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Awareness of Osteoporosis and its Related Factors After Distal Radius Fractures in Patients Aged 45 Years and Older
(Galenos Yayincilik, 2013) Sahin, Ebru; Dilek, Banu; Baydar, Meltem; Kosehasanogullari, Meryem; Ucku, Reyhan; Oncel, Sema
Objective: Osteoporosis is an important health problem with regard to morbidity, mortality, and negative effects on quality of life as well as health-related costs. Distal radius fracture is one of the most frequent fractures and it has been shown to be associated with an increased risk of further fractures. Awareness and treatment of osteoporosis is important to prevent further fractures in patients with osteoporosis. The aim of this study was to evaluate the awareness of osteoporosis and related factors in distal radius fracture patients. Materials and Methods: A total of 120 low-energy distal radius fracture patients aged 45 years and over were included in the study. A questionnaire was applied in all patients after they gave their consent. Results: In our patients 40.8% had awareness about osteoporosis, and 59.2% did not. About the educational levels 47.5% of patients were not able to read and write or were primary school graduates, 52.5% were secondary or high school graduates. Awareness of osteoporosis was positively correlated with education. With regard to sources of information, 50% of patients reported physicians as the main source of information. Conclusion: We demonstrated that the level of awareness of osteoporosis is associated with educational level in distal radius fracture patients. Awareness of osteoporosis and thus to begin treatment earlier is important to prevent further fractures in distal radius fracture patients. Turk J Phys Med Rehab 2013;59:52-6.
A Case of Spondyloepiphyseal Dysplasia Tarda Coexisting With Osteoporosis and Mimicking Spondyloarthropathy
(Galenos Yayincilik, 2013) Batmaz, Ibrahim; Sariyildiz, Mustafa Akif; Dilek, Banu; Ulu, Mehmet Ali; Verim, Sabahattin; Budulgan, Mahmut; Cevik, Remzi
Spondyloepiphyseal dysplasia tarda (SEDT), which is characterized by short stature with short trunk, may cause barrel chest, kyphoscoliosis, platyspondyly, coxa vara and genu varum/valgum deformities due to delayed formation of epiphyses. The association of SEDT with osteopenia and osteoporosis has been reported. Chronic back and buttock pain, swelling of the joints and morning stiffness are some of the clinical findings of SEDT which can be confused with inflamatory diseases. In this article, we present a 19-year-old male patient with SEDT who was diagnosed as having spondyloarthropathy because of back and buttock pain and morning stiffness associated with osteoporosis.
A Case With Type I Gaucher Primarily Involved Pelvis
(Elmer Press Inc, 2012) Dilek, Banu; Aydin, Fatma; Dag, Ilknur Sevin Buluttekin; Batmaz, Ibrahim; Nas, Kemal; Cevik, Remzi
Type 1 Gaucher disease is the most common lysosomal storage disorder which also affects the musculoskeletal system with various organ manifestations. Here, we aimed to present a case diagnosed Type 1 Gaucher disease which mainly involved pelvis.
Comparison of PA spine, lateral spine, and femoral BMD measurements to determine bone loss in ankylosing spondylitis
(Springer Heidelberg, 2013) Ulu, Mehmet Ali; Cevik, Remzi; Dilek, Banu
To evaluate bone loss in the early- and late-stage ankylosing spondylitis (AS) patients using posteroanterior (PA) and lateral lumbar and femoral bone mineral density (BMD) measurement methods. Eighty-six AS patients and 50 control subjects were enrolled. PA spine, lateral spine, and femur BMD values of patients and controls were measured. The presence of any syndesmophytes or compression fractures was determined. Patients were divided as early (< 10 years) and late stage (a parts per thousand yen10 years) according to the onset of the inflammatory pain. Mean PA spinal BMD was similar in patients and controls (p = 0.460). Femoral and lateral spine BMD values were significantly lower in patients (p = 0.012 and p = 0.001). When comparing early- and late-stage AS groups, mean PA spinal BMD was found to be lower in the early group (p = 0.005), while femoral and lateral spinal values were lower (although statistically not significant) in the late group. At least one compression fracture was present in 28 % of patients. Although not statistically significant, mean PA spinal BMD was higher in those with fractures. Femoral and lateral spinal BMD values were significantly lower in the fracture group (p = 0.034 and p = 0.004). Lateral spinal BMD values were significantly lower in patients with syndesmophytes (p = 0.004). Bone loss is increased in AS compared with control subjects. The BMD measurement at the lateral lumbar spine reflects bone loss and fracture risk better than PA spine and femoral measurements.
Depressive and Anxious Temperaments in Patients with Complex Regional Pain Syndrome Secondary to Tendon Injury
(Taylor & Francis Ltd, 2014) Batmaz, Ibrahim; Dilek, Banu; Sariyildiz, Mustafa Akif; Erbatur, Serkan; Bez, Yasin; Yazmalar, Levent; Bozkurt, Mehtap
Objective: To determine the affective temperaments and somatoform amplification of the symptoms and its relation with the complex regional pain syndrome [CRPS] in patients who had tendon injuries of the forearm and hand. Methods: Sixty-seven patients [60 males, 7 females] with a forearm or hand tendon injury were enrolled in the present study. The patients were divided into two groups: CRPS and non-CRPS. The patients' pain levels within the last 48 hours were assessed using the visual analog scale [VAS]. The temperament of the patients was evaluated using the Temperament Evaluation of Memphis, Pisa, Paris and San Diego Auto questionnaire [TEMPS-A]. Their anxiety levels were evaluated with the help of the State-Trait Anxiety Inventory [STAI]. The depression assessment was performed using the Beck Depression Inventory [BDI]. The Somato sensory Amplification Scale [SSAS] was employed for the evaluation of the somatoform disorders. Results: The mean age of the patients was 26.21 +/- 8.01 years [age range: 18 to 57 years]. Among the patients 24 [35.8%] had developed CRPS. When the patients with and without CRPS were compared in terms of their psychological scores, the STAI-II and BDI scores were observed to be significantly deteriorated in the CRPS group in comparison to the non-CRPS group [p<0.05]. Among the TEMPS-A subtypes, anxious [16.7%] and depressive [41.7%] temperaments were more dominant in the CRPS group and the ratio was significantly more deteriorated than the non-CRPS group [p<0.05]. No significant difference was observed between the groups regarding the SSAS scores [p>0.05]. Conclusion: The present study is the first one evaluating the affective temperaments of CRPS patients with tendon injury, and the main findings point out that depressive and anxious temperaments are the most common dominant affective temperaments among our patients.
THE EFFECT OF POSTURE SUPPORT CORSET ON BALANCE, QUALITY OF LIFE, DORSAL KYPHOSIS IN PATIENTS WITH KYPHOSIS DUE TO OSTEOPOROSIS
(Gunes Kitabevi Ltd Sti, 2013) Gundogdu, Mehtap; Oncel, Sema; Sahin, Ebru; Baydar, Meltem; Dilek, Banu
Introduction: The aim of this study was to investigate the effect of posture support corset (kypho-orthosis) on balance, quality of life, and dorsal kyphosis angle in patients with kyphosis due to osteoporosis. Materials and Method: Twenty-nine patients were randomized into two groups. One group (n=14) was given the conventional osteoporosis exercises, and the other group (n=15) was given the kypho-orthosis in addition to these exercises. Kyphosis angle and height were measured. Evaluations were done by Kinesthetic Ability Trainer device, single foot balance test, Timed Up & Go Test, Berg Balance Scale, Quality of Life Questionnaire of the European Foundation for Osteoporosis at baseline, and after one and three months. Results: In both groups, a significant improvement was found after treatment in terms of values measured by Timed Up & Go Test, Berg Balance Scale, right and left foot balance test, the physical and mental functional dimensions of quality of life and dorsal kyphosis angle. A significant difference was found in height at three months in the corset group. Conclusion: Using kypho-orthosis does not provide additional benefit to the exercise program on balance, dorsal kyphosis angle and the quality of life; but it contributes to height increase by providing the patients with a more vertical posture.
Effectiveness of training about kinesiotaping in myofascial pain syndrome: A prospective, single-blind,randomized-controlled study
(Bayçınar Medical Publications, 2021) Dilek, Banu; Batmaz, İbrahim; Sarıyıldız, Mustafa Akif; Şahin, Ebru; Bulut, Deniz; Akalın, Elif; Çevik, Remzi; Nas, Kemal
Abstract Objectives: In this study, we aimed to investigate whether there was any difference in kinesiotaping (KT) application on the upper trapezius muscle between a trained and untrained physiatrist in the management of patients with myofascial pain syndrome (MPS). Patients and methods: Between April 2013 and July 2015, a total of 45 patients (44 females, 1 males; mean age 31.9 +/- 8.0 years; range, 18 to 55 years) with MPS were included in this prospective, single-blind, randomized-controlled study. The patients were randomly divided into two groups. The first group (intervention group, n=24) was administered KT band with the muscle in a tense condition according to the muscle technique performed by a trained physiatrist, from the muscle origo toward its insertion point. The second group (control group, n=21) received no technique and KT was applied to the painful area by an untrained physiatrist using a randomly selected method. Primary outcome measures were pain at rest, during activity (0-10 cm visual analog scale), and threshold measurement with algometry (kg/cm(2)). Secondary outcome measures were function (Neck Pain and Disability Scale), degree of palpable muscle spasm, and quality of life (Nottingham Health Profile). All evaluations were performed at baseline, at three and six weeks after the treatment. Results: There were significant improvements in all parameters in both groups. There were no significant differences in any parameters at six weeks. We demonstrated that KT, which was applied on active trigger points on the upper trapezius muscle by trained and untrained physiatrists, improved pain, palpable muscle spasm, neck function, quality of life, and patient satisfaction degree in patients with MPS. Conclusion: Our study results show that KT, which is applied by trained and untrained physiatrists, improves pain, palpable muscle spasm, neck function, quality of life in patients with MPS.
Efficacy of Pulsed and Continuous Therapeutic Ultrasound in Myofascial Pain Syndrome A Randomized Controlled Study
(Lippincott Williams & Wilkins, 2015) Ilter, Leman; Dilek, Banu; Batmaz, Ibrahim; Ulu, Mehmet Ali; Sariyildiz, Mustafa A.; Nas, Kemal; Cevik, Remzi
Objectives This study aimed to compare continuous and pulsed ultrasound therapy with sham ultrasound in terms of pain, severity of muscle spasm, function, depression, and quality of life in patients with myofascial pain syndrome. Design Patients were randomly divided into three groups, including the continuous ultrasound group (3 MHz, 1 W/cm(2), n = 20), the pulsed ultrasound group (3 MHz, 1 W/cm(2), 1:1 ratio, n = 20), and control group (sham, n = 20). The primary outcome measures were severity of pain at rest and during activity (visual analog scale, 0-10 cm). The secondary outcome measures were function (Neck Pain and Disability Scale), depressive mood (Beck Depression Scale), and quality of life (Nottingham Health Profile). All evaluations were performed at baseline, after treatment, and at the 6th and 12th wks. Results All three groups had significant improvements in all of the pain scores, the severity of muscle spasms, function assessments, and certain subparameters of the quality of life scale (P < 0.05). The continuous ultrasound group had significantly greater improvements in pain at rest (P < 0.05). However, no statistically significant differences were observed in the other parameters (P > 0.05). Conclusions Continuous ultrasound therapy is more efficient in reducing pain at rest for myofascial pain syndrome patients than is sham or pulsed ultrasound therapy.
Efficiency of pulsed electromagnetic fields on pain, disability, anxiety, depression, and quality of life in patients with cervical disc herniation: A randomized controlled study
(Turkiye Klinikleri, 2019) Hattapoğlu, Erkam; Batmaz, İbrahim; Dilek, Banu; Karakoç, Mehmet; Em, Serda; Çevık, Remzi
Background/aim: In this study, it was aimed to investigate the effects of pulsed electromagnetic field (PEMF) therapy on pain, disability, psychological state, and quality of life in cervical disc herniation. Materials and methods: Patients were randomly divided into two groups, including Group 1, which received a therapy consisting of transcutaneous electrical nerve stimulation (TENS), hot pack (HP), and PEMF, and Group 2, which received a magnetic field (sham magnetic field) without current flow in addition to TENS and HP therapy. Pain was assessed by a visual analog scale (VAS, 0–10 cm). The other outcome measures were function (Neck Pain and Disability Scale), anxiety-depressive mood (Hospital Anxiety and Depression Scale), and quality of life (Nottingham Health Profile). All evaluations were performed at baseline, in the 3rd week, and in the 12th week after treatment. Results: A significant improvement was found in the neck pain, disability, depression, anxiety, and quality of life scores of both groups after treatment when compared to those before treatment. However, in the comparison between changes within groups, significant improvements were determined only in the VAS and Nottingham Health Profile sleep subparameter in the 12th week after treatment compared to those before treatment. Conclusion: PEMF therapy in cervical disc herniation can be used safely in routine treatment in addition to conventional physical therapy modalities
HLA-DRB1 Alleles Distribution in Patients With Rheumatoid Arthritis in A Tertiary Center in the Southeastern Anatolia Region of Turkey
(Galenos Yayincilik, 2013) Batmaz, Ibrahim; Sariyildiz, Mustafa Akif; Dilek, Banu; Yildiz, Ismail; Nas, Kemal; Ayyildiz, Orhan; Cevik, Remzi
Objective: The HLA-DRB1 alleles play an important role in the genetic predisposition to rheumatoid arthritis (RA). The relationship between HLA-DRB1 and rheumatoid arthritis show differences according to various ethnic groups and geographical distributions. The aim of this study was to determine the distribution of HLA-DRB1 among the Turkish RA patient population in the Southeastern Anatolia Region. Materials and Methods: 96 patients diagnosed with RA and a control group consisting of 84 healthy individuals were enrolled in the study. The HLA-DRB1 type and subtypes were specified using the polymerase chain reaction with sequence specific primers (PCR-SSP) method. The between-group HLA-DRB1 type and certain subtype frequencies were compared. Results: The DRB1*10 alleles were found to be statistically significantly higher in patients with RA compared to the control group (p=0.001). However, the DRB1*07 and DRB1*11 alleles were statistically significantly lower in patients with RA (p<0.001 and p=0.02, respectively). In the RA patient group, the DRB1*0401, DRB1*0408 and DRB1*1001 subtypes were found to be statistically significantly higher (p=0.04, p=0.01, p=0.005, respectively), while the DRB1*0402, DRB1*0403 and DRB1*0701 subtypes were statistically significantly lower (p=0.01, p=0.02, p<0.001, respectively). Conclusion: This study has revealed the HLA-DRB1 distribution in the Southeastern Anatolia Region of Turkey. DRB1*10 type and DRB1*0401, DRB1*0408, DRB1*1001 subtypes were observed to be related with RA. DRB1*07, BRB1*11 types and DRB1 *0402, DRB1*0403, DRB1*0701 subtypes were accepted as protective alleles and subtypes.
HLA-DRB1 EXPRESSION IN THE RHEUMATOID ARTHRITIS PATIENTS AMONG THE POPULATION IN THE SOUTHEAST ANATOLIAN REGION OF TURKEY
(Oxford Univ Press, 2012) Batmaz, Ibrahim; Sariyildiz, MehmetAkif; Dilek, Banu; Yildiz, Ismail; Ayyildiz, Orhan; Nas, Kemal; Cevik, Remzi
[Abstract Not Available]
Kinesio taping in patients with lateral epicondylitis
(Ios Press, 2016) Dilek, Banu; Batmaz, Ibrahim; Sariyildiz, Mustafa Akif; Sahin, Ebru; Ilter, Leman; Gulbahar, Selmin; Cevik, Remzi
BACKGROUND: Lateral epicondylitis (LE) is a painful condition that affects the tendinous tissue of the lateral epicondyle of the humerus and leads to loss of function of the affected limb. Therefore it can have a major impact on the patient's social and personal life. Many treatments are recommended for lateral epicondylitis; unfortunately the evidence is limited. OBJECTIVES: The aim of study was to investigate the effect of kinesio taping (KT) on pain, grip strength and function in patients LE. METHODS: Thirty-one (23 females, 8 males) patients with LE were included. KT was applied twice a week for 2 weeks. Pain at rest, activity of daily living (ADL), night and palpation on lateral epicondyle was evaluated with the visual analog scale (VAS 0-10 cm), and the grip strength was measured with a hand held dynamometer. The stage of the disease was evaluated by the Nirschl score and the functional status was assessed with Patient-Rated Forearm Evaluation Questionnaire (PRTEQ) score. These parameters were evaluated before, at 2 weeks and 6 weeks after treatment. Patients' satisfaction was also recorded on a Likert scale after treatment at 2 weeks and 6 weeks. RESULTS: The average age of the patients was 43.58 +/- 9.02. The dominant limb was affected in 64.5% (20) of the patients. After the application of KT on lateral epicondyle, there was a significant improvement in all parameters in terms of pain, Nirschl score, hand grip strength, patient satisfaction, and PRTEQ scores at 2 and 6 weeks. CONCLUSIONS: Kinesio taping can be an effective treatment method in LE. This application improves pain, grip strength and functional status of the patients with LE.
Kırk beş yaş ve üzeri hastalarda radius distal uç kırıklarından sonra osteoporoz farkındalığı ve etkileyen faktörler
(2013) Uçku, Reyhan; Şahin, Ebru; Kösehasanoğulları, Meryem; Öncel, Sema; Baydar, Meltem; Dilek, Banu
Amaç: Osteoporoz morbiditesi, mortalitesi, yaşam kalitesi üzerine olanolumsuz etkileri ve maliyeti açısından önemli bir sağlık sorunudur. Radiusdistal uç kırıkları (RDUK) en sık gözlenen kırıklardan biridir ve gelişebilecekdiğer kırıkların habercisi olarak kabul edilmektedir. Bu grup hastalardadaha ileri kırıkların önlenmesi açısından osteoporoz farkındalığı ve tedavisi önem taşımaktadır. Bu çalışmanın amacı RDUK’lu hastalarda osteoporoz farkındalığı ve etkileyen faktörleri değerlendirmektir. Gereç ve Yöntem: Çalışmaya düşük enerjili RDUK sonrası polikliniğimize başvuran veya özgeçmişinde RDUK öyküsü olan 45 yaş ve üzeri 120 hasta alındı. Hastalara onayları alındıktan sonra osteoporoz farkındalığı ile ilgili bir anket uygulandı. Bulgular: Hastaların %40,8’inin osteoporoz farkındalığının olduğu,%59,2’sinin farkındalığının olmadığı bulunmuştur. Çalışmaya katılanların%47,5’i hiç eğitim almamış veya ilkokul düzeyinde, %52,5’i iseaöğretim ve üzeri seviyede eğitim almıştı. Osteoporoz farkındalığıile eğitim düzeyi arasında istatistiksel olarak pozitif korelasyon saptandı.Hastaların osteoporoz konusundaki bilgi kaynakları sorulduğundadoktorlar %50 oranı ile ilk sırayı aldı. Sonuç: Biz çalışmamızda RDUK geçiren hastalarda, osteoporoz farkındalık düzeyinin eğitim düzeyi ile ilişkili olduğunu gösterdik. RDUK geçiren hastalarda osteoporoz farkındalığının olması ve bu sayede erken tedaviye başlanması gelişebilecek diğer kırıkları önlemek açısından önemlidir.
Mitochondrial miRNAs and fibromyalgia: new biomarker candidates
(Springer Science and Business Media B.V., 2025) Kavak, Deniz Evrim; Dilek, Banu; Rasulova, Khayala; Pehlivan, Melek; Kızıldağ, Sefa
ntroduction / objective: Fibromyalgia syndrome (FMS), affecting 3–10% of the population, presents a challenge due to its complex symptomatology. Mitochondrial miRNAs (mitomiRs) are highlighted for their significant role in metabolic disorders. This study aimed to assess demographic data in Primer FMS patients and explore potential targets through mitomiR profiling. Methods: In our study, we examined 17 FMS patients and 18 controls, chosen based on specific criteria. Mitochondria were isolated from PBMCs in patient/control blood samples using the MACS method. Mitochondrial purity was verified through RT-qPCR and Western Blot. Following this, we extracted microRNAs and analyzed the levels of 3 mitochondrial miRNAs linked to oxidative stress (mitomiR-145-5p, mitomiR-23a-3p, mitomiR-223-3p) using RT-qPCR. Results: It was found that pain (P < 0.0001), fatigue (P = 0.0005), sleep quality (P < 0.0001), and depression (P < 0.0001) scores were significantly different in the FMS patient group compared to the control group. But the average BMI values have no difference compared to the control group (p = 0.7473). For the first time, a significant increase in mitomiR-145-5p was observed in the PBMCs of FMS patients compared to the control group (p = 0.0010). There was no significant difference observed in the gene expression levels of mitomiR-223-3p (p = 0.1623) and mitomiR-23a-3p (p = 0.4897). Conclusion: We demonstrated that mitomiR-145-5p plays a significant role in the progression of FMS pathology. Our study offers new insights, suggesting that mitochondrial miRNAs may have roles in FMS patients, which has not been previously investigated in the literature, thus providing a fresh perspective on the condition.
OSTEOPOROSIS, SUBCLINICAL VERTEBRAL FRACTURES AND RELATED FACTORS IN PATIENTS WITH PERIPHERAL ARTERIAL DISEASE
(Gunes Kitabevi Ltd Sti, 2012) Baydar, Meltem; Karabay, Ozalp; Dilek, Banu; Sahin, Ebru; Karasel, Seide Alev; Manisali, Metin; Unal, Belgin
Introduction: The aim of the present study is to investigate the factors,affecting osteoporosis and subclinical vertebral fracture in patients with peripheral arterial disease(PAD). Materials and Method: Eighty patients over 45 years of age with a diagnosis of PAD and without a history of osteoporosis were included in the study. The patients were queried in terms of demographic characteristics,calcium intake and physical activity. BMD was measured by a dual energy X-ray absorbsiometer (DEXA). The loss of vertebral height was determined. PAD was staged according to Fontaine's classification. Serum calcium,phosphorus,alkaline phosphatase, 25(OH)D, parathormone, homocysteine and B12 levels were measured and thyroid,renal and hepatic function tests were performed. Results: According to the DEXA measurements, 19.17% (14)of the patients had osteoporosis while 63.01%(46) of them had osteopenia. Of the patients 28(36.70%)and 8(10.12%) had grade 1 and grade 2 vertebral fractures, respectively. Radiologically confirmed vertebral fractures were not present in 43(53.2%) patients. No significant relation was found between the stage of the PAD, BMD and t scores (p>0.05). On the other hand,subclinical vertebral fractures significantly correlated with the stage of the disease and the weakness symptom (p<0.05). Conclusion: The stage of the disease showed no correlation with osteoporosis,but correlated with the grade of subclinical vertebral fracture. Thus, this group of patients should be investigated for osteoporosis and evaluated both with BMD measurement and direct radiography.
Osteoporoza bağlı kifozu olan hastalarda omuz retraksiyon ortezinin denge, kifoz açısı ve yaşam kalitesi üzerine etkisi
(2013) Dilek, Banu; Şahin, Ebru; Öncel, Sema; Baydar, Meltem; Gündoğdu, Mehtap
Giriş: Bu çalışmanın amacı osteoporoza bağlı kifozu olan hastalarda omuz retraksiyon ortezinin (kifoortez) denge, yaşam kalitesi ve dorsal kifoz açısı üzerine olan etkisinin araştırılmasıdır.Gereç ve Yöntem: Yirmi dokuz hasta iki gruba randomize edildi. Bir gruba (n=14) konvansiyonel osteoporoz egzersizleri, diğer gruba (n=15) ek olarak kifoortez verildi. Kifoz açısı ve boy uzunluğu ölçüldü. Değerlendirmeler Kinestetic Ability Trainer cihazı, tek ayak denge testi, Zamanlı Ayağa Kalkma ve Yürüme Testi, Berg Denge Ölçeği, Quality of Life Questionnaire of the European Foundation for Osteoporosis anketi ile tedavi öncesi, tedavi sonrası birinci ve üçüncü aylarda yapıldı.Bulgular: İki grupta da tedavi ile; Berg Denge Ölçeği ile ölçülen denge değerlerinde, Zamanlı Ayağa Kalkma ve Yürüme Testinde sağ ve sol tek ayak denge testinde, yaşam kalitesinin fiziksel ve zihinsel fonksiyon boyutlarında ve dorsal kifoz açısında anlamlı düzelme bulundu. Ortez kullanan grupta boy uzunluğunda üçüncü ay sonunda anlamlı fark saptandı.Sonuç: Kifoortez kullanımının denge, dorsal kifoz açısı ve yaşam kalitesi üzerinde egzersize ek yarar sağlamadığı ancak daha dik postur sağlayarak boy uzunluk artışına katkısı olduğu gösterilmiştir.
Prevalence of osteoporosis and vertebral fractures and related factors in patients with ankylosing spondylitis
(Chinese Medical Assoc, 2014) Ulu, Mehmet Ali; Batmaz, Ibrahim; Dilek, Banu; Cevik, Remzi
Background Osteoporosis and vertebral factures are well recognized features in patients with ankylosing spondylitis (AS). The aim of this study was to investigate the prevalence and risk factors of osteoporosis and vertebral fractures in patients with AS. Methods Fifty-nine AS patients and 40 healthy controls were enrolled. Bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry (DEXA) at posterior-anterior (PA) lumbar, lateral lumbar and hip regions. Thoracic and lumbar X-rays were obtained for morphometric measurements. Clinical, biological and radiological statuses were evaluated with Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Radiology Index-total (BASRI-t), erythrocyte sedimentation rate (ESR) and the C-reactive protein levels. Results Osteoporosis was present in 32% of patients and 5% of controls according to lateral vertebral BMD measurements. Fracture was present in 31% of patients. The effect of some clinical and laboratory parameters on BMD status and vertebral fractures was analyzed in the patient group. Osteoporosis in lateral lumbar DEXA was associated with higher BASMI, BASFI, BASRI-t scores and ESR level. Low hip BMD was associated with low BMI and high BASF! and BASRI-t scores. Vertebral fractures were associated with advanced age, longer disease duration, longer duration since diagnosis, higher BASMI and BASRI-t scores, higher ESR level, reduced femoral and lateral lumbar BMD. Logistic regression analysis revealed that only BASRI-t score was significantly associated with low lateral spinal BMD and BMI and BASFI score were independently associated with low hip BMD. The presence of compression fractures was independently associated with BASRI-t score and low lateral lumbar BMD. Conclusions Osteoporosis and vertebral fractures in AS seem to be related to the extent of radiological involvement. A low lateral lumbar BMD is an important risk factor for vertebral fractures.
Relationship between serum leptin level and disease activity in patients with systemic sclerosis
(Springer London Ltd, 2014) Budulgan, Mahmut; Dilek, Banu; Dag, Sevin Buluttekin; Batmaz, Ibrahim; Yildiz, Ismail; Sariyildiz, Mustafa Akif; Cevik, Remzi
To determine the relationship between serum leptin levels and disease activity in systemic sclerosis (SSc). A total of 60 subjects (30 controls and 30 patients) were included. The inflammatory markers and leptin levels were evaluated and body mass index (BMI) was measured for both groups. The assessment of the skin involvement was performed based on the modified Rodnan skin score (mRSS). Disease activity was evaluated according to the Valentini scleroderma disease activity index. There was a significant difference between the patient and control groups in terms of BMI (p < 0.05); however there was no difference with regards to age and gender (p > 0.05). Valentini scores and mRSS were determined to be significantly higher in active patients (n = 14) than in inactive patients (n = 16) (p < 0.05). No significant difference was determined between groups in terms of leptin levels (p > 0.05). However, leptin levels were significantly lower in active patients than in inactive patients (p < 0.05). We found a significant positive correlation between serum leptin and BMI (p < 0.05), and leptin and serum C3 levels (p < 0.05); no relationship was detected between leptin and other parameters. Leptin can be used as an activity marker in SSc. Further studies, including larger series, should be carried out to clarify this relationship.
Relationship of the sexual functions with the clinical parameters, radiological scores and the quality of life in male patients with ankylosing spondylitis
(Springer Heidelberg, 2013) Sariyildiz, Mustafa Akif; Batmaz, Ibrahim; Dilek, Banu; Inanir, Ahmet; Bez, Yasin; Tahtasiz, Mehmet; Em, Serda
The aim of this study was to explore the impact of ankylosing spondylitis (AS) and the disease-related variables on the patients' sexual function according to the International Index of Erectile Function (IIEF) scoring system. A total of 70 sexually active male AS patients and 60 healthy controls were enrolled in this study. Their demographic data were evaluated, and the pain was assessed according to the visual analogue scale (VAS). Laboratory tests were conducted in order to measure the C-reactive protein (CRP) and erythrocyte sedimentation rates (ESR) of the patients. The disease activity was evaluated using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Functional statement was evaluated with the help of the Bath Ankylosing Spondylitis Functional Index (BASFI) and with the scores obtained from the spinal measurements with the Bath Ankylosing Spondylitis Metrology Index (BASMI). The Bath Ankylosing Spondylitis Radiology Index (BASRI) was used to evaluate the radiological damage. The disease-related quality of life was measured with the Ankylosing Spondylitis Quality of Life Questionnaire (ASQoL). The anxiety and depression level of the patients was revealed through the Hospital Anxiety and Depression Scale (HADS). In comparison with the healthy control group, patients with AS had significantly lower scores in each of the 5 domains of the IIEF (p < 0.0001). The BASDAI, BASFI, BASMI, BASRI, ASQoL, HADS scores and CRP levels were negatively correlated with IIEF (p < 0.05). Orgasmic function and sexual desire scores were significantly lower in patients with peripheral arthritis (p < 0.05). No significant correlation was observed with the disease duration, smoking status, pain (VAS), and ESR levels when the total scores and the scores from the domains of IIEF were compared. The multivariate regression analyses indicated that BASFI and BASMI were independently associated with the sexual function. The sexual function is impaired in male patients with AS. This impairment in the sexual function is especially correlated with the BASFI and BASMI among the clinical and laboratory parameters.
Serebral palsili çocukların annelerinde depresyon ve yaşam kalitesinin değerlendirilmesi
(Marmara Üniversitesi, 2013) Dilek, Banu; Batmaz, İbrahim; Karakoç, Mehmet; Sarıyıldız, Mustafa Akif; Aydın, Abdulkadir; Çavaş, Hüsamettin; Çevik, Remzi
Amaç: Serebral palsili (SP) çocukların annelerinde depresyon varlığının araştırılması ve yaşam kalitesinin değerlendirilmesi, çocuğu sağlıklı annelerden oluşan kontrollerle karşılaştırılmasıdır. Hastalar ve Yöntem: Çalışmaya 49 SP’li çocuk ve annesi ile sağlıklı çocuğu olan 30 anne alındı. SP tipi belirlenen çocukların; Kaba Motor Fonksiyon Sınıflama Sistemi (KMFSS) ile fonksiyonel düzeyi belirlendi. Annelerin depresyon durumu Beck Depresyon Ölçeği (BDÖ) ile, yaşam kalitesi Nottingham Sağlık Profili (NSP) ile değerlendirildi. Bulgular: SP’li çocukların yaş ortalaması 66.20 ± 43.73 aydı. Çocukların 28’ i diplejik, 1’i hemiplejik, 20’si kuadriplejik tipteydi. KMFSS’e göre; çocukların çoğu, düzey 2 (n=20) ve düzey 3 (n=17)’ tü. SP grubunun annelerinin yaş ortalaması 35.75 ± 7.44, kontrol grubunun ise 33.80 ± 7.21 bulundu. SP’li çocuğu olan anne grubunda akraba evliliği, annenin ev hanımı olma oranı, gelir düzeyi düşüklüğü, NSP ve BDÖ puanları anlamlı olarak yüksek bulundu (p<0.05). KMFSS düzeyi ve SP tipi ile annelerin BDÖ ve NSP puanları arasında anlamlı korelasyon saptanmadı (p>0.05). Sonuç: SP’li çocukların annelerinde yaşam kalitesinde bozulmanın ve depresyona eğilimin daha fazla olduğu saptanmıştır. Bu süreç çocuğun fonksiyonel durumundan ve serebral palsi tipinden etkilenmemektedir.

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