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Öğe Biomechanical and biochemical evaluation of the effect of systemic application of omeprazole on the osseointegration of titanium implants(Springer, 2021) Tekin, Samet; Dündar, Serkan; Demirci, Fatih; Bozoğlan, Alihan; Yıldırım, Tuba Talo; Güneş, Nedim; Acıkan, Izzet; Özcan, Erhan CahitBackground This study aimed to investigate the effects of systemic omeprazole treatment on the osseointegration of titanium implants. Material and methods After surgical insertion of titanium implants into the metaphyseal part of rats' both right and left tibial bones, the animals were randomly divided into three equal groups: control (n = 8), omeprazole dosage-1 (n = 8) (OME-1), and omeprazole dosage-2 (n = 8) (OME-2) and totally 48 implants were surgically integrated. The rats in the control group received no treatment during the four-week postoperative experimental period. In the OME-1 and OME-2 groups, the rats received omeprazole in doses of 5 and 10 mg/kg, respectively, every 3 days for 4 weeks. After the experimental period, the rats were euthanized. One rat died in each group and the study was completed with seven rats in each group. Blood serum was collected for biochemical analysis, and the implants and surrounding bone tissue were used for biomechanical reverse-torque analysis. In the biomechanical analysis, implants that were not properly placed and were not osseointegrated were excluded from the evaluation. Results One-way analysis of variance and Tukey's honestly significant difference test and Student's t test were used for statistical analysis. The reverse-torque test (control (n = 9), OME-1 (N = 7), and OME-2 (n = 7)) analysis of biochemical parameters (alkaline phosphatase, calcium, phosphorus, aspartate aminotransferase, alanine amino transferase, urea, and creatinine) revealed no significant differences between the groups (control (n = 7), OME-1 (N = 7), and OME-2 (n = 7)) (P > 0.05). Conclusions Omeprazole had no biomechanical or biochemical effects on the osseointegration process of titanium implants.Öğe The biomechanical investigation of osseointegration levels in titanium implants simultaniously placed with different bone grafts(Wolters Kluwer Medknow Publications, 2024) Güler, Rıdvan; Dündar, Serkan; Bozoǧlan, Alihan; Özcan, Erhan Cahit; Özüpek, Muhammet Fatih; Acıkan, İzzet; Güneş, NedimBackground:Dental implant-supported prostheses have been scientifically accepted and have been a common treatment choice in the case reconstructing of partial or total tooth loss. In additon, bone grafts (alloplast, xsenograft, allograft) are frequently used in implant and sinus lift surgical procedures. Aim:The aim of this study is to investigate the bone-implant osseointegration levels of titanium implants simultaniously placed with different bone grafts. Materials and Methods:In the study, 32 female S. Dawley rats were divided into four groups. In the control group (n = 8), turned surface implants with a 2.5 mm diameter and a 4 mm length were placed in the tibia of the rats without the use of a graft material. In the experimental groups, bone cavities were opened in the tibias of the rats and a synthetic (alloplast) graft (n = 8), human allograft (n = 8), and bovine xsenograft (n = 8) were placed simultaniously with a 2.5 mm diameter and a 4 mm length turned surface titanium implants. The cavities in the experimental groups were opened with a 4 mm diameter and a 5 mm length. After 8 weeks of recovery, all rats were sacrificed at the end of the experimental period. The implants and surrounding bone tissue were removed. The removed tissue was subjected to biomechanical analysis in order to evaluate bone-implant osseointegration and peri-implant new bone formation. The Kolmogorov-Smirnov test, Kruskal-Wallis test, and Mann-Whitney U-test were used in the study. Significance was evaluated at the P < 0.05 level. Results:In the biomechanical analyses, it was determined that there was no statistically significant difference between the control group and the other three groups in which different graft materials were applied in terms of bone-implant osseointegration (P > 0.05). In other words, in the biomechanical analyses, no statistical difference was found between any of the groups. Conclusions:As a result of this study, it can be thought that different graft materials can be successfully used in peri-implant-guided bone regeneration and may be an alternative to autogenous grafts.Öğe Effects of local application of bovine amniotic fluid on fracture healing in rats (Rattus norvegicus)(Universidad del Zulia, Facultad de Ciencias Veterinarias, 2024) Tanrısever, Murat; İstek, Özmen; Eröksüz, Hatice; Karabulut, Burak; Özcan, Erhan Cahit; Bingül, Bahattin; Güler, Rıdvan; Dündar, SerkanIn this study, it was aim to examine the local application of bovine amniotic fluid on bone fracture healing in rats. Twenty female Sprague dawley rats included in the study were divided into 2 groups of 10. The sham group (n=10): Bone fractures were created in the right tibia bones of the rats and fixed with kirschner wire. After a four–week recovery period, the subjects were sacrificed. Local bovine amniotic fluid group (n=10): Bone fractures were created in the right tibia bones of the rats and local bovine amniotic fuid was applied during fixation with kirschner wire. After a four–week recovery period, the subjects were sacrificed. Samples from all subjects were decalcified, stained with hematoxylin and eosin, and new bone formation and fibrosis were analyzed. When the groups were evaluated in terms of new bone regeneration, it was determined that the new bone regeneration in the subjects treated with local bovine amniotic fluid were statistically significantly higher than sham group (P<0.05). When the groups were evaluated in terms of fibrosis, the fibrosis value in the sham group was found to be statistically significantly higher when compared with the local bovine amniotic fluid group (P<0.05). It can be stated that local bovine amniotic fluid application may positively affect the healing of bone fractures.Öğe Effects of local application of the ankaferd blood stopper on osseointegration in three different surface titanium implants(Elsevier B.V., 2021) Özcan, Erhan Cahit; Gül, Mehmet; Dündar, Serkan; Bozoğlan, Alihan; Karasu, Necmettin; Bal, Ali; Güneş, Nedim; Bingül, Muhammet BahattinAbstract Objective Researchs of the effects of ankaferd blood stopper (ABS) on bone healing metabolism have revealed that it affects bone regeneration positively. The exact mechanism by which this positive effect on bone tissue metabolism is not known. The aim of this study is to biomechanic and biochemical analysis of the effects of the local ABS application on osseointegration of 3 different surfaced titanium implants. Material & Methods Spraque dawley rats were divided machined surfaced (MS) (n = 10), sandblasted and large acid grid (SLA) (n = 10) and resorbable blast material (RBM) (n = 10) surfaced implants. ABS applied locally during the surgical application of the titanium implant before insertion in bone sockets. After 4 weeks experimental period the rats sacrificed and implants with surrounding bone tissues were removed to reverse torque analysis (Newton), blood samples collected to biochemical analysis (ALP, calcium, P) Results Biomechanic bone implant contact ratio detected higher in SLA surfaced implants compared with the RBM and controls (P < 0,05). Phosphor levels detected lower in RBM implant group compared with the controls and SLA (P < 0,05). Additionally; phosphor levels detected highly in controls compared with the RBM implants. Conclusion According the biomechanical parameters ABS may be more effective in SLA and RBM surfaced implants when locally applied.Öğe Evaluation of stress distributions in peri-implant and periodontal bone tissues in 3- and 5-unit tooth and implant-supported fixed zirconia restorations by finite elements analysis(Dental Investigations Society, 2015) Güven, Sedat; Beydemir, Köksal; Dündar, Serkan; Eratilla, VeyselObjective: In this study, it is aimed to compare the distribution of stress on periodontal and peri-implant bone tissues in 3- and 5-unit-dental and implant-supported zirconia restorations using finite element analysis. Materials and Methods: Stress distribution formed in periodontal and peri-implant bone tissues as a result of chewing forces was analyzed in dental and implant-supported three-dimensional (3D) finite element models of zirconia restoration with 5-unit placed on the numbers of 43, 44, 45, 46, and 47 and with 3-unit placed on the number of 45, 46, and 47. Four different loading conditions were used. 200 N force was applied in 30° from the buccal inclination of number 43, 45, and 47 restorations separately and totally 850 N force was applied in 30° from the buccal inclination of whole restoration. The study was performed through static nonlinear analysis with the 3D finite element analysis method. Results: Stress accumulation in bone tissues in the tooth-supported model was found less than in implant-supported models. Stress accumulation was observed in the cervical portion of the implant in implant-supported models, and stress accumulation was observed surrounding bone of roots in tooth-supported models. The highest stress values were occurred in 5 unit implant-supported model in all loadings. Conclusion: In posterior restorations increased in the number of supported teeth and implant can reduce the destructive forces on periodontal and peri-implant bone tissues and may allow longer period retention of the restorations in the mouth.Öğe The evalution of stress distributions in 3 and 5 unit dental and implant supported fixed zirconia restorations: finite element analysis(Sivas Cumhuriyet Üniversitesi, 2015) Güven, Sedat; Eratilla, Veysel; Beydemir, Köksal; Dündar, SerkanPurpose: In this study, it is aimed to compare the distribution of stress on teeth and implants in 3-and-5-unit-dental and implant supported zirconia restorations by using finite element analysis. Material and Method: Stress distribution formed in teeth and implants as a result of chewing forces was analyzed in dental and implant (Astra Tech Microthread Osseo Speed, Sweeden) supported models of zirconia restoration with 5-unit placed on the numbers of 43, 44, 45, 46 and 47 and with 3-unit placed on the number of 45, 46 and 47. The study was performed through static nonlinear analysis with the three-dimensional finite element analysis method. Results: The highest and the lowest stress were respectively found on the number of 45 and 47 in 3-unit tooth supported model. The highest and the lowest stress in 5-unit tooth supported model were respectively found on the tooth of number 45 and on the root apex of the implant of number 43. Stress accumulation was observed in the cervical portion of the implant in implantsupported models. Stress accumulation in the tooth-supported model was found less than in implant-supported modelsConclusion: The extreme forces on the dental and implant-supported restorations with increased units can reduce survival rate of restorations in mouth. In posterior restorations increased in the number of supported teeth and implant can reduce the destructive forces on teeth and implant and may allow longer period retention of the restorations in the mouth.Öğe The histopathological evaluation of effects of application of the bovine amniotic fluid with graft on peri-implant bone regeneration(Kafkas Universitesi Veteriner Fakultesi, 2023) İstek, Özmen; Tanrısever, Murat; Eröksüz, Hatice; Karabulut, Burak; Özcan, Erhan Cahit; Bingül, Muhammet Bahattin; Güler, Rıdvan; Dündar, SerkanThis study aimed to determine the effects of bovine amniotic fluid combined with bone graft in treating peri-implant bone defects with guided bone regeneration. Twenty female Sprague–Dawley rats were divided into two groups. Bone sockets with a diameter of 4 mm in the coronal part and a diameter of 2.5 mm in the apical part of the implant were created into the corticocancellous bone in the metaphyseal parts of the right tibia bones of all subjects. Implants with a length of 4 mm and a diameter of 2.5 mm were placed in the bone sockets. In the sham surgery group (n = 10) was the circumferential bone defect equivalent to half of the 4-mm implant length, which occurred between the implant and the bone, filled with bovine xenograft. Bovine xenografts were filled with amniotic fluid mixture in the experimental group (n = 10). After 8 weeks of recovery, all rats were sacrificed. The implants were extracted from the soft tissues and the surrounding bone. Subsequently, the bones were decalcified and prepared for histological analysis. The percentage of newly regenerated bone (NRB) formation and fibrosis in the bone defect area around the implant was calculated from all sections. NRB was found in 37.4±4.4% of controls and 41.4±2.63% of test animals (P<0.05 and P=0.024, respectively). Fibrosis formation was found at a rate of 38.6±5.06% in the control group and 33.2±5.38% in the test group (P<0.05 and P=0.033, respectively). It was considered that combining bovine amniotic fluid with bone transplant could be a useful way of treating bone abnormalities.Öğe The investigation of bone-implant connection and new bone formation in fasting and high-fatty diet rats(2024) Yavuz, M. C.; Güler, Rıdvan; Özcan, Erhan Cahit; Bozoğlan, Alihan; Kirtay, Mustafa; Kaya, C. A.; Dündar, SerkanBACKGROUND: Hyperlipidemia caused by a high-fat diet (HFD) has many adverse effects on the cardiovascular system, including vascular problems. In addition, a HFD also has significant adverse effects on bone health. AIM: The aim of this study is to examine bone-implant osteointegration and new bone formation in peri-implant defects in fasting and high-fatty diet applied rats. MATERIALS AND METHODS: In this study, 28 female Sprague Dawley rats were used. The rats were divided into four groups, with seven rats in each group: the control group on a normal diet (Group 1) (n = 7), the fasted group (Group 2) (n = 7), the high-fatty diet (HFD) group (Group 3) (n = 7), and the fasted and HFD group (Group 4) (n = 7). Titanium implants with a diameter of 2.5 mm and a length of 4 mm were placed in the right tibia bones of the subjects, and a bone graft corresponding to 2 mm of the implant length was placed in the bone defect applied to the neck region. All rats that continued the administered diet for 12 weeks were sacrificed at the end of the experiment period. The implants and surrounding bone tissue were surgically removed and subjected to biomechanical analysis to assess bone-implant osteointegration and peri-implant new bone formation. RESULTS: It was determined that there was no statistically significant difference between the rats in the control group and the other three groups in terms of bone-implant osteointegration and peri-implant new bone formation (P > 0.05). CONCLUSION: As a result of this study, it was determined that fasting or maintaining a HFD does not adversely affect bone-implant osteointegration or peri-implant new bone formation in the tibias of rats.Öğe Investigation of the effects of quercetin and xenograft on the healing of bone defects: An experimental study(Elsevier B.V., 2023) Durmaz, Bekir; Güneş, Nedim; Koparal, Mahmut; Gül, Mehmet; Dündar, Serkan; Bingül, Muhammet BahattinObjective: In this study, it was aimed to histologic and immunohistochemical examined that the effects of quercetin on new bone formation and bone regeneration in critical size rat tibial bone defects. Material & methods: In the study, 56 rats were divided into 4 groups with 14 rats in each group. Control (C) (n = 14): A defect was created in the corticocancellous bone in the metaphyseal part of the tibia bones of the rats and no additional procedure was applied until the end of the experimental setup. Xenograft (X) group (n = 14): Bone defects were created in the tibia bones of the rats and the defects were filled with xenograft. No additional process was applied until the end of the experimental setup. Quercetin (Q) group (n = 14): A defect was created in the tibia bones of the rats and 0.1 mg/kg quercetin was administered by oral gavage until the end of the experimental setup dailly. Quercetin and Xenograft (Q + X) group (n = 14): A defect was created in the corticocancellous bone in the metaphyseal part of the tibia bones of the rats and the defect was filled with xenograft. Until the end of the experimental setup, 0.1 mg/kg quercetin was administered by oral gavage dailly. Rats were sacrificed after 4. and 8 week and tibial bone collected for histomorphometic analysis. Results: It was observed that the parameters related to bone healing were higher in the quercetin administered groups compared to the controls (P < 0,05). Conclusion: Quercetin given by oral gavage may increase bone healing.Öğe Lokal ve Sistemik Borik Asit Uygulamasının Titanyum ?mplantların Osseointegrasyon Düzeylerine Etkileri(2022) Güneş, Nedim; Dündar, Serkan; Bozoğlan, AlihanAmaç: Bu çalışmada, sıçan tibialarında titanyum implantların osseointegrasyonuna lokal ve sistemik borik asit (BA) uygulamasının etkilerini araştırmayı amaçladık. Gereç ve Yöntem: Titanyum implantlar, 32 sıçandan oluşan bir numune grubunun sağ tibia kemiğine cerrahi olarak entegre edildi. Sıçanlar dört tedavi grubuna ayrıldı: kontroller (CNT) (n=8), lokal BA (LBA) (n=8), sistemik BA (SBA) (n=8) ve sistemik ve lokal BA (SLBA) ( n=8). Kontroller, implant cerrahisinden sonra herhangi bir uygulama görmedi. LBA grubunda implant soketlerine lokal BA uygulandı, ardından implantlar soketlere yerleştirildi. SBA grubuna periton içi 8 mg/kg BA uygulandı. SLBA grubunda implant soketlerine lokal BA uygulandı, ardından implantlar soketlere yerleştirildi; ardından günde 8 mg/kg BA periton içi uygulandı. Deney periyodu 28 gün sürmüş, bundan sonra hayvanlara ötenazi uygulanmış ve implantlar çevredeki kemik dokusu ile birlite alınmıştır. Bulgular: Dekalsifiye olmayan histolojik yöntem kullanılarak kemik-implant kaynaşması (KİK) oranları (%) incelendi. SLBA ve SBA gruplarında KİK oranları, kontroller ve LBA grubu ile karşılaştırıldığında yüksekti (p<0.05) (p=0.004 p=0.002 p=0.011 p=0.013). SLBA grubunda KİK oranı SBA grubuna göre nümerik düzeyde olsa da istatistiksel düzeyde fark oluşturmadı (p>0.05 p=0.38). Sonuç: Bu çalışmanın sınırlamaları dahilinde, lokal uygulama ile sistemik ve sadece sistemik BA uygulamasının titanyum implantların osseointegrasyonunu artırabileceği sonucuna varılabilir.Öğe Lokal ve sistemik borik asit uygulamasının titanyum implantların osseointegrasyon düzeylerine etkileri(Fırat Üniversitesi, 2022) Güneş, Nedim; Bozoğlan, Alihan; Dündar, SerkanAmaç: Bu çalışmada, sıçan tibialarında titanyum implantların osseointegrasyonuna lokal ve sistemik borik asit (BA) uygulamasının etkilerini araştırmayı amaçladık. Gereç ve Yöntem: Titanyum implantlar, 32 sıçandan oluşan bir numune grubunun sağ tibia kemiğine cerrahi olarak entegre edildi. Sıçanlar dört tedavi grubuna ayrıldı: kontroller (CNT) (n=8), lokal BA (LBA) (n=8), sistemik BA (SBA) (n=8) ve sistemik ve lokal BA (SLBA) ( n=8). Kontroller, implant cerrahisinden sonra herhangi bir uygulama görmedi. LBA grubunda implant soketlerine lokal BA uygulandı, ardından implantlar soketlere yerleştirildi. SBA grubuna periton içi 8 mg/kg BA uygulandı. SLBA grubunda implant soketlerine lokal BA uygulandı, ardından implantlar soketlere yerleştirildi; ardından günde 8 mg/kg BA periton içi uygulandı. Deney periyodu 28 gün sürmüş, bundan sonra hayvanlara ötenazi uygulanmış ve implantlar çevredeki kemik dokusu ile birlite alınmıştır. Bulgular: Dekalsifiye olmayan histolojik yöntem kullanılarak kemik-implant kaynaşması (KİK) oranları (%) incelendi. SLBA ve SBA gruplarında KİK oranları, kontroller ve LBA grubu ile karşılaştırıldığında yüksekti (p<0.05) (p=0.004 p=0.002 p=0.011 p=0.013). SLBA grubunda KİK oranı SBA grubuna göre nümerik düzeyde olsa da istatistiksel düzeyde fark oluşturmadı (p>0.05 p=0.38). Sonuç: Bu çalışmanın sınırlamaları dahilinde, lokal uygulama ile sistemik ve sadece sistemik BA uygulamasının titanyum implantların osseointegrasyonunu artırabileceği sonucuna varılabilir.Öğe A retrospective evaluation of bifid mandibular canal prevalence of Southeastern Anatolia population by cone-beam computed tomography(Sivas Cumhuriyet Üniversitesi, 2022) Güneş, Nedim; Güler, Rıdvan; Ağın, Hatice Demircan; Dündar, Serkan; Eratilla, VeyselIntroduction: Bifid mandibular canal (BMC) is often detected incidentally on radiological examination and can be observed in unilateral or bilateral forms. The correct localization of the BMC plays an important role in the prevention of complications such as paresthesia, anesthesia, bleeding, traumatic neuroma, which may occur during or after surgical operations on the mandible such as sagittal split ramus osteotomy, impacted third molar tooth extraction, and dental implant surgery. Objective: This study aims to retrospectively evaluate the prevalence of bifid mandibular canal (BMC) in the Southeastern Anatolian population via Conical Beam Computed Tomography (CBCT). Material and Method: In this retrospective study, CBCT images of 615 patients, who applied to the Department of Oral and Maxillofacial Surgery in the Faculty of Dentistry at Dicle University, Turkey, for various reasons from 2015 to 2020, is evaluated and cases with bifid mandibular canals are examined. The prevalence evaluation is conducted by statistical analyses in terms of sex and laterality. Results: According to the analyses, the BMC prevalence did not constitute a significant difference in terms of the age variable (p>0.05). The incidence of unilateral BMC was higher than bilateral BMC (p<0.05; p=0.016). Additionally, the prevalence of BMC was higher in males compared to females (p<0.05; p=0.008). Conclusion: BMC, which can be detected more easily and frequently via CBCT technology, is an anatomical formation that should be taken into account during oral and maxillofacial practices.
