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    Editorial: Acute leukemias: molecular characterization, leukemia-initiating cells, and influence of the microenvironment, volume II
    (Frontiers, 06.01.2025) Varışli, Lokman; Dancik, Garrett M.; Copland, John A.; Vlahopoulos, Spiros A.
    Acute leukemia is a wide group of hematologic malignancies that arise from leukemiainitiating cells (LICs), also known as leukemic stem cells (LSCs), which originate from transformed hematopoietic stem cells (HSCs) in the bone marrow. Leukemic cells accumulate various genetic and epigenetic defects, both inherited from the LICs they originate from and acquired later. Genetic defects in leukemic cells determine their biological behavior and, as expected, affect the prognosis of the disease and its response to treatment. Therefore, molecular characterization of the disease is important for all stages of the disease, such as predicting prognosis, determining the treatment approach, and evaluating the possibility of recurrence. In this context, a better understanding of the molecular mechanisms of acute leukemia will enable the emergence of simpler and more effective treatment approaches and increase the rate of treated patients.