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    Expression of endothelin-1 and Ki-67 in normotensive and severe preeclamptic placentas
    (Universidad de la Frontera, 2018) Ekinci, Aysun; Aktaş, Ayfer; Dönder, Ahmet; Ekinci, Cenap; Turgut, Abdulkadir; Deveci, Şenay; Deveci, Engin
    Severe preeclampsia (HELLP syndrome) is a life-threatening pregnancy complication, usually a severe form of preeclampsia. In this study, we aimed to examine histopathologic changes and Endothelin-1 and KI-67 expression levels by immunohistochemical methods in severe preeclamptic placentas. Severe preeclampsia and obstetric characteristics and biochemical and hematological characteristics of healthy subjects were compared. Placenta sections were stained with hematoxylin-eosin for histopathological examination. In the histopathological examination of severe preeclamptic placenta, degeneration in synaptic and cytotrophoblastic cells, increase in insidious knots, fibrinoid necrosis, degeneration in endothelial cells, calcification and hyaline villous stains were observed. In the severe preeclampsia group, Ki-67 expression increased in decidua cells and inflammatory cells, while endothelial cells in the vessel wall and inflammatory cells in the villus and intervillous spaces increased. It is thought that angiogenetic and cellular proliferation is induced in a co-ordinated manner and significantly influences fetal development.
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    Histopathological changes in incisive teeth of the newborn pups of cadmium-applied female rats during pregnancy
    (Universidad de la Frontera, 2010) Deveci, Şenay; Deveci, Engin
    Cadmium Chloride is a well known teratogen compared to other metals. Cadmium affects placental function, may cross the placental barrier and modify fetal development. In this study, 12 female wistar albino rats weighted between 180-200gr were used. They were divided into two groups as experimental and control groups each comprising 6 female animals. 2mg/kg/day cadmium chloride dissolved in 1ml isotonic solution were intravenously injected from tail vein of experimental rats during 17-21 days of pregnancy. At first day of birth, the total body weights of control and experimental newborn pups were taken. This study aims to evaluate morphologically the effects of cadmium chloride on the incisive teeth development of pups born to the cadmium-applied female rats during pregnancy.
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    Immunoexpression of vascular endothelial growth factor, ?-cell lymphoma 2 and cluster of differentiation 68 in cerebellar tissue of rats treated with Ganoderma lucidum
    (Universidad de la Frontera, 2018) Özevren, Hüseyin; İrtegün, Sevgi; Ekingen, Arzu; Tuncer, Cudi Mehmet; Özkorkmaz, Ebru Gökalp; Deveci, Engin; Deveci, Şenay
    Traumatic brain injury (TBI) can potentially lead to hemorrhages in all areas of the skull, which can damage cells andnerve connections. This study aims to investigate the protective effects of Ganoderma lucidum polysaccharides (GLPS) as a antioxidant oncerebellar cell tissues after traumatic brain injury in rats. Sprague Dawley rats were subjected to TBI with a weight-drop device using 300 g-1m weight-height impact. The groups are consisted of control, trauma, and trauma+Ganoderma lucidum groups. At seven days post-braininjury, experimental rats were decapitated after intraperitoneal administration of ketamine HCL (0.15 ml/100 g body weight). Cereballarsamples were taken for histological examination or determination of malondialdehyde (MDA) and glutathione (GSH) levels andmyeloperoxidase (MPO) activity. Significant improvement was observed in cells and vascular structures of Ganoderma lucidum treatedgroups when compared to untreated groups. It is believed that Ganoderma lucidum may have an effect on the progression of traumatic braininjury. Ganoderma lucidum application may affect angiogenetic development in blood vessel endothelial cells, decrease inflammatory cellaccumulation by affecting cytokine mechanism and may create apoptotic nerve cells and neuroprotective mechanism in glial cells
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    Neuroprotective effects of ganoderma lucidum on spinal cord injury
    (Universidad de la Frontera, 2018) Ekinci, Aysun; Özevren, Hüseyin; Bilgiç, Bülent Emre; Ekinci, Cenap; Deveci, Şenay; Deveci, Engin
    Traumatic injury to the spinal cord results in the delayed dysfunction and neuronal death. Impaired mitochondrial function, generation of reactive oxygen species (ROS), and lipid peroxidation occur soon after traumatic spinal cord injury (SCI), while the activation of compensatory molecules that neutralize ROS occurs at later time points. The aim of the current study was to investigate the putative neuroprotective effect of Ganoderma lucidum in a rat model of SCI. In order to induce SCI, a standard weight-drop method that induced a moderately severe injury (100 g/cm force) at T10, was used. Injured animals were given either 20 mL/kg Ganoderma lucidum or saline 30 min post injury per day by gastric gavage. At seven days postinjury, rats were decapitated. Spinal cord samples were taken for histological examination or determination of malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity. SCI caused a significant decrease in spinal cord GSH content, which was accompanied with significant increases in MDA levels, MPO activity. On the other hand, Ganoderma lucidum treatment reversed all these biochemical parameters as well as SCI-induced histopathological alterations. Furthermore, impairment of the neurological functions due to SCI was improved by meloxicam treatment. The present study suggests that Ganoderma Lucidum, reduces SCI-induced oxidative stress and exerts neuroprotection by inhibiting lipid peroxidation, GSH depletion.