Investigation of Some Sera Biomarker Levels in Fascioliasis Patient
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Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Kafkas Univ, Veteriner Fakultesi Dergisi
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Fasciola sp. that are generally known as liver trematode of sheep and cattle cause infections also in the human. In this study, we investigated in the sera of patients with fascioliasis how paraoxonase, total oxidant level, total antioxidant capacity, apolipoprotein A-I, apolipoprotein B, transferrin and nitric oxide levels are affected. For this purpose, 45 patients with fascioliasis and 38 healthy controls were enrolled in the study. Fascioliasis was diagnosed with ELISA IgG, stool examination and radiologic imaging. Number of females and males were determined as 34/11 and 30/8 in patient and control groups. Mean age was 38.1 +/- 11.7and 35.8 +/- 16.9 years in patient and control groups, respectively. A statistically significant difference was not detected between groups in terms of age, gender and body mass index (P>0.05). As the result of the study, paraoxonase (P<0.001), Apolipoprotein A-I (P<0.001), transferrin (P<0.001) and total antioxidant capacity (P<0.024) levels were found lower in patient group compared to control group and the difference was statistically significant (P<0.001). A difference was not detected between two groups in terms of apolipoprotein B levels. Lower paraoxonase, total antioxidant capacity, transferrin and Apolipoprotein A-I levels in patients with fascioliasis compared to controls and higher nitric oxide and total oxidant status may be guide for understanding pathogenesis and immunity of fascioliasis and for novel biomarkers that could aid for diagnosis.
Açıklama
Anahtar Kelimeler
Fascioliasis, Human, Sera Biomarker
Kaynak
Kafkas Universitesi Veteriner Fakultesi Dergisi
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
18
