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    Effect of fish oil on indometacin-induced gastric lesions in rats
    (1995) Guzel C.; Ulak G.; Sermet A.; Cicek R.; Ulak M.
    The effect of fish oil in promoting the healing of indometacin-induced gastric lesions was investigated in Wistar albino rats. After indometacin treatment (30 mg/kg, s.c.), animals were given fish oil, olive oil, or normal diet for 48 h. The ulcer index was found to be decreased to 2.1 ± 1.8 mm with fish oil, 13.7 ± 5.4 mm with olive oil, and 14.6 ± 2.4 mm with normal diet. Fish oil showed a potent healing-promoting effect on acute gastric erosions and ulcers induced by indometacin and significantly enhanced the mucus content of the mucosa (p < 0.05).
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    Influence of zinc on imipenem susceptibility of Pseudomonas aeruginosa
    (1996) Atmaca S.; Gul K.; Ulak G.; Cicek R.; Atmaca M.
    The influence of zinc on imipenem susceptibility of Pseudomonas aeruginosa was investigated. In this study, two different amounts of zinc containing media were used, the first of which was Oxoid MHA containing 0.45 ?g/ml zinc, and the second Oxoid MHA supplemented with zinc-acetate, 64 times as much zinc as the first media. The percentage of P. aeruginosa isolates resistant to imipenem significantly increased (P < 0.001) in zinc-supplemented media, whereas the activity of ceftazidime against P. aeruginosa isolates was similar in both media.
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    Nitrendipine and stress-induced ulcers: Preliminary tudy
    (1997) Inalöz S.; Ozaydin M.; Sari I.; Cicek R.; Guney B.; Yenice N.
    Nitrendipine is a derivative of the dihydropyridine of calcium channel blockers and released for angina and hypertension. The therapeutic effect of nitrendipine was observed histologically against stress-induced gastric and duodenal ulcers in rats. Twenty-four male Wistar-albino rats were separated into three groups (n = 8), a control (non-stress) and two stress groups. The stressed group rats were exposed to starvation and cold-restraint in this study. The first stress group was given only a placebo whereas the second stress group was treated with nitrendipine. After treatment with nitrendipine, the total rea of the affected lesional mucosa was considerably reduced in both duodenal and gastric mucosa. Macroscopically, the surface area of the affected lesional mucosa was measured as 1/5 of the total duodenal mucosa. Moreover, the surface area of the affected lesional mucosa was measured as 1/8 of the total surface area in the stomach. In microscopic examination, tissue regeneration was conspicuous particularly in the gastric epithelium. A few hyperchromatic epithelial cells were noticed in some fields of the duodenal mucosa. Furthermore, tissue regeneration was not conspicuous as in the gastric mucosa. So we think that nitrendipine can be used in both gastric and duodenal stress ulcer treatment. However, in the healing process, therapeutic effect of nitrendipine was superior in stomach with conspicuous tissue regeneration.
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    Preventive action of omeprazole, famotidine or nitrendipine against stress ulcer formation in rats
    (1994) Canoruc N.; Ulak G.; Guzel C.; Kaya H.; Cicek R.
    The effects of H+/K+-ATP ase inhibitor, omeprazole, the H2-receptor antagonist, famotodine, and the calcium channel antagonist, nitrendipine, on gastric ulcers, gastric mucosal barrier and gastrin release were investigated in cold-restraint stress-induced rats. Omeprazole (30 mg/kg i.g.) famotidine (1 mg/kg, i.g.) and nitrendipine (16 mg/kg, i.p.) significantly prevented gastric ulceration. Nitrendipine reduced the mucus secretion and exhibited no important change in phospholipid content; thus, it failed to restore the damage in the gastric mucosal barrier due to cold-restraint stress. Omeprazole increased mucus secretion and phospholipid content of gastric mucosal barrier whereas famotidine tended to cause an increase in mucus and phospholipid levels; however, this difference did not attain statistical significance. Serum gastrin levels revealed lower values in the nitrendipine group as compared with controls; whereas it increased in omeprazole and famotidine groups, but more significantly in the omeprazole treated group.