iliği biyopsisinin patolojik değerlendirme sonucu KHAK metastazı olarak raporlandı. Klinik olarak kemik metastazı şüphesi bulunan ve kemik sintigrafisi normal olan hastalarda kemik ve kemik iliği metastazlarını göstermek için FDG-PET/BT görüntüleme akılda tutulmalıdırÖğe Is there any significance of lung cancer histology to compare the diagnostic accuracies of 18F-FDG-PET/CT and 99mTc-MDP BS for the detection of bone metastases in advanced NSCLC?(Termedia Publishing House Ltd, 2014) Inal, Ali; Kaplan, Muhammed Ali; Kucukoner, Mehmet; Urakci, Zuhat; Dostbil, Zeki; Komek, Hail; Onder, HakanAim of the study: Bone scintigraphy (BS) and fluorine-18 deoxyglucose positron emission tomography computed tomography (18F-FDG-PET/CT) are widely used for the detection of bone involvement. The optimal imaging modality for the detection of bone metastases in histological subgroups of non-small cell lung cancer (NSCLC) remains ambiguous. The aim of this study was to compare the efficacy of 18F-FDG-PET/C and Tc-99m-methylene diphosphonate (Tc-99m-MDP) BS in the detection of bone metastases of patients in NSCLC. Specifically, we compared the diagnostic accuracies of these imaging techniques evaluating bone metastasis in histological subgroups of NSCLC. Material and methods: Fifty-three patients with advanced NSCLC, who had undergone both 18F-FDG-PET/CT and BS and were eventually diagnosed as having bone metastasis, were enrolled in this retrospective study. Results: The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 18F-FDG-PET/CT and BS were 90.4%, 99.4%, 98.1%, 96.6%, 97.0% and 84.6%, 93.1%, 82.5%, 93.2, 90.8%, respectively. The. statistics were calculated for 18F-FDG-PET/CT and BS. The kappa-value was 0.67 between 18F-FDG-PET/CT and BS in all patients. On the other hand, the kappa-value was 0.65 in adenocarcinoma, and 0.61 in squamous cell carcinoma between 18F-FDG-PET/CT and BS. The kappa-values suggested excellent agreement between all patients and histological subgroups of NSCLC. Conclusions: 18F-FDG-PET/CT was more favorable than BS in the screening of metastatic bone lesions, but the trend did not reach statistical significance in all patients and histological subgroups of NSCLC. Our results need to be validated in prospective and larger study clinical trials to further clarify this topic.Öğe Malign melanomlu bir hastada yapılan pozitron emisyon tomografide rastlantısal olarak tespit edilen tiroid papiller karsinom(2012) Sarı, Oktay; Varoğlu, Erhan; Dostbil, Zeki; İsmailoğlu, Murat; Kaya, Buğra18F-Florodeoksiglukoz pozitron emisyon tomografi (18FDG PET) görüntülemede tiroid bezinde difüz ya da fokal artmış 18FDG tutulumu ile zaman zaman karşılaşılmaktadır. Tiroid bezindeki nodüllerde artmış 18FDG tutulumu benign ya da malign tümörlere bağlı olabilir. Malign melanom tanısı bulunan olgumuza tümör evrelemesi amacıyla yapılan 18FDG PET/BT esnasında tiroid bezindeki bir nodülde fokal artmış 18FDG tutulumu dikkati çekti. Bu nodüle yapılan ince iğne aspirasyon biyopsisinde tiroid papiller karsinomu (Ca) düşündüren bulgular rapor edilmesi üzerine hastaya total tiroidektomi yapıldı. Histopatolojik olarak papiller tiroid Ca tanısı koyuldu. Bunun üzerine malign melanom tanısıyla takip ettiğimiz bu olgumuza ilave olarak rastlantısal tiroid papiller Ca tedavisi başlandı.Öğe Meme kanserli bir hastada 18-Floro-de-oksi-Glukoz pozitron emisyon tomografisinde multiple kemik metastazları: Olgu sunumu ve literatürün gözden geçirilmesi(2012) Sarı, Oktay; Dostbil, Zeki; İsmailoğlu, Murat; Kaya, Buğra; Varoğlu, ErhanKemik sintigrafisi, meme kanserli hastaların iskelet sistemi metastazlarının değerlendirilmesinde halen yaygın olarak kullanılmaktadır. 18F-FDG-PET/BT, malign hücrelerde artmış glukoz metabolizmasının görüntülenmesi prensibine dayanarak metastazları tespit etmede son yıllarda yaygın kullanım alanı kazanmış diğer bir görüntüleme yöntemidir. Genel olarak, meme kanserinin kemik metastazlarının tespitinde bu iki yöntem benzer sonuçlar vermektedir. Meme kanserli bu olguda 99mTc-MDP kemik sintigrafisi kemik metastazı yönünden normal bulgular göstermesine karşın 18F-FDG-PET/BT, kontrastlı BT ve MRda iskelet sisteminde birçok odakta kemik metastazları tespit edilmiştir.Öğe Miyokard perfüzyon sintigrafisi, eforlu EKG ve koroner anjiografi sonuçlarının karşılaştırılması(Dicle Üniversitesi Tıp Fakültesi, 2010) Dostbil, Zeki; Çil, Habib; Atılgan, Zuhal Arıtürk; Tekbaş, Ebru; Kaya, Buğra; Kaya, SavaşAmaç: Koroner arter hastalığı tüm dünyada en sık görülen mortalite ve morbidite sebeplerinden birisidir. Koroner arterlerdeki aterosklerotik darlığın kesin tanısında koroner anjiografi kullanılmaktadır. Bu çalışmada koroner arter hastalığı tanısında kullanılan eforlu EKG ve miyokard perfüzyon sintigrafi ve koroner anjiografi bulguları karşılaşrtırıldı. Gereç ve Yöntem: 101 hasta (47 erkek, 54 kadın; yaş ortalaması: 55 ± 10.95 yıl) çalışmaya alındı. Bu hastalara treadmill cihazıyla efor yaptırılarak 99m Tc-MIBI miyokard perfüzyon sintigrafisi çekildi. Bir ay içerisinde koroner anjiografi yapılan hastalar çalışmaya dahil edildi. Bulgular: Efor testi pozitif olan hastaların %55’i, şüpheli olanların %82’si ve negatif olanların ise %29’unda koroner anjiografide darlık tespit edilirken miyokard perfüzyon sintigrafisinde iskemi gözlenen hastaların %66’sında ve normal değerlendirilen hastaların %12’sinde darlık görüldü. Sonuç: Koroner arter darlığının tanı ve takibinde efor testi ve miyokard perfüzyon sintigrafisi gibi noninvaziv testler kullanılmaktadır. Bu testlerin sonuçları birlikte değerlendirildiğinde koroner arter darlığını göstermedeki doğrulukları artmaktadır.Öğe Miyokard perfüzyon sintigrafsi, eforlu EKG ve koroner anjiograf sonuçlarının karşılaştırılması(2010) Tekbaş, Ebru; Çil, Habib; Dostbil, Zeki; Kaya, Buğra; Sarıkaya, Savaş; Atılgan, Zuhal ArıtürkAmaç: Koroner arter hastalığı tüm dünyada en sık görülen mortalite ve morbidite sebeplerinden birisidir. Koroner arterlerdeki aterosklerotik darlığın kesin tanısında koroner anjiograf kullanılmaktadır. Bu çalışmada koroner arter hastalığı tanısında kullanılan eforlu EKG ve miyokard perfüzyon sintigraf ve koroner anjiograf bulguları karşılaşrtırıldı. Gereç ve Yöntem: 101 hasta (47 erkek, 54 kadın; yaş ortalaması: 55 ± 10.95 yıl) çalışmaya alındı. Bu hastalara treadmill cihazıyla efor yaptırılarak 99m Tc-MIBI miyokard perfüzyon sintigrafsi çekildi. Bir ay içerisinde koroner anjiograf yapılan hastalar çalışmaya dahil edildi.Bulgular: Efor testi pozitif olan hastaların %55’i, şüpheli olanların %82’si ve negatif olanların ise %29’unda koroner anjiografde darlık tespit edilirken miyokard perfüzyon sintigrafsinde iskemi gözlenen hastaların %66’sında ve normal değerlendirilen hastaların %12’sinde darlık görüldü. Sonuç: Koroner arter darlığının tanı ve takibinde efor testi ve miyokard perfüzyon sintigrafsi gibi noninvaziv testler kullanılmaktadır. Bu testlerin sonuçları birlikte değerlendirildiğinde koroner arter darlığını göstermedeki doğrulukları artmaktadır.Öğe Myocardial perfusion scintigraphy fi ndings in patients with mild coronary atherosclerotic lesions on coronary angiography(Dicle Üniversitesi Tıp Fakültesi, 2010) Dostbil, Zeki; Çil, Habib; Tekbaş, Ebru Öntürk; Atılgan, Zuhal Arıtürk; İslamoğlu, Yahya; Taşdemir, Bekir; Dağ, YusufObjectives: Myocardial perfusion scintigraphy (MPS) is widely used in functional assessment of myocardial perfusion. But, some study results are in contradiction with severity of coronary artery disease detected by coronary angiography (CA). It is frequently encountered case that CA is completely normal whereas MPS describes ischemia. In this study, we aimed to investigate whether mild atherosclerotic lesions cause ischemia. Materials and methods: MPS with 99mTc-MIBI was performed in 52 patients who applied to cardiology clinics for history of chest pain and underwent diagnostic CA within 3 months. Results: In 22 of 52 patients with mild atherosclerotic lesions, ischemia in various degrees was detected on MPS. In statistical analysis, any signifi cant relationship was not found between ischemia and gender, hypertension, DM, dyslipidemia, smoking, mitral valve insuffi ciency, left ventricular hypertrophy, exercise testing result and affected coronary artery. Conclusion: Our study fi ndings have shown that mild atherosclerotic lesions even at very early stage may cause myocardial ischemiaÖğe Skin Ulcers: A Sign of Disseminated Tuberculosis(Daedalus Enterprises Inc, 2011) Tekbas, Guven; Abakay, Abdurrahman; Tanrikulu, Abdullah Cetin; Firat, Ugur; Ekici, Faysal; Dostbil, Zeki; Sula, Bilal[Abstract Not Available]Öğe Tc-99m MIBI SPECT miyokard perfüzyon sintigrafisindeki revers redistribüsyon paterninin sol ventrikül ejeksiyon fraksiyonu üzerindeki etkisi(2015) Yüksel, Murat; Taşdemir, Bekir; Dostbil, Zeki; Sezgin, İlhanAmaç: Revers redistribüsyon paterni (RRP)'nin nedenleri ve prognostik önemi henüz netlik kazanmamıştır. Bu çalışmada amacımız; RRP'nin sol ventrikül ejeksiyon fraksiyonu (EF) üzerindeki etkisini değerlendirmektir.Yöntemler: Teknesyum-99m sestamibi miyokard perfüzyon sintigrafisi yapılmış ve normal olarak değerlendirilmiş hastaların görüntüleri retrospektif olarak incelendi. Tek gün protokolü ve/veya farmakolojik stres testi uygulanan hastalar çalışma dışı bırakıldı. RRP saptanan toplam 21 hasta çalışma kriterlerini sağladı. Bu hastaların tamamı RRP grubu olarak çalışmaya dahil edildi. Randomize seçilen 21 RRP saptanmayan hasta ise kontrol grubu olarak çalışmaya alındı. Transiyel iskemik dilatasyon (TID) skorları ve EF değerleri Quantitative Gated SPECT (QGS) programı kullanılarak otomatik olarak hesaplandı. Bulgular: Yaş, cinsiyet, hipertansiyon, aile hikayesi, hiperlipidemi ve diyabet yönünden RRP ve kontrol grubu arasında istatistiksel olarak anlamlı bir fark saptanmazken (p>0,05), sigara kullanımı yönünden anlamlı fark tespit edildi (p=0,019). RRP grubundaki TID skorları, kontrol grubuna kıyasla anlamlı bir şekilde daha düşüktü (p<0,001). Ayrıca RRP grubunda, istirahat görüntülerindeki EF değerlerinde, stres görüntülerindekilere kıyasla anlamlı bir şekilde düşüş tespit edildi (p=0,002). Dahası bu düşüş, kontrol grubundakine kıyasla anlamlı bir şekilde daha yüksekti (p=0,034). Sonuç: TID skoru ve EF değerleri ile ilgili bulgular, RRP zemininde iskemik bir nedenin varlığını düşündürmektedir. Ayrıca, sigara kullanımı ile RRP arasında saptanan ilişki; sigara kullanımının taşikardik atak ve/veya koroner spazm yapıcı etkisi ile ilişkili olabilir
