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    Assessment of Technetium-99m Labeled Macroaggregated Albumin Rhinoscintigraphy for the Measurement of Nasal Mucociliary Transport Rate: Intratest, Interobserver, and Intraobserver Reproducibility
    (Hindawi Ltd, 2014) Dostbil, Zeki; Dag, Yusuf; Cetinkaya, Ozlem; Akdag, Mehmet; Tasdemir, Bekir
    Objectives. The measurement of mucociliary transport velocity by rhinoscintigraphy with Tc-99m-macroaggregated albumin (Tc-99m-MAA) is reliable measure of mucociliary clearance. The aim of this study is to assess the intratest, interobserver, and intraobserver reproducibility of nasal mucociliary transport rate (NMTR) measurement. Materials and Methods. Twenty-two subjects were evaluated to determine intratest reproducibility and a group of 35 subjects was examined to determine inter and intraobserver reproducibility. Rhinoscintigraphy with Tc-99m-MAA was used to measure NMTR in all study subjects. Paired NMTR measurements were compared using a range of statistical methodologies. Intraclass correlation coefficients (ICC) and repeatability coefficients and Bland-Altman plots were applied to assess the degree of intratest, interobserver, and intraobserver variation. Results. Statistical analysis of test and retest experiments demonstrated the statistical equivalence of intratest NMTR measurements, interobserver NMTR measurements, and intraobserver NMTR measurements. The intratest ICC, interobserver ICC, and intraobserver ICC were 0.96, 0.83, and 0.91, respectively, indicating that intratest and intraobserver reproducibility are excellent and interobserver reproducibility is good. Conclusions. Rhinoscintigraphy using Tc-99m-MAAresults in highly reproducible measurement of NMTR. The use of radionuclide imaging in measuring NMTR results in excellent intratest and intraobserver reproducibility and good interobserver reliability.
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    Öğe
    Effect of cigarette smoking on nasal mucociliary transport rate: Rhinoscintigraphic evaluation with using 99mTc-macroaggregated albumin
    (Drunpp-Sarajevo, 2012) Dostbil, Zeki; Dag, Yusuf; Abakay, Abdurrahman; Bakir, Salih; Sezgi, Cengizhan; Abakay, Ozlem; Sen, Hadice
    Objectives: Cigarette smoking has harmful effects on mucociliary transport (MCT) in respiratory system. We aimed to investigate the association between nasal mucociliary transport rate (NMTR) and duration and amount of smoking in chronic cigarette smokers. Materials and Methods: Fifty four current cigarette smokers and 40 healthy non-smokers were included in this study. In all cases, we measured the NMTR using Tc-99m-macroaggregated albumin (Tc-99m-MAA) rhinoscintigraphy. Results: The mean NMTR of the smokers was lower than that of the healthy non-smoker controls (5.63 +/- 2.78; 9.44 +/- 2.09, respectively) (p<0.0001). There were not statistically significant correlation between NMTRs and year of smoking, and smoking pack-year in smokers (p>0.05; r=0.003, r=-0.2, respectively) whereas there was a statistically significant correlation between NMTRs and cigarettes per day in smokers (p=0.024; r=-0.307). Conclusions: Our findings demonstrated that cigarette smoking decreases the nasal NMTR in chronic term. Impaired mucociliary transport in respiratory system may have harmful effects on the human health. The degree of impairment in NMTRs in smokers may increase as the number of cigarettes per day increases.