Yazar "Denli O." seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • [ X ]
    Öğe
    Effect of oral pyridoxine hydrochloride supplementation on in vitro platelet sensitivity to different agonists
    (1995) Sermet A.; Aybak M.; Ulak G.; Guzel C.; Denli O.
    Effect of vitamin B6 (pyridoxine-HCl, CAS 58-56-0) on platelet aggregation, plasma lipids and serum zinc level was investigated. The trial comprised 24 healthy male volunteers, aged between 19-24 years. The subjects were randomized in two groups of 12 and treated for 4 weeks by a single daily oral dose of 5 mg/kg vitamin B6 or placebo. Pyridoxine inhibited ADP- or epinephrine-induced aggregation by 48% and 41% (p < 0.001), respectively, whereas there was no change in control group. No significant effect on either, bleeding time, coagulation time or on platelet count was demonstrated in subjects given placebo. Pyridoxine prolonged both bleeding and coagulation time but not over the physiological limits. It had no effect on platelet count. These observations strongly suggest that vitamin B6, with no effect on platelet count, not only inhibits platelet aggregation but also prelongs clotting time. Pyridoxine significantly reduced total plasma lipid and cholesterol levels, whereas it enhanced HDL-cholesterol level. Serum zinc level was also significantly increased by pyridoxine (p < 0.001). These findings suggest that oral vitamin B6 inhibits platelet aggregation in normal subjects.
  • [ X ]
    Öğe
    The effects of octreotide on gastric lesions and gastric mucosal barrier in rats which applied stress
    (1999) Guzel C.; Kanay Z.; Onen A.; Kurt D.; Denli O.; Canoruc F.
    The aim of this research was to investigate the effects of octreatide on gastric lesions and mucosal barrier in rats exposed cold +immobilisation stress. Twenty four Swiss Albino rats (approx 150-200 g) were used for this study. Feeds were witheld from to rats for 24 hours, after which they were divided in to three groups. Each group consisted of seven rats; I (n=7) non/stress-induced control group, 2 (n=7): cold and immobilisation stress was induced, 3 (n=7): 100 ?g/kg octreatide was administered subcutaneously one hour prior to stress induction. The rats were then killed and their stomachs examined for ulcerative lesions and ulcer indexes considered. The amounts of mucus and phospholipid, important components of the gastric mucosal barrier, were then rated using Corn and Baur methods and were found to be significantly decreased (p<0.05, p>0.05) in rats exposed to stress. In the third group given sandostatin, it was found that gastric lesions had been prevented. Moreover, mucus and phospholipid levels were higher in this group than the stress exposed control group. (p<0.05, p<0.05 respectively). According to our findings, octreatide is effective in preventing acute hemorrhagic gastric lesions caused by stress and in maintaining gastric mucosal barrier parameters.
  • [ X ]
    Öğe
    An Investigation of the Copper (Cu), Zinc (Zn) and Selenium (Se) Levels of Blood Serum and the Cu and Zn Levels of Wool of Akkaraman Ewes in the Diyarbakir Region
    (2001) Kurt D.; Denli O.; Kanay Z.; Güzel C.; Ceylan K.
    The aim of this study is to determine the copper, zinc and selenium levels of blood serum and the Cu and Zn levels of wool of healthy Akkaraman ewes grazed in the meadows in the Diyarbakir region. A total of 60 units of blood and wool samples from various villages in different counties of Diyarbakir (Bismil, Çinar, Ergani, Silvan, Kocaköy and some Diyarbakir villages) were studied. The Cu, Zn and Se levels of sera and the Cu and Zn levels of wool were analyzed by flameless atomic absorption spectrophotometer. We found significant differences in Cu and Se levels of sera, in Cu levels of wool (p<0.01) and in Zn levels of wool (p<0.05) in ewes from various counties, whereas no significant differences were observed in Zn levels of sera (p>0.05). Although there were considerable differences from county to county, the avarage values of these counties and herds that indicated the lowest values in respect to Cu and Zn contents were found to be either simillar to or just over the normal values. However, in the case of the selenium content, the average serum Se level of the Akkaraman ewes from various counties of Diyarbakir, except the central county, was found to be remarkably lower than the normal values. In the light of these findings, the rations of animals grazing in meadows are recommended to be reinforced with Se content.
  • [ X ]
    Öğe
    Protective effect of fish oil against stress-induced gastric injury in rats
    (1995) Ulak G.; Cicek B.; Sermet A.; Guzel C.; Ulak M.; Denli O.
    The effect of fish oil and olive oil on the gastric mucosal damage induced by cold-restraint stress was investigated in rats. The oils were dietary supplemented for 3 weeks. The results demonstrate that a diet containing fish oil, when ingested for 3 weeks before exposure to stress, protected from gastric ulceration significantly (p < 0.01) and led to a statistically significant increase both in mucus and phospholipid content of the gastric mucosal barrier (p < 0.02 and p < 0.001, resp.) in cold-restraint stress-induced gastric injury in rats. However, further studies are required to determine the role of dietary fish oils in the prophylaxis and treatment of peptic ulcer.