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Öğe ASSOCIATION OF DEMODICOSIS WITH ACNE ROSACEA(Professional Medical Publications, 2010) Cengiz, Tas Z.; Yilmaz, Hasan; Akdeniz, Necmettin; Cicek, Mutalip; Ozkol, Halil; Calka, OemerObjectives: Demodex spp of humans are encountered frequently all over the world. The role of these parasites is controversial in the causation of skin diseases. This study was carried out to determine the prevalence and the association of Demodex spp with acne rosacea. Methodology: The study was conducted between the years of 2005-2008 in the output clinic of Dermatology and Parasitology Laboratory of Health Research and Training Hospital of Yuzuncu Yil University. One hundred two patients (patient group) composing of 59 females and 43 males with acne rosacea and randomly selected 50 healthy subjects (control group) were examined for Demodex spp. Twenty seven patients were under the age of 35, and 75 patients were aging 35 years old and over. Samples were plucked out from surface of nose and forehead of patients with acne rosacea and healthy subjects by standardized surface skin biopsy (SSSB) method in the Laboratory. The preparations prepared in Hoyer solution were examined under 4X and 10X objectives of light microscope. Results: The detected parasites were higher in the patient group with acne rosacea (67.65%) than the control group (6%), in females (76.27%) than males (55.81%) and in patients aging 35 years old and over (74.67%) than the patients under 35 years of age (48.15%). Significant relationships were detected between acne rosacea and demodicosis, sex and demodicosis, and age and demodicosis (p<0.001, p<0.05 and p<0.05, respectively). Conclusion: It was concluded that there is a relationship between the demodicosis and acne rosacea, and dermatologists should take into consideration the Demodex spp. in the etiology of acne rosacea.Öğe Determination the Subtypes of Blastocystis sp. and Evaluate the Effect of These Subtypes on Pathogenicity(Springer International Publishing Ag, 2019) Cakir, Fatih; Cicek, Mutalip; Yildirim, Ibrahim HalilPurposeThe present study aimed to determine the frequency of subtypes of Blastocystis sp. in the immunosuppressed individuals, in patients with chronic urticaria, and in patients with GIS complaints to investigate the difference of Blastocystis sp. subtype distribution between patient and control groups.MethodsA total of 345 stool samples were collected from the patients and samples were studied by native-Lugol, trichrome staining, and Jones medium culture method. Positively detected samples were subjected to PCR to determine the subtypes. ResultsThis is the first study of nine subtypes of Blastocystis sp. investigated in our country and the most frequently found subtype was ST3, and then, the other subtypes were ST1, ST2, ST5, and ST6, respectively. Mix subtype was detected in the 11.6% and no subtype was detected in the 17.4% of the samples. The ST5 was detected first time in the control group and ST6, which is reported limitedly in our country, was found in patients with GIS complaints. ST1 and ST2 were found higher in the patient group.ConclusionThis study confirmed that the subtype (ST) differences are an important factor affecting the pathogenesis of Blastocystis sp.Öğe Evaluation of demographic, clinic and treatment features of patients and a cross-sectional survey of cyclosporiasis in patients with diarrhea in Southeastern Turkey(Academic Journals, 2012) Cicek, Mutalip; Palanci, Yilmaz; Ceylan, Ali; Ozekinci, Tuncer; Kaya, MuhsinIn this research, we aimed at reporting the results of a cross-sectional epidemiological scanning performed on an outbreak of cyclosporiasis, occurring in a family and patients' socio-demographic epidemiological, clinical, diagnostic and therapeutic features, after detecting Cyclospora oocysts on stool sample of a person admitted to gastroenterology polyclinic. Scanning was performed in the neighborhood of the patient. The investigation group consisted of 75 individuals with diarrheal occurring from neighbor and family of patients. A questionnaire was performed for information on epicrisis of diarrheal persons and the samples were collected in stool containers. The samples were examined with native-lugol, sedimentation and modified acid fast staining methods. The stools were cultured in Salmonella-Shigella agar medium to investigate their bacteriological properties. The different vegetables from the mobile market place (peddler) founded in the neighborhood and water samples from house were collected to detect the infection source. Parasitosis (single or mix parasite) were encountered in 20 out of 75 persons in the examined samples (26.6%) and C. oocysts were detected in 13 out of 75 persons (17.3%). Out of the total number of patients having cyclosporiasis, none has immunodeficiency and chronic diseases. All cases were determined in the month of July. Oocysts were detected in six different families. Bacteria were not cultivated in stool cultures and occult blood was negative. The agent was not encountered in green vegetables, though water samples were examined to detect infection resource. Examination of the samples for Cyclospora was not neglected in diarrhea individuals; as such an examination was performed for the source of transmission of the infection. Cyclospora may generate family infection in individuals and if detected in one individual of a family, all the family individuals were examined for this infection.Öğe Human infection with Dicrocoelium dendriticum in Turkey(K Faisal Spec Hosp Res Centre, 2010) Cengiz, Zeynep Tas; Yilmaz, Hasan; Dulger, Ahmet Cumhur; Cicek, MutalipHuman dicrocoeliosis is reported sporadically in various parts of the world. We report a case in a 21-year-old male, who had right upper abdominal pain, weight loss, and chronic relapsing watery diarrhea three to four times daily for four weeks. The patient had abdominal tenderness to palpation in the right upper quadrant. Alkaline phosphatase, alanine aminotransferase, and serum immunoglobulin E levels were slightly elevated; all other biochemical and hematological findings were in their normal ranges. The duodenal biopsy samples were normal and an abdominal ultrasonography showed no biliary or hepatic abnormality. Stool microscopy revealed numerous eggs of Dicrocoelium dendriticum. As pseudoparasitosis can result from eating raw, infected animal liver, the patient was given a liver-free diet for three days, to rule out that possibility. Subsequent stool examinations showed eggs in each of the samples indicating that the infection was genuine. The patient was treated with triclabendazole 10 mg/kg in a single dose. Four weeks later, no parasite eggs were detected in the microscopic examination of the stool samples. The patient got better gradually and the symptoms disappeared. Physicians should keep in mind parasitic diseases such as the rarely encountered dicrocoeliosis.Öğe Investigation of Some Sera Biomarker Levels in Fascioliasis Patient(Kafkas Univ, Veteriner Fakultesi Dergisi, 2012) Cicek, Mutalip; Evliyaoglu, Osman; Boyuk, Abdullah; Tekin, AlicemFasciola sp. that are generally known as liver trematode of sheep and cattle cause infections also in the human. In this study, we investigated in the sera of patients with fascioliasis how paraoxonase, total oxidant level, total antioxidant capacity, apolipoprotein A-I, apolipoprotein B, transferrin and nitric oxide levels are affected. For this purpose, 45 patients with fascioliasis and 38 healthy controls were enrolled in the study. Fascioliasis was diagnosed with ELISA IgG, stool examination and radiologic imaging. Number of females and males were determined as 34/11 and 30/8 in patient and control groups. Mean age was 38.1 +/- 11.7and 35.8 +/- 16.9 years in patient and control groups, respectively. A statistically significant difference was not detected between groups in terms of age, gender and body mass index (P>0.05). As the result of the study, paraoxonase (P<0.001), Apolipoprotein A-I (P<0.001), transferrin (P<0.001) and total antioxidant capacity (P<0.024) levels were found lower in patient group compared to control group and the difference was statistically significant (P<0.001). A difference was not detected between two groups in terms of apolipoprotein B levels. Lower paraoxonase, total antioxidant capacity, transferrin and Apolipoprotein A-I levels in patients with fascioliasis compared to controls and higher nitric oxide and total oxidant status may be guide for understanding pathogenesis and immunity of fascioliasis and for novel biomarkers that could aid for diagnosis.Öğe An investigation of the relationship between clinical features of amoebiasis and Entamoeba histolytica genotypes(Tubitak Scientific & Technological Research Council Turkey, 2012) Araz, Remzi Engin; Koru, Ozgur; Tanyuksel, Mehmet; Ozekinci, Tuncer; Ceylan, Ali; Guclu Kilbas, Hatice Zeynep; Cicek, MutalipAim: To determine the presence of Entamoeba histolytica/E. dispar and E. moshkovskii in stool samples, tRNA-based short tandem repeat gene polymorphism in E. histolytica isolates, and the relationship between amoeba load and clinical outcome in studies. Materials and methods: This study involved 840 stools samples of individuals having diarrhea/dysentery and individuals who were asymptomatic by using microscopy, culture, E. histolytica antigen ELISA, and conventional/real-time PCR methods. Results: Of the 840 samples analyzed, 4.3% (36/840), 2.6% (22/840), and 7.4% (62/840) of the stool samples were determined to be positive by E. histolytica antigen ELISA, and real-time PCR for E. histolytica and E. dispar, respectively. Thirty-five of the 62 (56.4%) samples positive for E. dispar and 20 of the 22 (91.0%) samples positive for E. histolytica were from dysenteric individuals as revealed by real-time PCR. Although there was no statistically significant difference in patients with diarrhea, a correlation might be seen between amoeba load and clinical outcome in those infected with E. histolytica, since amoeba load was usually determined 103 copies/mL or higher in patients with diarrhea. In this study, 3 different genotypes were defined in 16 isolates by using 6 loci (A-L, N-K2, D-A, R-R, S-D, and S-TGA-Q). Conclusion: Our results demonstrated that real-time PCR is a useful, reliable, and sensitive method for the determination of E. histolytica in stools and for differentiation from E. dispar. It is suggested that parasite load might affect clinical outcome.Öğe Radiological Imaging Features of Fasciola hepatica Infection A Pictorial Review(Medknow Publications & Media Pvt Ltd, 2012) Dusak, Abdurrahim; Onur, Mehmet R.; Cicek, Mutalip; Firat, Ugur; Ren, Tianbo; Dogra, Vikram S.Fascioliasis refers to a zoonosis caused by Fasciola hepatica, a trematode infecting herbivores, but also occurs in humans who ingest the metacercaria found in fresh water plants. Infection in humans is common in developing countries and is also not uncommon in Europe. Diagnosis of this infection is difficult, as the history and symptoms are nonspecific and stool analysis for eggs is negative until the disease is in an advanced state by when the parasite has reached the biliary system. The clinical course consists of two phases; first a hepatic parenchymal phase in which immature larvae invade the liver parenchyma, followed by a ductal phase characterized by the excretion of larvae into the bile ducts. Parenchymal Phase: Ultrasonography (US) findings are nonspecific in this early phase. Computerized tomography (CT) may demonstrate subcapsular low attenuation regions in the liver. Magnetic Resonance imaging (MRI) can also be utilized to establish liver parenchymal involvement, and is better than CT in characterizing hemorrhagic lesions, as well as identifying more lesions relative to CT. Ductal Phase: US examination is most useful at this stage, with its ability to demonstrate the live movement of the worms within the dilated ducts. A CT demonstrates dilated central biliary ducts with periportal tracking, whereas, mild ductal dilatation is poorly appreciated under MRI. Therefore, familiarity with the multimodality imaging features of fascioliasis, in combination with an available confirmatory enzyme-linked immunoassay, would be most helpful for early diagnosis.Öğe THE RELATIONSHIP BETWEEN TRACE ELEMENTS AND CERULOPLASMIN WITH SEVERITY OF FASCIOLIASIS PATIENTS(Carbone Editore, 2013) Basarali, Mustafa Kemal; Kaplan, Ibrahim; Cicek, Mutalip; Cakir, FatihThe aim of our study is to evaluate the relationship between trace elements, as zinc (Zn) and copper (Cu), and acute phase reactant ceruloplasmin (CP) levels during fascioliasis hepatic infection. 45 patients with fascioliasis and 38 healthy controls were enrolled in the study. Fascioliasis was diagnosed with ELISA IgG, stool examination and radiologic imaging. Number of females and males were determined as 34111 and 3018 in patient and control groups respectively. Mean age was 38.1 +/- 11.7 and 358 +/- 16.9 years in patient and control groups, respectively. Blood samples were collected to determine plasma Zn, Cu, and CP levels. As a result of the study serum Cu (from 1.4 to 1.8) and CP (from 26.7 to 33.4) levels were rised in while Zn (from 1.1 to 1.9) level was decreased in patient group. We determinated significant correlation (r: 0.781) of fasciola titers with ceruloplasmine that increased by acute phase in the patients with fascioliasis. In conclusion, an high correlation between CP and Cu levels in patients suffering from fascioliasis can be noted. On the other hand, low Zn levels, especially in endemic areas of disease, suggested that Zn can be given in addition to medical treatment, or as a dietary supplement. This situation may lead the way in terms of increasing the efficiency of treatment of fascioliasis.Öğe Sonographic Findings of Hepatobiliary Fascioliasis Accompanied by Extrahepatic Expansion and Ectopic Lesions(Wiley, 2014) Teke, Memik; Onder, Hakan; Cicek, Mutalip; Hamidi, Cihad; Goya, Cemil; Cetincakmak, Mehmet Guli; Hattapoglu, SalihObjectives-The aim of the study was to describe the sonographic findings of hepatobiliary fascioliasis with extrahepatic expansion and ectopic lesions. Methods-The study included 45 patients with fascioliasis. All diagnoses were confirmed via serologic enzyme-linked immunosorbent assays. Sonographic findings in the hepatobiliary system, extrahepatic expansion, and ectopic lesions were defined. Results-The most common hepatic lesions were subcapsular localized, small, confluent, multiple hypoechoic nodules with poorly defined borders. We also detected ectopic lesion in 5 patients (11.1%) and live parasites in the gallbladder and bile duct in 11 (24.4%). Conclusions-The large spectrum of entities in the differential diagnosis of hepatobiliary fascioliasis may lead to misdiagnosis and incorrect treatment. However, the diagnosis can be made when the characteristic sonographic features are seen, such as heterogeneity of the liver with multiple poorly defined hypoechoic-isoechoic lesions and multiple echogenic nonshadowing particles in the gallbladder or common bile ducts. Nonetheless, the differential diagnosis of fascioliasis versus other hepatic lesions may still be difficult. In these situations, pathologic confirmation should be performed to exclude the possibility of malignancy.Öğe Two Diarrhea Cases Caused by Cyclospora cayetanensis(Ankara Microbiology Soc, 2011) Cicek, Mutalip; Ucmak, Feyzullah; Ozekinci, TuncerCyclospora cayetanensis is an intestinal protozoon that has emerged as an important cause of endemic or epidemic diarrheal disease in children and adults worldwide. Cases of cyclosporiasis have been frequently missed, since it is difficult to detect the parasite in fecal sample, despite an increasing amount of data regarding this parasite. In this case report two patients admitted to hospital with complaints of diarrhea and abdominal pain, were presented. Blood and urine biochemistry of both of the patients were within the normal limits and no pathogenic bacteria were grown in their stool samples. Occult blood in stool were negative in both cases. Both of the cases had normal serum immunoglobulin levels and had negative viral hepatitis, HIV and autoimmune markers. Direct microscopic examination and modified acid-fast staining of the stool samples revealed C.cayetanensis oocysts. Clinical response and eradication of the parasite were achieved with two weeks trimethoprim/sulphamethoxazole (2 x 160/240 mg) therapy. Since both cases applied in July 2009, an epidemiological investigation was initiated, however, no relation was determined. Although Cyclospora infections are assumed to be endemic in our country, the sporadic case reports might be attributed to the lack of relevant information about the parasite by the clinicians, lack of appropriate laboratory diagnosis and specialized personel for parasitic examination. Thus, screening studies performed with appropriate diagnostic methods for Cyclospora, might provide more informative epidemiological data related to this infection in Turkey.
