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Immunological Parameters in Migraine Patients
(Ortadogu Ad Pres & Publ Co, 2009) Tasdemir, Nebahat; Ulug, Nuray Can; Dogan, Bahar Burtan
Objective: In this study, we aimed to investigate by measuring differences between the levels of plasma cytokines interleukin-1 beta (IL-1 beta), IL-2 receptor, IL-6, IL-8, IL-10, turnout necrotizing factor alpha (TNF-alpha), compleman 3 (Q) and 4 (C4); immunoglobulins G (IgG), IgA, IgM, IgE during migraine attacks and headache-free periods. Material and Methods: Seventy-two patients and 41 age and sex matched healthy people were enrolled in the study. The diagnosis was made according to the International Classification of Headache Disorders (ICHD-II) criteria. Thirty patients out of 72 were in a migraine status while 42 were headache-free. The plasma levels of the cytokines such as IL-10, IL-2 receptor, IL-6, IL-8, IL-10, TNF-alpha, complements (C3, C4) and immunoglobulins were measured in all patients and the controls. Results: The level of TNF-alpha was higher during the attack and the headache-free period in migraine patients than in the healthy control group. The level of C3 was higher during a headache-free period than in the healthy control group. There were significant differences between groups regarding IL-1 beta, IL-6, IL-10 and IgG levels. Conclusion: Immunologic alterations and activity of proinflammatory markers were present during the migraine attack and headache free period in migraine patients.