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    Öğe
    Myocardial Performance Index for Patients with Overt and Subclinical Hypothyroidism
    (Int Scientific Literature, Inc, 2017) Karabulut, Aziz; Dogan, Abdullah; Tuzcu, Alparslan Kemal
    Background: Hypothyroid has several effects on the cardiovascular system. Global myocardial performance index (MPI) is used in assessment of both left ventricular (LV) systolic and diastolic function. We compared MPI in hypothyroidism patients vs. normal control subjects. Material/Methods: Eighty-two hypothyroid patients were divided into 2 groups: a subclinical hypothyroid (SH) group (n=50), and an overt hypothyroid (OH) group (n=32). The healthy control group (CG) constituted of 37 patients. TSH, FT3, and FT4, anti-TPO, anti-TG, insulin, lipid values, and fasting glucose levels were studied. All patients underwent an echocardiographic examination. Myocardial performance indexes were assessed and standard echocardiographic examinations were investigated. Results: MPI averages in OH, SH, and control groups were 0.53 +/- 0.06, 0.51 +/- 0.05, and 0.44 +/- 0.75 mm, respectively. MPI was increased in the OH and SH groups in comparison to CG (p < 0.001, p < 0.001, respectively). Conclusions: MPI value was significantly higher in hypothyroid patients in comparison to the control group, showing that regression in global left ventricular functions is an important echocardiographic finding. Future studies are required to determine the effects of this finding on long-term cardiovascular outcomes.
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    Öğe
    SYMPTOMATIC HYPOCALCAEMIA FOLLOWING INTRAVENOUS ADMINISTRATION OF ZOLEDRONIC ACID IN A FEMALE PATIENT WITH OSTEOPOROSIS
    (Carbone Editore, 2015) Senates, Banu Erkalma; Dogan, Abdullah; Senates, Ebubekir
    Bisphosphonates (BPs) are widely used in the treatment of postmenopausal osteoporosis. Zoledronic acid has the highest affinity with the bone as well as alters mineral surface properties, allowing greater adsorption. A 58-year-old woman presented with osteoporosis, was treated with a once-a-year IV of 5 mg of Zoledronic Acid. Before this once-a-year treatment, her serum calcium levels were normal although after the treatment, she was hospitalized with nausea, perioral and acral paresthesias and tingling. Biochemical analysis recorded Calcium levels as 5.94 mg/dl and low levels of vitamin D Serum. The Hypocalcaemia was initially treated with IV Calcium Gluconate solution followed by oral calcium and vitamin D supplements.